CH02_FLYNN_ML4DD.ipynb

{
  "cells": [
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "1amqCjoSzCMW"
      },
      "source": [
        "# 📚 Chapter 2: Ligand-based Screening: Filtering & Similarity Searching"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
        "*This notebook contains the code examples in chapter 2. For readability, the chapter notebooks only contain runnable code blocks and section titles. They omit the rest of the material in the book, i.e., text paragraphs, figures (unless generated as part of one of the code blocks), equations, and pseudocode. I recommend reading the notebooks side-by-side with the book!*\n",
        "\n",
        "You can work through this notebook locally as well as via Google Colab:\n",
        "<a target=\"_blank\" href=\"https://colab.research.google.com/github/nrflynn2/ml-drug-discovery/blob/main/CH02_FLYNN_ML4DD.ipynb\">\n",
        "  <img src=\"https://colab.research.google.com/assets/colab-badge.svg\" alt=\"Open In Colab\"/>\n",
        "</a>\n",
        "\n",
        "This chapter covers\n",
        "- Virtual screening taxonomy with focus on ligand-based screening\n",
        "- How to acquire, curate, visualize, and represent molecule datasets\n",
        "- Compound filtering of undesirable properties and substructures\n",
        "- Similarity searching to uncover antimalarial hit compounds"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
        "## ⚙️ Part 0: Installation and Setup\n",
        "\n",
        "**❗️NOTE:** After setting up a local environment, install the required packages via:\n",
        "`!pip install -r https://raw.githubusercontent.com/nrflynn2/ml-drug-discovery/main/requirements.txt --quiet`\n",
        "\n",
        "**❗️NOTE:** If running notebook via Colab, be sure to install RDKit via: `!pip install rdkit`"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
        "### Import and Setup Packages "
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 6,
      "metadata": {
        "id": "0fcsIDXU9kO_"
      },
      "outputs": [],
      "source": [
        "!gzip -d data/Specs.sdf.gz"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 3,
      "metadata": {
        "id": "rl_70xI-9J2c"
      },
      "outputs": [],
      "source": [
        "import numpy as np\n",
        "import pandas as pd\n",
        "\n",
        "import matplotlib as mpl\n",
        "import matplotlib.pyplot as plt\n",
        "import seaborn as sns"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 4,
      "metadata": {
        "id": "7DJXVSwy9ESM"
      },
      "outputs": [],
      "source": [
        "np.random.seed(42)\n",
        "\n",
        "colors = [\"#A20025\", \"#6C8EBF\"]\n",
        "sns.set_palette(sns.color_palette(colors))"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 5,
      "metadata": {
        "id": "2uFKFw4eW896"
      },
      "outputs": [],
      "source": [
        "from rdkit.Chem import Draw\n",
        "d2d = Draw.MolDraw2DSVG(-1, -1)\n",
        "dopts = d2d.drawOptions()\n",
        "dopts.useBWAtomPalette()\n",
        "dopts.setHighlightColour((.635,.0,.145,.4))\n",
        "dopts.baseFontSize = 1.0\n",
        "dopts.additionalAtomLabelPadding = 0.15\n",
        "dopts.dotsPerAngstrom = 100"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {},
      "source": [
        "## 1️⃣ What is Virtual Screening?\n",
        "\n",
        "*Companion code does not accompany this section of the book.*"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "nZ5YHwqf0iTl"
      },
      "source": [
        "## 2️⃣ Loading a Virtual Screening Library"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "0w0xnmsl0pie"
      },
      "source": [
        "### Understanding the Dataset as a Structure Data File"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 7,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "GFP10Ef6-3pP",
        "outputId": "75d896df-d5e7-4a55-b697-fdec7fadfc3b"
      },
      "outputs": [
        {
          "name": "stderr",
          "output_type": "stream",
          "text": [
            "[10:03:48] Warning: ambiguous stereochemistry - linear bond arrangement - at atom 8 ignored\n",
            "[10:05:17] Warning: ambiguous stereochemistry - opposing bonds have opposite wedging - at atom 2 ignored.\n",
            "[10:05:33] Explicit valence for atom # 9 N, 4, is greater than permitted\n",
            "[10:05:33] ERROR: Could not sanitize molecule ending on line 6498564\n",
            "[10:05:33] ERROR: Explicit valence for atom # 9 N, 4, is greater than permitted\n",
            "[10:06:01] Explicit valence for atom # 9 N, 4, is greater than permitted\n",
            "[10:06:01] ERROR: Could not sanitize molecule ending on line 8305274\n",
            "[10:06:01] ERROR: Explicit valence for atom # 9 N, 4, is greater than permitted\n",
            "[10:06:01] Explicit valence for atom # 10 N, 4, is greater than permitted\n",
            "[10:06:01] ERROR: Could not sanitize molecule ending on line 8315499\n",
            "[10:06:01] ERROR: Explicit valence for atom # 10 N, 4, is greater than permitted\n",
            "[10:06:18] Warning: ambiguous stereochemistry - opposing bonds have opposite wedging - at atom 3 ignored.\n",
            "[10:06:18] Warning: ambiguous stereochemistry - opposing bonds have opposite wedging - at atom 2 ignored.\n",
            "[10:06:42] Warning: ambiguous stereochemistry - opposing bonds have opposite wedging - at atom 4 ignored.\n",
            "[10:06:42] Warning: ambiguous stereochemistry - opposing bonds have opposite wedging - at atom 4 ignored.\n",
            "[10:08:37] Warning: ambiguous stereochemistry - opposing bonds have opposite wedging - at atom 5 ignored.\n",
            "[10:08:37] Warning: ambiguous stereochemistry - opposing bonds have opposite wedging - at atom 4 ignored.\n",
            "[10:09:30] Explicit valence for atom # 2 N, 4, is greater than permitted\n",
            "[10:09:30] ERROR: Could not sanitize molecule ending on line 20625298\n",
            "[10:09:30] ERROR: Explicit valence for atom # 2 N, 4, is greater than permitted\n"
          ]
        }
      ],
      "source": [
        "from rdkit.Chem import PandasTools\n",
        "\n",
        "specs = PandasTools.LoadSDF(\n",
        "  \"data/Specs.sdf\", smilesName='smiles', molColName=None\n",
        ")[[\"PUBCHEM_SUBSTANCE_ID\", \"smiles\"]]\n",
        "\n",
        "PandasTools.AddMoleculeColumnToFrame(specs, 'smiles', 'mol')"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 8,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "yB7RcSRHE8l5",
        "outputId": "d336b91e-43ee-448f-f8ed-cbf74a4d4e9f"
      },
      "outputs": [
        {
          "data": {
            "text/plain": [
              "(212670, 3)"
            ]
          },
          "execution_count": 8,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "specs.shape"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 167
        },
        "id": "2mHPg1J5VHDE",
        "outputId": "6bbf5c54-044a-40f9-9bd5-78c8a9383f63"
      },
      "outputs": [
        {
          "data": {
            "image/png": "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",
            "text/plain": [
              "<rdkit.Chem.rdchem.Mol at 0x79b9faea7530>"
            ]
          },
          "execution_count": 10,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "from rdkit.Chem import MolFromSmiles\n",
        "\n",
        "mol = MolFromSmiles(specs.smiles[0])\n",
        "mol"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "pyj8DHgTVzd7",
        "outputId": "c52cb9e6-eecb-42cc-c663-ff0f3dc7e8df"
      },
      "outputs": [
        {
          "data": {
            "text/plain": [
              "rdkit.Chem.rdchem.Mol"
            ]
          },
          "execution_count": 11,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "type(mol)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "Cav5GtM-RQkC"
      },
      "outputs": [],
      "source": [
        "img = Draw.MolsToGridImage(\n",
        "  mols=[mol], molsPerRow=1, useSVG=True, drawOptions=dopts,\n",
        ")"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 221
        },
        "id": "7m3EtTctRZvh",
        "outputId": "ca25268b-95de-4f62-9fd7-aed1a8f76e50"
      },
      "outputs": [
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"200px\" height=\"200px\" viewBox=\"0 0 200 200\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"200.0\" height=\"200.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 190.9,124.3 L 188.3,112.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 179.8,103.1 L 168.0,99.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 168.0,99.4 L 153.6,112.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 164.8,98.4 L 152.9,109.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 153.6,112.6 L 135.0,106.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 135.0,106.8 L 130.7,87.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 137.5,104.5 L 134.0,88.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 130.7,87.7 L 118.2,83.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 108.3,74.7 L 103.1,64.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 104.0,66.4 L 108.0,53.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 101.2,65.5 L 105.2,52.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-7 atom-9\" d=\"M 103.1,64.6 L 85.8,73.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 85.8,73.6 L 94.8,90.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 94.8,90.9 L 77.5,100.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 76.1,99.1 L 75.5,112.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 79.0,99.2 L 78.4,112.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-11 atom-13\" d=\"M 77.5,100.0 L 67.1,93.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 54.9,92.7 L 43.7,98.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-14 atom-15\" d=\"M 43.7,98.6 L 27.2,88.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-14 atom-15\" d=\"M 40.7,100.1 L 27.1,91.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 27.2,88.1 L 28.0,68.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-15 atom-17\" d=\"M 27.2,88.1 L 9.9,97.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 9.9,97.1 L 9.1,116.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 12.8,99.0 L 12.1,115.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 9.1,116.7 L 25.6,127.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 25.6,127.1 L 42.9,118.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 25.7,123.7 L 40.0,116.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 42.9,118.1 L 59.4,128.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-10 atom-22\" d=\"M 94.8,90.9 L 103.9,108.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-22 atom-23\" d=\"M 103.9,108.2 L 123.2,111.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-22 atom-23\" d=\"M 105.5,111.4 L 120.6,113.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-23 atom-23 atom-24\" d=\"M 123.2,111.1 L 126.4,130.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-24 atom-24 atom-25\" d=\"M 126.4,130.4 L 109.1,139.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-24 atom-24 atom-25\" d=\"M 123.2,128.7 L 109.6,135.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-25 atom-25 atom-26\" d=\"M 109.1,139.4 L 106.3,158.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-26 atom-25 atom-27\" d=\"M 109.1,139.4 L 102.0,132.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-27 atom-5 atom-28\" d=\"M 130.7,87.7 L 145.1,74.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-28 atom-28 atom-29\" d=\"M 145.1,74.5 L 163.8,80.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-28 atom-28 atom-29\" d=\"M 145.9,77.8 L 161.3,82.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-29 atom-29 atom-2\" d=\"M 163.8,80.4 L 168.0,99.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-30 atom-10 atom-6\" d=\"M 94.8,90.9 L 106.0,85.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-31 atom-20 atom-14\" d=\"M 42.9,118.1 L 43.7,98.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-32 atom-27 atom-22\" d=\"M 98.8,118.5 L 103.9,108.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 154.4,112.0 L 153.6,112.6 L 152.7,112.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 135.9,107.1 L 135.0,106.8 L 134.8,105.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 103.3,65.1 L 103.1,64.6 L 102.2,65.0\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 86.6,73.2 L 85.8,73.6 L 86.2,74.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 78.4,99.5 L 77.5,100.0 L 77.0,99.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 10.8,96.7 L 9.9,97.1 L 9.9,98.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 9.1,115.7 L 9.1,116.7 L 9.9,117.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 24.8,126.6 L 25.6,127.1 L 26.4,126.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 122.2,111.0 L 123.2,111.1 L 123.3,112.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 126.3,129.4 L 126.4,130.4 L 125.6,130.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 144.4,75.2 L 145.1,74.5 L 146.1,74.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 162.8,80.1 L 163.8,80.4 L 164.0,81.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-1\" d=\"M 182.4 105.3 Q 182.4 103.1, 183.5 101.8 Q 184.6 100.6, 186.7 100.6 Q 188.7 100.6, 189.8 101.8 Q 190.9 103.1, 190.9 105.3 Q 190.9 107.5, 189.8 108.8 Q 188.7 110.1, 186.7 110.1 Q 184.6 110.1, 183.5 108.8 Q 182.4 107.5, 182.4 105.3 M 186.7 109.0 Q 188.1 109.0, 188.8 108.1 Q 189.6 107.1, 189.6 105.3 Q 189.6 103.5, 188.8 102.6 Q 188.1 101.6, 186.7 101.6 Q 185.2 101.6, 184.5 102.5 Q 183.7 103.5, 183.7 105.3 Q 183.7 107.1, 184.5 108.1 Q 185.2 109.0, 186.7 109.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-6\" d=\"M 110.1 77.3 L 113.1 82.2 Q 113.4 82.6, 113.9 83.5 Q 114.4 84.4, 114.4 84.4 L 114.4 77.3 L 115.6 77.3 L 115.6 86.5 L 114.3 86.5 L 111.1 81.2 Q 110.7 80.5, 110.3 79.8 Q 109.9 79.1, 109.8 78.9 L 109.8 86.5 L 108.6 86.5 L 108.6 77.3 L 110.1 77.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-8\" d=\"M 104.7 46.0 Q 104.7 43.8, 105.8 42.5 Q 106.9 41.3, 108.9 41.3 Q 111.0 41.3, 112.0 42.5 Q 113.1 43.8, 113.1 46.0 Q 113.1 48.2, 112.0 49.5 Q 110.9 50.8, 108.9 50.8 Q 106.9 50.8, 105.8 49.5 Q 104.7 48.2, 104.7 46.0 M 108.9 49.7 Q 110.3 49.7, 111.1 48.8 Q 111.8 47.8, 111.8 46.0 Q 111.8 44.2, 111.1 43.3 Q 110.3 42.3, 108.9 42.3 Q 107.5 42.3, 106.7 43.2 Q 106.0 44.1, 106.0 46.0 Q 106.0 47.8, 106.7 48.8 Q 107.5 49.7, 108.9 49.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 72.4 119.5 Q 72.4 117.3, 73.5 116.1 Q 74.6 114.8, 76.7 114.8 Q 78.7 114.8, 79.8 116.1 Q 80.9 117.3, 80.9 119.5 Q 80.9 121.8, 79.8 123.0 Q 78.7 124.3, 76.7 124.3 Q 74.6 124.3, 73.5 123.0 Q 72.4 121.8, 72.4 119.5 M 76.7 123.3 Q 78.1 123.3, 78.8 122.3 Q 79.6 121.4, 79.6 119.5 Q 79.6 117.7, 78.8 116.8 Q 78.1 115.9, 76.7 115.9 Q 75.3 115.9, 74.5 116.8 Q 73.8 117.7, 73.8 119.5 Q 73.8 121.4, 74.5 122.3 Q 75.3 123.3, 76.7 123.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-13\" d=\"M 59.0 84.9 L 62.0 89.8 Q 62.3 90.3, 62.8 91.1 Q 63.3 92.0, 63.3 92.1 L 63.3 84.9 L 64.5 84.9 L 64.5 94.1 L 63.2 94.1 L 60.0 88.8 Q 59.6 88.2, 59.2 87.4 Q 58.8 86.7, 58.7 86.5 L 58.7 94.1 L 57.5 94.1 L 57.5 84.9 L 59.0 84.9 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-13\" d=\"M 57.4 74.8 L 58.7 74.8 L 58.7 78.7 L 63.4 78.7 L 63.4 74.8 L 64.6 74.8 L 64.6 84.0 L 63.4 84.0 L 63.4 79.7 L 58.7 79.7 L 58.7 84.0 L 57.4 84.0 L 57.4 74.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-27\" d=\"M 90.9 125.8 Q 90.9 123.5, 92.0 122.3 Q 93.1 121.1, 95.2 121.1 Q 97.2 121.1, 98.3 122.3 Q 99.4 123.5, 99.4 125.8 Q 99.4 128.0, 98.3 129.3 Q 97.2 130.5, 95.2 130.5 Q 93.1 130.5, 92.0 129.3 Q 90.9 128.0, 90.9 125.8 M 95.2 129.5 Q 96.6 129.5, 97.3 128.6 Q 98.1 127.6, 98.1 125.8 Q 98.1 123.9, 97.3 123.0 Q 96.6 122.1, 95.2 122.1 Q 93.8 122.1, 93.0 123.0 Q 92.2 123.9, 92.2 125.8 Q 92.2 127.6, 93.0 128.6 Q 93.8 129.5, 95.2 129.5 \" fill=\"#000000\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "execution_count": 13,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "img"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "7pExqGuUsG3A"
      },
      "outputs": [],
      "source": [
        "with open(\"figures/ch02/example_mol.svg\", \"w\") as f:\n",
        "  f.write(img.data)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "F-to_j6kgcy2"
      },
      "source": [
        "### Molecular Descriptors"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 9,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "qU1cpMSxXjHp",
        "outputId": "762a9de3-b062-470d-b01d-2658b59b55af"
      },
      "outputs": [
        {
          "name": "stdout",
          "output_type": "stream",
          "text": [
            "211\n",
            "[('MaxAbsEStateIndex', <function MaxAbsEStateIndex at 0x7fbe0b9e70a0>), ('MaxEStateIndex', <function MaxEStateIndex at 0x7fbe0b9e71c0>), ('MinAbsEStateIndex', <function MinAbsEStateIndex at 0x7fbe0b9e7010>)]\n"
          ]
        }
      ],
      "source": [
        "from rdkit.Chem import Descriptors\n",
        "print(len(Descriptors._descList))\n",
        "print(Descriptors._descList[:3])"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 10,
      "metadata": {
        "id": "CysxlFF3aaT3"
      },
      "outputs": [],
      "source": [
        "RDKIT_DESCRIPTORS = { desc : func for desc, func in Descriptors._descList }\n",
        "RO5_PROPS = ['ExactMolWt', 'NumHAcceptors', 'NumHDonors', 'MolLogP']\n",
        "\n",
        "def compute_descriptors(mol, func, missing_val=None):\n",
        "  try:\n",
        "    return func(mol)\n",
        "  except:\n",
        "    return missing_val\n",
        "\n",
        "for desc in RO5_PROPS:\n",
        "  specs[desc] = specs[\"mol\"].apply(\n",
        "    lambda x: compute_descriptors(x, RDKIT_DESCRIPTORS[desc])\n",
        "  )\n",
        "\n",
        "specs = specs.dropna(subset=RO5_PROPS)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 206
        },
        "id": "IuNSIcFoehys",
        "outputId": "8b57bc01-7c7e-458a-a787-4329b2716455"
      },
      "outputs": [
        {
          "data": {
            "text/html": [
              "\n",
              "  <div id=\"df-6f62e497-fd2c-4c45-bd63-a3bf36537b0a\" class=\"colab-df-container\">\n",
              "    <div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>PUBCHEM_SUBSTANCE_ID</th>\n",
              "      <th>smiles</th>\n",
              "      <th>mol</th>\n",
              "      <th>ExactMolWt</th>\n",
              "      <th>NumHAcceptors</th>\n",
              "      <th>NumHDonors</th>\n",
              "      <th>MolLogP</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>0</th>\n",
              "      <td>469753576</td>\n",
              "      <td>COc1ccc(N2C(=O)CC2(C(=O)Nc2c(C)cccc2C)c2ccc(C)...</td>\n",
              "      <td>&lt;rdkit.Chem.rdchem.Mol object at 0x7b5f958bbf40&gt;</td>\n",
              "      <td>404.173607</td>\n",
              "      <td>4</td>\n",
              "      <td>1</td>\n",
              "      <td>4.48436</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>1</th>\n",
              "      <td>469753575</td>\n",
              "      <td>CCOC(=O)c1ccc(NC2SC(=O)N(Cc3ccc(C(=O)OC)cc3)C2...</td>\n",
              "      <td>&lt;rdkit.Chem.rdchem.Mol object at 0x7b5f958bbe60&gt;</td>\n",
              "      <td>428.104207</td>\n",
              "      <td>8</td>\n",
              "      <td>1</td>\n",
              "      <td>3.28350</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>2</th>\n",
              "      <td>469753574</td>\n",
              "      <td>Cc1cc(Br)cc([N+](=O)[O-])c1N</td>\n",
              "      <td>&lt;rdkit.Chem.rdchem.Mol object at 0x7b5f958bbdf0&gt;</td>\n",
              "      <td>229.969090</td>\n",
              "      <td>3</td>\n",
              "      <td>1</td>\n",
              "      <td>2.24792</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>3</th>\n",
              "      <td>469753573</td>\n",
              "      <td>Oc1ccc(CN2CCN(c3ccccn3)CC2)c2cccnc12</td>\n",
              "      <td>&lt;rdkit.Chem.rdchem.Mol object at 0x7b5f958bbd80&gt;</td>\n",
              "      <td>320.163711</td>\n",
              "      <td>5</td>\n",
              "      <td>1</td>\n",
              "      <td>2.65760</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>4</th>\n",
              "      <td>469753572</td>\n",
              "      <td>Cc1cccnc1C(N)=O</td>\n",
              "      <td>&lt;rdkit.Chem.rdchem.Mol object at 0x7b5f958bbd10&gt;</td>\n",
              "      <td>136.063663</td>\n",
              "      <td>2</td>\n",
              "      <td>1</td>\n",
              "      <td>0.48892</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "</div>\n",
