diff --git a/docs/README.md b/docs/README.md
index 5263cf2e..cbee96fc 100644
--- a/docs/README.md
+++ b/docs/README.md
@@ -22,454 +22,454 @@ Zoom to Node: <select id="node_select">
 <p>
 <a href="./model-desc">Additional model files</a>
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 <title>Perl</title>
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+<!-- study_admin -->
+<g id="node9" class="node">
+<title>study_admin</title>
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+<!-- study_funding&#45;&gt;study -->
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diff --git a/docs/model-desc/ccdi-model-nodes-only.svg b/docs/model-desc/ccdi-model-nodes-only.svg
index c29b865f..adc4f56f 100644
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 <title>Perl</title>
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-<text text-anchor="middle" x="70.1938" y="-101.3" font-family="Times,serif" font-size="14.00" fill="#000000">study_admin</text>
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+<text text-anchor="middle" x="2218.0444" y="-362.3" font-family="Times,serif" font-size="14.00" fill="#000000">pdx</text>
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+<ellipse fill="none" stroke="#000000" cx="2029.0444" cy="-279" rx="44.393" ry="18"/>
+<text text-anchor="middle" x="2029.0444" y="-275.3" font-family="Times,serif" font-size="14.00" fill="#000000">sample</text>
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+<title>pdx&#45;&gt;sample</title>
+<path fill="none" stroke="#000000" d="M2195.1853,-355.4519C2189.0426,-352.8251 2182.3523,-350.1486 2176.0444,-348 2145.6367,-337.6426 2135.3974,-343.05 2106.0444,-330 2088.9364,-322.394 2071.4156,-311.1163 2057.4178,-301.0987"/>
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+<text text-anchor="middle" x="1370.0444" y="-449.3" font-family="Times,serif" font-size="14.00" fill="#000000">single_cell_sequencing_file</text>
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 <g id="node14" class="node">
 <title>participant</title>
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+<text text-anchor="middle" x="1479.0444" y="-101.3" font-family="Times,serif" font-size="14.00" fill="#000000">participant</text>
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+</g>
+<!-- sample&#45;&gt;pdx -->
+<g id="edge11" class="edge">
+<title>sample&#45;&gt;pdx</title>
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-<title>pdx</title>
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+<!-- clinical_measure_file -->
+<g id="node6" class="node">
+<title>clinical_measure_file</title>
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+<text text-anchor="middle" x="392.0444" y="-188.3" font-family="Times,serif" font-size="14.00" fill="#000000">clinical_measure_file</text>
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-<!-- sample&#45;&gt;pdx -->
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+<!-- clinical_measure_file&#45;&gt;study -->
+<g id="edge6" class="edge">
+<title>clinical_measure_file&#45;&gt;study</title>
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+</g>
+<!-- clinical_measure_file&#45;&gt;participant -->
+<g id="edge39" class="edge">
+<title>clinical_measure_file&#45;&gt;participant</title>
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 </g>
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+<g id="node7" class="node">
 <title>exposure</title>
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-<text text-anchor="middle" x="989.1938" y="-188.3" font-family="Times,serif" font-size="14.00" fill="#000000">exposure</text>
+<ellipse fill="none" stroke="#000000" cx="790.0444" cy="-192" rx="53.0913" ry="18"/>
+<text text-anchor="middle" x="790.0444" y="-188.3" font-family="Times,serif" font-size="14.00" fill="#000000">exposure</text>
 </g>
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+<g id="edge8" class="edge">
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-<!-- sequencing_file&#45;&gt;cell_line -->
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-<!-- sequencing_file&#45;&gt;sample -->
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+<!-- therapeutic_procedure -->
+<g id="node8" class="node">
+<title>therapeutic_procedure</title>
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+<text text-anchor="middle" x="979.0444" y="-188.3" font-family="Times,serif" font-size="14.00" fill="#000000">therapeutic_procedure</text>
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-<!-- sequencing_file&#45;&gt;pdx -->
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+<!-- therapeutic_procedure&#45;&gt;participant -->
+<g id="edge13" class="edge">
