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<!DOCTYPE html>
<html>
<head>
<link rel="stylesheet" href="/static/sass/style.sass" />
<link rel="stylesheet" href="/static/sass/locomotive-scroll.sass" />
</head>
<body>
<nav>
<ul>
<li>
<span class="dropdown">Team <ion-icon name="chevron-down-outline"></ion-icon></span>
<ul class="submenu">
<li><a href="./wiki/team.html">Team Page</a></li>
<li><a href="./wiki/attributions.html">Attributions</a></li>
<li><a href="./wiki/collaborations.html">Collaborations</a></li>
</ul>
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<span class="dropdown">Project <ion-icon name="chevron-down-outline"></ion-icon></span>
<ul class="submenu">
<li><a href="./wiki/contribution.html">Contribution</a></li>
<li><a href="./wiki/description.html">Description</a></li>
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<span class="dropdown">Lab <ion-icon name="chevron-down-outline"></ion-icon></span>
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<li><a href="./wiki/design.html">Design</a></li>
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<li><a href="./wiki/notebook.html">Notebook</a></li>
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<li><a href="./wiki/parts.html">Parts</a></li>
<li><a href="./wiki/safety.html">Safety</a></li>
<li><a href="./wiki/hardware.html">Hardware</a></li>
</ul>
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<li>
<span class="dropdown">Human Practices <ion-icon name="chevron-down-outline"></ion-icon></span>
<ul class="submenu">
<li>
<a href="./wiki/implementation.html">Proposed Implementation</a>
</li>
<li><a href="./wiki/human-practices.html">Human Practices</a></li>
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<li><a href="./wiki/education.html">Education</a></li>
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</ul>
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</ul>
</nav>
<div id="smooth-wrapper" data-scroll-container>
<div class="landing-hero hero" data-scroll-section>
<div class="color" style="background: radial-gradient(circle farthest-side, rgb(29, 157, 27), transparent); opacity: 0.18" data-scroll></div>
<div class="text">
<h1 data-scroll data-scroll-speed="1.5">Schisto<span class="gradient-anim-fill">GONE</span></h1>
<h4 data-scroll data-scroll-speed="1.5">
Novel Prevention of Parasitic Diseases<span style="color: #ffe04a; margin: 0 1rem">•</span>CCA iGEM 2022
</h4>
</div>
<img class="img-bg img-bg-ultrawide" src="https://static.igem.wiki/teams/4261/wiki/landing-page/ultrawide.png" data-scroll />
<img
src="https://static.igem.wiki/teams/4261/wiki/landing-page/spark1.svg"
class="img-bg"
style="left: 3vw; top: 10vh; animation: spark1_float 10s ease infinite"
data-scroll
data-scroll-speed="-1"
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data-scroll
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<img
src="https://static.igem.wiki/teams/4261/wiki/landing-page/star2.svg"
class="img-bg"
style="bottom: 30vh; right: 9vw; width: 10rem; animation: star2_growth 5s ease-in-out infinite"
data-scroll
data-scroll-speed="-0.5"
/>
</div>
<div class="wrapper animation-wrapper">
<div class="container cols" data-scroll-section>
<div
class="color"
style="background: radial-gradient(circle farthest-side, #e455bc, transparent); opacity: 0.18; left: calc(100% + 20vw); top: -8vh"
data-scroll
></div>
<div class="content-box centered">
<h1 data-scroll data-scroll-call="countUp" id="wrap-counter"><span id="counter">240</span>,000,000</h1>
<p data-scroll data-scroll-offset="150">
That's how many people are afflicted each year with schistosomiasis, a neglected waterborne parasitic disease that is common in
third-world countries. If left untreated, it can cause symptoms such as fever, organ failure, and eventual death.
</p>
</div>
</div>
<div class="spacer"></div>
<div class="container cols" data-scroll-section>
<img class="img-bg" src="https://static.igem.wiki/teams/4261/wiki/landing-page/spark2.svg" style="left: -8vw" data-scroll />
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<p data-scroll data-scroll-offset="150">
The disease is caused by the parasite
<em>Schistosoma mansoni</em>, which invades freshwater snails as an intermediate host. Once it is grown, the parasite infects humans by
penetration through the skin.
</p>
</div>
<div class="content-anim">
<img
src="https://static.igem.wiki/teams/4261/wiki/landing-page/wormenterssnail.png"
class="drawing"
data-scroll
data-scroll-offset="50"
data-scroll-speed="0.5"
/>
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<div class="content-anim">
<lottie-player
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<div class="content-box">
<p data-scroll data-scroll-offset="150">
Currently, only one viable treatment for this disease exists—<span class="emph">praziquantel</span>. Unfortunately, due to a lack
of accessible healthcare in third-world countries, it often reaches schistosomiasis patients too late.
</p>
</div>
</div>
<div class="spacer"></div>
<div class="container cols" data-scroll-section>
<div
class="color"
style="background: radial-gradient(circle farthest-side, #5587e4, transparent); opacity: 0.18; left: -20vw; top: 10vh"
data-scroll
></div>
<div class="content-box">
<p data-scroll data-scroll-offset="150">
Our solution, SchistoGONE, targets schistosomiasis before it even infects humans. A bioreactor cultivates yeast cells that produce
<span class="emph">sanguinarine</span>, a compound that is toxic to parasites but not other animals.
</p>
</div>
<div class="content-anim">
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</div>
<div class="spacer"></div>
<div class="container cols" data-scroll-section>
<div class="content-anim">
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<div class="content-box">
<p data-scroll data-scroll-offset="150">
Plates with yeast will be placed on shores of infected waters, which will attract snails, the intermediate hosts for these parasites.
Inside the snail, the yeast cells will lyse and release the compound, curing the snails of the parasites.
</p>
</div>
</div>
<div class="container cols" data-scroll-section>
<div class="content-box centered">
<lottie-player
class="drawing"
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<p data-scroll data-scroll-offset="150">
By reducing schistosomiasis cases globally, we can improve economic conditions in third-world countries and break the poverty cycle.
</p>
<a href="./wiki/description.html" data-scroll
><button>
Learn More
<ion-icon name="arrow-forward-outline"></ion-icon></button
></a>
</div>
</div>
<div class="container-promo" data-scroll-section>
<h1>Watch our promo video</h1>
<img src="https://static.igem.wiki/teams/4261/wiki/landing-page/arrow-left.svg" alt="" />
<iframe
src="https://video.igem.org/videos/embed/9ff1291a-095e-465b-a09b-492b3688ca76"
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