              "    <div class=\"colab-df-buttons\">\n",
              "\n",
              "  <div class=\"colab-df-container\">\n",
              "    <button class=\"colab-df-convert\" onclick=\"convertToInteractive('df-6f62e497-fd2c-4c45-bd63-a3bf36537b0a')\"\n",
              "            title=\"Convert this dataframe to an interactive table.\"\n",
              "            style=\"display:none;\">\n",
              "\n",
              "  <svg xmlns=\"http://www.w3.org/2000/svg\" height=\"24px\" viewBox=\"0 -960 960 960\">\n",
              "    <path d=\"M120-120v-720h720v720H120Zm60-500h600v-160H180v160Zm220 220h160v-160H400v160Zm0 220h160v-160H400v160ZM180-400h160v-160H180v160Zm440 0h160v-160H620v160ZM180-180h160v-160H180v160Zm440 0h160v-160H620v160Z\"/>\n",
              "  </svg>\n",
              "    </button>\n",
              "\n",
              "  <style>\n",
              "    .colab-df-container {\n",
              "      display:flex;\n",
              "      gap: 12px;\n",
              "    }\n",
              "\n",
              "    .colab-df-convert {\n",
              "      background-color: #E8F0FE;\n",
              "      border: none;\n",
              "      border-radius: 50%;\n",
              "      cursor: pointer;\n",
              "      display: none;\n",
              "      fill: #1967D2;\n",
              "      height: 32px;\n",
              "      padding: 0 0 0 0;\n",
              "      width: 32px;\n",
              "    }\n",
              "\n",
              "    .colab-df-convert:hover {\n",
              "      background-color: #E2EBFA;\n",
              "      box-shadow: 0px 1px 2px rgba(60, 64, 67, 0.3), 0px 1px 3px 1px rgba(60, 64, 67, 0.15);\n",
              "      fill: #174EA6;\n",
              "    }\n",
              "\n",
              "    .colab-df-buttons div {\n",
              "      margin-bottom: 4px;\n",
              "    }\n",
              "\n",
              "    [theme=dark] .colab-df-convert {\n",
              "      background-color: #3B4455;\n",
              "      fill: #D2E3FC;\n",
              "    }\n",
              "\n",
              "    [theme=dark] .colab-df-convert:hover {\n",
              "      background-color: #434B5C;\n",
              "      box-shadow: 0px 1px 3px 1px rgba(0, 0, 0, 0.15);\n",
              "      filter: drop-shadow(0px 1px 2px rgba(0, 0, 0, 0.3));\n",
              "      fill: #FFFFFF;\n",
              "    }\n",
              "  </style>\n",
              "\n",
              "    <script>\n",
              "      const buttonEl =\n",
              "        document.querySelector('#df-6f62e497-fd2c-4c45-bd63-a3bf36537b0a button.colab-df-convert');\n",
              "      buttonEl.style.display =\n",
              "        google.colab.kernel.accessAllowed ? 'block' : 'none';\n",
              "\n",
              "      async function convertToInteractive(key) {\n",
              "        const element = document.querySelector('#df-6f62e497-fd2c-4c45-bd63-a3bf36537b0a');\n",
              "        const dataTable =\n",
              "          await google.colab.kernel.invokeFunction('convertToInteractive',\n",
              "                                                    [key], {});\n",
              "        if (!dataTable) return;\n",
              "\n",
              "        const docLinkHtml = 'Like what you see? Visit the ' +\n",
              "          '<a target=\"_blank\" href=https://colab.research.google.com/notebooks/data_table.ipynb>data table notebook</a>'\n",
              "          + ' to learn more about interactive tables.';\n",
              "        element.innerHTML = '';\n",
              "        dataTable['output_type'] = 'display_data';\n",
              "        await google.colab.output.renderOutput(dataTable, element);\n",
              "        const docLink = document.createElement('div');\n",
              "        docLink.innerHTML = docLinkHtml;\n",
              "        element.appendChild(docLink);\n",
              "      }\n",
              "    </script>\n",
              "  </div>\n",
              "\n",
              "\n",
              "<div id=\"df-af7499ae-9ead-4445-8035-a2102b4d8707\">\n",
              "  <button class=\"colab-df-quickchart\" onclick=\"quickchart('df-af7499ae-9ead-4445-8035-a2102b4d8707')\"\n",
              "            title=\"Suggest charts.\"\n",
              "            style=\"display:none;\">\n",
              "\n",
              "<svg xmlns=\"http://www.w3.org/2000/svg\" height=\"24px\"viewBox=\"0 0 24 24\"\n",
              "     width=\"24px\">\n",
              "    <g>\n",
              "        <path d=\"M19 3H5c-1.1 0-2 .9-2 2v14c0 1.1.9 2 2 2h14c1.1 0 2-.9 2-2V5c0-1.1-.9-2-2-2zM9 17H7v-7h2v7zm4 0h-2V7h2v10zm4 0h-2v-4h2v4z\"/>\n",
              "    </g>\n",
              "</svg>\n",
              "  </button>\n",
              "\n",
              "<style>\n",
              "  .colab-df-quickchart {\n",
              "    background-color: #E8F0FE;\n",
              "    border: none;\n",
              "    border-radius: 50%;\n",
              "    cursor: pointer;\n",
              "    display: none;\n",
              "    fill: #1967D2;\n",
              "    height: 32px;\n",
              "    padding: 0 0 0 0;\n",
              "    width: 32px;\n",
              "  }\n",
              "\n",
              "  .colab-df-quickchart:hover {\n",
              "    background-color: #E2EBFA;\n",
              "    box-shadow: 0px 1px 2px rgba(60, 64, 67, 0.3), 0px 1px 3px 1px rgba(60, 64, 67, 0.15);\n",
              "    fill: #174EA6;\n",
              "  }\n",
              "\n",
              "  [theme=dark] .colab-df-quickchart {\n",
              "    background-color: #3B4455;\n",
              "    fill: #D2E3FC;\n",
              "  }\n",
              "\n",
              "  [theme=dark] .colab-df-quickchart:hover {\n",
              "    background-color: #434B5C;\n",
              "    box-shadow: 0px 1px 3px 1px rgba(0, 0, 0, 0.15);\n",
              "    filter: drop-shadow(0px 1px 2px rgba(0, 0, 0, 0.3));\n",
              "    fill: #FFFFFF;\n",
              "  }\n",
              "</style>\n",
              "\n",
              "  <script>\n",
              "    async function quickchart(key) {\n",
              "      const charts = await google.colab.kernel.invokeFunction(\n",
              "          'suggestCharts', [key], {});\n",
              "    }\n",
              "    (() => {\n",
              "      let quickchartButtonEl =\n",
              "        document.querySelector('#df-af7499ae-9ead-4445-8035-a2102b4d8707 button');\n",
              "      quickchartButtonEl.style.display =\n",
              "        google.colab.kernel.accessAllowed ? 'block' : 'none';\n",
              "    })();\n",
              "  </script>\n",
              "</div>\n",
              "    </div>\n",
              "  </div>\n"
            ],
            "text/plain": [
              "  PUBCHEM_SUBSTANCE_ID                                             smiles  \\\n",
              "0            469753576  COc1ccc(N2C(=O)CC2(C(=O)Nc2c(C)cccc2C)c2ccc(C)...   \n",
              "1            469753575  CCOC(=O)c1ccc(NC2SC(=O)N(Cc3ccc(C(=O)OC)cc3)C2...   \n",
              "2            469753574                       Cc1cc(Br)cc([N+](=O)[O-])c1N   \n",
              "3            469753573               Oc1ccc(CN2CCN(c3ccccn3)CC2)c2cccnc12   \n",
              "4            469753572                                    Cc1cccnc1C(N)=O   \n",
              "\n",
              "                                                mol  ExactMolWt  \\\n",
              "0  <rdkit.Chem.rdchem.Mol object at 0x7b5f958bbf40>  404.173607   \n",
              "1  <rdkit.Chem.rdchem.Mol object at 0x7b5f958bbe60>  428.104207   \n",
              "2  <rdkit.Chem.rdchem.Mol object at 0x7b5f958bbdf0>  229.969090   \n",
              "3  <rdkit.Chem.rdchem.Mol object at 0x7b5f958bbd80>  320.163711   \n",
              "4  <rdkit.Chem.rdchem.Mol object at 0x7b5f958bbd10>  136.063663   \n",
              "\n",
              "   NumHAcceptors  NumHDonors  MolLogP  \n",
              "0              4           1  4.48436  \n",
              "1              8           1  3.28350  \n",
              "2              3           1  2.24792  \n",
              "3              5           1  2.65760  \n",
              "4              2           1  0.48892  "
            ]
          },
          "execution_count": 12,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "specs.head()"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 12,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 300
        },
        "id": "HCq2fILYfn1g",
        "outputId": "83afa417-6b41-4a69-d4e0-57d10e967fe0"
      },
      "outputs": [
        {
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>ExactMolWt</th>\n",
              "      <th>NumHAcceptors</th>\n",
              "      <th>NumHDonors</th>\n",
              "      <th>MolLogP</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>count</th>\n",
              "      <td>212670.000000</td>\n",
              "      <td>212670.000000</td>\n",
              "      <td>212670.000000</td>\n",
              "      <td>212670.000000</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>mean</th>\n",
              "      <td>371.738321</td>\n",
              "      <td>4.512531</td>\n",
              "      <td>0.990046</td>\n",
              "      <td>3.917192</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>std</th>\n",
              "      <td>93.585321</td>\n",
              "      <td>1.905391</td>\n",
              "      <td>0.796672</td>\n",
              "      <td>1.587613</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>min</th>\n",
              "      <td>68.025421</td>\n",
              "      <td>0.000000</td>\n",
              "      <td>0.000000</td>\n",
              "      <td>-4.195200</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>25%</th>\n",
              "      <td>306.136828</td>\n",
              "      <td>3.000000</td>\n",
              "      <td>0.000000</td>\n",
              "      <td>2.885940</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>50%</th>\n",
              "      <td>369.020203</td>\n",
              "      <td>4.000000</td>\n",
              "      <td>1.000000</td>\n",
              "      <td>3.855710</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>75%</th>\n",
              "      <td>432.133005</td>\n",
              "      <td>6.000000</td>\n",
              "      <td>1.000000</td>\n",
              "      <td>4.923815</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>max</th>\n",
              "      <td>1161.548016</td>\n",
              "      <td>21.000000</td>\n",
              "      <td>8.000000</td>\n",
              "      <td>15.329400</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "</div>"
            ],
            "text/plain": [
              "          ExactMolWt  NumHAcceptors     NumHDonors        MolLogP\n",
              "count  212670.000000  212670.000000  212670.000000  212670.000000\n",
              "mean      371.738321       4.512531       0.990046       3.917192\n",
              "std        93.585321       1.905391       0.796672       1.587613\n",
              "min        68.025421       0.000000       0.000000      -4.195200\n",
              "25%       306.136828       3.000000       0.000000       2.885940\n",
              "50%       369.020203       4.000000       1.000000       3.855710\n",
              "75%       432.133005       6.000000       1.000000       4.923815\n",
              "max      1161.548016      21.000000       8.000000      15.329400"
            ]
          },
          "execution_count": 12,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "specs.describe()"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "f2sUkBJ006JI"
      },
      "source": [
        "## 3️⃣ Compound Filters"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "W7eAtc0G08r-"
      },
      "source": [
        "### Property-based Filters"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 19,
      "metadata": {},
      "outputs": [],
      "source": [
        "def lipinski_filter(row):\n",
        "    \"\"\"\n",
        "    Apply Lipinski's Rule of Five to filter molecules.\n",
        "    Returns True if the molecule violates no more than one rule.\n",
        "    \"\"\"\n",
        "    violations = 0\n",
        "    # Check each rule\n",
        "    if row[3] > 500: violations += 1\n",
        "    if row[6] > 5: violations += 1\n",
        "    if row[5] > 5: violations += 1\n",
        "    if row[4] > 10: violations += 1\n",
        "\n",
        "    # Return True if no more than one rule is violated\n",
        "    return violations <= 1"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 20,
      "metadata": {},
      "outputs": [],
      "source": [
        "specs[\"ro5_compliant\"] = specs.apply(lipinski_filter, axis=1)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 22,
      "metadata": {
        "id": "l7nuVcE4fMzy"
      },
      "outputs": [],
      "source": [
        "specs_ro5_compliant = specs[specs[\"ro5_compliant\"]]\n",
        "specs_ro5_violated = specs[~specs[\"ro5_compliant\"]]"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 23,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "RqVwtGBXJoc4",
        "outputId": "e373f7b3-28c7-4f95-84a5-feda45c1b62b"
      },
      "outputs": [
        {
          "name": "stdout",
          "output_type": "stream",
          "text": [
            "Compound library size pre-RO5 filter: 212670\n",
            "Compound library size post-RO5 filter: 199481\n"
          ]
        }
      ],
      "source": [
        "print(f\"Compound library size pre-RO5 filter: {len(specs)}\")\n",
        "print(f\"Compound library size post-RO5 filter: {len(specs_ro5_compliant)}\")"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 24,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 300
        },
        "id": "-STLXI4GDh2Z",
        "outputId": "db68dc8e-4507-4c19-abdf-2d83205c67a3"
      },
      "outputs": [
        {
          "data": {
            "text/html": [
              "<div>\n",
              "<style scoped>\n",
              "    .dataframe tbody tr th:only-of-type {\n",
              "        vertical-align: middle;\n",
              "    }\n",
              "\n",
              "    .dataframe tbody tr th {\n",
              "        vertical-align: top;\n",
              "    }\n",
              "\n",
              "    .dataframe thead th {\n",
              "        text-align: right;\n",
              "    }\n",
              "</style>\n",
              "<table border=\"1\" class=\"dataframe\">\n",
              "  <thead>\n",
              "    <tr style=\"text-align: right;\">\n",
              "      <th></th>\n",
              "      <th>ExactMolWt</th>\n",
              "      <th>NumHAcceptors</th>\n",
              "      <th>NumHDonors</th>\n",
              "      <th>MolLogP</th>\n",
              "    </tr>\n",
              "  </thead>\n",
              "  <tbody>\n",
              "    <tr>\n",
              "      <th>count</th>\n",
              "      <td>199481.000000</td>\n",
              "      <td>199481.000000</td>\n",
              "      <td>199481.000000</td>\n",
              "      <td>199481.000000</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>mean</th>\n",
              "      <td>359.359352</td>\n",
              "      <td>4.398524</td>\n",
              "      <td>0.994050</td>\n",
              "      <td>3.745281</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>std</th>\n",
              "      <td>81.695399</td>\n",
              "      <td>1.827768</td>\n",
              "      <td>0.795352</td>\n",
              "      <td>1.448762</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>min</th>\n",
              "      <td>68.025421</td>\n",
              "      <td>0.000000</td>\n",
              "      <td>0.000000</td>\n",
              "      <td>-3.679400</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>25%</th>\n",
              "      <td>302.036128</td>\n",
              "      <td>3.000000</td>\n",
              "      <td>0.000000</td>\n",
              "      <td>2.818100</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>50%</th>\n",
              "      <td>361.142641</td>\n",
              "      <td>4.000000</td>\n",
              "      <td>1.000000</td>\n",
              "      <td>3.744100</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>75%</th>\n",
              "      <td>419.067284</td>\n",
              "      <td>6.000000</td>\n",
              "      <td>1.000000</td>\n",
              "      <td>4.697100</td>\n",
              "    </tr>\n",
              "    <tr>\n",
              "      <th>max</th>\n",
              "      <td>758.331564</td>\n",
              "      <td>18.000000</td>\n",
              "      <td>8.000000</td>\n",
              "      <td>10.683600</td>\n",
              "    </tr>\n",
              "  </tbody>\n",
              "</table>\n",
              "</div>"
            ],
            "text/plain": [
              "          ExactMolWt  NumHAcceptors     NumHDonors        MolLogP\n",
              "count  199481.000000  199481.000000  199481.000000  199481.000000\n",
              "mean      359.359352       4.398524       0.994050       3.745281\n",
              "std        81.695399       1.827768       0.795352       1.448762\n",
              "min        68.025421       0.000000       0.000000      -3.679400\n",
              "25%       302.036128       3.000000       0.000000       2.818100\n",
              "50%       361.142641       4.000000       1.000000       3.744100\n",
              "75%       419.067284       6.000000       1.000000       4.697100\n",
              "max       758.331564      18.000000       8.000000      10.683600"
            ]
          },
          "execution_count": 24,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "specs_ro5_compliant.describe()"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "8ACGKRzY1BLT"
      },
      "source": [
        "**Code for Figure 2.6. Comparison of RO5 compliant and non-compliant distributions for exact molecular weight**"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 524
        },
        "id": "sKwXo9OM3vB6",
        "outputId": "b0ecc1d5-7009-4301-8ee9-9ad2cabb27dc"
      },
      "outputs": [
        {
          "data": {
            "text/plain": [
              "<Figure size 640x480 with 0 Axes>"
            ]
          },
          "metadata": {},
          "output_type": "display_data"
        },
        {
          "data": {
            "image/png": "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",
            "text/plain": [
              "<Figure size 609.986x500 with 1 Axes>"
            ]
          },
          "metadata": {},
          "output_type": "display_data"
        }
      ],
      "source": [
        "plt.figure()\n",
        "sns.displot(specs, x='ExactMolWt', hue='ro5_compliant', kde=True)\n",
        "plt.xlabel('Exact Molecular Weight')\n",
        "plt.tight_layout()\n",
        "plt.savefig('figures/ch02/exactmolwt_dist.png', bbox_inches='tight', dpi=600)\n",
        "plt.savefig('figures/ch02/exactmolwt_dist.pdf', bbox_inches='tight', dpi=600)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "OkUsIMRZevR7"
      },
      "outputs": [],
      "source": [
        "ro5_avgs_df = pd.DataFrame(data = {\n",
        "    'property' : ['NumHAcceptors', 'NumHDonors', 'MolLogP'],\n",
        "    'RO5 Compliant Mols' : [specs_ro5_compliant['NumHAcceptors'].mean(), specs_ro5_compliant['NumHDonors'].mean(), specs_ro5_compliant['MolLogP'].mean()],\n",
        "    'RO5 Violated Mols' : [specs_ro5_violated['NumHAcceptors'].mean(), specs_ro5_violated['NumHDonors'].mean(), specs_ro5_violated['MolLogP'].mean()]\n",
        "})"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "5usuCT_q91et"
      },
      "outputs": [],
      "source": [
        "ro5_avgs_df['rel_change'] = (ro5_avgs_df['RO5 Compliant Mols'] - ro5_avgs_df['RO5 Violated Mols']) / ro5_avgs_df['RO5 Violated Mols']\n",
        "ordered_df = ro5_avgs_df.sort_values(by='RO5 Compliant Mols')\n",
        "my_range = range(1, len(ordered_df.index) + 1)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 487
        },
        "id": "X_ylKvDi_S0H",
        "outputId": "b5d4846f-5a5c-4701-c430-9f1a3202fa3d"
      },
      "outputs": [
        {
          "data": {
            "image/png": "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",
            "text/plain": [
