diff --git a/DESCRIPTION b/DESCRIPTION index 2277fca..bf7dcfe 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,8 +1,8 @@ Package: dreamlet Type: Package Title: Scalable differential expression analysis of single cell transcriptomics datasets with complex study designs -Version: 1.1.17 -Date: 2024-02-12 +Version: 1.1.18 +Date: 2024-02-14 Authors@R: person("Gabriel", "Hoffman", role=c("aut", "cre"), email="gabriel.hoffman@mssm.edu", comment=c(ORCID="0000-0002-0957-0224")) Description: Recent advances in single cell/nucleus transcriptomic technology has enabled collection of cohort-scale datasets to study cell type specific gene expression differences associated disease state, stimulus, and genetic regulation. The scale of these data, complex study designs, and low read count per cell mean that characterizing cell type specific molecular mechanisms requires a user-frieldly, purpose-build analytical framework. We have developed the dreamlet package that applies a pseudobulk approach and fits a regression model for each gene and cell cluster to test differential expression across individuals associated with a trait of interest. Use of precision-weighted linear mixed models enables accounting for repeated measures study designs, high dimensional batch effects, and varying sequencing depth or observed cells per biosample. VignetteBuilder: knitr diff --git a/NEWS.md b/NEWS.md index 290cb23..6cf07e3 100644 --- a/NEWS.md +++ b/NEWS.md @@ -1,4 +1,7 @@ +# dreamlet 1.1.18 + - bug fix + # dreamlet 1.1.17 - new functionality in `plotPCA()` and `outlierByAssay()` - works on any `list`, not just `dreamletProcessedData` diff --git a/docs/404.html b/docs/404.html index 6812b2a..50df57e 100644 --- a/docs/404.html +++ b/docs/404.html @@ -31,7 +31,7 @@ dreamlet - 1.1.17 + 1.1.18