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-<text text-anchor="middle" x="480.1938" y="-275.3" font-family="Times,serif" font-size="14.00" fill="#000000">synonym</text>
+<!-- study_admin -->
+<g id="node9" class="node">
+<title>study_admin</title>
+<ellipse fill="none" stroke="#000000" cx="2215.0444" cy="-105" rx="70.3881" ry="18"/>
+<text text-anchor="middle" x="2215.0444" y="-101.3" font-family="Times,serif" font-size="14.00" fill="#000000">study_admin</text>
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-<!-- synonym&#45;&gt;sample -->
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+<!-- study_admin&#45;&gt;study -->
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-<!-- synonym&#45;&gt;participant -->
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+<!-- family_relationship -->
 <g id="node22" class="node">
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 </g>
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+<!-- pathology_file -->
 <g id="node23" class="node">
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+<g id="edge30" class="edge">
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+<!-- sequencing_file -->
 <g id="node24" class="node">
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diff --git a/docs/model-desc/ccdi-model-props.yml b/docs/model-desc/ccdi-model-props.yml
index 6b0504ad..7e751290 100644
--- a/docs/model-desc/ccdi-model-props.yml
+++ b/docs/model-desc/ccdi-model-props.yml
@@ -3172,6 +3172,7 @@ PropDefinitions:
       Enum:
         - 'CNS Diagnosis Category'
         - 'ICD-O-3.2'
+        - 'Indication for Study'
         - 'WHO CNS5 Integrated Diagnosis'
         - 'Unknown'
         - 'Not Reported'
diff --git a/docs/model-desc/ccdi-model.txt b/docs/model-desc/ccdi-model.txt
index c77dd7b7..f0ad1903 100644
--- a/docs/model-desc/ccdi-model.txt
+++ b/docs/model-desc/ccdi-model.txt
@@ -1,5 +1,5 @@
 repo https://github.com/CBIIT/ccdi-model
-commit 2989dee
+commit a56e422
 node	property	value_or_TYPE
 cell_line	cell_line_id	STRING
 cell_line	id	STRING
@@ -255,47 +255,47 @@ therapeutic_procedure	id	STRING
 therapeutic_procedure	therapeutic_procedure_id	STRING
 
 relationship	source_node	destination_node	property	value_or_TYPE
-of_cell_line	cell_line	participant	NA	NA
 of_cell_line	cell_line	sample	NA	NA
 of_cell_line	cell_line	study	NA	NA
+of_cell_line	cell_line	participant	NA	NA
 of_clinical_measure_file	clinical_measure_file	study	NA	NA
 of_clinical_measure_file_participant	clinical_measure_file	participant	NA	NA
 of_cytogenomic_file	cytogenomic_file	sample	NA	NA
-of_cytogenomic_file	cytogenomic_file	cell_line	NA	NA
 of_cytogenomic_file	cytogenomic_file	pdx	NA	NA
+of_cytogenomic_file	cytogenomic_file	cell_line	NA	NA
 of_diagnosis	diagnosis	participant	NA	NA
 of_exposure	exposure	participant	NA	NA
 of_family_relationship	family_relationship	participant	NA	NA
 of_follow_up	follow_up	participant	NA	NA
 of_medical_history	medical_history	participant	NA	NA
+of_methylation_array_file	methylation_array_file	cell_line	NA	NA
 of_methylation_array_file	methylation_array_file	sample	NA	NA
 of_methylation_array_file	methylation_array_file	pdx	NA	NA
-of_methylation_array_file	methylation_array_file	cell_line	NA	NA
 of_molecular_test	molecular_test	participant	NA	NA
 of_participant	participant	study	NA	NA
-of_pathology_file	pathology_file	cell_line	NA	NA
-of_pathology_file	pathology_file	pdx	NA	NA
 of_pathology_file	pathology_file	sample	NA	NA
-of_pdx	pdx	study	NA	NA
+of_pathology_file	pathology_file	pdx	NA	NA
+of_pathology_file	pathology_file	cell_line	NA	NA
 of_pdx	pdx	sample	NA	NA
+of_pdx	pdx	study	NA	NA
 of_publication	publication	study	NA	NA
 of_radiology_file	radiology_file	participant	NA	NA
 of_sample	sample	participant	NA	NA
 of_sample	sample	cell_line	NA	NA
 of_sample	sample	pdx	NA	NA
+of_sequencing_file	sequencing_file	cell_line	NA	NA
 of_sequencing_file	sequencing_file	sample	NA	NA
 of_sequencing_file	sequencing_file	pdx	NA	NA
-of_sequencing_file	sequencing_file	cell_line	NA	NA
-of_single_cell_sequencing_file	single_cell_sequencing_file	sample	NA	NA
 of_single_cell_sequencing_file	single_cell_sequencing_file	pdx	NA	NA
+of_single_cell_sequencing_file	single_cell_sequencing_file	sample	NA	NA
 of_single_cell_sequencing_file	single_cell_sequencing_file	cell_line	NA	NA
 of_study_admin	study_admin	study	NA	NA
 of_study_arm	study_arm	study	NA	NA
 of_study_funding	study_funding	study	NA	NA
 of_study_personnel	study_personnel	study	NA	NA
+of_synonym	synonym	participant	NA	NA
 of_synonym	synonym	study	NA	NA
 of_synonym	synonym	sample	NA	NA
-of_synonym	synonym	participant	NA	NA
 of_therapeutic_procedure	therapeutic_procedure	participant	NA	NA
 
 property	description