              "<Figure size 640x480 with 1 Axes>"
            ]
          },
          "metadata": {},
          "output_type": "display_data"
        }
      ],
      "source": [
        "plt.figure()\n",
        "plt.axes(frameon=False)\n",
        "plt.hlines(y=my_range, xmin=ordered_df['RO5 Violated Mols'], xmax=ordered_df['RO5 Compliant Mols'], color='#B0ABAC')\n",
        "\n",
        "for x, y, ann in zip(ordered_df['RO5 Compliant Mols'], my_range, ordered_df['rel_change']):\n",
        "  if y > 1:\n",
        "    plt.text(x - 0.1, y, f'{ann * 100:.1f}%', ha='right', va='center')\n",
        "  else:\n",
        "    plt.text(x + 0.1, y, f'+{ann * 100:.1f}%', ha='left', va='center')\n",
        "\n",
        "plt.scatter(ordered_df['RO5 Violated Mols'], my_range, zorder=3, label=\"RO5 Violated Mols\")\n",
        "plt.scatter(ordered_df['RO5 Compliant Mols'], my_range, zorder=3, label=\"RO5 Compliant Mols\")\n",
        "plt.legend(ncol=2, bbox_to_anchor=(1.,1.01), loc=\"lower right\", frameon=False)\n",
        "#plt.legend(loc=\"lower right\", frameon=False)\n",
        "\n",
        "plt.yticks(my_range, ordered_df['property'])\n",
        "plt.xlabel('Property Value')\n",
        "plt.ylabel('Property')\n",
        "plt.tight_layout()\n",
        "plt.savefig('figures/ch02/relchange_ro5.png', bbox_inches='tight', dpi=600)\n",
        "plt.savefig('figures/ch02/relchange_ro5.pdf', bbox_inches='tight', dpi=600)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "c1Vp2-S-iism"
      },
      "source": [
        "### Structure-based Filters"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 25,
      "metadata": {
        "id": "n5jdyPC7ileM"
      },
      "outputs": [],
      "source": [
        "from rdkit.Chem import FilterCatalog\n",
        "filter_params = FilterCatalog.FilterCatalogParams()\n",
        "filter_params.AddCatalog(filter_params.FilterCatalogs.PAINS)\n",
        "filter_params.AddCatalog(filter_params.FilterCatalogs.BRENK)\n",
        "catalog = FilterCatalog.FilterCatalog(filter_params)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 26,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "4SbXmQSEg_mF",
        "outputId": "0a811318-1403-4b34-8c1c-c05311a16f64"
      },
      "outputs": [
        {
          "name": "stderr",
          "output_type": "stream",
          "text": [
            "/tmp/ipykernel_7313/2468989558.py:1: SettingWithCopyWarning: \n",
            "A value is trying to be set on a copy of a slice from a DataFrame.\n",
            "Try using .loc[row_indexer,col_indexer] = value instead\n",
            "\n",
            "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n",
            "  specs_ro5_compliant[\"PAINS_BRENK_compliant\"] = specs_ro5_compliant['mol'].apply(catalog.HasMatch)\n"
          ]
        }
      ],
      "source": [
        "specs_ro5_compliant[\"PAINS_BRENK_compliant\"] = specs_ro5_compliant['mol'].apply(catalog.HasMatch)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 27,
      "metadata": {
        "id": "ikZRKnzhOPmG"
      },
      "outputs": [],
      "source": [
        "specs_ro5_pains_brenk_compliant = specs_ro5_compliant[specs_ro5_compliant[\"PAINS_BRENK_compliant\"]]"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 28,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "QEev-4Pul87N",
        "outputId": "89801f62-7b2a-4b33-cfaf-e119b026fe01"
      },
      "outputs": [
        {
          "name": "stdout",
          "output_type": "stream",
          "text": [
            "SPECS compounds compliant with RO5, PAINS, and BRENK: 93915\n"
          ]
        }
      ],
      "source": [
        "print(f\"SPECS compounds compliant with RO5, PAINS, and BRENK: {specs_ro5_compliant['PAINS_BRENK_compliant'].sum()}\")"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 29,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "LnpY8Bx3mBQz",
        "outputId": "a660d601-9cb9-4aa2-fdd8-bc1df0d6fff6"
      },
      "outputs": [
        {
          "name": "stdout",
          "output_type": "stream",
          "text": [
            "Number of Glaxo Wellcome structural alerts: 55\n"
          ]
        }
      ],
      "source": [
        "from rdkit.Chem import Draw, MolFromSmarts\n",
        "glaxo_alerts = pd.read_csv(\"data/glaxo_structural_alerts.csv\")\n",
        "glaxo_alerts[\"ROMol\"] = glaxo_alerts.smarts.apply(MolFromSmarts)\n",
        "print(f\"Number of Glaxo Wellcome structural alerts: {len(glaxo_alerts)}\")"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "XaMdpR6J1Ul2"
      },
      "source": [
        "**Code for Figure 2.8. Example substructures within the Glaxo Wllcome hard filters**"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "g3Iiglwdyu_G"
      },
      "outputs": [],
      "source": [
        "d2d = Draw.MolDraw2DSVG(-1, -1)\n",
        "dopts = d2d.drawOptions()\n",
        "dopts.useBWAtomPalette()\n",
        "dopts.setHighlightColour((.635,.0,.145,.4))\n",
        "dopts.additionalAtomLabelPadding = 0.15"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 421
        },
        "id": "FCZdwGWXQh6X",
        "outputId": "cda193a6-15f1-4565-d9c0-24f951e0a715"
      },
      "outputs": [
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"600px\" height=\"400px\" viewBox=\"0 0 600 400\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"600.0\" height=\"400.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 50.7,87.9 L 69.9,99.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 53.1,83.8 L 69.9,93.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 69.9,99.0 L 79.8,93.3\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 79.8,93.3 L 89.8,87.5\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 78.6,88.4 L 87.4,83.4\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 106.2,85.5 L 118.5,92.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 103.9,89.6 L 116.1,96.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 139.4,93.4 L 146.0,89.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 137.0,89.3 L 143.6,85.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 69.4,98.7 L 69.9,99.0 L 70.1,98.9\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-0\" d=\"M 39.5 81.1 Q 39.5 78.9, 40.5 77.7 Q 41.6 76.5, 43.6 76.5 Q 45.6 76.5, 46.6 77.7 Q 47.7 78.9, 47.7 81.1 Q 47.7 83.3, 46.6 84.5 Q 45.5 85.7, 43.6 85.7 Q 41.6 85.7, 40.5 84.5 Q 39.5 83.3, 39.5 81.1 M 43.6 84.7 Q 45.0 84.7, 45.7 83.8 Q 46.4 82.9, 46.4 81.1 Q 46.4 79.3, 45.7 78.4 Q 45.0 77.5, 43.6 77.5 Q 42.2 77.5, 41.5 78.4 Q 40.7 79.3, 40.7 81.1 Q 40.7 82.9, 41.5 83.8 Q 42.2 84.7, 43.6 84.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-2\" d=\"M 95.4 78.6 L 98.4 83.4 Q 98.7 83.9, 99.1 84.7 Q 99.6 85.6, 99.6 85.6 L 99.6 78.6 L 100.8 78.6 L 100.8 87.6 L 99.6 87.6 L 96.4 82.4 Q 96.1 81.8, 95.7 81.1 Q 95.3 80.4, 95.2 80.2 L 95.2 87.6 L 94.0 87.6 L 94.0 78.6 L 95.4 78.6 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 122.9 94.5 L 125.9 99.3 Q 126.2 99.7, 126.6 100.6 Q 127.1 101.4, 127.1 101.5 L 127.1 94.5 L 128.3 94.5 L 128.3 103.5 L 127.1 103.5 L 123.9 98.3 Q 123.6 97.7, 123.2 97.0 Q 122.8 96.3, 122.7 96.1 L 122.7 103.5 L 121.5 103.5 L 121.5 94.5 L 122.9 94.5 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 130.0 96.1 L 131.6 96.1 L 131.6 94.5 L 132.3 94.5 L 132.3 96.1 L 133.9 96.1 L 133.9 96.7 L 132.3 96.7 L 132.3 98.4 L 131.6 98.4 L 131.6 96.7 L 130.0 96.7 L 130.0 96.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-4\" d=\"M 150.4 78.6 L 153.4 83.4 Q 153.7 83.9, 154.2 84.7 Q 154.6 85.6, 154.6 85.6 L 154.6 78.6 L 155.8 78.6 L 155.8 87.6 L 154.6 87.6 L 151.4 82.4 Q 151.1 81.8, 150.7 81.1 Q 150.3 80.4, 150.2 80.2 L 150.2 87.6 L 149.0 87.6 L 149.0 78.6 L 150.4 78.6 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-4\" d=\"M 157.5 80.1 L 160.5 80.1 L 160.5 80.8 L 157.5 80.8 L 157.5 80.1 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 61.8 189.1 Q 61.8 186.3, 63.1 184.8 Q 64.5 183.4, 67.0 183.4 Q 69.3 183.4, 70.5 185.0 L 69.5 185.9 Q 68.6 184.7, 67.0 184.7 Q 65.3 184.7, 64.3 185.8 Q 63.4 187.0, 63.4 189.1 Q 63.4 191.4, 64.4 192.5 Q 65.3 193.7, 67.1 193.7 Q 68.4 193.7, 69.8 192.9 L 70.3 194.1 Q 69.7 194.5, 68.8 194.7 Q 67.9 195.0, 66.9 195.0 Q 64.5 195.0, 63.1 193.4 Q 61.8 191.9, 61.8 189.1 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 71.8 192.6 Q 71.8 191.3, 72.9 190.6 Q 73.9 189.8, 75.9 189.8 L 77.1 189.8 L 77.1 189.5 Q 77.1 188.5, 76.6 188.1 Q 76.2 187.6, 75.2 187.6 Q 74.6 187.6, 74.0 187.8 Q 73.5 187.9, 72.7 188.2 L 72.3 187.2 Q 73.8 186.4, 75.2 186.4 Q 77.0 186.4, 77.8 187.2 Q 78.6 187.9, 78.6 189.5 L 78.6 194.8 L 77.4 194.8 Q 77.4 194.7, 77.4 194.5 Q 77.3 194.2, 77.2 193.8 Q 76.1 195.0, 74.5 195.0 Q 73.3 195.0, 72.6 194.3 Q 71.8 193.7, 71.8 192.6 M 73.3 192.6 Q 73.3 193.2, 73.7 193.5 Q 74.1 193.8, 74.8 193.8 Q 75.4 193.8, 76.1 193.5 Q 76.7 193.2, 77.1 192.7 L 77.1 191.0 L 76.0 191.0 Q 74.6 191.0, 74.0 191.4 Q 73.3 191.8, 73.3 192.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 81.7 186.6 L 81.8 187.7 Q 82.7 186.4, 84.1 186.4 Q 84.6 186.4, 85.2 186.6 L 84.9 187.9 Q 84.2 187.8, 83.9 187.8 Q 83.2 187.8, 82.7 188.1 Q 82.3 188.3, 81.9 188.9 L 81.9 194.8 L 80.4 194.8 L 80.4 186.6 L 81.7 186.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 89.9 186.4 Q 91.6 186.4, 92.5 187.5 Q 93.5 188.6, 93.5 190.6 Q 93.5 192.6, 92.4 193.8 Q 91.2 194.9, 89.3 194.9 Q 88.0 194.9, 86.8 194.5 L 86.0 194.3 L 86.0 182.7 L 87.5 182.7 L 87.5 187.5 Q 88.4 186.4, 89.9 186.4 M 89.2 193.8 Q 90.5 193.8, 91.2 192.9 Q 92.0 192.1, 92.0 190.6 Q 92.0 189.1, 91.4 188.4 Q 90.8 187.6, 89.8 187.6 Q 88.9 187.6, 88.4 188.1 Q 87.8 188.5, 87.5 189.3 L 87.5 193.5 Q 88.4 193.8, 89.2 193.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 94.9 192.6 Q 94.9 191.3, 95.9 190.6 Q 97.0 189.8, 98.9 189.8 L 100.1 189.8 L 100.1 189.5 Q 100.1 188.5, 99.7 188.1 Q 99.3 187.6, 98.2 187.6 Q 97.6 187.6, 97.1 187.8 Q 96.6 187.9, 95.8 188.2 L 95.3 187.2 Q 96.8 186.4, 98.3 186.4 Q 100.0 186.4, 100.8 187.2 Q 101.6 187.9, 101.6 189.5 L 101.6 194.8 L 100.5 194.8 Q 100.4 194.7, 100.4 194.5 Q 100.3 194.2, 100.2 193.8 Q 99.1 195.0, 97.6 195.0 Q 96.3 195.0, 95.6 194.3 Q 94.9 193.7, 94.9 192.6 M 96.4 192.6 Q 96.4 193.2, 96.7 193.5 Q 97.1 193.8, 97.8 193.8 Q 98.5 193.8, 99.1 193.5 Q 99.7 193.2, 100.1 192.7 L 100.1 191.0 L 99.0 191.0 Q 97.7 191.0, 97.0 191.4 Q 96.4 191.8, 96.4 192.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 105.3 193.6 L 109.8 193.6 L 109.8 194.8 L 103.5 194.8 L 103.5 193.8 L 107.8 187.8 L 103.7 187.8 L 103.7 186.6 L 109.6 186.6 L 109.6 187.5 L 105.3 193.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 111.0 183.5 L 112.5 183.5 L 112.5 184.9 L 111.0 184.9 L 111.0 183.5 M 111.0 186.6 L 112.5 186.6 L 112.5 194.8 L 111.0 194.8 L 111.0 186.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 121.9 182.7 L 121.9 194.8 L 120.7 194.8 L 120.5 193.8 Q 119.6 194.9, 118.1 194.9 Q 116.4 194.9, 115.4 193.9 Q 114.5 192.8, 114.5 190.8 Q 114.5 188.8, 115.6 187.6 Q 116.7 186.4, 118.7 186.4 Q 119.5 186.4, 120.4 186.7 L 120.4 182.7 L 121.9 182.7 M 118.2 193.8 Q 119.0 193.8, 119.6 193.3 Q 120.2 192.8, 120.4 192.0 L 120.4 187.9 Q 119.6 187.6, 118.7 187.6 Q 117.4 187.6, 116.7 188.5 Q 116.0 189.3, 116.0 190.8 Q 116.0 192.2, 116.6 193.0 Q 117.1 193.8, 118.2 193.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 123.8 190.7 Q 123.8 188.7, 124.9 187.6 Q 125.9 186.4, 127.7 186.4 Q 129.5 186.4, 130.3 187.5 Q 131.1 188.6, 131.1 190.6 L 131.1 190.9 L 125.4 190.9 Q 125.4 192.3, 126.0 193.0 Q 126.7 193.8, 127.8 193.8 Q 128.5 193.8, 129.1 193.6 Q 129.7 193.4, 130.4 193.1 L 130.8 194.2 Q 130.0 194.6, 129.3 194.8 Q 128.5 194.9, 127.8 194.9 Q 125.9 194.9, 124.9 193.8 Q 123.8 192.7, 123.8 190.7 M 127.7 187.6 Q 126.8 187.6, 126.2 188.2 Q 125.6 188.7, 125.4 189.8 L 129.5 189.8 Q 129.4 188.7, 129.0 188.2 Q 128.5 187.6, 127.7 187.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 132.8 193.1 Q 133.5 193.4, 134.1 193.6 Q 134.6 193.7, 135.1 193.7 Q 135.9 193.7, 136.3 193.4 Q 136.7 193.1, 136.7 192.5 Q 136.7 192.1, 136.5 191.9 Q 136.3 191.7, 136.0 191.6 Q 135.7 191.4, 135.0 191.2 Q 134.9 191.2, 134.2 190.9 Q 133.4 190.7, 133.0 190.1 Q 132.6 189.6, 132.6 188.8 Q 132.6 187.8, 133.4 187.1 Q 134.2 186.4, 135.7 186.4 Q 136.3 186.4, 136.8 186.6 Q 137.4 186.7, 138.0 187.0 L 137.6 188.2 Q 137.1 187.9, 136.6 187.8 Q 136.2 187.7, 135.7 187.7 Q 134.9 187.7, 134.5 188.0 Q 134.1 188.3, 134.1 188.8 Q 134.1 189.2, 134.4 189.4 Q 134.7 189.6, 135.4 189.9 Q 135.6 189.9, 135.7 190.0 L 136.1 190.1 Q 136.8 190.4, 137.2 190.6 Q 137.6 190.8, 137.9 191.3 Q 138.2 191.7, 138.2 192.5 Q 138.2 193.7, 137.3 194.3 Q 136.5 195.0, 135.2 195.0 Q 134.4 195.0, 133.7 194.8 Q 133.0 194.6, 132.4 194.3 L 132.8 193.1 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 240.9,62.6 L 252.6,62.6\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 252.6,60.2 L 264.3,60.2\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 252.6,65.0 L 264.3,65.0\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 277.8,71.5 L 280.6,76.5\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 282.7,75.3 L 285.6,80.2\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 278.6,77.7 L 281.4,82.6\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:0.5,0.666667\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 281.3,97.9 L 275.6,107.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 285.4,100.3 L 279.8,110.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-2 atom-4\" d=\"M 295.6,90.1 L 303.8,90.1\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-2 atom-4\" d=\"M 303.8,87.7 L 311.9,87.7\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-2 atom-4\" d=\"M 303.8,92.5 L 311.9,92.5\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 325.4,81.3 L 328.0,76.8\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 330.0,78.0 L 332.7,73.5\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 325.9,75.6 L 328.5,71.1\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:0.5,0.666667\"/>\n",
              "<path class=\"atom-1\" d=\"M 268.5 62.6 Q 268.5 60.5, 269.6 59.3 Q 270.6 58.1, 272.6 58.1 Q 274.6 58.1, 275.7 59.3 Q 276.8 60.5, 276.8 62.6 Q 276.8 64.8, 275.7 66.1 Q 274.6 67.3, 272.6 67.3 Q 270.7 67.3, 269.6 66.1 Q 268.5 64.8, 268.5 62.6 M 272.6 66.3 Q 274.0 66.3, 274.8 65.4 Q 275.5 64.4, 275.5 62.6 Q 275.5 60.9, 274.8 60.0 Q 274.0 59.1, 272.6 59.1 Q 271.3 59.1, 270.5 60.0 Q 269.8 60.9, 269.8 62.6 Q 269.8 64.4, 270.5 65.4 Q 271.3 66.3, 272.6 66.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-2\" d=\"M 286.0 93.2 Q 286.1 93.2, 286.5 93.4 Q 286.9 93.6, 287.4 93.7 Q 287.9 93.8, 288.3 93.8 Q 289.2 93.8, 289.7 93.4 Q 290.2 93.0, 290.2 92.3 Q 290.2 91.8, 289.9 91.5 Q 289.7 91.2, 289.3 91.0 Q 288.9 90.8, 288.3 90.6 Q 287.5 90.4, 287.0 90.2 Q 286.5 89.9, 286.2 89.5 Q 285.8 89.0, 285.8 88.2 Q 285.8 87.0, 286.6 86.3 Q 287.4 85.6, 288.9 85.6 Q 289.9 85.6, 291.1 86.1 L 290.8 87.1 Q 289.7 86.7, 288.9 86.7 Q 288.1 86.7, 287.6 87.0 Q 287.1 87.4, 287.1 88.0 Q 287.1 88.5, 287.3 88.8 Q 287.6 89.1, 288.0 89.2 Q 288.3 89.4, 288.9 89.6 Q 289.7 89.8, 290.2 90.1 Q 290.7 90.4, 291.1 90.9 Q 291.4 91.4, 291.4 92.3 Q 291.4 93.5, 290.6 94.2 Q 289.7 94.8, 288.4 94.8 Q 287.6 94.8, 287.0 94.7 Q 286.4 94.5, 285.6 94.2 L 286.0 93.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 268.5 117.7 Q 268.5 115.5, 269.6 114.3 Q 270.6 113.1, 272.6 113.1 Q 274.6 113.1, 275.7 114.3 Q 276.8 115.5, 276.8 117.7 Q 276.8 119.8, 275.7 121.1 Q 274.6 122.3, 272.6 122.3 Q 270.7 122.3, 269.6 121.1 Q 268.5 119.8, 268.5 117.7 M 272.6 121.3 Q 274.0 121.3, 274.8 120.4 Q 275.5 119.5, 275.5 117.7 Q 275.5 115.9, 274.8 115.0 Q 274.0 114.1, 272.6 114.1 Q 271.3 114.1, 270.5 115.0 Q 269.8 115.9, 269.8 117.7 Q 269.8 119.5, 270.5 120.4 Q 271.3 121.3, 272.6 121.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-4\" d=\"M 316.2 90.1 Q 316.2 88.0, 317.2 86.8 Q 318.3 85.6, 320.3 85.6 Q 322.3 85.6, 323.4 86.8 Q 324.4 88.0, 324.4 90.1 Q 324.4 92.3, 323.3 93.6 Q 322.3 94.8, 320.3 94.8 Q 318.3 94.8, 317.2 93.6 Q 316.2 92.3, 316.2 90.1 M 320.3 93.8 Q 321.7 93.8, 322.4 92.9 Q 323.2 91.9, 323.2 90.1 Q 323.2 88.4, 322.4 87.5 Q 321.7 86.6, 320.3 86.6 Q 318.9 86.6, 318.2 87.5 Q 317.4 88.4, 317.4 90.1 Q 317.4 92.0, 318.2 92.9 Q 318.9 93.8, 320.3 93.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 334.8 57.7 L 337.5 57.7 L 337.5 58.6 L 335.9 58.6 L 335.9 69.1 L 337.5 69.1 L 337.5 70.0 L 334.8 70.0 L 334.8 57.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 338.2 63.0 Q 338.2 60.8, 339.2 59.6 Q 340.3 58.4, 342.3 58.4 Q 344.1 58.4, 345.1 59.7 L 344.3 60.4 Q 343.6 59.5, 342.3 59.5 Q 340.9 59.5, 340.2 60.4 Q 339.5 61.3, 339.5 63.0 Q 339.5 64.8, 340.2 65.7 Q 341.0 66.6, 342.4 66.6 Q 343.4 66.6, 344.6 66.0 L 344.9 67.0 Q 344.5 67.3, 343.7 67.5 Q 343.0 67.6, 342.2 67.6 Q 340.3 67.6, 339.2 66.4 Q 338.2 65.2, 338.2 63.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 346.1 66.3 L 347.3 66.3 L 347.3 67.3 L 347.1 69.0 L 346.6 69.0 L 346.6 67.5 L 346.1 67.5 L 346.1 66.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 348.6 63.0 Q 348.6 60.8, 349.6 59.6 Q 350.7 58.4, 352.7 58.4 Q 354.5 58.4, 355.5 59.7 L 354.7 60.4 Q 353.9 59.5, 352.7 59.5 Q 351.3 59.5, 350.6 60.4 Q 349.9 61.3, 349.9 63.0 Q 349.9 64.8, 350.6 65.7 Q 351.3 66.6, 352.8 66.6 Q 353.8 66.6, 354.9 66.0 L 355.3 67.0 Q 354.8 67.3, 354.1 67.5 Q 353.4 67.6, 352.6 67.6 Q 350.7 67.6, 349.6 66.4 Q 348.6 65.2, 348.6 63.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 359.1 57.7 L 359.1 70.0 L 356.4 70.0 L 356.4 69.1 L 358.1 69.1 L 358.1 58.6 L 356.4 58.6 L 356.4 57.7 L 359.1 57.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 249.0 189.7 Q 249.2 189.7, 249.6 190.0 Q 250.1 190.2, 250.7 190.3 Q 251.2 190.4, 251.8 190.4 Q 252.8 190.4, 253.4 189.9 Q 253.9 189.4, 253.9 188.6 Q 253.9 188.0, 253.6 187.6 Q 253.4 187.3, 252.9 187.1 Q 252.5 186.9, 251.7 186.7 Q 250.8 186.4, 250.2 186.1 Q 249.6 185.9, 249.2 185.3 Q 248.9 184.7, 248.9 183.8 Q 248.9 182.4, 249.8 181.6 Q 250.7 180.8, 252.5 180.8 Q 253.7 180.8, 255.1 181.4 L 254.7 182.5 Q 253.5 182.0, 252.5 182.0 Q 251.5 182.0, 250.9 182.4 Q 250.3 182.9, 250.3 183.6 Q 250.3 184.2, 250.6 184.5 Q 250.9 184.8, 251.3 185.0 Q 251.8 185.2, 252.5 185.5 Q 253.5 185.8, 254.0 186.1 Q 254.6 186.3, 255.0 187.0 Q 255.4 187.6, 255.4 188.6 Q 255.4 190.1, 254.4 190.8 Q 253.5 191.6, 251.8 191.6 Q 250.9 191.6, 250.2 191.4 Q 249.5 191.2, 248.6 190.9 L 249.0 189.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 263.2 183.7 L 263.2 191.3 L 262.0 191.3 L 261.9 190.3 Q 260.9 191.5, 259.3 191.5 Q 258.0 191.5, 257.3 190.8 Q 256.7 190.1, 256.7 188.7 L 256.7 183.7 L 258.1 183.7 L 258.1 188.6 Q 258.1 189.5, 258.4 190.0 Q 258.8 190.4, 259.5 190.4 Q 260.2 190.4, 260.8 190.1 Q 261.4 189.7, 261.8 189.2 L 261.8 183.7 L 263.2 183.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 264.9 180.0 L 266.3 180.0 L 266.3 191.3 L 264.9 191.3 L 264.9 180.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 271.7 183.5 Q 273.3 183.5, 274.2 184.5 Q 275.1 185.5, 275.1 187.4 Q 275.1 189.3, 274.0 190.4 Q 273.0 191.5, 271.1 191.5 Q 270.3 191.5, 269.5 191.2 L 269.5 195.0 L 268.1 195.0 L 268.1 183.7 L 269.3 183.7 L 269.5 184.6 Q 269.9 184.1, 270.4 183.8 Q 271.0 183.5, 271.7 183.5 M 271.1 190.4 Q 272.3 190.4, 273.0 189.6 Q 273.7 188.8, 273.7 187.4 Q 273.7 186.1, 273.1 185.3 Q 272.6 184.6, 271.6 184.6 Q 270.9 184.6, 270.3 185.0 Q 269.8 185.4, 269.5 186.2 L 269.5 190.1 Q 270.3 190.4, 271.1 190.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 280.3 183.5 Q 281.5 183.5, 282.2 184.2 Q 282.8 184.9, 282.8 186.3 L 282.8 191.3 L 281.4 191.3 L 281.4 186.4 Q 281.4 185.5, 281.1 185.0 Q 280.7 184.6, 279.9 184.6 Q 279.2 184.6, 278.7 185.0 Q 278.1 185.3, 277.7 185.8 L 277.7 191.3 L 276.3 191.3 L 276.3 180.0 L 277.7 180.0 L 277.7 184.6 Q 278.7 183.5, 280.3 183.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 284.5 189.3 Q 284.5 188.0, 285.5 187.4 Q 286.5 186.7, 288.3 186.7 L 289.4 186.7 L 289.4 186.4 Q 289.4 185.4, 289.0 185.0 Q 288.6 184.6, 287.7 184.6 Q 287.1 184.6, 286.6 184.8 Q 286.1 184.9, 285.4 185.2 L 284.9 184.2 Q 286.4 183.5, 287.7 183.5 Q 289.3 183.5, 290.1 184.2 Q 290.8 184.9, 290.8 186.4 L 290.8 191.3 L 289.7 191.3 Q 289.7 191.3, 289.7 191.1 Q 289.6 190.8, 289.5 190.4 Q 288.5 191.5, 287.0 191.5 Q 285.9 191.5, 285.2 190.9 Q 284.5 190.3, 284.5 189.3 M 285.9 189.2 Q 285.9 189.8, 286.3 190.1 Q 286.6 190.4, 287.3 190.4 Q 287.9 190.4, 288.5 190.1 Q 289.0 189.9, 289.4 189.4 L 289.4 187.7 L 288.4 187.7 Q 287.2 187.7, 286.5 188.1 Q 285.9 188.5, 285.9 189.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 292.5 184.7 L 292.5 183.7 L 294.0 183.7 L 294.2 181.4 L 295.3 181.4 L 295.3 183.7 L 297.6 183.7 L 297.6 184.7 L 295.3 184.7 L 295.3 189.0 Q 295.3 190.3, 296.4 190.3 Q 296.8 190.3, 297.5 190.1 L 297.7 191.1 Q 296.9 191.4, 296.1 191.4 Q 295.1 191.4, 294.5 190.8 Q 293.9 190.2, 293.9 189.1 L 293.9 184.7 L 292.5 184.