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README.html
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<html>
<p>Model
files in the NEURON simulation environment (v8.0.0) from the paper:</p>
<p><b>"T-type Ca 2+ and persistent Na + currents synergistically elevate ventral, not dorsal, entorhinal
cortical stellate cell excitability.
”</b></p>
<p>By
Aleksandra Topczewska 1 , Elisabetta Giacalone 2 , Wendy S. Pratt 3 , Michele Migliore 2 , Annette
C. Dolphin 3 and Mala M. Shah 1* .
1 Pharmacology, School of Pharmacy, University College London, WC1N 4AX UK; 2 Institute
of Biophysics, National Research Council, 90146 Palermo, Italy; 3 Neuroscience, Physiology
and Pharmacology, University College London, WC1E 6BT, UK.
<p></p>
<p>Auto-launch
from ModelDB or:</p>
<p>Compile
the mod files with mknrndll (mswin or graphical mac) or nrnivmodl
(unix/linux)). Start the simulation by (unix/linux) typing on the
command line:</p>
<p>nrngui
mosinit.hoc</p>
<p>or
(mac os x) drag and dropping the mosinit.hoc file on the nrngui icon
or (mswin) double clicking on the mosinit.hoc file.</p>
<p><br/>
<br/>
</p>
<p>mosinit.hoc will reproduce the simulated traces in Fig.5 of the paper.</p>
<p>Click on buttons "50pA", "100pA", "200pA", "250pA" to run the simulations at different current injection in all the conditions:</p>
<p><br/>
- Control (black line)<p/>
<p/>
- No CaT (red line)<p/>
<p/>
- No NaP (blue line)<p/>
<p/>
- No CaT + No NaP (green line)<p/>
<p/>
Questions on how to use this model should be directed to elisabetta.giacalone@ibf.cnr.it
If you need more help running the model on your platform, please consult this page:<p/>
<a href="https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml">https://senselab.med.yale.edu/ModelDB/NEURON_DwnldGuide.cshtml</a>
<br/>
</p>
</html>