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 298.6 187.5 Q 298.6 185.6, 299.6 184.6 Q 300.5 183.5, 302.2 183.5 Q 303.9 183.5, 304.7 184.5 Q 305.4 185.5, 305.4 187.4 L 305.4 187.7 L 300.1 187.7 Q 300.1 189.0, 300.7 189.7 Q 301.3 190.4, 302.4 190.4 Q 303.0 190.4, 303.5 190.2 Q 304.1 190.1, 304.7 189.8 L 305.1 190.7 Q 304.4 191.1, 303.7 191.3 Q 303.0 191.5, 302.3 191.5 Q 300.6 191.5, 299.6 190.4 Q 298.6 189.4, 298.6 187.5 M 302.2 184.6 Q 301.4 184.6, 300.8 185.1 Q 300.3 185.6, 300.1 186.6 L 304.0 186.6 Q 303.9 185.6, 303.4 185.1 Q 303.0 184.6, 302.2 184.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 312.1 187.5 Q 312.1 185.6, 313.0 184.6 Q 313.9 183.5, 315.7 183.5 Q 317.4 183.5, 318.1 184.5 Q 318.9 185.5, 318.9 187.4 L 318.9 187.7 L 313.5 187.7 Q 313.5 189.0, 314.1 189.7 Q 314.7 190.4, 315.8 190.4 Q 316.4 190.4, 316.9 190.2 Q 317.5 190.1, 318.2 189.8 L 318.6 190.7 Q 317.8 191.1, 317.1 191.3 Q 316.4 191.5, 315.7 191.5 Q 314.0 191.5, 313.0 190.4 Q 312.1 189.4, 312.1 187.5 M 315.7 184.6 Q 314.8 184.6, 314.2 185.1 Q 313.7 185.6, 313.6 186.6 L 317.4 186.6 Q 317.3 185.6, 316.9 185.1 Q 316.4 184.6, 315.7 184.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 320.4 189.8 Q 321.1 190.0, 321.6 190.2 Q 322.0 190.3, 322.6 190.3 Q 323.2 190.3, 323.6 190.0 Q 324.0 189.7, 324.0 189.2 Q 324.0 188.8, 323.8 188.6 Q 323.6 188.4, 323.3 188.3 Q 323.1 188.2, 322.4 188.0 Q 322.3 187.9, 321.6 187.7 Q 321.0 187.5, 320.6 187.0 Q 320.2 186.5, 320.2 185.7 Q 320.2 184.8, 320.9 184.2 Q 321.7 183.5, 323.0 183.5 Q 323.6 183.5, 324.1 183.7 Q 324.7 183.8, 325.2 184.0 L 324.9 185.1 Q 324.4 184.9, 323.9 184.8 Q 323.5 184.7, 323.0 184.7 Q 322.3 184.7, 322.0 185.0 Q 321.6 185.2, 321.6 185.7 Q 321.6 186.1, 321.9 186.3 Q 322.2 186.5, 322.8 186.7 Q 323.0 186.8, 323.1 186.8 L 323.5 187.0 Q 324.1 187.2, 324.5 187.4 Q 324.9 187.6, 325.1 188.0 Q 325.4 188.5, 325.4 189.2 Q 325.4 190.3, 324.6 190.9 Q 323.8 191.5, 322.6 191.5 Q 321.9 191.5, 321.2 191.3 Q 320.6 191.2, 320.0 190.9 L 320.4 189.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 326.7 184.7 L 326.7 183.7 L 328.2 183.7 L 328.4 181.4 L 329.5 181.4 L 329.5 183.7 L 331.8 183.7 L 331.8 184.7 L 329.5 184.7 L 329.5 189.0 Q 329.5 190.3, 330.6 190.3 Q 331.1 190.3, 331.7 190.1 L 331.9 191.1 Q 331.1 191.4, 330.4 191.4 Q 329.4 191.4, 328.7 190.8 Q 328.1 190.2, 328.1 189.1 L 328.1 184.7 L 326.7 184.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 332.9 187.5 Q 332.9 185.6, 333.8 184.6 Q 334.7 183.5, 336.5 183.5 Q 338.1 183.5, 338.9 184.5 Q 339.7 185.5, 339.7 187.4 L 339.7 187.7 L 334.3 187.7 Q 334.3 189.0, 334.9 189.7 Q 335.5 190.4, 336.6 190.4 Q 337.2 190.4, 337.7 190.2 Q 338.3 190.1, 339.0 189.8 L 339.4 190.7 Q 338.6 191.1, 337.9 191.3 Q 337.2 191.5, 336.5 191.5 Q 334.8 191.5, 333.8 190.4 Q 332.9 189.4, 332.9 187.5 M 336.5 184.6 Q 335.6 184.6, 335.0 185.1 Q 334.5 185.6, 334.4 186.6 L 338.2 186.6 Q 338.1 185.6, 337.7 185.1 Q 337.2 184.6, 336.5 184.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 341.9 183.7 L 342.1 184.7 Q 342.9 183.5, 344.2 183.5 Q 344.6 183.5, 345.2 183.7 L 344.9 184.9 Q 344.3 184.8, 343.9 184.8 Q 343.3 184.8, 342.9 185.0 Q 342.5 185.3, 342.2 185.9 L 342.2 191.3 L 340.8 191.3 L 340.8 183.7 L 341.9 183.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 346.4 189.8 Q 347.0 190.0, 347.5 190.2 Q 348.0 190.3, 348.5 190.3 Q 349.2 190.3, 349.6 190.0 Q 350.0 189.7, 350.0 189.2 Q 350.0 188.8, 349.8 188.6 Q 349.6 188.4, 349.3 188.3 Q 349.1 188.2, 348.4 188.0 Q 348.3 187.9, 347.6 187.7 Q 346.9 187.5, 346.5 187.0 Q 346.2 186.5, 346.2 185.7 Q 346.2 184.8, 346.9 184.2 Q 347.6 183.5, 349.0 183.5 Q 349.6 183.5, 350.1 183.7 Q 350.6 183.8, 351.2 184.0 L 350.8 185.1 Q 350.3 184.9, 349.9 184.8 Q 349.5 184.7, 349.0 184.7 Q 348.3 184.7, 347.9 185.0 Q 347.6 185.2, 347.6 185.7 Q 347.6 186.1, 347.9 186.3 Q 348.2 186.5, 348.8 186.7 Q 348.9 186.8, 349.1 186.8 L 349.4 187.0 Q 350.1 187.2, 350.4 187.4 Q 350.8 187.6, 351.1 188.0 Q 351.4 188.5, 351.4 189.2 Q 351.4 190.3, 350.6 190.9 Q 349.8 191.5, 348.5 191.5 Q 347.8 191.5, 347.2 191.3 Q 346.6 191.2, 345.9 190.9 L 346.4 189.8 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 546.9,90.1 L 537.3,84.6\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 536.2,86.6 L 526.6,81.1\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 538.5,82.5 L 529.0,77.0\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 511.1,79.1 L 505.0,82.5\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 506.2,84.6 L 500.2,88.1\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 503.8,80.5 L 497.8,83.9\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:0.5,0.666667\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 495.0,100.3 L 500.7,110.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 499.1,97.9 L 504.8,107.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-2 atom-4\" d=\"M 483.6,92.2 L 471.6,99.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-2 atom-4\" d=\"M 486.0,96.3 L 473.9,103.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-2 atom-5\" d=\"M 486.9,81.4 L 484.2,76.8\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-2 atom-5\" d=\"M 486.3,75.6 L 483.7,71.1\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-2 atom-5\" d=\"M 482.2,78.0 L 479.5,73.5\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:0.5,0.666667\"/>\n",
              "<path class=\"atom-1\" d=\"M 515.3 74.3 Q 515.3 72.1, 516.4 70.9 Q 517.4 69.7, 519.4 69.7 Q 521.4 69.7, 522.5 70.9 Q 523.5 72.1, 523.5 74.3 Q 523.5 76.4, 522.5 77.7 Q 521.4 78.9, 519.4 78.9 Q 517.4 78.9, 516.4 77.7 Q 515.3 76.5, 515.3 74.3 M 519.4 77.9 Q 520.8 77.9, 521.5 77.0 Q 522.3 76.1, 522.3 74.3 Q 522.3 72.5, 521.5 71.6 Q 520.8 70.7, 519.4 70.7 Q 518.0 70.7, 517.3 71.6 Q 516.6 72.5, 516.6 74.3 Q 516.6 76.1, 517.3 77.0 Q 518.0 77.9, 519.4 77.9 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-2\" d=\"M 489.4 93.2 Q 489.5 93.2, 489.9 93.4 Q 490.3 93.6, 490.8 93.7 Q 491.2 93.8, 491.7 93.8 Q 492.5 93.8, 493.0 93.4 Q 493.5 93.0, 493.5 92.3 Q 493.5 91.8, 493.3 91.5 Q 493.0 91.2, 492.7 91.0 Q 492.3 90.8, 491.6 90.6 Q 490.8 90.4, 490.4 90.2 Q 489.9 89.9, 489.5 89.5 Q 489.2 89.0, 489.2 88.2 Q 489.2 87.0, 490.0 86.3 Q 490.7 85.6, 492.3 85.6 Q 493.3 85.6, 494.5 86.1 L 494.2 87.1 Q 493.1 86.7, 492.3 86.7 Q 491.4 86.7, 491.0 87.0 Q 490.5 87.4, 490.5 88.0 Q 490.5 88.5, 490.7 88.8 Q 491.0 89.1, 491.3 89.2 Q 491.7 89.4, 492.3 89.6 Q 493.1 89.8, 493.6 90.1 Q 494.1 90.4, 494.4 90.9 Q 494.8 91.4, 494.8 92.3 Q 494.8 93.5, 494.0 94.2 Q 493.1 94.8, 491.7 94.8 Q 490.9 94.8, 490.3 94.7 Q 489.7 94.5, 489.0 94.2 L 489.4 93.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 503.7 117.7 Q 503.7 115.5, 504.7 114.3 Q 505.8 113.1, 507.8 113.1 Q 509.8 113.1, 510.9 114.3 Q 511.9 115.5, 511.9 117.7 Q 511.9 119.8, 510.8 121.1 Q 509.8 122.3, 507.8 122.3 Q 505.8 122.3, 504.7 121.1 Q 503.7 119.8, 503.7 117.7 M 507.8 121.3 Q 509.2 121.3, 509.9 120.4 Q 510.6 119.5, 510.6 117.7 Q 510.6 115.9, 509.9 115.0 Q 509.2 114.1, 507.8 114.1 Q 506.4 114.1, 505.7 115.0 Q 504.9 115.9, 504.9 117.7 Q 504.9 119.5, 505.7 120.4 Q 506.4 121.3, 507.8 121.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-4\" d=\"M 460.3 106.0 Q 460.3 103.9, 461.3 102.7 Q 462.4 101.4, 464.4 101.4 Q 466.4 101.4, 467.5 102.7 Q 468.5 103.9, 468.5 106.0 Q 468.5 108.2, 467.4 109.5 Q 466.4 110.7, 464.4 110.7 Q 462.4 110.7, 461.3 109.5 Q 460.3 108.2, 460.3 106.0 M 464.4 109.7 Q 465.8 109.7, 466.5 108.8 Q 467.3 107.8, 467.3 106.0 Q 467.3 104.3, 466.5 103.4 Q 465.8 102.5, 464.4 102.5 Q 463.0 102.5, 462.3 103.4 Q 461.5 104.2, 461.5 106.0 Q 461.5 107.8, 462.3 108.8 Q 463.0 109.7, 464.4 109.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 453.1 57.7 L 455.8 57.7 L 455.8 58.6 L 454.1 58.6 L 454.1 69.1 L 455.8 69.1 L 455.8 70.0 L 453.1 70.0 L 453.1 57.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 456.4 63.0 Q 456.4 60.8, 457.5 59.6 Q 458.5 58.4, 460.5 58.4 Q 462.4 58.4, 463.4 59.7 L 462.5 60.4 Q 461.8 59.5, 460.5 59.5 Q 459.2 59.5, 458.5 60.4 Q 457.7 61.3, 457.7 63.0 Q 457.7 64.8, 458.5 65.7 Q 459.2 66.6, 460.7 66.6 Q 461.7 66.6, 462.8 66.0 L 463.2 67.0 Q 462.7 67.3, 462.0 67.5 Q 461.3 67.6, 460.5 67.6 Q 458.5 67.6, 457.5 66.4 Q 456.4 65.2, 456.4 63.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 464.3 66.3 L 465.6 66.3 L 465.6 67.3 L 465.3 69.0 L 464.9 69.0 L 464.9 67.5 L 464.3 67.5 L 464.3 66.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 466.8 63.0 Q 466.8 60.8, 467.9 59.6 Q 468.9 58.4, 470.9 58.4 Q 472.8 58.4, 473.7 59.7 L 472.9 60.4 Q 472.2 59.5, 470.9 59.5 Q 469.5 59.5, 468.8 60.4 Q 468.1 61.3, 468.1 63.0 Q 468.1 64.8, 468.8 65.7 Q 469.6 66.6, 471.0 66.6 Q 472.0 66.6, 473.2 66.0 L 473.5 67.0 Q 473.1 67.3, 472.4 67.5 Q 471.7 67.6, 470.9 67.6 Q 468.9 67.6, 467.9 66.4 Q 466.8 65.2, 466.8 63.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 477.4 57.7 L 477.4 70.0 L 474.7 70.0 L 474.7 69.1 L 476.3 69.1 L 476.3 58.6 L 474.7 58.6 L 474.7 57.7 L 477.4 57.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 460.1 189.7 Q 460.2 189.7, 460.7 190.0 Q 461.2 190.2, 461.7 190.3 Q 462.3 190.4, 462.8 190.4 Q 463.8 190.4, 464.4 189.9 Q 465.0 189.4, 465.0 188.6 Q 465.0 188.0, 464.7 187.6 Q 464.4 187.3, 463.9 187.1 Q 463.5 186.9, 462.7 186.7 Q 461.8 186.4, 461.2 186.1 Q 460.7 185.9, 460.3 185.3 Q 459.9 184.7, 459.9 183.8 Q 459.9 182.4, 460.8 181.6 Q 461.7 180.8, 463.5 180.8 Q 464.7 180.8, 466.1 181.4 L 465.7 182.5 Q 464.5 182.0, 463.5 182.0 Q 462.5 182.0, 461.9 182.4 Q 461.4 182.9, 461.4 183.6 Q 461.4 184.2, 461.7 184.5 Q 462.0 184.8, 462.4 185.0 Q 462.8 185.2, 463.5 185.5 Q 464.5 185.8, 465.0 186.1 Q 465.6 186.3, 466.0 187.0 Q 466.4 187.6, 466.4 188.6 Q 466.4 190.1, 465.5 190.8 Q 464.5 191.6, 462.9 191.6 Q 461.9 191.6, 461.2 191.4 Q 460.5 191.2, 459.7 190.9 L 460.1 189.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 474.3 183.7 L 474.3 191.3 L 473.1 191.3 L 473.0 190.3 Q 471.9 191.5, 470.4 191.5 Q 469.1 191.5, 468.4 190.8 Q 467.7 190.1, 467.7 188.7 L 467.7 183.7 L 469.1 183.7 L 469.1 188.6 Q 469.1 189.5, 469.5 190.0 Q 469.8 190.4, 470.6 190.4 Q 471.3 190.4, 471.9 190.1 Q 472.5 189.7, 472.9 189.2 L 472.9 183.7 L 474.3 183.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 476.1 180.0 L 477.5 180.0 L 477.5 191.3 L 476.1 191.3 L 476.1 180.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 482.9 183.5 Q 484.5 183.5, 485.4 184.5 Q 486.3 185.5, 486.3 187.4 Q 486.3 189.3, 485.2 190.4 Q 484.2 191.5, 482.3 191.5 Q 481.5 191.5, 480.7 191.2 L 480.7 195.0 L 479.3 195.0 L 479.3 183.7 L 480.5 183.7 L 480.7 184.6 Q 481.1 184.1, 481.6 183.8 Q 482.2 183.5, 482.9 183.5 M 482.3 190.4 Q 483.5 190.4, 484.2 189.6 Q 484.9 188.8, 484.9 187.4 Q 484.9 186.1, 484.3 185.3 Q 483.8 184.6, 482.8 184.6 Q 482.1 184.6, 481.5 185.0 Q 481.0 185.4, 480.7 186.2 L 480.7 190.1 Q 481.5 190.4, 482.3 190.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 491.6 183.5 Q 492.8 183.5, 493.4 184.2 Q 494.1 184.9, 494.1 186.3 L 494.1 191.3 L 492.7 191.3 L 492.7 186.4 Q 492.7 185.5, 492.3 185.0 Q 492.0 184.6, 491.2 184.6 Q 490.5 184.6, 489.9 185.0 Q 489.3 185.3, 489.0 185.8 L 489.0 191.3 L 487.6 191.3 L 487.6 180.0 L 489.0 180.0 L 489.0 184.6 Q 490.0 183.5, 491.6 183.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 495.8 187.5 Q 495.8 185.6, 496.8 184.6 Q 497.7 183.5, 499.5 183.5 Q 501.2 183.5, 502.2 184.6 Q 503.1 185.6, 503.1 187.5 Q 503.1 189.4, 502.2 190.4 Q 501.2 191.5, 499.5 191.5 Q 497.7 191.5, 496.8 190.4 Q 495.8 189.4, 495.8 187.5 M 497.3 187.5 Q 497.3 188.9, 497.8 189.6 Q 498.4 190.4, 499.5 190.4 Q 500.5 190.4, 501.1 189.6 Q 501.7 188.9, 501.7 187.5 Q 501.7 186.1, 501.1 185.4 Q 500.5 184.6, 499.5 184.6 Q 498.4 184.6, 497.8 185.4 Q 497.3 186.1, 497.3 187.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 508.4 183.5 Q 509.6 183.5, 510.3 184.2 Q 510.9 184.9, 510.9 186.3 L 510.9 191.3 L 509.5 191.3 L 509.5 186.4 Q 509.5 185.5, 509.2 185.0 Q 508.8 184.6, 508.1 184.6 Q 507.4 184.6, 506.8 185.0 Q 506.2 185.3, 505.8 185.8 L 505.8 191.3 L 504.4 191.3 L 504.4 183.7 L 505.6 183.7 L 505.7 184.7 Q 506.8 183.5, 508.4 183.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 512.7 189.3 Q 512.7 188.0, 513.7 187.4 Q 514.7 186.7, 516.5 186.7 L 517.6 186.7 L 517.6 186.4 Q 517.6 185.4, 517.2 185.0 Q 516.8 184.6, 515.9 184.6 Q 515.2 184.6, 514.8 184.8 Q 514.3 184.9, 513.5 185.2 L 513.1 184.2 Q 514.5 183.5, 515.9 183.5 Q 517.5 183.5, 518.3 184.2 Q 519.0 184.9, 519.0 186.4 L 519.0 191.3 L 517.9 191.3 Q 517.9 191.3, 517.9 191.1 Q 517.8 190.8, 517.7 190.4 Q 516.7 191.5, 515.2 191.5 Q 514.1 191.5, 513.4 190.9 Q 512.7 190.3, 512.7 189.3 M 514.1 189.2 Q 514.1 189.8, 514.5 190.1 Q 514.8 190.4, 515.5 190.4 Q 516.1 190.4, 516.7 190.1 Q 517.2 189.9, 517.6 189.4 L 517.6 187.7 L 516.6 187.7 Q 515.3 187.7, 514.7 188.1 Q 514.1 188.5, 514.1 189.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 520.8 184.7 L 520.8 183.7 L 522.2 183.7 L 522.5 181.4 L 523.5 181.4 L 523.5 183.7 L 525.9 183.7 L 525.9 184.7 L 523.5 184.7 L 523.5 189.0 Q 523.5 190.3, 524.6 190.3 Q 525.1 190.3, 525.7 190.1 L 526.0 191.1 Q 525.2 191.4, 524.4 191.4 Q 523.4 191.4, 522.7 190.8 Q 522.1 190.2, 522.1 189.1 L 522.1 184.7 L 520.8 184.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 526.9 187.5 Q 526.9 185.6, 527.9 184.6 Q 528.8 183.5, 530.5 183.5 Q 532.2 183.5, 533.0 184.5 Q 533.7 185.5, 533.7 187.4 L 533.7 187.7 L 528.4 187.7 Q 528.4 189.0, 529.0 189.7 Q 529.6 190.4, 530.7 190.4 Q 531.3 190.4, 531.8 190.2 Q 532.4 190.1, 533.0 189.8 L 533.4 190.7 Q 532.7 191.1, 532.0 191.3 Q 531.3 191.5, 530.6 191.5 Q 528.9 191.5, 527.9 190.4 Q 526.9 189.4, 526.9 187.5 M 530.5 184.6 Q 529.7 184.6, 529.1 185.1 Q 528.6 185.6, 528.4 186.6 L 532.3 186.6 Q 532.2 185.6, 531.7 185.1 Q 531.3 184.6, 530.5 184.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 535.3 189.8 Q 536.0 190.0, 536.5 190.2 Q 537.0 190.3, 537.5 190.3 Q 538.2 190.3, 538.6 190.0 Q 538.9 189.7, 538.9 189.2 Q 538.9 188.8, 538.7 188.6 Q 538.5 188.4, 538.3 188.3 Q 538.0 188.2, 537.4 188.0 Q 537.3 187.9, 536.6 187.7 Q 535.9 187.5, 535.5 187.0 Q 535.2 186.5, 535.2 185.7 Q 535.2 184.8, 535.9 184.2 Q 536.6 183.5, 538.0 183.5 Q 538.6 183.5, 539.1 183.7 Q 539.6 183.8, 540.2 184.0 L 539.8 185.1 Q 539.3 184.9, 538.9 184.8 Q 538.4 184.7, 538.0 184.7 Q 537.3 184.7, 536.9 185.0 Q 536.6 185.2, 536.6 185.7 Q 536.6 186.1, 536.9 186.3 Q 537.1 186.5, 537.8 186.7 Q 537.9 186.8, 538.1 186.8 L 538.4 187.0 Q 539.0 187.2, 539.4 187.4 Q 539.8 187.6, 540.1 188.0 Q 540.3 188.5, 540.3 189.2 Q 540.3 190.3, 539.6 190.9 Q 538.8 191.5, 537.5 191.5 Q 536.8 191.5, 536.2 191.3 Q 535.5 191.2, 534.9 190.9 L 535.3 189.8 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 127.5,299.2 L 146.7,288.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 127.5,293.7 L 144.3,284.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-0 atom-2\" d=\"M 127.5,299.2 L 117.9,293.7\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-0 atom-2\" d=\"M 117.9,293.7 L 108.4,288.1\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-0 atom-2\" d=\"M 119.1,288.8 L 110.7,284.0\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 91.6,288.1 L 82.1,293.7\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 82.1,293.7 L 72.5,299.2\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 84.4,297.8 L 74.9,303.3\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 72.5,299.2 L 53.3,288.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 72.5,293.7 L 55.7,284.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 128.0,298.9 L 127.5,299.2 L 127.3,299.0\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 72.7,299.0 L 72.5,299.2 L 72.0,298.9\" style=\"fill:none;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-1\" d=\"M 149.7 281.3 Q 149.7 279.1, 150.8 277.9 Q 151.8 276.7, 153.8 276.7 Q 155.8 276.7, 156.9 277.9 Q 158.0 279.1, 158.0 281.3 Q 158.0 283.4, 156.9 284.7 Q 155.8 285.9, 153.8 285.9 Q 151.8 285.9, 150.8 284.7 Q 149.7 283.5, 149.7 281.3 M 153.8 284.9 Q 155.2 284.9, 155.9 284.0 Q 156.7 283.1, 156.7 281.3 Q 156.7 279.5, 155.9 278.6 Q 155.2 277.7, 153.8 277.7 Q 152.5 277.7, 151.7 278.6 Q 151.0 279.5, 151.0 281.3 Q 151.0 283.1, 151.7 284.0 Q 152.5 284.9, 153.8 284.9 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-2\" d=\"M 95.9 283.3 Q 95.9 281.2, 96.9 280.0 Q 98.0 278.8, 100.0 278.8 Q 102.0 278.8, 103.1 280.0 Q 104.1 281.2, 104.1 283.3 Q 104.1 285.5, 103.0 286.8 Q 102.0 288.0, 100.0 288.0 Q 98.0 288.0, 96.9 286.8 Q 95.9 285.5, 95.9 283.3 M 100.0 287.0 Q 101.4 287.0, 102.1 286.1 Q 102.9 285.1, 102.9 283.3 Q 102.9 281.6, 102.1 280.7 Q 101.4 279.8, 100.0 279.8 Q 98.6 279.8, 97.9 280.7 Q 97.1 281.5, 97.1 283.3 Q 97.1 285.1, 97.9 286.1 Q 98.6 287.0, 100.0 287.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-4\" d=\"M 42.0 281.3 Q 42.0 279.1, 43.1 277.9 Q 44.2 276.7, 46.2 276.7 Q 48.2 276.7, 49.2 277.9 Q 50.3 279.1, 50.3 281.3 Q 50.3 283.4, 49.2 284.7 Q 48.1 285.9, 46.2 285.9 Q 44.2 285.9, 43.1 284.7 Q 42.0 283.5, 42.0 281.3 M 46.2 284.9 Q 47.5 284.9, 48.3 284.0 Q 49.0 283.1, 49.0 281.3 Q 49.0 279.5, 48.3 278.6 Q 47.5 277.7, 46.2 277.7 Q 44.8 277.7, 44.0 278.6 Q 43.3 279.5, 43.3 281.3 Q 43.3 283.1, 44.0 284.0 Q 44.8 284.9, 46.2 284.9 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 54.7 391.3 L 53.6 388.2 L 49.4 388.2 L 48.4 391.3 L 46.9 391.3 L 50.6 380.8 L 52.3 380.8 L 56.1 391.3 L 54.7 391.3 M 49.8 387.0 L 53.2 387.0 L 51.5 382.2 L 49.8 387.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 56.8 387.5 Q 56.8 385.6, 57.8 384.6 Q 58.7 383.5, 60.5 383.5 Q 62.2 383.5, 63.2 384.8 L 62.2 385.5 Q 61.9 385.1, 61.4 384.9 Q 61.0 384.6, 60.5 384.6 Q 59.4 384.6, 58.8 385.4 Q 58.3 386.1, 58.3 387.5 Q 58.3 388.9, 58.9 389.6 Q 59.5 390.3, 60.6 390.3 Q 61.2 390.3, 61.6 390.2 Q 62.1 390.1, 62.6 389.8 L 63.0 390.8 Q 61.9 391.4, 60.5 391.4 Q 58.7 391.4, 57.8 390.4 Q 56.8 389.3, 56.8 387.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 64.1 380.8 L 65.4 380.8 L 65.4 382.1 L 64.1 382.1 L 64.1 380.8 M 64.1 383.7 L 65.4 383.7 L 65.4 391.3 L 64.1 391.3 L 64.1 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 74.2 380.0 L 74.2 391.3 L 73.1 391.3 L 72.9 390.4 Q 72.1 391.4, 70.6 391.4 Q 69.0 391.4, 68.2 390.5 Q 67.3 389.5, 67.3 387.6 Q 67.3 385.7, 68.3 384.6 Q 69.4 383.5, 71.2 383.5 Q 72.0 383.5, 72.8 383.7 L 72.8 380.0 L 74.2 380.0 M 70.7 390.3 Q 71.5 390.3, 72.1 389.9 Q 72.6 389.5, 72.8 388.7 L 72.8 384.9 Q 72.1 384.6, 71.2 384.6 Q 70.0 384.6, 69.4 385.4 Q 68.7 386.2, 68.7 387.6 Q 68.7 388.9, 69.2 389.6 Q 69.8 390.3, 70.7 390.3 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 81.5 389.3 Q 81.5 388.0, 82.5 387.4 Q 83.5 386.7, 85.3 386.7 L 86.4 386.7 L 86.4 386.4 Q 86.4 385.4, 86.0 385.0 Q 85.6 384.6, 84.7 384.6 Q 84.1 384.6, 83.6 384.7 Q 83.1 384.9, 82.4 385.2 L 81.9 384.2 Q 83.3 383.5, 84.7 383.5 Q 86.3 383.5, 87.1 384.2 Q 87.8 384.9, 87.8 386.4 L 87.8 391.3 L 86.7 391.3 Q 86.7 391.3, 86.7 391.0 Q 86.6 390.8, 86.5 390.4 Q 85.5 391.5, 84.0 391.5 Q 82.9 391.5, 82.2 390.9 Q 81.5 390.3, 81.5 389.3 M 82.9 389.2 Q 82.9 389.8, 83.3 390.1 Q 83.6 390.4, 84.3 390.4 Q 84.9 390.4, 85.5 390.1 Q 86.0 389.9, 86.4 389.4 L 86.4 387.7 L 85.4 387.7 Q 84.1 387.7, 83.5 388.1 Q 82.9 388.5, 82.9 389.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 93.5 383.5 Q 94.7 383.5, 95.4 384.2 Q 96.0 384.9, 96.0 386.3 L 96.0 391.3 L 94.6 391.3 L 94.6 386.4 Q 94.6 385.4, 94.3 385.0 Q 93.9 384.6, 93.2 384.6 Q 92.5 384.6, 91.9 385.0 Q 91.3 385.3, 90.9 385.8 L 90.9 391.3 L 89.5 391.3 L 89.5 383.7 L 90.7 383.7 L 90.8 384.7 Q 91.9 383.5, 93.5 383.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 101.7 383.5 Q 103.0 383.5, 103.6 384.2 Q 104.3 384.9, 104.3 386.3 L 104.3 391.3 L 102.9 391.3 L 102.9 386.4 Q 102.9 385.4, 102.5 385.0 Q 102.2 384.6, 101.4 384.6 Q 100.7 384.6, 100.1 385.0 Q 99.5 385.3, 99.1 385.8 L 99.1 391.3 L 97.7 391.3 L 97.7 380.0 L 99.1 380.0 L 99.1 384.6 Q 100.2 383.5, 101.7 383.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 111.9 383.7 L 113.2 383.7 L 109.3 395.0 L 108.0 395.0 L 109.3 391.3 L 108.7 391.3 L 106.0 383.7 L 107.4 383.7 L 109.7 390.1 L 111.9 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 120.9 380.0 L 120.9 391.3 L 119.8 391.3 L 119.6 390.4 Q 118.7 391.4, 117.3 391.4 Q 115.7 391.4, 114.8 390.5 Q 113.9 389.5, 113.9 387.6 Q 113.9 385.7, 115.0 384.6 Q 116.0 383.5, 117.9 383.5 Q 118.7 383.5, 119.5 383.7 L 119.5 380.0 L 120.9 380.0 M 117.4 390.3 Q 118.2 390.3, 118.7 389.9 Q 119.3 389.5, 119.5 388.7 L 119.5 384.9 Q 118.7 384.6, 117.9 384.6 Q 116.7 384.6, 116.0 385.4 Q 115.4 386.2, 115.4 387.6 Q 115.4 388.9, 115.9 389.6 Q 116.4 390.3, 117.4 390.3 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 123.8 383.7 L 123.9 384.7 Q 124.7 383.5, 126.1 383.5 Q 126.5 383.5, 127.0 383.7 L 126.8 384.9 Q 126.2 384.8, 125.8 384.8 Q 125.2 384.8, 124.8 385.0 Q 124.4 385.3, 124.0 385.9 L 124.0 391.3 L 122.6 391.3 L 122.6 383.7 L 123.8 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 127.8 380.8 L 129.2 380.8 L 129.2 382.1 L 127.8 382.1 L 127.8 380.8 M 127.8 383.7 L 129.2 383.7 L 129.2 391.3 L 127.8 391.3 L 127.8 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 138.0 380.0 L 138.0 391.3 L 136.9 391.3 L 136.7 390.4 Q 135.8 391.4, 134.4 391.4 Q 132.8 391.4, 131.9 390.5 Q 131.0 389.5, 131.0 387.6 Q 131.0 385.7, 132.1 384.6 Q 133.1 383.5, 135.0 383.5 Q 135.8 383.5, 136.6 383.7 L 136.6 380.0 L 138.0 380.0 M 134.5 390.3 Q 135.3 390.3, 135.8 389.9 Q 136.4 389.5, 136.6 388.7 L 136.6 384.9 Q 135.8 384.6, 135.0 384.6 Q 133.8 384.6, 133.1 385.4 Q 132.5 386.2, 132.5 387.6 Q 132.5 388.9, 133.0 389.6 Q 133.5 390.3, 134.5 390.3 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 139.7 387.5 Q 139.7 385.6, 140.7 384.6 Q 141.6 383.5, 143.3 383.5 Q 145.0 383.5, 145.8 384.5 Q 146.5 385.5, 146.5 387.4 L 146.5 387.7 L 141.2 387.7 Q 141.2 389.0, 141.8 389.7 Q 142.4 390.3, 143.5 390.3 Q 144.1 390.3, 144.6 390.2 Q 145.2 390.1, 145.8 389.8 L 146.2 390.7 Q 145.5 391.1, 144.8 391.3 Q 144.1 391.4, 143.4 391.4 Q 141.6 391.4, 140.7 390.4 Q 139.7 389.4, 139.7 387.5 M 143.3 384.6 Q 142.5 384.6, 141.9 385.1 Q 141.4 385.6, 141.2 386.6 L 145.1 386.6 Q 144.9 385.6, 144.5 385.1 Q 144.1 384.6, 143.3 384.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 148.1 389.7 Q 148.8 390.0, 149.2 390.2 Q 149.7 390.3, 150.2 390.3 Q 150.9 390.3, 151.3 390.0 Q 151.7 389.7, 151.7 389.2 Q 151.7 388.8, 151.5 388.6 Q 151.3 388.4, 151.0 388.3 Q 150.8 388.2, 150.1 388.0 Q 150.0 387.9, 149.3 387.7 Q 148.6 387.5, 148.3 387.0 Q 147.9 386.4, 147.9 385.7 Q 147.9 384.8, 148.6 384.1 Q 149.3 383.5, 150.7 383.5 Q 151.3 383.5, 151.8 383.7 Q 152.3 383.8, 152.9 384.0 L 152.5 385.1 Q 152.0 384.9, 151.6 384.8 Q 151.2 384.7, 150.7 384.7 Q 150.0 384.7, 149.7 385.0 Q 149.3 385.2, 149.3 385.7 Q 149.3 386.1, 149.6 386.3 Q 149.9 386.5, 150.5 386.7 Q 150.7 386.8, 150.8 386.8 L 151.2 387.0 Q 151.8 387.2, 152.2 387.4 Q 152.5 387.6, 152.8 388.0 Q 153.1 388.4, 153.1 389.1 Q 153.1 390.3, 152.3 390.9 Q 151.5 391.5, 150.3 391.5 Q 149.5 391.5, 148.9 391.3 Q 148.3 391.1, 147.6 390.9 L 148.1 389.7 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 292.5,289.9 L 300.0,289.9\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 300.0,287.5 L 307.5,287.5\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 300.0,292.3 L 307.5,292.3\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"atom-0\" d=\"M 280.0 290.0 Q 280.0 287.8, 281.1 286.6 Q 282.1 285.4, 284.1 285.4 Q 286.1 285.4, 287.2 286.6 Q 288.2 287.8, 288.2 290.0 Q 288.2 292.1, 287.2 293.4 Q 286.1 294.6, 284.1 294.6 Q 282.1 294.6, 281.1 293.4 Q 280.0 292.2, 280.0 290.0 M 284.1 293.6 Q 285.5 293.6, 286.2 292.7 Q 287.0 291.8, 287.0 290.0 Q 287.0 288.2, 286.2 287.3 Q 285.5 286.4, 284.1 286.4 Q 282.7 286.4, 282.0 287.3 Q 281.3 288.2, 281.3 290.0 Q 281.3 291.8, 282.0 292.7 Q 282.7 293.6, 284.1 293.6 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-1\" d=\"M 311.8 290.0 Q 311.8 287.8, 312.8 286.6 Q 313.9 285.4, 315.9 285.4 Q 317.9 285.4, 318.9 286.6 Q 320.0 287.8, 320.0 290.0 Q 320.0 292.1, 318.9 293.4 Q 317.9 294.6, 315.9 294.6 Q 313.9 294.6, 312.8 293.4 Q 311.8 292.2, 311.8 290.0 M 315.9 293.6 Q 317.3 293.6, 318.0 292.7 Q 318.7 291.8, 318.7 290.0 Q 318.7 288.2, 318.0 287.3 Q 317.3 286.4, 315.9 286.4 Q 314.5 286.4, 313.8 287.3 Q 313.0 288.2, 313.0 290.0 Q 313.0 291.8, 313.8 292.7 Q 314.5 293.6, 315.9 293.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 269.5 383.5 Q 271.5 383.5, 272.4 384.4 Q 273.4 385.3, 273.4 386.9 Q 273.4 388.4, 272.4 389.3 Q 271.4 390.2, 269.5 390.2 L 267.7 390.2 L 267.7 394.9 L 266.2 394.9 L 266.2 383.5 L 269.5 383.5 M 269.5 388.9 Q 270.6 388.9, 271.2 388.4 Q 271.8 387.9, 271.8 386.9 Q 271.8 385.8, 271.2 385.3 Q 270.6 384.8, 269.5 384.8 L 267.7 384.8 L 267.7 388.9 L 269.5 388.9 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 274.8 390.7 Q 274.8 388.7, 275.8 387.6 Q 276.8 386.5, 278.6 386.5 Q 280.5 386.5, 281.3 387.6 Q 282.1 388.6, 282.1 390.7 L 282.1 390.9 L 276.3 390.9 Q 276.4 392.3, 277.0 393.1 Q 277.6 393.8, 278.8 393.8 Q 279.4 393.8, 280.0 393.7 Q 280.6 393.5, 281.3 393.2 L 281.8 394.2 Q 280.9 394.6, 280.2 394.8 Q 279.5 395.0, 278.7 395.0 Q 276.8 395.0, 275.8 393.9 Q 274.8 392.7, 274.8 390.7 M 278.6 387.7 Q 277.7 387.7, 277.1 388.2 Q 276.6 388.8, 276.4 389.8 L 280.5 389.8 Q 280.4 388.7, 279.9 388.2 Q 279.5 387.7, 278.6 387.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 284.5 386.6 L 284.7 387.8 Q 285.6 386.5, 287.0 386.5 Q 287.4 386.5, 288.0 386.6 L 287.8 388.0 Q 287.1 387.8, 286.7 387.8 Q 286.0 387.8, 285.6 388.1 Q 285.2 388.4, 284.8 389.0 L 284.8 394.9 L 283.3 394.9 L 283.3 386.6 L 284.5 386.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 288.9 390.7 Q 288.9 388.7, 289.9 387.6 Q 290.9 386.5, 292.8 386.5 Q 294.7 386.5, 295.7 387.6 Q 296.7 388.7, 296.7 390.7 Q 296.7 392.7, 295.7 393.9 Q 294.7 395.0, 292.8 395.0 Q 290.9 395.0, 289.9 393.9 Q 288.9 392.7, 288.9 390.7 M 290.4 390.7 Q 290.4 392.2, 291.0 393.0 Q 291.7 393.8, 292.8 393.8 Q 293.9 393.8, 294.6 393.0 Q 295.2 392.2, 295.2 390.7 Q 295.2 389.2, 294.6 388.5 Q 293.9 387.7, 292.8 387.7 Q 291.7 387.7, 291.0 388.5 Q 290.4 389.2, 290.4 390.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 301.1 390.6 L 298.3 386.6 L 300.0 386.6 L 302.0 389.4 L 304.0 386.6 L 305.6 386.6 L 302.8 390.6 L 305.8 394.9 L 304.1 394.9 L 301.9 391.8 L 299.7 394.9 L 298.1 394.9 L 301.1 390.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 306.6 383.5 L 308.1 383.5 L 308.1 384.9 L 306.6 384.9 L 306.6 383.5 M 306.6 386.6 L 308.1 386.6 L 308.1 394.9 L 306.6 394.9 L 306.6 386.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 317.6 382.7 L 317.6 394.8 L 316.4 394.8 L 316.1 393.8 Q 315.2 395.0, 313.7 395.0 Q 312.0 395.0, 311.0 393.9 Q 310.1 392.9, 310.1 390.9 Q 310.1 388.8, 311.2 387.7 Q 312.4 386.5, 314.3 386.5 Q 315.2 386.5, 316.1 386.7 L 316.1 382.7 L 317.6 382.7 M 313.8 393.8 Q 314.6 393.8, 315.2 393.4 Q 315.8 392.9, 316.1 392.1 L 316.1 387.9 Q 315.2 387.7, 314.3 387.7 Q 313.1 387.7, 312.4 388.5 Q 311.6 389.4, 311.6 390.9 Q 311.6 392.3, 312.2 393.0 Q 312.8 393.8, 313.8 393.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 319.5 390.7 Q 319.5 388.7, 320.5 387.6 Q 321.5 386.5, 323.3 386.5 Q 325.1 386.5, 325.9 387.6 Q 326.8 388.6, 326.8 390.7 L 326.8 390.9 L 321.0 390.9 Q 321.0 392.3, 321.7 393.1 Q 322.3 393.8, 323.5 393.8 Q 324.1 393.8, 324.7 393.7 Q 325.3 393.5, 326.0 393.2 L 326.4 394.2 Q 325.6 394.6, 324.9 394.8 Q 324.2 395.0, 323.4 395.0 Q 321.5 395.0, 320.5 393.9 Q 319.5 392.7, 319.5 390.7 M 323.3 387.7 Q 322.4 387.7, 321.8 388.2 Q 321.3 388.8, 321.1 389.8 L 325.2 389.8 Q 325.1 388.7, 324.6 388.2 Q 324.2 387.7, 323.3 387.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 328.5 393.2 Q 329.2 393.5, 329.7 393.6 Q 330.2 393.8, 330.8 393.8 Q 331.5 393.8, 331.9 393.4 Q 332.3 393.1, 332.3 392.6 Q 332.3 392.2, 332.1 392.0 Q 331.9 391.7, 331.6 391.6 Q 331.4 391.5, 330.6 391.3 Q 330.5 391.2, 329.8 391.0 Q 329.1 390.7, 328.7 390.2 Q 328.3 389.6, 328.3 388.8 Q 328.3 387.8, 329.0 387.2 Q 329.8 386.5, 331.3 386.5 Q 331.9 386.5, 332.5 386.6 Q 333.0 386.8, 333.6 387.0 L 333.2 388.2 Q 332.7 388.0, 332.2 387.9 Q 331.8 387.7, 331.3 387.7 Q 330.5 387.7, 330.2 388.0 Q 329.8 388.3, 329.8 388.8 Q 329.8 389.3, 330.1 389.5 Q 330.4 389.7, 331.1 389.9 Q 331.2 390.0, 331.4 390.0 L 331.8 390.2 Q 332.4 390.4, 332.8 390.6 Q 333.2 390.9, 333.5 391.3 Q 333.8 391.8, 333.8 392.5 Q 333.8 393.7, 333.0 394.4 Q 332.1 395.0, 330.8 395.0 Q 330.0 395.0, 329.3 394.8 Q 328.7 394.7, 328.0 394.4 L 328.5 393.2 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 443.2,284.9 L 420.9,291.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 441.8,290.3 L 422.2,295.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-0 atom-2\" d=\"M 443.2,284.9 L 450.3,292.0\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-0 atom-2\" d=\"M 450.3,292.0 L 457.5,299.0\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-0 atom-2\" d=\"M 448.0,296.3 L 454.2,302.4\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 474.2,304.8 L 485.4,301.7\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 485.4,301.7 L 496.5,298.6\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 482.7,297.5 L 492.5,294.7\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 496.5,298.6 L 500.4,283.2\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 500.4,283.2 L 504.3,267.8\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 505.0,284.4 L 508.3,271.6\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 504.3,267.8 L 496.4,260.1\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 498.6,258.8 L 490.2,250.6\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 495.3,262.3 L 486.9,254.0\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-5 atom-4 atom-6\" d=\"M 504.3,267.8 L 519.6,263.5\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-4 atom-6\" d=\"M 519.6,263.5 L 534.9,259.2\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-4 atom-6\" d=\"M 520.9,268.1 L 533.6,264.6\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 534.9,259.2 L 537.7,248.2\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 539.9,249.5 L 542.9,237.8\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 535.3,248.3 L 538.3,236.6\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-7 atom-6 atom-8\" d=\"M 534.9,259.2 L 546.3,270.3\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-6 atom-8\" d=\"M 546.3,270.3 L 557.6,281.4\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-6 atom-8\" d=\"M 543.0,273.7 L 552.3,282.9\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 557.6,281.4 L 569.5,278.1\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 569.5,280.6 L 582.0,277.1\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 568.2,276.0 L 580.7,272.5\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-9 atom-8 atom-10\" d=\"M 557.6,281.4 L 553.7,296.8\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-8 atom-10\" d=\"M 553.7,296.8 L 549.8,312.2\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-8 atom-10\" d=\"M 549.1,295.6 L 545.8,308.4\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 549.8,312.2 L 557.7,319.9\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 555.5,321.2 L 563.9,329.4\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 558.9,317.7 L 567.3,326.0\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-11 atom-10 atom-12\" d=\"M 549.8,312.2 L 534.5,316.5\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-10 atom-12\" d=\"M 534.5,316.5 L 519.2,320.8\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-10 atom-12\" d=\"M 533.2,311.9 L 520.6,315.4\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 519.2,320.8 L 516.4,331.8\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 514.2,330.5 L 511.2,342.2\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 518.8,331.7 L 515.9,343.4\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path class=\"bond-13 atom-12 atom-3\" d=\"M 519.2,320.8 L 507.8,309.7\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-12 atom-3\" d=\"M 507.8,309.7 L 496.5,298.6\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-12 atom-3\" d=\"M 511.2,306.3 L 501.8,297.1\" style=\"fill:none;fill-rule:evenodd;stroke:#7F7F7F;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:1,1.33333\"/>\n",
              "<path d=\"M 442.6,285.1 L 443.2,284.9 L 443.3,285.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-1\" d=\"M 409.1 295.8 Q 409.1 293.7, 410.2 292.5 Q 411.2 291.3, 413.2 291.3 Q 415.2 291.3, 416.3 292.5 Q 417.4 293.7, 417.4 295.8 Q 417.4 298.0, 416.3 299.3 Q 415.2 300.5, 413.2 300.5 Q 411.2 300.5, 410.2 299.3 Q 409.1 298.0, 409.1 295.8 M 413.2 299.5 Q 414.6 299.5, 415.3 298.6 Q 416.1 297.6, 416.1 295.8 Q 416.1 294.1, 415.3 293.2 Q 414.6 292.3, 413.2 292.3 Q 411.8 292.3, 411.1 293.2 Q 410.4 294.1, 410.4 295.8 Q 410.4 297.7, 411.1 298.6 Q 411.8 299.5, 413.2 299.5 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-2\" d=\"M 461.8 307.2 Q 461.8 305.0, 462.8 303.8 Q 463.9 302.6, 465.9 302.6 Q 467.9 302.6, 468.9 303.8 Q 470.0 305.0, 470.0 307.2 Q 470.0 309.4, 468.9 310.6 Q 467.9 311.8, 465.9 311.8 Q 463.9 311.8, 462.8 310.6 Q 461.8 309.4, 461.8 307.2 M 465.9 310.8 Q 467.3 310.8, 468.0 309.9 Q 468.7 309.0, 468.7 307.2 Q 468.7 305.4, 468.0 304.5 Q 467.3 303.6, 465.9 303.6 Q 464.5 303.6, 463.8 304.5 Q 463.0 305.4, 463.0 307.2 Q 463.0 309.0, 463.8 309.9 Q 464.5 310.8, 465.9 310.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 478.9 241.1 L 484.3 241.1 L 484.3 242.1 L 480.2 242.1 L 480.2 244.9 L 483.8 244.9 L 483.8 245.9 L 480.2 245.9 L 480.2 250.1 L 478.9 250.1 L 478.9 241.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-7\" d=\"M 540.1 223.9 L 545.5 223.9 L 545.5 225.0 L 541.3 225.0 L 541.3 227.7 L 545.0 227.7 L 545.0 228.8 L 541.3 228.8 L 541.3 232.9 L 540.1 232.9 L 540.1 223.9 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-9\" d=\"M 585.6 268.4 L 590.9 268.4 L 590.9 269.4 L 586.8 269.4 L 586.8 272.1 L 590.5 272.1 L 590.5 273.2 L 586.8 273.2 L 586.8 277.4 L 585.6 277.4 L 585.6 268.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-11\" d=\"M 569.8 329.9 L 575.2 329.9 L 575.2 330.9 L 571.0 330.9 L 571.0 333.7 L 574.7 333.7 L 574.7 334.7 L 571.0 334.7 L 571.0 338.9 L 569.8 338.9 L 569.8 329.9 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-13\" d=\"M 508.6 347.1 L 514.0 347.1 L 514.0 348.1 L 509.9 348.1 L 509.9 350.8 L 513.5 350.8 L 513.5 351.9 L 509.9 351.9 L 509.9 356.1 L 508.6 356.1 L 508.6 347.1 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 420.0 380.8 Q 421.8 380.8, 422.7 381.6 Q 423.6 382.4, 423.6 383.9 Q 423.6 385.3, 422.6 386.2 Q 421.7 387.0, 420.0 387.0 L 418.3 387.0 L 418.3 391.3 L 416.8 391.3 L 416.8 380.8 L 420.0 380.8 M 420.0 385.8 Q 421.0 385.8, 421.5 385.3 Q 422.1 384.8, 422.1 383.9 Q 422.1 382.9, 421.5 382.5 Q 421.0 382.0, 420.0 382.0 L 418.3 382.0 L 418.3 385.8 L 420.0 385.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 424.8 387.5 Q 424.8 385.6, 425.8 384.6 Q 426.7 383.5, 428.4 383.5 Q 430.1 383.5, 430.9 384.5 Q 431.6 385.5, 431.6 387.4 L 431.6 387.7 L 426.3 387.7 Q 426.3 389.0, 426.9 389.7 Q 427.5 390.3, 428.6 390.3 Q 429.2 390.3, 429.7 390.2 Q 430.3 390.1, 430.9 389.8 L 431.3 390.7 Q 430.6 391.1, 429.9 391.3 Q 429.2 391.5, 428.5 391.5 Q 426.7 391.5, 425.8 390.4 Q 424.8 389.4, 424.8 387.5 M 428.4 384.6 Q 427.6 384.6, 427.0 385.1 Q 426.5 385.7, 426.3 386.6 L 430.1 386.6 Q 430.0 385.6, 429.6 385.1 Q 429.2 384.6, 428.4 384.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 436.7 383.5 Q 438.0 383.5, 438.6 384.2 Q 439.3 384.9, 439.3 386.3 L 439.3 391.3 L 437.9 391.3 L 437.9 386.4 Q 437.9 385.5, 437.5 385.1 Q 437.2 384.6, 436.4 384.6 Q 435.7 384.6, 435.1 385.0 Q 434.5 385.3, 434.1 385.8 L 434.1 391.3 L 432.7 391.3 L 432.7 383.7 L 433.9 383.7 L 434.1 384.7 Q 435.1 383.5, 436.7 383.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 441.0 384.7 L 441.0 383.7 L 442.4 383.7 L 442.7 381.4 L 443.7 381.4 L 443.7 383.7 L 446.1 383.7 L 446.1 384.7 L 443.7 384.7 L 443.7 389.0 Q 443.7 390.3, 444.8 390.3 Q 445.3 390.3, 445.9 390.1 L 446.2 391.1 Q 445.4 391.4, 444.6 391.4 Q 443.6 391.4, 442.9 390.8 Q 442.3 390.2, 442.3 389.1 L 442.3 384.7 L 441.0 384.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 447.1 389.3 Q 447.1 388.0, 448.1 387.4 Q 449.1 386.7, 450.9 386.7 L 452.0 386.7 L 452.0 386.4 Q 452.0 385.4, 451.6 385.0 Q 451.2 384.6, 450.3 384.6 Q 449.7 384.6, 449.2 384.8 Q 448.7 384.9, 448.0 385.2 L 447.5 384.2 Q 448.9 383.5, 450.3 383.5 Q 451.9 383.5, 452.7 384.2 Q 453.4 384.9, 453.4 386.4 L 453.4 391.3 L 452.3 391.3 Q 452.3 391.3, 452.3 391.0 Q 452.2 390.8, 452.1 390.4 Q 451.1 391.5, 449.6 391.5 Q 448.5 391.5, 447.8 390.9 Q 447.1 390.3, 447.1 389.3 M 448.5 389.2 Q 448.5 389.8, 448.9 390.1 Q 449.2 390.4, 449.9 390.4 Q 450.5 390.4, 451.1 390.1 Q 451.6 389.9, 452.0 389.4 L 452.0 387.7 L 451.0 387.7 Q 449.7 387.7, 449.1 388.1 Q 448.5 388.5, 448.5 389.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 455.1 384.7 L 455.1 383.7 L 456.5 383.7 L 456.5 382.5 Q 456.5 381.2, 457.1 380.6 Q 457.8 380.0, 458.9 380.0 Q 459.4 380.0, 459.8 380.1 Q 460.3 380.2, 460.7 380.4 L 460.3 381.4 Q 459.6 381.1, 459.0 381.1 Q 458.5 381.1, 458.2 381.5 Q 457.9 381.8, 457.9 382.4 L 457.9 383.7 L 460.2 383.7 L 460.2 384.7 L 457.9 384.7 L 457.9 393.7 L 456.5 393.7 L 456.5 384.7 L 455.1 384.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 460.9 380.0 L 462.3 380.0 L 462.3 391.3 L 460.9 391.3 L 460.9 380.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 470.6 383.7 L 470.6 391.3 L 469.5 391.3 L 469.3 390.3 Q 468.3 391.5, 466.7 391.5 Q 465.4 391.5, 464.8 390.8 Q 464.1 390.1, 464.1 388.7 L 464.1 383.7 L 465.5 383.7 L 465.5 388.6 Q 465.5 389.5, 465.9 390.0 Q 466.2 390.4, 467.0 390.4 Q 467.7 390.4, 468.3 390.0 Q 468.9 389.7, 469.2 389.2 L 469.2 383.7 L 470.6 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 472.4 387.5 Q 472.4 385.6, 473.3 384.6 Q 474.3 383.5, 476.0 383.5 Q 477.8 383.5, 478.7 384.6 Q 479.7 385.6, 479.7 387.5 Q 479.7 389.3, 478.7 390.4 Q 477.8 391.5, 476.0 391.5 Q 474.3 391.5, 473.3 390.4 Q 472.4 389.3, 472.4 387.5 M 473.8 387.5 Q 473.8 388.9, 474.4 389.6 Q 475.0 390.3, 476.0 390.3 Q 477.1 390.3, 477.7 389.6 Q 478.3 388.9, 478.3 387.5 Q 478.3 386.1, 477.7 385.4 Q 477.1 384.6, 476.0 384.6 Q 475.0 384.6, 474.4 385.4 Q 473.8 386.1, 473.8 387.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 482.1 383.7 L 482.2 384.7 Q 483.0 383.5, 484.3 383.5 Q 484.8 383.5, 485.3 383.7 L 485.1 384.9 Q 484.5 384.8, 484.1 384.8 Q 483.5 384.8, 483.1 385.0 Q 482.7 385.3, 482.3 385.9 L 482.3 391.3 L 480.9 391.3 L 480.9 383.7 L 482.1 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 486.1 387.5 Q 486.1 385.6, 487.0 384.6 Q 488.0 383.5, 489.7 383.5 Q 491.5 383.5, 492.4 384.6 Q 493.4 385.6, 493.4 387.5 Q 493.4 389.3, 492.4 390.4 Q 491.5 391.5, 489.7 391.5 Q 488.0 391.5, 487.0 390.4 Q 486.1 389.3, 486.1 387.5 M 487.5 387.5 Q 487.5 388.9, 488.1 389.6 Q 488.7 390.3, 489.7 390.3 Q 490.8 390.3, 491.4 389.6 Q 491.9 388.9, 491.9 387.5 Q 491.9 386.1, 491.4 385.4 Q 490.8 384.6, 489.7 384.6 Q 488.7 384.6, 488.1 385.4 Q 487.5 386.1, 487.5 387.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 498.2 383.5 Q 499.8 383.5, 500.7 384.5 Q 501.6 385.5, 501.6 387.4 Q 501.6 389.3, 500.5 390.4 Q 499.5 391.5, 497.6 391.5 Q 496.8 391.5, 496.0 391.2 L 496.0 395.0 L 494.6 395.0 L 494.6 383.7 L 495.8 383.7 L 495.9 384.6 Q 496.3 384.1, 496.9 383.8 Q 497.5 383.5, 498.2 383.5 M 497.6 390.3 Q 498.8 390.3, 499.5 389.6 Q 500.1 388.8, 500.1 387.4 Q 500.1 386.1, 499.6 385.4 Q 499.1 384.6, 498.1 384.6 Q 497.3 384.6, 496.8 385.0 Q 496.2 385.4, 496.0 386.2 L 496.0 390.1 Q 496.8 390.3, 497.6 390.3 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 506.8 383.5 Q 508.0 383.5, 508.6 384.2 Q 509.3 384.9, 509.3 386.3 L 509.3 391.3 L 507.9 391.3 L 507.9 386.4 Q 507.9 385.5, 507.5 385.1 Q 507.2 384.6, 506.4 384.6 Q 505.7 384.6, 505.1 385.0 Q 504.6 385.3, 504.2 385.8 L 504.2 391.3 L 502.8 391.3 L 502.8 380.0 L 504.2 380.0 L 504.2 384.6 Q 505.2 383.5, 506.8 383.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 511.0 387.5 Q 511.0 385.6, 511.9 384.6 Q 512.9 383.5, 514.6 383.5 Q 516.3 383.5, 517.0 384.5 Q 517.8 385.5, 517.8 387.4 L 517.8 387.7 L 512.4 387.7 Q 512.5 389.0, 513.0 389.7 Q 513.6 390.3, 514.7 390.3 Q 515.3 390.3, 515.9 390.2 Q 516.4 390.1, 517.1 389.8 L 517.5 390.7 Q 516.7 391.1, 516.0 391.3 Q 515.4 391.5, 514.6 391.5 Q 512.9 391.5, 512.0 390.4 Q 511.0 389.4, 511.0 387.5 M 514.6 384.6 Q 513.7 384.6, 513.2 385.1 Q 512.7 385.7, 512.5 386.6 L 516.3 386.6 Q 516.2 385.6, 515.8 385.1 Q 515.4 384.6, 514.6 384.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 522.9 383.5 Q 524.1 383.5, 524.8 384.2 Q 525.4 384.9, 525.4 386.3 L 525.4 391.3 L 524.0 391.3 L 524.0 386.4 Q 524.0 385.5, 523.7 385.1 Q 523.3 384.6, 522.5 384.6 Q 521.8 384.6, 521.3 385.0 Q 520.7 385.3, 520.3 385.8 L 520.3 391.3 L 518.9 391.3 L 518.9 383.7 L 520.1 383.7 L 520.2 384.7 Q 521.2 383.5, 522.9 383.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 533.0 383.7 L 534.4 383.7 L 530.4 395.0 L 529.2 395.0 L 530.4 391.3 L 529.8 391.3 L 527.1 383.7 L 528.6 383.7 L 530.8 390.2 L 533.0 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 535.1 380.0 L 536.5 380.0 L 536.5 391.3 L 535.1 391.3 L 535.1 380.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 543.8 387.5 Q 543.8 385.6, 544.8 384.6 Q 545.7 383.5, 547.4 383.5 Q 549.1 383.5, 549.9 384.5 Q 550.6 385.5, 550.6 387.4 L 550.6 387.7 L 545.3 387.7 Q 545.3 389.0, 545.9 389.7 Q 546.5 390.3, 547.5 390.3 Q 548.1 390.3, 548.7 390.2 Q 549.2 390.1, 549.9 389.8 L 550.3 390.7 Q 549.6 391.1, 548.9 391.3 Q 548.2 391.5, 547.5 391.5 Q 545.7 391.5, 544.8 390.4 Q 543.8 389.4, 543.8 387.5 M 547.4 384.6 Q 546.5 384.6, 546.0 385.1 Q 545.5 385.7, 545.3 386.6 L 549.1 386.6 Q 549.0 385.6, 548.6 385.1 Q 548.2 384.6, 547.4 384.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 552.2 389.8 Q 552.8 390.0, 553.3 390.2 Q 553.8 390.3, 554.3 390.3 Q 555.0 390.3, 555.4 390.0 Q 555.8 389.7, 555.8 389.2 Q 555.8 388.8, 555.6 388.6 Q 555.4 388.4, 555.1 388.3 Q 554.9 388.2, 554.2 388.0 Q 554.1 387.9, 553.4 387.7 Q 552.7 387.5, 552.3 387.0 Q 552.0 386.5, 552.0 385.7 Q 552.0 384.8, 552.7 384.2 Q 553.4 383.5, 554.8 383.5 Q 555.4 383.5, 555.9 383.7 Q 556.4 383.8, 557.0 384.0 L 556.6 385.1 Q 556.1 384.9, 555.7 384.8 Q 555.3 384.7, 554.8 384.7 Q 554.1 384.7, 553.7 385.0 Q 553.4 385.2, 553.4 385.7 Q 553.4 386.1, 553.7 386.3 Q 554.0 386.5, 554.6 386.7 Q 554.7 386.8, 554.9 386.8 L 555.2 387.0 Q 555.9 387.2, 556.2 387.4 Q 556.6 387.6, 556.9 388.0 Q 557.2 388.5, 557.2 389.2 Q 557.2 390.3, 556.4 390.9 Q 555.6 391.5, 554.3 391.5 Q 553.6 391.5, 553.0 391.3 Q 552.4 391.2, 551.7 390.9 L 552.2 389.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 558.5 384.7 L 558.5 383.7 L 560.0 383.7 L 560.2 381.4 L 561.3 381.4 L 561.3 383.7 L 563.6 383.7 L 563.6 384.7 L 561.3 384.7 L 561.3 389.0 Q 561.3 390.3, 562.4 390.3 Q 562.8 390.3, 563.5 390.1 L 563.7 391.1 Q 562.9 391.4, 562.1 391.4 Q 561.1 391.4, 560.5 390.8 Q 559.9 390.2, 559.9 389.1 L 559.9 384.7 L 558.5 384.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 564.6 387.5 Q 564.6 385.6, 565.6 384.6 Q 566.5 383.5, 568.2 383.5 Q 569.9 383.5, 570.7 384.5 Q 571.4 385.5, 571.4 387.4 L 571.4 387.7 L 566.1 387.7 Q 566.1 389.0, 566.7 389.7 Q 567.3 390.3, 568.4 390.3 Q 569.0 390.3, 569.5 390.2 Q 570.1 390.1, 570.7 389.8 L 571.1 390.7 Q 570.4 391.1, 569.7 391.3 Q 569.0 391.5, 568.3 391.5 Q 566.6 391.5, 565.6 390.4 Q 564.6 389.4, 564.6 387.5 M 568.2 384.6 Q 567.4 384.6, 566.8 385.1 Q 566.3 385.7, 566.1 386.6 L 570.0 386.6 Q 569.8 385.6, 569.4 385.1 Q 569.0 384.6, 568.2 384.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 573.7 383.7 L 573.8 384.7 Q 574.7 383.5, 576.0 383.5 Q 576.4 383.5, 576.9 383.7 L 576.7 384.9 Q 576.1 384.8, 575.7 384.8 Q 575.1 384.8, 574.7 385.0 Q 574.3 385.3, 574.0 385.9 L 574.0 391.3 L 572.5 391.3 L 572.5 383.7 L 573.7 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 578.2 389.8 Q 578.8 390.0, 579.3 390.2 Q 579.8 390.3, 580.3 390.3 Q 581.0 390.3, 581.4 390.0 Q 581.8 389.7, 581.8 389.2 Q 581.8 388.8, 581.5 388.6 Q 581.4 388.4, 581.1 388.3 Q 580.9 388.2, 580.2 388.0 Q 580.1 387.9, 579.4 387.7 Q 578.7 387.5, 578.3 387.0 Q 578.0 386.5, 578.0 385.7 Q 578.0 384.8, 578.7 384.2 Q 579.4 383.5, 580.8 383.5 Q 581.4 383.5, 581.9 383.7 Q 582.4 383.8, 583.0 384.0 L 582.6 385.1 Q 582.1 384.9, 581.7 384.8 Q 581.3 384.7, 580.8 384.7 Q 580.1 384.7, 579.7 385.0 Q 579.4 385.2, 579.4 385.7 Q 579.4 386.1, 579.7 386.3 Q 579.9 386.5, 580.6 386.7 Q 580.7 386.8, 580.9 386.8 L 581.2 387.0 Q 581.9 387.2, 582.2 387.4 Q 582.6 387.6, 582.9 388.0 Q 583.2 388.5, 583.2 389.2 Q 583.2 390.3, 582.4 390.9 Q 581.6 391.5, 580.3 391.5 Q 579.6 391.5, 579.0 391.3 Q 578.4 391.2, 577.7 390.9 L 578.2 389.8 \" fill=\"#000000\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "execution_count": 37,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "img = Draw.MolsToGridImage(\n",
        "  mols=glaxo_alerts[\"ROMol\"].iloc[2:8].tolist(), molsPerRow=3, legends=glaxo_alerts[\"description\"].iloc[2:8].tolist(), useSVG=True, drawOptions=dopts,\n",
        ")\n",
        "img"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "XrkNFl8-KzUs"
      },
      "outputs": [],
      "source": [
        "with open(\"figures/ch02/glaxo_alerts_examples.svg\", \"w\") as f:\n",
        "  f.write(img.data)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": 30,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "aTqKF7dtOFxu",
        "outputId": "091ac884-9dcd-4a92-f79a-a4010dfbf66a"
      },
      "outputs": [
        {
          "name": "stdout",
          "output_type": "stream",
          "text": [
            "Compound library size after filtering: 78711\n"
          ]
        },
        {
          "name": "stderr",
          "output_type": "stream",
          "text": [
            "/tmp/ipykernel_7313/1774589771.py:14: SettingWithCopyWarning: \n",
            "A value is trying to be set on a copy of a slice from a DataFrame.\n",
            "Try using .loc[row_indexer,col_indexer] = value instead\n",
            "\n",
            "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n",
            "  specs_ro5_pains_brenk_compliant[\"GLAXO_compliant\"] = ~specs_ro5_pains_brenk_compliant['mol'].apply(glaxo_filter, alerts=glaxo_alerts)\n"
          ]
        },
        {
          "data": {
            "text/plain": [
              "acylhydrazide                                10529\n",
              "Reactive alkyl halides                        1067\n",
              "Thiols                                        1048\n",
              "Aliphatic methylene chains 7 or more long      962\n",
              "Cytochalasin derivatives                       575\n",
              "Name: description, dtype: int64"
            ]
          },
          "execution_count": 30,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "glaxo_sa_matches = []\n",
        "def glaxo_filter(mol, alerts):\n",
        "  match_ = False\n",
        "  for _, alert in alerts.iterrows():\n",
        "    if mol.HasSubstructMatch(alert.ROMol):\n",
        "      glaxo_sa_matches.append({\n",
        "        \"mol\": mol,\n",
        "        \"alert\": alert.ROMol,\n",
        "        \"description\": alert.description,\n",
        "      })\n",
        "      match_ = True\n",
        "  return match_\n",
        "\n",
        "specs_ro5_pains_brenk_compliant[\"GLAXO_compliant\"] = ~specs_ro5_pains_brenk_compliant['mol'].apply(glaxo_filter, alerts=glaxo_alerts)\n",
        "specs_filtered = specs_ro5_pains_brenk_compliant[specs_ro5_pains_brenk_compliant[\"GLAXO_compliant\"]]\n",
        "glaxo_sa_matches = pd.DataFrame(glaxo_sa_matches)\n",
        "print(f\"Compound library size after filtering: {specs_ro5_pains_brenk_compliant['GLAXO_compliant'].sum()}\")\n",
        "glaxo_sa_matches[\"description\"].value_counts()[:5]"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "gpdrdcEQ1j9G"
      },
      "source": [
        "**Code for Figure 2.9. Examples of hits against the Glaxo Wellcome hard filters**"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "tgn6dyoaXSKQ"
      },
      "outputs": [],
      "source": [
        "d2d = Draw.MolDraw2DSVG(-1, -1)\n",
        "dopts = d2d.drawOptions()\n",
        "dopts.useBWAtomPalette()\n",
        "dopts.setHighlightColour((.635,.0,.145,.1))\n",
        "dopts.baseFontSize = 1.0\n",
        "dopts.additionalAtomLabelPadding = 0.15"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "oHFGaulhd8MC"
      },
      "outputs": [],
      "source": [
        "highlights = [mol.GetSubstructMatch(alert) for mol, alert in zip(glaxo_sa_matches.mol, glaxo_sa_matches.alert)]"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "U3SO3MfHXTZB"
      },
      "outputs": [],
      "source": [
        "img = Draw.MolsToGridImage(\n",
        "  glaxo_sa_matches.mol.iloc[2:8].tolist(),\n",
        "  highlightAtomLists=highlights[2:8],\n",
        "  molsPerRow=3,\n",
        "  #subImgSize=(300, 300),\n",
        "  legends=glaxo_sa_matches.description.iloc[2:8].tolist(),\n",
        "  drawOptions=dopts,\n",
        "  useSVG=True\n",
        ")"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 421
        },
        "id": "xXrHt6JEdtDk",
        "outputId": "61c28d45-e57e-4b38-f9bd-2d68a1ee0f98"
      },
      "outputs": [
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"600px\" height=\"400px\" viewBox=\"0 0 600 400\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"600.0\" height=\"400.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 41.8,85.4 L 55.1,95.0 L 54.7,99.2 L 39.7,88.4 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 69.1,88.7 L 72.6,91.2 L 54.7,99.2 L 55.1,95.0 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 70.7,72.4 L 74.4,72.8 L 72.6,91.2 L 69.1,88.7 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<ellipse cx=\"40.8\" cy=\"86.9\" rx=\"3.5\" ry=\"3.5\" class=\"atom-0\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"54.9\" cy=\"97.2\" rx=\"3.7\" ry=\"6.0\" class=\"atom-1\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"70.8\" cy=\"89.9\" rx=\"3.5\" ry=\"3.5\" class=\"atom-2\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"72.6\" cy=\"72.7\" rx=\"3.7\" ry=\"6.0\" class=\"atom-3\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 40.8,86.9 L 50.0,93.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 59.9,94.9 L 70.8,89.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 72.0,90.8 L 73.2,79.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 69.4,90.5 L 70.6,79.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-2 atom-4\" d=\"M 70.8,89.9 L 79.5,96.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 90.4,97.7 L 95.4,95.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 106.3,96.9 L 115.0,103.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 104.8,99.0 L 113.5,105.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 115.0,103.1 L 130.9,96.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 130.9,96.0 L 132.7,78.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 133.7,94.7 L 135.1,80.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 132.7,78.6 L 148.6,71.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 148.6,71.4 L 162.7,81.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 148.3,74.4 L 160.0,82.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 162.7,81.6 L 161.0,99.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 161.0,99.0 L 150.5,103.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 158.5,97.2 L 149.5,101.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-7\" d=\"M 139.6,102.2 L 130.9,96.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 70.3,90.2 L 70.8,89.9 L 71.3,90.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 114.6,102.8 L 115.0,103.1 L 115.8,102.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 132.6,79.5 L 132.7,78.6 L 133.5,78.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 147.8,71.8 L 148.6,71.4 L 149.3,71.9\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 162.0,81.1 L 162.7,81.6 L 162.6,82.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 161.1,98.1 L 161.0,99.0 L 160.5,99.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-1\" d=\"M 52.6 99.9 Q 52.7 100.0, 53.1 100.1 Q 53.5 100.3, 53.9 100.4 Q 54.3 100.5, 54.7 100.5 Q 55.5 100.5, 56.0 100.1 Q 56.4 99.7, 56.4 99.1 Q 56.4 98.6, 56.2 98.3 Q 56.0 98.0, 55.6 97.9 Q 55.3 97.7, 54.7 97.6 Q 53.9 97.3, 53.5 97.1 Q 53.1 96.9, 52.8 96.5 Q 52.5 96.0, 52.5 95.3 Q 52.5 94.3, 53.1 93.6 Q 53.9 93.0, 55.3 93.0 Q 56.2 93.0, 57.3 93.4 L 57.0 94.3 Q 56.0 93.9, 55.3 93.9 Q 54.5 93.9, 54.0 94.3 Q 53.6 94.6, 53.6 95.2 Q 53.6 95.6, 53.8 95.9 Q 54.1 96.1, 54.4 96.3 Q 54.7 96.4, 55.3 96.6 Q 56.0 96.8, 56.5 97.1 Q 56.9 97.3, 57.2 97.8 Q 57.6 98.3, 57.6 99.1 Q 57.6 100.2, 56.8 100.8 Q 56.0 101.4, 54.8 101.4 Q 54.0 101.4, 53.5 101.3 Q 52.9 101.1, 52.3 100.8 L 52.6 99.9 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 70.2 75.4 Q 70.3 75.4, 70.7 75.6 Q 71.1 75.8, 71.5 75.9 Q 71.9 76.0, 72.4 76.0 Q 73.1 76.0, 73.6 75.6 Q 74.0 75.2, 74.0 74.5 Q 74.0 74.1, 73.8 73.8 Q 73.6 73.5, 73.2 73.4 Q 72.9 73.2, 72.3 73.0 Q 71.6 72.8, 71.1 72.6 Q 70.7 72.4, 70.4 72.0 Q 70.1 71.5, 70.1 70.8 Q 70.1 69.7, 70.8 69.1 Q 71.5 68.5, 72.9 68.5 Q 73.8 68.5, 74.9 68.9 L 74.7 69.8 Q 73.7 69.4, 72.9 69.4 Q 72.1 69.4, 71.7 69.7 Q 71.2 70.1, 71.3 70.6 Q 71.3 71.1, 71.5 71.3 Q 71.7 71.6, 72.0 71.8 Q 72.4 71.9, 72.9 72.1 Q 73.7 72.3, 74.1 72.6 Q 74.6 72.8, 74.9 73.3 Q 75.2 73.7, 75.2 74.5 Q 75.2 75.7, 74.4 76.3 Q 73.7 76.9, 72.4 76.9 Q 71.7 76.9, 71.1 76.7 Q 70.6 76.6, 69.9 76.3 L 70.2 75.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-4\" d=\"M 83.2 96.0 L 85.9 100.4 Q 86.1 100.8, 86.6 101.6 Q 87.0 102.3, 87.0 102.4 L 87.0 96.0 L 88.1 96.0 L 88.1 104.2 L 87.0 104.2 L 84.1 99.5 Q 83.7 98.9, 83.4 98.3 Q 83.0 97.6, 82.9 97.4 L 82.9 104.2 L 81.9 104.2 L 81.9 96.0 L 83.2 96.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-4\" d=\"M 81.8 105.0 L 82.9 105.0 L 82.9 108.5 L 87.1 108.5 L 87.1 105.0 L 88.2 105.0 L 88.2 113.3 L 87.1 113.3 L 87.1 109.5 L 82.9 109.5 L 82.9 113.3 L 81.8 113.3 L 81.8 105.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 99.1 88.8 L 101.8 93.2 Q 102.0 93.6, 102.4 94.4 Q 102.9 95.2, 102.9 95.2 L 102.9 88.8 L 104.0 88.8 L 104.0 97.1 L 102.9 97.1 L 100.0 92.3 Q 99.6 91.7, 99.3 91.1 Q 98.9 90.5, 98.8 90.3 L 98.8 97.1 L 97.8 97.1 L 97.8 88.8 L 99.1 88.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 143.3 102.0 L 146.0 106.4 Q 146.2 106.8, 146.7 107.6 Q 147.1 108.4, 147.1 108.4 L 147.1 102.0 L 148.2 102.0 L 148.2 110.3 L 147.1 110.3 L 144.2 105.5 Q 143.9 104.9, 143.5 104.3 Q 143.1 103.6, 143.0 103.5 L 143.0 110.3 L 142.0 110.3 L 142.0 102.0 L 143.3 102.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 67.2 184.8 L 63.7 184.8 L 63.7 183.5 L 72.0 183.5 L 72.0 184.8 L 68.7 184.8 L 68.7 194.9 L 67.2 194.9 L 67.2 184.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 76.9 186.5 Q 78.2 186.5, 78.9 187.2 Q 79.6 188.0, 79.6 189.4 L 79.6 194.9 L 78.1 194.9 L 78.1 189.5 Q 78.1 188.6, 77.7 188.1 Q 77.4 187.7, 76.5 187.7 Q 75.8 187.7, 75.1 188.0 Q 74.5 188.4, 74.1 189.0 L 74.1 194.9 L 72.6 194.9 L 72.6 182.7 L 74.1 182.7 L 74.1 187.7 Q 75.2 186.5, 76.9 186.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 81.5 183.5 L 82.9 183.5 L 82.9 184.9 L 81.5 184.9 L 81.5 183.5 M 81.5 186.6 L 82.9 186.6 L 82.9 194.9 L 81.5 194.9 L 81.5 186.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 84.9 190.7 Q 84.9 188.7, 85.9 187.6 Q 86.9 186.5, 88.8 186.5 Q 90.7 186.5, 91.7 187.6 Q 92.7 188.7, 92.7 190.7 Q 92.7 192.7, 91.7 193.9 Q 90.7 195.0, 88.8 195.0 Q 86.9 195.0, 85.9 193.9 Q 84.9 192.7, 84.9 190.7 M 86.5 190.7 Q 86.5 192.2, 87.1 193.0 Q 87.7 193.8, 88.8 193.8 Q 90.0 193.8, 90.6 193.0 Q 91.2 192.2, 91.2 190.7 Q 91.2 189.2, 90.6 188.5 Q 90.0 187.7, 88.8 187.7 Q 87.7 187.7, 87.1 188.5 Q 86.5 189.2, 86.5 190.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 94.1 190.7 Q 94.1 188.7, 95.1 187.6 Q 96.1 186.5, 97.9 186.5 Q 99.7 186.5, 100.5 187.6 Q 101.4 188.6, 101.4 190.7 L 101.4 190.9 L 95.6 190.9 Q 95.6 192.3, 96.3 193.1 Q 96.9 193.8, 98.1 193.8 Q 98.7 193.8, 99.3 193.7 Q 99.9 193.5, 100.6 193.2 L 101.0 194.2 Q 100.2 194.6, 99.5 194.8 Q 98.7 195.0, 98.0 195.0 Q 96.1 195.0, 95.1 193.9 Q 94.1 192.7, 94.1 190.7 M 97.9 187.7 Q 97.0 187.7, 96.4 188.2 Q 95.8 188.8, 95.7 189.8 L 99.8 189.8 Q 99.7 188.7, 99.2 188.2 Q 98.8 187.7, 97.9 187.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 103.0 193.2 Q 103.8 193.5, 104.3 193.6 Q 104.8 193.8, 105.4 193.8 Q 106.1 193.8, 106.5 193.4 Q 106.9 193.1, 106.9 192.6 Q 106.9 192.2, 106.7 192.0 Q 106.5 191.7, 106.2 191.6 Q 105.9 191.5, 105.2 191.3 Q 105.1 191.2, 104.4 191.0 Q 103.6 190.7, 103.2 190.2 Q 102.8 189.6, 102.8 188.8 Q 102.8 187.8, 103.6 187.2 Q 104.4 186.5, 105.9 186.5 Q 106.5 186.5, 107.0 186.6 Q 107.6 186.8, 108.2 187.0 L 107.8 188.2 Q 107.3 188.0, 106.8 187.9 Q 106.4 187.7, 105.9 187.7 Q 105.1 187.7, 104.7 188.0 Q 104.3 188.3, 104.3 188.8 Q 104.3 189.3, 104.6 189.5 Q 105.0 189.7, 105.6 189.9 Q 105.8 190.0, 105.9 190.0 L 106.3 190.2 Q 107.0 190.4, 107.4 190.6 Q 107.8 190.9, 108.1 191.3 Q 108.4 191.8, 108.4 192.5 Q 108.4 193.7, 107.5 194.4 Q 106.7 195.0, 105.4 195.0 Q 104.6 195.0, 103.9 194.8 Q 103.2 194.7, 102.6 194.4 L 103.0 193.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 109.9 187.8 L 109.9 186.6 L 111.4 186.6 L 111.7 184.2 L 112.8 184.2 L 112.8 186.6 L 115.3 186.6 L 115.3 187.8 L 112.8 187.8 L 112.8 192.3 Q 112.8 193.8, 114.0 193.8 Q 114.5 193.8, 115.2 193.5 L 115.4 194.6 Q 114.6 195.0, 113.7 195.0 Q 112.7 195.0, 112.0 194.3 Q 111.3 193.7, 111.3 192.4 L 111.3 187.8 L 109.9 187.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 116.4 190.7 Q 116.4 188.7, 117.5 187.6 Q 118.5 186.5, 120.3 186.5 Q 122.1 186.5, 122.9 187.6 Q 123.7 188.6, 123.7 190.7 L 123.7 190.9 L 118.0 190.9 Q 118.0 192.3, 118.6 193.1 Q 119.3 193.8, 120.4 193.8 Q 121.1 193.8, 121.7 193.7 Q 122.3 193.5, 123.0 193.2 L 123.4 194.2 Q 122.6 194.6, 121.9 194.8 Q 121.1 195.0, 120.4 195.0 Q 118.5 195.0, 117.5 193.9 Q 116.4 192.7, 116.4 190.7 M 120.3 187.7 Q 119.4 187.7, 118.8 188.2 Q 118.2 188.8, 118.0 189.8 L 122.1 189.8 Q 122.0 188.7, 121.6 188.2 Q 121.1 187.7, 120.3 187.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 126.2 186.6 L 126.3 187.8 Q 127.2 186.5, 128.6 186.5 Q 129.1 186.5, 129.7 186.6 L 129.4 188.0 Q 128.7 187.8, 128.4 187.8 Q 127.7 187.8, 127.2 188.1 Q 126.8 188.4, 126.5 189.0 L 126.5 194.9 L 124.9 194.9 L 124.9 186.6 L 126.2 186.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 131.0 193.2 Q 131.7 193.5, 132.2 193.6 Q 132.7 193.8, 133.3 193.8 Q 134.0 193.8, 134.4 193.4 Q 134.8 193.1, 134.8 192.6 Q 134.8 192.2, 134.6 192.0 Q 134.4 191.7, 134.1 191.6 Q 133.9 191.5, 133.2 191.3 Q 133.0 191.2, 132.3 191.0 Q 131.6 190.7, 131.2 190.2 Q 130.8 189.6, 130.8 188.8 Q 130.8 187.8, 131.6 187.2 Q 132.3 186.5, 133.8 186.5 Q 134.4 186.5, 135.0 186.6 Q 135.5 186.8, 136.2 187.0 L 135.8 188.2 Q 135.2 188.0, 134.8 187.9 Q 134.3 187.7, 133.8 187.7 Q 133.1 187.7, 132.7 188.0 Q 132.3 188.3, 132.3 188.8 Q 132.3 189.3, 132.6 189.5 Q 132.9 189.7, 133.6 189.9 Q 133.8 190.0, 133.9 190.0 L 134.3 190.2 Q 135.0 190.4, 135.4 190.6 Q 135.8 190.9, 136.1 191.3 Q 136.3 191.8, 136.3 192.5 Q 136.3 193.7, 135.5 194.4 Q 134.7 195.0, 133.3 195.0 Q 132.5 195.0, 131.9 194.8 Q 131.2 194.7, 130.5 194.4 L 131.0 193.2 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 278.4,70.4 L 282.1,70.7 L 280.3,89.5 L 276.6,89.2 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<ellipse cx=\"280.2\" cy=\"70.6\" rx=\"3.7\" ry=\"6.0\" class=\"atom-7\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"278.4\" cy=\"89.4\" rx=\"3.7\" ry=\"6.0\" class=\"atom-8\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 286.7,116.3 L 301.0,106.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 286.8,113.1 L 297.9,105.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 301.0,106.3 L 318.0,110.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 318.0,110.2 L 329.9,97.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 329.9,97.4 L 324.7,80.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 324.7,80.7 L 307.7,76.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 307.7,76.8 L 296.3,63.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 304.2,76.8 L 295.5,66.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 296.3,63.7 L 285.2,68.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 279.6,77.2 L 279.0,82.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 283.4,89.4 L 295.9,89.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 283.3,92.0 L 293.9,92.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-8 atom-10\" d=\"M 276.1,96.0 L 275.0,99.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-0\" d=\"M 277.7,109.6 L 286.7,116.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-9 atom-1\" d=\"M 295.9,89.6 L 301.0,106.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-9 atom-5\" d=\"M 295.9,89.6 L 307.7,76.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 287.4,115.8 L 286.7,116.3 L 286.3,116.0\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 317.1,110.0 L 318.0,110.2 L 318.6,109.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 329.3,98.0 L 329.9,97.4 L 329.6,96.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 325.0,81.6 L 324.7,80.7 L 323.9,80.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 296.8,64.3 L 296.3,63.7 L 295.7,63.9\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-7\" d=\"M 277.9 73.4 Q 278.0 73.4, 278.4 73.6 Q 278.8 73.7, 279.2 73.8 Q 279.6 73.9, 280.0 73.9 Q 280.8 73.9, 281.3 73.5 Q 281.7 73.2, 281.7 72.5 Q 281.7 72.0, 281.5 71.8 Q 281.3 71.5, 280.9 71.3 Q 280.6 71.2, 280.0 71.0 Q 279.2 70.8, 278.8 70.6 Q 278.4 70.4, 278.1 69.9 Q 277.8 69.5, 277.8 68.7 Q 277.8 67.7, 278.5 67.1 Q 279.2 66.4, 280.6 66.4 Q 281.5 66.4, 282.6 66.9 L 282.3 67.8 Q 281.3 67.4, 280.6 67.4 Q 279.8 67.4, 279.4 67.7 Q 278.9 68.0, 278.9 68.6 Q 278.9 69.0, 279.1 69.3 Q 279.4 69.6, 279.7 69.7 Q 280.0 69.9, 280.6 70.1 Q 281.3 70.3, 281.8 70.5 Q 282.2 70.8, 282.5 71.2 Q 282.9 71.7, 282.9 72.5 Q 282.9 73.6, 282.1 74.3 Q 281.3 74.9, 280.1 74.9 Q 279.3 74.9, 278.8 74.7 Q 278.2 74.5, 277.6 74.3 L 277.9 73.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-8\" d=\"M 276.1 92.2 Q 276.2 92.2, 276.6 92.4 Q 277.0 92.5, 277.4 92.6 Q 277.8 92.7, 278.2 92.7 Q 279.0 92.7, 279.5 92.3 Q 279.9 92.0, 279.9 91.3 Q 279.9 90.8, 279.7 90.6 Q 279.5 90.3, 279.1 90.1 Q 278.8 90.0, 278.2 89.8 Q 277.4 89.6, 277.0 89.4 Q 276.6 89.2, 276.3 88.7 Q 276.0 88.3, 276.0 87.5 Q 276.0 86.5, 276.7 85.9 Q 277.4 85.2, 278.8 85.2 Q 279.7 85.2, 280.8 85.7 L 280.5 86.6 Q 279.5 86.2, 278.8 86.2 Q 278.0 86.2, 277.6 86.5 Q 277.1 86.8, 277.1 87.4 Q 277.1 87.8, 277.3 88.1 Q 277.6 88.4, 277.9 88.5 Q 278.2 88.7, 278.8 88.9 Q 279.5 89.1, 280.0 89.3 Q 280.4 89.6, 280.7 90.0 Q 281.1 90.5, 281.1 91.3 Q 281.1 92.4, 280.3 93.1 Q 279.5 93.7, 278.3 93.7 Q 277.5 93.7, 277.0 93.5 Q 276.4 93.3, 275.8 93.1 L 276.1 92.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-10\" d=\"M 270.4 108.7 Q 270.5 108.7, 270.9 108.9 Q 271.3 109.0, 271.7 109.1 Q 272.2 109.2, 272.6 109.2 Q 273.4 109.2, 273.8 108.9 Q 274.3 108.5, 274.3 107.8 Q 274.3 107.4, 274.0 107.1 Q 273.8 106.8, 273.5 106.6 Q 273.1 106.5, 272.5 106.3 Q 271.8 106.1, 271.4 105.9 Q 270.9 105.7, 270.6 105.2 Q 270.3 104.8, 270.3 104.0 Q 270.3 103.0, 271.0 102.4 Q 271.7 101.7, 273.1 101.7 Q 274.1 101.7, 275.1 102.2 L 274.9 103.1 Q 273.9 102.7, 273.1 102.7 Q 272.3 102.7, 271.9 103.0 Q 271.5 103.3, 271.5 103.9 Q 271.5 104.4, 271.7 104.6 Q 271.9 104.9, 272.3 105.0 Q 272.6 105.2, 273.1 105.4 Q 273.9 105.6, 274.3 105.8 Q 274.8 106.1, 275.1 106.5 Q 275.4 107.0, 275.4 107.8 Q 275.4 108.9, 274.6 109.6 Q 273.9 110.2, 272.6 110.2 Q 271.9 110.2, 271.3 110.0 Q 270.8 109.9, 270.1 109.6 L 270.4 108.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 267.2 180.8 Q 269.6 180.8, 270.8 182.2 Q 272.1 183.5, 272.1 186.0 Q 272.1 188.5, 270.8 189.9 Q 269.6 191.3, 267.2 191.3 L 263.8 191.3 L 263.8 180.8 L 267.2 180.8 M 267.2 190.1 Q 268.8 190.1, 269.7 189.1 Q 270.6 188.1, 270.6 186.0 Q 270.6 184.0, 269.7 183.0 Q 268.8 182.0, 267.2 182.0 L 265.2 182.0 L 265.2 190.1 L 267.2 190.1 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 273.3 180.8 L 274.7 180.8 L 274.7 182.1 L 273.3 182.1 L 273.3 180.8 M 273.3 183.7 L 274.7 183.7 L 274.7 191.3 L 273.3 191.3 L 273.3 183.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 276.9 189.8 Q 277.6 190.0, 278.0 190.2 Q 278.5 190.3, 279.1 190.3 Q 279.7 190.3, 280.1 190.0 Q 280.5 189.7, 280.5 189.2 Q 280.5 188.8, 280.3 188.6 Q 280.1 188.4, 279.8 188.3 Q 279.6 188.2, 278.9 188.0 Q 278.8 187.9, 278.1 187.7 Q 277.4 187.5, 277.1 187.0 Q 276.7 186.5, 276.7 185.7 Q 276.7 184.8, 277.4 184.2 Q 278.1 183.5, 279.5 183.5 Q 280.1 183.5, 280.6 183.7 Q 281.2 183.8, 281.7 184.0 L 281.3 185.1 Q 280.9 184.9, 280.4 184.8 Q 280.0 184.7, 279.5 184.7 Q 278.8 184.7, 278.5 185.0 Q 278.1 185.2, 278.1 185.7 Q 278.1 186.1, 278.4 186.3 Q 278.7 186.5, 279.3 186.7 Q 279.5 186.8, 279.6 186.8 L 280.0 187.0 Q 280.6 187.2, 281.0 187.4 Q 281.4 187.6, 281.6 188.0 Q 281.9 188.5, 281.9 189.2 Q 281.9 190.3, 281.1 190.9 Q 280.3 191.5, 279.1 191.5 Q 278.3 191.5, 277.7 191.3 Q 277.1 191.2, 276.5 190.9 L 276.9 189.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 289.7 183.7 L 289.7 191.3 L 288.6 191.3 L 288.4 190.3 Q 287.4 191.5, 285.8 191.5 Q 284.5 191.5, 283.9 190.8 Q 283.2 190.1, 283.2 188.7 L 283.2 183.7 L 284.6 183.7 L 284.6 188.6 Q 284.6 189.5, 285.0 190.0 Q 285.3 190.4, 286.1 190.4 Q 286.8 190.4, 287.4 190.1 Q 288.0 189.7, 288.3 189.2 L 288.3 183.7 L 289.7 183.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 291.5 180.0 L 292.9 180.0 L 292.9 191.3 L 291.5 191.3 L 291.5 180.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 298.2 183.5 Q 299.8 183.5, 300.7 184.5 Q 301.6 185.5, 301.6 187.4 Q 301.6 189.3, 300.5 190.4 Q 299.5 191.5, 297.7 191.5 Q 296.8 191.5, 296.1 191.2 L 296.1 195.0 L 294.7 195.0 L 294.7 183.7 L 295.8 183.7 L 296.0 184.6 Q 296.4 184.1, 296.9 183.8 Q 297.5 183.5, 298.2 183.5 M 297.6 190.4 Q 298.8 190.4, 299.5 189.6 Q 300.2 188.8, 300.2 187.4 Q 300.2 186.1, 299.6 185.3 Q 299.1 184.6, 298.1 184.6 Q 297.4 184.6, 296.8 185.0 Q 296.3 185.4, 296.1 186.2 L 296.1 190.1 Q 296.8 190.4, 297.6 190.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 306.8 183.5 Q 308.0 183.5, 308.7 184.2 Q 309.3 184.9, 309.3 186.3 L 309.3 191.3 L 307.9 191.3 L 307.9 186.4 Q 307.9 185.5, 307.6 185.0 Q 307.2 184.6, 306.4 184.6 Q 305.7 184.6, 305.2 185.0 Q 304.6 185.3, 304.2 185.8 L 304.2 191.3 L 302.8 191.3 L 302.8 180.0 L 304.2 180.0 L 304.2 184.6 Q 305.2 183.5, 306.8 183.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 311.0 180.8 L 312.4 180.8 L 312.4 182.1 L 311.0 182.1 L 311.0 180.8 M 311.0 183.7 L 312.4 183.7 L 312.4 191.3 L 311.0 191.3 L 311.0 183.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 321.2 180.0 L 321.2 191.3 L 320.0 191.3 L 319.8 190.4 Q 319.0 191.5, 317.5 191.5 Q 316.0 191.5, 315.1 190.5 Q 314.2 189.5, 314.2 187.6 Q 314.2 185.7, 315.2 184.6 Q 316.3 183.5, 318.1 183.5 Q 318.9 183.5, 319.7 183.7 L 319.7 180.0 L 321.2 180.0 M 317.6 190.4 Q 318.4 190.4, 319.0 189.9 Q 319.5 189.5, 319.7 188.7 L 319.7 184.9 Q 319.0 184.6, 318.1 184.6 Q 317.0 184.6, 316.3 185.4 Q 315.6 186.2, 315.6 187.6 Q 315.6 188.9, 316.1 189.7 Q 316.7 190.4, 317.6 190.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 322.9 187.5 Q 322.9 185.6, 323.8 184.6 Q 324.7 183.5, 326.5 183.5 Q 328.2 183.5, 328.9 184.5 Q 329.7 185.5, 329.7 187.4 L 329.7 187.7 L 324.3 187.7 Q 324.3 189.0, 324.9 189.7 Q 325.5 190.4, 326.6 190.4 Q 327.2 190.4, 327.7 190.2 Q 328.3 190.1, 329.0 189.8 L 329.4 190.7 Q 328.6 191.1, 327.9 191.3 Q 327.2 191.5, 326.5 191.5 Q 324.8 191.5, 323.8 190.4 Q 322.9 189.4, 322.9 187.5 M 326.5 184.6 Q 325.6 184.6, 325.0 185.1 Q 324.5 185.6, 324.4 186.6 L 328.2 186.6 Q 328.1 185.6, 327.7 185.1 Q 327.2 184.6, 326.5 184.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 331.2 189.8 Q 331.9 190.0, 332.3 190.2 Q 332.8 190.3, 333.3 190.3 Q 334.0 190.3, 334.4 190.0 Q 334.8 189.7, 334.8 189.2 Q 334.8 188.8, 334.6 188.6 Q 334.4 188.4, 334.1 188.3 Q 333.9 188.2, 333.2 188.0 Q 333.1 187.9, 332.4 187.7 Q 331.7 187.5, 331.4 187.0 Q 331.0 186.5, 331.0 185.7 Q 331.0 184.8, 331.7 184.2 Q 332.4 183.5, 333.8 183.5 Q 334.4 183.5, 334.9 183.7 Q 335.4 183.8, 336.0 184.0 L 335.6 185.1 Q 335.1 184.9, 334.7 184.8 Q 334.3 184.7, 333.8 184.7 Q 333.1 184.7, 332.8 185.0 Q 332.4 185.2, 332.4 185.7 Q 332.4 186.1, 332.7 186.3 Q 333.0 186.5, 333.6 186.7 Q 333.8 186.8, 333.9 186.8 L 334.3 187.0 Q 334.9 187.2, 335.3 187.4 Q 335.6 187.6, 335.9 188.0 Q 336.2 188.5, 336.2 189.2 Q 336.2 190.3, 335.4 190.9 Q 334.6 191.5, 333.4 191.5 Q 332.6 191.5, 332.0 191.3 Q 331.4 191.2, 330.7 190.9 L 331.2 189.8 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 517.1,87.5 L 516.2,91.7 L 500.6,96.7 L 499.4,93.2 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 517.1,87.5 L 531.6,100.7 L 527.5,102.0 L 516.2,91.7 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 531.6,100.7 L 527.6,118.8 L 524.0,118.0 L 527.5,102.0 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<ellipse cx=\"500.0\" cy=\"94.9\" rx=\"4.4\" ry=\"5.8\" class=\"atom-2\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"516.6\" cy=\"85.1\" rx=\"4.6\" ry=\"12.2\" class=\"atom-3\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"529.5\" cy=\"101.3\" rx=\"3.5\" ry=\"3.5\" class=\"atom-4\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"525.8\" cy=\"118.4\" rx=\"5.3\" ry=\"6.0\" class=\"atom-5\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 490.8,66.2 L 487.1,83.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 487.1,83.2 L 494.6,90.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 490.0,82.3 L 496.3,88.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 505.4,93.2 L 511.2,91.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 522.1,94.5 L 529.5,101.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 528.4,100.3 L 526.0,111.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 531.0,100.9 L 528.5,112.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-4 atom-6\" d=\"M 529.5,101.3 L 546.1,96.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 546.1,96.0 L 559.0,107.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 549.0,95.1 L 559.7,104.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 559.0,107.7 L 575.7,102.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 575.7,102.4 L 579.4,85.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 573.4,100.4 L 576.5,86.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 579.4,85.4 L 571.9,78.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 561.0,75.4 L 549.8,79.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 561.8,77.9 L 552.1,81.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-1 atom-12\" d=\"M 487.1,83.2 L 470.5,88.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 470.5,88.5 L 457.6,76.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 467.6,89.4 L 456.9,79.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 457.6,76.8 L 459.8,66.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-13 atom-15\" d=\"M 457.6,76.8 L 441.0,82.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 441.0,82.1 L 437.3,99.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 443.2,84.2 L 440.1,98.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 437.3,99.2 L 420.6,104.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-16 atom-18\" d=\"M 437.3,99.2 L 444.1,105.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 456.3,108.9 L 466.8,105.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 465.3,106.0 L 472.7,112.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 467.1,104.1 L 474.5,110.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-11 atom-6\" d=\"M 549.8,79.0 L 546.1,96.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-19 atom-12\" d=\"M 466.8,105.6 L 470.5,88.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 529.1,101.0 L 529.5,101.3 L 530.4,101.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 558.4,107.1 L 559.0,107.7 L 559.9,107.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 574.8,102.7 L 575.7,102.4 L 575.8,101.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 579.2,86.2 L 579.4,85.4 L 579.0,85.0\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 550.4,78.8 L 549.8,79.0 L 549.6,79.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 441.8,81.9 L 441.0,82.1 L 440.8,83.0\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 466.3,105.7 L 466.8,105.6 L 467.0,104.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-2\" d=\"M 498.2 90.8 L 500.9 95.2 Q 501.1 95.6, 501.6 96.4 Q 502.0 97.2, 502.0 97.2 L 502.0 90.8 L 503.1 90.8 L 503.1 99.0 L 502.0 99.0 L 499.1 94.3 Q 498.8 93.7, 498.4 93.1 Q 498.1 92.4, 497.9 92.2 L 497.9 99.0 L 496.9 99.0 L 496.9 90.8 L 498.2 90.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 514.8 85.5 L 517.5 89.8 Q 517.8 90.3, 518.2 91.1 Q 518.6 91.8, 518.6 91.9 L 518.6 85.5 L 519.7 85.5 L 519.7 93.7 L 518.6 93.7 L 515.7 88.9 Q 515.4 88.4, 515.0 87.8 Q 514.7 87.1, 514.6 86.9 L 514.6 93.7 L 513.5 93.7 L 513.5 85.5 L 514.8 85.5 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 513.4 76.4 L 514.5 76.4 L 514.5 79.9 L 518.7 79.9 L 518.7 76.4 L 519.8 76.4 L 519.8 84.7 L 518.7 84.7 L 518.7 80.9 L 514.5 80.9 L 514.5 84.7 L 513.4 84.7 L 513.4 76.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 522.0 118.4 Q 522.0 116.4, 523.0 115.3 Q 524.0 114.2, 525.8 114.2 Q 527.7 114.2, 528.6 115.3 Q 529.6 116.4, 529.6 118.4 Q 529.6 120.4, 528.6 121.5 Q 527.6 122.7, 525.8 122.7 Q 524.0 122.7, 523.0 121.5 Q 522.0 120.4, 522.0 118.4 M 525.8 121.7 Q 527.1 121.7, 527.8 120.9 Q 528.4 120.0, 528.4 118.4 Q 528.4 116.8, 527.8 116.0 Q 527.1 115.1, 525.8 115.1 Q 524.6 115.1, 523.9 115.9 Q 523.2 116.8, 523.2 118.4 Q 523.2 120.1, 523.9 120.9 Q 524.6 121.7, 525.8 121.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-10\" d=\"M 564.6 69.5 L 567.3 73.9 Q 567.6 74.3, 568.0 75.1 Q 568.4 75.9, 568.5 75.9 L 568.5 69.5 L 569.6 69.5 L 569.6 77.7 L 568.4 77.7 L 565.5 73.0 Q 565.2 72.4, 564.8 71.8 Q 564.5 71.1, 564.4 70.9 L 564.4 77.7 L 563.3 77.7 L 563.3 69.5 L 564.6 69.5 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-14\" d=\"M 457.5 59.8 Q 457.5 57.8, 458.5 56.7 Q 459.4 55.6, 461.3 55.6 Q 463.1 55.6, 464.1 56.7 Q 465.0 57.8, 465.0 59.8 Q 465.0 61.8, 464.0 62.9 Q 463.1 64.0, 461.3 64.0 Q 459.4 64.0, 458.5 62.9 Q 457.5 61.8, 457.5 59.8 M 461.3 63.1 Q 462.5 63.1, 463.2 62.3 Q 463.9 61.4, 463.9 59.8 Q 463.9 58.2, 463.2 57.3 Q 462.5 56.5, 461.3 56.5 Q 460.0 56.5, 459.3 57.3 Q 458.6 58.1, 458.6 59.8 Q 458.6 61.4, 459.3 62.3 Q 460.0 63.1, 461.3 63.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-14\" d=\"M 466.3 55.7 L 467.4 55.7 L 467.4 59.2 L 471.6 59.2 L 471.6 55.7 L 472.8 55.7 L 472.8 63.9 L 471.6 63.9 L 471.6 60.1 L 467.4 60.1 L 467.4 63.9 L 466.3 63.9 L 466.3 55.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-18\" d=\"M 446.4 110.9 Q 446.4 108.9, 447.4 107.8 Q 448.3 106.7, 450.2 106.7 Q 452.0 106.7, 453.0 107.8 Q 454.0 108.9, 454.0 110.9 Q 454.0 112.9, 453.0 114.1 Q 452.0 115.2, 450.2 115.2 Q 448.4 115.2, 447.4 114.1 Q 446.4 112.9, 446.4 110.9 M 450.2 114.2 Q 451.4 114.2, 452.1 113.4 Q 452.8 112.6, 452.8 110.9 Q 452.8 109.3, 452.1 108.5 Q 451.4 107.7, 450.2 107.7 Q 448.9 107.7, 448.2 108.5 Q 447.6 109.3, 447.6 110.9 Q 447.6 112.6, 448.2 113.4 Q 448.9 114.2, 450.2 114.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-20\" d=\"M 475.9 117.3 Q 475.9 115.3, 476.9 114.2 Q 477.9 113.1, 479.7 113.1 Q 481.5 113.1, 482.5 114.2 Q 483.5 115.3, 483.5 117.3 Q 483.5 119.3, 482.5 120.5 Q 481.5 121.6, 479.7 121.6 Q 477.9 121.6, 476.9 120.5 Q 475.9 119.3, 475.9 117.3 M 479.7 120.6 Q 481.0 120.6, 481.6 119.8 Q 482.3 119.0, 482.3 117.3 Q 482.3 115.7, 481.6 114.9 Q 481.0 114.1, 479.7 114.1 Q 478.4 114.1, 477.8 114.9 Q 477.1 115.7, 477.1 117.3 Q 477.1 119.0, 477.8 119.8 Q 478.4 120.6, 479.7 120.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 454.8 189.3 Q 454.8 188.0, 455.8 187.4 Q 456.8 186.7, 458.6 186.7 L 459.7 186.7 L 459.7 186.4 Q 459.7 185.4, 459.3 185.0 Q 458.9 184.6, 458.0 184.6 Q 457.3 184.6, 456.9 184.7 Q 456.4 184.9, 455.6 185.2 L 455.2 184.2 Q 456.6 183.5, 458.0 183.5 Q 459.6 183.5, 460.4 184.2 Q 461.1 184.9, 461.1 186.4 L 461.1 191.3 L 460.0 191.3 Q 460.0 191.3, 460.0 191.0 Q 459.9 190.8, 459.8 190.4 Q 458.8 191.5, 457.3 191.5 Q 456.2 191.5, 455.5 190.9 Q 454.8 190.3, 454.8 189.3 M 456.2 189.2 Q 456.2 189.8, 456.6 190.1 Q 456.9 190.4, 457.6 190.4 Q 458.2 190.4, 458.8 190.1 Q 459.3 189.9, 459.7 189.4 L 459.7 187.7 L 458.7 187.7 Q 457.4 187.7, 456.8 188.1 Q 456.2 188.5, 456.2 189.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 462.8 187.5 Q 462.8 185.6, 463.8 184.6 Q 464.7 183.5, 466.5 183.5 Q 468.2 183.5, 469.2 184.8 L 468.2 185.5 Q 467.9 185.1, 467.4 184.9 Q 467.0 184.6, 466.5 184.6 Q 465.4 184.6, 464.8 185.4 Q 464.3 186.1, 464.3 187.5 Q 464.3 188.9, 464.9 189.6 Q 465.5 190.3, 466.6 190.3 Q 467.2 190.3, 467.6 190.2 Q 468.1 190.1, 468.6 189.8 L 469.0 190.8 Q 467.9 191.4, 466.5 191.4 Q 464.7 191.4, 463.8 190.4 Q 462.8 189.3, 462.8 187.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 476.0 183.7 L 477.3 183.7 L 473.4 195.0 L 472.1 195.0 L 473.4 191.3 L 472.8 191.3 L 470.1 183.7 L 471.5 183.7 L 473.8 190.1 L 476.0 183.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 478.1 180.0 L 479.4 180.0 L 479.4 191.3 L 478.1 191.3 L 478.1 180.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 485.3 183.5 Q 486.5 183.5, 487.2 184.2 Q 487.8 184.9, 487.8 186.3 L 487.8 191.3 L 486.4 191.3 L 486.4 186.4 Q 486.4 185.4, 486.1 185.0 Q 485.7 184.6, 484.9 184.6 Q 484.2 184.6, 483.6 185.0 Q 483.1 185.3, 482.7 185.8 L 482.7 191.3 L 481.3 191.3 L 481.3 180.0 L 482.7 180.0 L 482.7 184.6 Q 483.7 183.5, 485.3 183.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 495.4 183.7 L 496.8 183.7 L 492.8 195.0 L 491.6 195.0 L 492.8 191.3 L 492.2 191.3 L 489.5 183.7 L 491.0 183.7 L 493.2 190.1 L 495.4 183.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 504.5 180.0 L 504.5 191.3 L 503.4 191.3 L 503.2 190.4 Q 502.3 191.4, 500.9 191.4 Q 499.3 191.4, 498.4 190.5 Q 497.5 189.5, 497.5 187.6 Q 497.5 185.7, 498.6 184.6 Q 499.6 183.5, 501.5 183.5 Q 502.2 183.5, 503.1 183.7 L 503.1 180.0 L 504.5 180.0 M 501.0 190.3 Q 501.8 190.3, 502.3 189.9 Q 502.9 189.5, 503.1 188.7 L 503.1 184.9 Q 502.3 184.6, 501.5 184.6 Q 500.3 184.6, 499.6 185.4 Q 498.9 186.2, 498.9 187.6 Q 498.9 188.9, 499.5 189.6 Q 500.0 190.3, 501.0 190.3 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 507.4 183.7 L 507.5 184.7 Q 508.4 183.5, 509.7 183.5 Q 510.1 183.5, 510.6 183.7 L 510.4 184.9 Q 509.8 184.8, 509.4 184.8 Q 508.8 184.8, 508.4 185.0 Q 508.0 185.3, 507.6 185.9 L 507.6 191.3 L 506.2 191.3 L 506.2 183.7 L 507.4 183.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 511.4 189.3 Q 511.4 188.0, 512.4 187.4 Q 513.4 186.7, 515.2 186.7 L 516.4 186.7 L 516.4 186.4 Q 516.4 185.4, 515.9 185.0 Q 515.6 184.6, 514.6 184.6 Q 514.0 184.6, 513.5 184.7 Q 513.0 184.9, 512.3 185.2 L 511.9 184.2 Q 513.3 183.5, 514.6 183.5 Q 516.3 183.5, 517.0 184.2 Q 517.8 184.9, 517.8 186.4 L 517.8 191.3 L 516.7 191.3 Q 516.7 191.3, 516.6 191.0 Q 516.6 190.8, 516.5 190.4 Q 515.4 191.5, 514.0 191.5 Q 512.8 191.5, 512.1 190.9 Q 511.4 190.3, 511.4 189.3 M 512.8 189.2 Q 512.8 189.8, 513.2 190.1 Q 513.6 190.4, 514.2 190.4 Q 514.8 190.4, 515.4 190.1 Q 516.0 189.9, 516.4 189.4 L 516.4 187.7 L 515.3 187.7 Q 514.1 187.7, 513.5 188.1 Q 512.8 188.5, 512.8 189.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 521.1 190.2 L 525.4 190.2 L 525.4 191.3 L 519.5 191.3 L 519.5 190.4 L 523.5 184.8 L 519.7 184.8 L 519.7 183.7 L 525.2 183.7 L 525.2 184.5 L 521.1 190.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 526.5 180.8 L 527.8 180.8 L 527.8 182.1 L 526.5 182.1 L 526.5 180.8 M 526.5 183.7 L 527.8 183.7 L 527.8 191.3 L 526.5 191.3 L 526.5 183.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 536.7 180.0 L 536.7 191.3 L 535.5 191.3 L 535.3 190.4 Q 534.5 191.4, 533.1 191.4 Q 531.5 191.4, 530.6 190.5 Q 529.7 189.5, 529.7 187.6 Q 529.7 185.7, 530.7 184.6 Q 531.8 183.5, 533.6 183.5 Q 534.4 183.5, 535.2 183.7 L 535.2 180.0 L 536.7 180.0 M 533.1 190.3 Q 533.9 190.3, 534.5 189.9 Q 535.0 189.5, 535.2 188.7 L 535.2 184.9 Q 534.5 184.6, 533.6 184.6 Q 532.5 184.6, 531.8 185.4 Q 531.1 186.2, 531.1 187.6 Q 531.1 188.9, 531.6 189.6 Q 532.2 190.3, 533.1 190.3 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 538.4 187.5 Q 538.4 185.6, 539.4 184.6 Q 540.3 183.5, 542.0 183.5 Q 543.7 183.5, 544.4 184.5 Q 545.2 185.5, 545.2 187.4 L 545.2 187.7 L 539.8 187.7 Q 539.9 189.0, 540.5 189.7 Q 541.0 190.3, 542.1 190.3 Q 542.7 190.3, 543.3 190.2 Q 543.8 190.1, 544.5 189.8 L 544.9 190.7 Q 544.1 191.1, 543.5 191.3 Q 542.8 191.4, 542.1 191.4 Q 540.3 191.4, 539.4 190.4 Q 538.4 189.4, 538.4 187.5 M 542.0 184.6 Q 541.1 184.6, 540.6 185.1 Q 540.1 185.6, 539.9 186.6 L 543.7 186.6 Q 543.6 185.6, 543.2 185.1 Q 542.8 184.6, 542.0 184.6 \" fill=\"#000000\"/>\n",
              "<ellipse cx=\"150.4\" cy=\"262.4\" rx=\"9.1\" ry=\"6.0\" class=\"atom-15\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 77.9,262.6 L 70.1,278.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 70.1,278.3 L 52.9,281.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 68.7,281.2 L 55.3,283.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 52.9,281.2 L 50.4,298.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 50.4,298.4 L 35.0,306.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 35.0,306.5 L 24.3,312.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-4 atom-6\" d=\"M 35.0,306.5 L 30.2,297.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-4 atom-7\" d=\"M 35.0,306.5 L 39.7,315.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-3 atom-8\" d=\"M 50.4,298.4 L 60.6,303.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-3 atom-8\" d=\"M 53.3,296.9 L 61.8,301.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 71.5,300.6 L 72.8,299.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 83.7,294.5 L 95.5,296.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 95.5,296.3 L 106.3,282.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 106.3,282.6 L 103.4,272.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 108.3,280.1 L 105.9,271.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 107.1,262.2 L 110.7,259.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 121.6,260.4 L 129.8,267.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 120.0,262.5 L 126.7,267.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-14 atom-15\" d=\"M 129.8,267.0 L 141.6,263.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-14 atom-16\" d=\"M 129.8,267.0 L 126.1,276.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 128.0,289.7 L 133.4,297.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 133.4,297.8 L 125.6,313.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 135.1,300.3 L 128.7,313.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 125.6,313.5 L 135.3,328.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 135.3,328.0 L 152.7,326.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 136.6,325.3 L 151.0,324.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 152.7,326.9 L 160.5,311.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-21 atom-22\" d=\"M 160.5,311.3 L 172.4,310.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-21 atom-23\" d=\"M 160.5,311.3 L 150.8,296.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-21 atom-23\" d=\"M 157.4,311.4 L 149.5,299.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-23 atom-9 atom-1\" d=\"M 74.9,287.3 L 70.1,278.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-24 atom-16 atom-11\" d=\"M 118.3,283.1 L 106.3,282.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-25 atom-23 atom-17\" d=\"M 150.8,296.7 L 133.4,297.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 53.8,281.0 L 52.9,281.2 L 52.8,282.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 94.9,296.2 L 95.5,296.3 L 96.0,295.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 126.0,312.7 L 125.6,313.5 L 126.1,314.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 134.8,327.3 L 135.3,328.0 L 136.2,327.9\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 151.8,326.9 L 152.7,326.9 L 153.1,326.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 151.3,297.5 L 150.8,296.7 L 149.9,296.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-5\" d=\"M 17.1 310.5 L 21.9 310.5 L 21.9 311.4 L 18.2 311.4 L 18.2 313.9 L 21.5 313.9 L 21.5 314.9 L 18.2 314.9 L 18.2 318.7 L 17.1 318.7 L 17.1 310.5 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-6\" d=\"M 24.4 287.0 L 29.3 287.0 L 29.3 287.9 L 25.5 287.9 L 25.5 290.4 L 28.9 290.4 L 28.9 291.4 L 25.5 291.4 L 25.5 295.2 L 24.4 295.2 L 24.4 287.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-7\" d=\"M 40.6 317.9 L 45.5 317.9 L 45.5 318.8 L 41.7 318.8 L 41.7 321.3 L 45.1 321.3 L 45.1 322.3 L 41.7 322.3 L 41.7 326.1 L 40.6 326.1 L 40.6 317.9 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-8\" d=\"M 64.2 302.1 L 66.9 306.4 Q 67.2 306.9, 67.6 307.6 Q 68.0 308.4, 68.1 308.5 L 68.1 302.1 L 69.2 302.1 L 69.2 310.3 L 68.0 310.3 L 65.1 305.5 Q 64.8 305.0, 64.4 304.3 Q 64.1 303.7, 64.0 303.5 L 64.0 310.3 L 62.9 310.3 L 62.9 302.1 L 64.2 302.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-9\" d=\"M 76.4 289.6 L 79.1 294.0 Q 79.4 294.4, 79.8 295.2 Q 80.2 296.0, 80.3 296.0 L 80.3 289.6 L 81.4 289.6 L 81.4 297.8 L 80.2 297.8 L 77.3 293.1 Q 77.0 292.5, 76.6 291.9 Q 76.3 291.2, 76.2 291.0 L 76.2 297.8 L 75.1 297.8 L 75.1 289.6 L 76.4 289.6 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 99.8 261.7 L 102.5 266.0 Q 102.8 266.5, 103.2 267.2 Q 103.6 268.0, 103.6 268.1 L 103.6 261.7 L 104.7 261.7 L 104.7 269.9 L 103.6 269.9 L 100.7 265.1 Q 100.4 264.6, 100.0 263.9 Q 99.7 263.3, 99.6 263.1 L 99.6 269.9 L 98.5 269.9 L 98.5 261.7 L 99.8 261.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-13\" d=\"M 114.3 252.0 L 117.0 256.4 Q 117.3 256.8, 117.7 257.6 Q 118.1 258.4, 118.2 258.4 L 118.2 252.0 L 119.3 252.0 L 119.3 260.3 L 118.1 260.3 L 115.2 255.5 Q 114.9 254.9, 114.5 254.3 Q 114.2 253.6, 114.1 253.4 L 114.1 260.3 L 113.0 260.3 L 113.0 252.0 L 114.3 252.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-15\" d=\"M 144.3 265.1 Q 144.4 265.1, 144.8 265.3 Q 145.1 265.5, 145.6 265.6 Q 146.0 265.7, 146.4 265.7 Q 147.2 265.7, 147.6 265.3 Q 148.1 264.9, 148.1 264.2 Q 148.1 263.8, 147.9 263.5 Q 147.6 263.2, 147.3 263.1 Q 146.9 262.9, 146.4 262.8 Q 145.6 262.5, 145.2 262.3 Q 144.8 262.1, 144.4 261.7 Q 144.1 261.2, 144.1 260.5 Q 144.1 259.4, 144.8 258.8 Q 145.5 258.2, 146.9 258.2 Q 147.9 258.2, 149.0 258.6 L 148.7 259.5 Q 147.7 259.1, 147.0 259.1 Q 146.2 259.1, 145.7 259.4 Q 145.3 259.8, 145.3 260.3 Q 145.3 260.8, 145.5 261.1 Q 145.8 261.3, 146.1 261.5 Q 146.4 261.6, 147.0 261.8 Q 147.7 262.0, 148.2 262.3 Q 148.6 262.5, 148.9 263.0 Q 149.2 263.4, 149.2 264.2 Q 149.2 265.4, 148.5 266.0 Q 147.7 266.6, 146.5 266.6 Q 145.7 266.6, 145.2 266.4 Q 144.6 266.3, 144.0 266.0 L 144.3 265.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-15\" d=\"M 150.4 258.1 L 151.5 258.1 L 151.5 261.6 L 155.7 261.6 L 155.7 258.1 L 156.8 258.1 L 156.8 266.4 L 155.7 266.4 L 155.7 262.6 L 151.5 262.6 L 151.5 266.4 L 150.4 266.4 L 150.4 258.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-16\" d=\"M 121.9 279.2 L 124.6 283.6 Q 124.9 284.0, 125.3 284.8 Q 125.7 285.5, 125.8 285.6 L 125.8 279.2 L 126.9 279.2 L 126.9 287.4 L 125.7 287.4 L 122.8 282.7 Q 122.5 282.1, 122.1 281.5 Q 121.8 280.8, 121.7 280.6 L 121.7 287.4 L 120.6 287.4 L 120.6 279.2 L 121.9 279.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-22\" d=\"M 174.7 310.4 Q 174.7 308.4, 175.6 307.3 Q 176.6 306.2, 178.4 306.2 Q 180.1 306.2, 181.0 307.4 L 180.3 308.1 Q 179.6 307.2, 178.4 307.2 Q 177.2 307.2, 176.5 308.0 Q 175.9 308.9, 175.9 310.4 Q 175.9 312.1, 176.6 312.9 Q 177.2 313.7, 178.6 313.7 Q 179.5 313.7, 180.5 313.2 L 180.9 314.1 Q 180.4 314.3, 179.8 314.5 Q 179.1 314.7, 178.4 314.7 Q 176.6 314.7, 175.6 313.6 Q 174.7 312.5, 174.7 310.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-22\" d=\"M 181.9 305.7 L 182.9 305.7 L 182.9 314.6 L 181.9 314.6 L 181.9 305.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 83.9 384.8 L 80.3 384.8 L 80.3 383.5 L 88.7 383.5 L 88.7 384.8 L 85.4 384.8 L 85.4 394.9 L 83.9 394.9 L 83.9 384.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 93.5 386.5 Q 94.8 386.5, 95.5 387.2 Q 96.2 388.0, 96.2 389.4 L 96.2 394.9 L 94.7 394.9 L 94.7 389.5 Q 94.7 388.6, 94.3 388.1 Q 94.0 387.7, 93.1 387.7 Q 92.4 387.7, 91.8 388.0 Q 91.1 388.4, 90.7 389.0 L 90.7 394.9 L 89.2 394.9 L 89.2 382.7 L 90.7 382.7 L 90.7 387.7 Q 91.8 386.5, 93.5 386.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 98.0 383.5 L 99.5 383.5 L 99.5 384.9 L 98.0 384.9 L 98.0 383.5 M 98.0 386.6 L 99.5 386.6 L 99.5 394.9 L 98.0 394.9 L 98.0 386.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 101.4 390.7 Q 101.4 388.7, 102.4 387.6 Q 103.4 386.5, 105.3 386.5 Q 107.1 386.5, 108.2 387.6 Q 109.2 388.7, 109.2 390.7 Q 109.2 392.7, 108.2 393.9 Q 107.1 395.0, 105.3 395.0 Q 103.4 395.0, 102.4 393.9 Q 101.4 392.7, 101.4 390.7 M 102.9 390.7 Q 102.9 392.2, 103.5 393.0 Q 104.1 393.8, 105.3 393.8 Q 106.4 393.8, 107.0 393.0 Q 107.6 392.2, 107.6 390.7 Q 107.6 389.2, 107.0 388.5 Q 106.4 387.7, 105.3 387.7 Q 104.1 387.7, 103.5 388.5 Q 102.9 389.2, 102.9 390.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 110.4 382.7 L 111.9 382.7 L 111.9 394.9 L 110.4 394.9 L 110.4 382.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 114.3 393.2 Q 115.0 393.5, 115.5 393.6 Q 116.0 393.8, 116.6 393.8 Q 117.3 393.8, 117.7 393.4 Q 118.1 393.1, 118.1 392.6 Q 118.1 392.2, 117.9 392.0 Q 117.7 391.7, 117.4 391.6 Q 117.2 391.5, 116.5 391.3 Q 116.4 391.2, 115.6 391.0 Q 114.9 390.7, 114.5 390.2 Q 114.1 389.6, 114.1 388.8 Q 114.1 387.8, 114.9 387.2 Q 115.6 386.5, 117.1 386.5 Q 117.7 386.5, 118.3 386.6 Q 118.8 386.8, 119.5 387.0 L 119.1 388.2 Q 118.5 388.0, 118.1 387.9 Q 117.6 387.7, 117.1 387.7 Q 116.4 387.7, 116.0 388.0 Q 115.6 388.3, 115.6 388.8 Q 115.6 389.3, 115.9 389.5 Q 116.2 389.7, 116.9 389.9 Q 117.1 390.0, 117.2 390.0 L 117.6 390.2 Q 118.3 390.4, 118.7 390.6 Q 119.1 390.9, 119.4 391.3 Q 119.6 391.8, 119.6 392.5 Q 119.6 393.7, 118.8 394.4 Q 118.0 395.0, 116.6 395.0 Q 115.8 395.0, 115.2 394.8 Q 114.5 394.7, 113.8 394.4 L 114.3 393.2 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 360.9,231.4 L 363.6,234.0 L 352.4,245.9 L 348.2,244.9 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-12 atom-11 atom-13\" d=\"M 348.2,244.9 L 352.4,245.9 L 356.8,260.6 L 353.9,263.7 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 356.8,260.6 L 372.8,264.3 L 371.9,267.9 L 353.9,263.7 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<ellipse cx=\"350.3\" cy=\"245.4\" rx=\"3.5\" ry=\"3.5\" class=\"atom-11\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"362.3\" cy=\"232.8\" rx=\"5.3\" ry=\"6.0\" class=\"atom-12\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"351.3\" cy=\"262.1\" rx=\"10.1\" ry=\"5.8\" class=\"atom-13\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"372.3\" cy=\"266.1\" rx=\"4.4\" ry=\"5.8\" class=\"atom-14\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 222.6,294.9 L 238.7,288.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 238.7,288.1 L 240.9,270.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 241.5,286.9 L 243.3,272.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 240.9,270.8 L 257.0,264.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 257.0,264.1 L 270.9,274.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 256.6,267.1 L 268.1,275.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 270.9,274.6 L 280.8,270.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 287.8,261.4 L 289.1,250.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 289.1,250.5 L 305.2,243.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 305.2,243.8 L 309.2,226.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 308.2,242.5 L 311.3,229.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 309.2,226.8 L 326.6,225.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 326.6,225.4 L 333.3,241.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 324.9,228.1 L 330.2,240.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 333.3,241.4 L 350.3,245.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 350.8,246.9 L 357.1,240.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 348.8,245.1 L 355.2,238.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-11 atom-13\" d=\"M 350.3,245.4 L 353.4,255.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 360.8,263.4 L 366.9,264.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-14 atom-15\" d=\"M 374.3,272.5 L 377.4,282.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-14 atom-15\" d=\"M 371.8,273.3 L 374.4,282.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 377.4,282.8 L 365.4,295.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 365.4,295.5 L 348.5,291.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 363.4,297.7 L 349.3,294.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 348.5,291.5 L 336.5,304.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 336.5,304.2 L 341.5,320.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 339.4,304.9 L 343.6,318.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 341.5,320.9 L 335.7,327.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 330.3,340.5 L 331.4,344.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 332.8,339.7 L 333.9,343.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-20 atom-22\" d=\"M 324.2,332.4 L 318.7,331.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-19 atom-23\" d=\"M 341.5,320.9 L 358.5,324.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-23 atom-23 atom-24\" d=\"M 358.5,324.9 L 370.5,312.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-23 atom-23 atom-24\" d=\"M 357.7,322.0 L 367.5,311.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-24 atom-10 atom-25\" d=\"M 333.3,241.4 L 326.2,247.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-25 atom-4 atom-26\" d=\"M 270.9,274.6 L 268.7,291.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-26 atom-26 atom-27\" d=\"M 268.7,291.9 L 277.1,298.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-27 atom-27 atom-28\" d=\"M 293.6,299.2 L 299.2,296.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-27 atom-27 atom-28\" d=\"M 292.6,296.8 L 298.1,294.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-28 atom-27 atom-29\" d=\"M 281.8,308.9 L 281.2,313.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-29 atom-26 atom-30\" d=\"M 268.7,291.9 L 252.6,298.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-29 atom-26 atom-30\" d=\"M 266.3,290.1 L 253.0,295.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-30 atom-30 atom-1\" d=\"M 252.6,298.7 L 238.7,288.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-31 atom-25 atom-7\" d=\"M 314.0,249.1 L 305.2,243.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-32 atom-24 atom-16\" d=\"M 370.5,312.2 L 365.4,295.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 240.8,271.7 L 240.9,270.8 L 241.7,270.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 256.2,264.4 L 257.0,264.1 L 257.7,264.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 289.1,251.1 L 289.1,250.5 L 289.9,250.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 309.0,227.7 L 309.2,226.8 L 310.1,226.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 325.7,225.4 L 326.6,225.4 L 326.9,226.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 349.5,245.2 L 350.3,245.4 L 350.5,245.9\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 377.2,282.3 L 377.4,282.8 L 376.8,283.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 349.3,291.7 L 348.5,291.5 L 347.9,292.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 337.1,303.6 L 336.5,304.2 L 336.8,305.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 357.7,324.7 L 358.5,324.9 L 359.1,324.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 369.9,312.9 L 370.5,312.2 L 370.2,311.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 253.4,298.3 L 252.6,298.7 L 251.9,298.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-5\" d=\"M 283.2 267.9 Q 283.2 265.9, 284.1 264.8 Q 285.1 263.7, 286.9 263.7 Q 288.8 263.7, 289.7 264.8 Q 290.7 265.9, 290.7 267.9 Q 290.7 269.9, 289.7 271.0 Q 288.7 272.1, 286.9 272.1 Q 285.1 272.1, 284.1 271.0 Q 283.2 269.9, 283.2 267.9 M 286.9 271.2 Q 288.2 271.2, 288.9 270.4 Q 289.6 269.5, 289.6 267.9 Q 289.6 266.3, 288.9 265.4 Q 288.2 264.6, 286.9 264.6 Q 285.7 264.6, 285.0 265.4 Q 284.3 266.2, 284.3 267.9 Q 284.3 269.5, 285.0 270.4 Q 285.7 271.2, 286.9 271.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 358.5 232.7 Q 358.5 230.8, 359.5 229.7 Q 360.4 228.6, 362.3 228.6 Q 364.1 228.6, 365.1 229.7 Q 366.0 230.8, 366.0 232.7 Q 366.0 234.7, 365.1 235.9 Q 364.1 237.0, 362.3 237.0 Q 360.4 237.0, 359.5 235.9 Q 358.5 234.7, 358.5 232.7 M 362.3 236.1 Q 363.5 236.1, 364.2 235.2 Q 364.9 234.4, 364.9 232.7 Q 364.9 231.1, 364.2 230.3 Q 363.5 229.5, 362.3 229.5 Q 361.0 229.5, 360.3 230.3 Q 359.6 231.1, 359.6 232.7 Q 359.6 234.4, 360.3 235.2 Q 361.0 236.1, 362.3 236.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-13\" d=\"M 344.2 258.0 L 345.3 258.0 L 345.3 261.5 L 349.5 261.5 L 349.5 258.0 L 350.6 258.0 L 350.6 266.2 L 349.5 266.2 L 349.5 262.4 L 345.3 262.4 L 345.3 266.2 L 344.2 266.2 L 344.2 258.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-13\" d=\"M 353.5 258.0 L 356.2 262.4 Q 356.5 262.8, 356.9 263.6 Q 357.4 264.4, 357.4 264.4 L 357.4 258.0 L 358.5 258.0 L 358.5 266.2 L 357.3 266.2 L 354.5 261.5 Q 354.1 260.9, 353.8 260.3 Q 353.4 259.6, 353.3 259.4 L 353.3 266.2 L 352.2 266.2 L 352.2 258.0 L 353.5 258.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-14\" d=\"M 370.5 262.0 L 373.2 266.4 Q 373.5 266.8, 373.9 267.6 Q 374.3 268.3, 374.4 268.4 L 374.4 262.0 L 375.5 262.0 L 375.5 270.2 L 374.3 270.2 L 371.4 265.5 Q 371.1 264.9, 370.7 264.3 Q 370.4 263.6, 370.3 263.4 L 370.3 270.2 L 369.2 270.2 L 369.2 262.0 L 370.5 262.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-20\" d=\"M 327.8 329.5 L 330.5 333.9 Q 330.7 334.3, 331.2 335.1 Q 331.6 335.9, 331.6 335.9 L 331.6 329.5 L 332.7 329.5 L 332.7 337.8 L 331.6 337.8 L 328.7 333.0 Q 328.4 332.4, 328.0 331.8 Q 327.7 331.2, 327.6 331.0 L 327.6 337.8 L 326.5 337.8 L 326.5 329.5 L 327.8 329.5 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-20\" d=\"M 334.3 331.0 L 335.7 331.0 L 335.7 329.5 L 336.4 329.5 L 336.4 331.0 L 337.9 331.0 L 337.9 331.6 L 336.4 331.6 L 336.4 333.1 L 335.7 333.1 L 335.7 331.6 L 334.3 331.6 L 334.3 331.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-21\" d=\"M 330.9 350.4 Q 330.9 348.4, 331.8 347.3 Q 332.8 346.2, 334.6 346.2 Q 336.5 346.2, 337.4 347.3 Q 338.4 348.4, 338.4 350.4 Q 338.4 352.4, 337.4 353.5 Q 336.4 354.6, 334.6 354.6 Q 332.8 354.6, 331.8 353.5 Q 330.9 352.4, 330.9 350.4 M 334.6 353.7 Q 335.9 353.7, 336.6 352.9 Q 337.3 352.0, 337.3 350.4 Q 337.3 348.8, 336.6 347.9 Q 335.9 347.1, 334.6 347.1 Q 333.4 347.1, 332.7 347.9 Q 332.0 348.7, 332.0 350.4 Q 332.0 352.0, 332.7 352.9 Q 333.4 353.7, 334.6 353.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-22\" d=\"M 308.8 329.7 Q 308.8 327.7, 309.8 326.6 Q 310.8 325.5, 312.6 325.5 Q 314.4 325.5, 315.4 326.6 Q 316.4 327.7, 316.4 329.7 Q 316.4 331.7, 315.4 332.8 Q 314.4 334.0, 312.6 334.0 Q 310.8 334.0, 309.8 332.8 Q 308.8 331.7, 308.8 329.7 M 312.6 333.0 Q 313.9 333.0, 314.6 332.2 Q 315.2 331.3, 315.2 329.7 Q 315.2 328.1, 314.6 327.3 Q 313.9 326.4, 312.6 326.4 Q 311.4 326.4, 310.7 327.2 Q 310.0 328.1, 310.0 329.7 Q 310.0 331.4, 310.7 332.2 Q 311.4 333.0, 312.6 333.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-22\" d=\"M 317.6 326.8 L 320.4 326.8 L 320.4 327.5 L 317.6 327.5 L 317.6 326.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-25\" d=\"M 316.4 252.9 Q 316.4 250.9, 317.3 249.8 Q 318.3 248.7, 320.1 248.7 Q 322.0 248.7, 322.9 249.8 Q 323.9 250.9, 323.9 252.9 Q 323.9 254.9, 322.9 256.0 Q 321.9 257.1, 320.1 257.1 Q 318.3 257.1, 317.3 256.0 Q 316.4 254.9, 316.4 252.9 M 320.1 256.2 Q 321.4 256.2, 322.1 255.4 Q 322.7 254.5, 322.7 252.9 Q 322.7 251.2, 322.1 250.4 Q 321.4 249.6, 320.1 249.6 Q 318.9 249.6, 318.2 250.4 Q 317.5 251.2, 317.5 252.9 Q 317.5 254.5, 318.2 255.4 Q 318.9 256.2, 320.1 256.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-27\" d=\"M 280.7 298.3 L 283.4 302.7 Q 283.7 303.1, 284.1 303.9 Q 284.6 304.7, 284.6 304.7 L 284.6 298.3 L 285.7 298.3 L 285.7 306.6 L 284.6 306.6 L 281.7 301.8 Q 281.3 301.2, 281.0 300.6 Q 280.6 300.0, 280.5 299.8 L 280.5 306.6 L 279.4 306.6 L 279.4 298.3 L 280.7 298.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-27\" d=\"M 287.2 299.8 L 288.7 299.8 L 288.7 298.3 L 289.3 298.3 L 289.3 299.8 L 290.8 299.8 L 290.8 300.4 L 289.3 300.4 L 289.3 301.9 L 288.7 301.9 L 288.7 300.4 L 287.2 300.4 L 287.2 299.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-28\" d=\"M 294.9 295.7 Q 294.9 293.7, 295.8 292.6 Q 296.8 291.5, 298.6 291.5 Q 300.5 291.5, 301.4 292.6 Q 302.4 293.7, 302.4 295.7 Q 302.4 297.7, 301.4 298.9 Q 300.4 300.0, 298.6 300.0 Q 296.8 300.0, 295.8 298.9 Q 294.9 297.7, 294.9 295.7 M 298.6 299.1 Q 299.9 299.1, 300.6 298.2 Q 301.3 297.4, 301.3 295.7 Q 301.3 294.1, 300.6 293.3 Q 299.9 292.5, 298.6 292.5 Q 297.4 292.5, 296.7 293.3 Q 296.0 294.1, 296.0 295.7 Q 296.0 297.4, 296.7 298.2 Q 297.4 299.1, 298.6 299.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-29\" d=\"M 276.6 319.8 Q 276.6 317.8, 277.6 316.7 Q 278.6 315.6, 280.4 315.6 Q 282.2 315.6, 283.2 316.7 Q 284.2 317.8, 284.2 319.8 Q 284.2 321.8, 283.2 322.9 Q 282.2 324.1, 280.4 324.1 Q 278.6 324.1, 277.6 322.9 Q 276.6 321.8, 276.6 319.8 M 280.4 323.1 Q 281.6 323.1, 282.3 322.3 Q 283.0 321.4, 283.0 319.8 Q 283.0 318.2, 282.3 317.4 Q 281.6 316.5, 280.4 316.5 Q 279.1 316.5, 278.4 317.3 Q 277.8 318.2, 277.8 319.8 Q 277.8 321.4, 278.4 322.3 Q 279.1 323.1, 280.4 323.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-29\" d=\"M 285.3 316.9 L 288.1 316.9 L 288.1 317.6 L 285.3 317.6 L 285.3 316.9 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 254.8 389.3 Q 254.8 388.0, 255.8 387.4 Q 256.8 386.7, 258.6 386.7 L 259.7 386.7 L 259.7 386.4 Q 259.7 385.4, 259.3 385.0 Q 258.9 384.6, 258.0 384.6 Q 257.3 384.6, 256.9 384.7 Q 256.4 384.9, 255.6 385.2 L 255.2 384.2 Q 256.6 383.5, 258.0 383.5 Q 259.6 383.5, 260.4 384.2 Q 261.1 384.9, 261.1 386.4 L 261.1 391.3 L 260.0 391.3 Q 260.0 391.3, 260.0 391.0 Q 259.9 390.8, 259.8 390.4 Q 258.8 391.5, 257.3 391.5 Q 256.2 391.5, 255.5 390.9 Q 254.8 390.3, 254.8 389.3 M 256.2 389.2 Q 256.2 389.8, 256.6 390.1 Q 256.9 390.4, 257.6 390.4 Q 258.2 390.4, 258.8 390.1 Q 259.3 389.9, 259.7 389.4 L 259.7 387.7 L 258.7 387.7 Q 257.4 387.7, 256.8 388.1 Q 256.2 388.5, 256.2 389.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 262.8 387.5 Q 262.8 385.6, 263.8 384.6 Q 264.7 383.5, 266.5 383.5 Q 268.2 383.5, 269.2 384.8 L 268.2 385.5 Q 267.9 385.1, 267.4 384.9 Q 267.0 384.6, 266.5 384.6 Q 265.4 384.6, 264.8 385.4 Q 264.3 386.1, 264.3 387.5 Q 264.3 388.9, 264.9 389.6 Q 265.5 390.3, 266.6 390.3 Q 267.2 390.3, 267.6 390.2 Q 268.1 390.1, 268.6 389.8 L 269.0 390.8 Q 267.9 391.4, 266.5 391.4 Q 264.7 391.4, 263.8 390.4 Q 262.8 389.3, 262.8 387.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 276.0 383.7 L 277.3 383.7 L 273.4 395.0 L 272.1 395.0 L 273.4 391.3 L 272.8 391.3 L 270.1 383.7 L 271.5 383.7 L 273.8 390.1 L 276.0 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 278.1 380.0 L 279.4 380.0 L 279.4 391.3 L 278.1 391.3 L 278.1 380.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 285.3 383.5 Q 286.5 383.5, 287.2 384.2 Q 287.8 384.9, 287.8 386.3 L 287.8 391.3 L 286.4 391.3 L 286.4 386.4 Q 286.4 385.4, 286.1 385.0 Q 285.7 384.6, 284.9 384.6 Q 284.2 384.6, 283.6 385.0 Q 283.1 385.3, 282.7 385.8 L 282.7 391.3 L 281.3 391.3 L 281.3 380.0 L 282.7 380.0 L 282.7 384.6 Q 283.7 383.5, 285.3 383.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 295.4 383.7 L 296.8 383.7 L 292.8 395.0 L 291.6 395.0 L 292.8 391.3 L 292.2 391.3 L 289.5 383.7 L 291.0 383.7 L 293.2 390.1 L 295.4 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 304.5 380.0 L 304.5 391.3 L 303.4 391.3 L 303.2 390.4 Q 302.3 391.4, 300.9 391.4 Q 299.3 391.4, 298.4 390.5 Q 297.5 389.5, 297.5 387.6 Q 297.5 385.7, 298.6 384.6 Q 299.6 383.5, 301.5 383.5 Q 302.2 383.5, 303.1 383.7 L 303.1 380.0 L 304.5 380.0 M 301.0 390.3 Q 301.8 390.3, 302.3 389.9 Q 302.9 389.5, 303.1 388.7 L 303.1 384.9 Q 302.3 384.6, 301.5 384.6 Q 300.3 384.6, 299.6 385.4 Q 298.9 386.2, 298.9 387.6 Q 298.9 388.9, 299.5 389.6 Q 300.0 390.3, 301.0 390.3 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 307.4 383.7 L 307.5 384.7 Q 308.4 383.5, 309.7 383.5 Q 310.1 383.5, 310.6 383.7 L 310.4 384.9 Q 309.8 384.8, 309.4 384.8 Q 308.8 384.8, 308.4 385.0 Q 308.0 385.3, 307.6 385.9 L 307.6 391.3 L 306.2 391.3 L 306.2 383.7 L 307.4 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 311.4 389.3 Q 311.4 388.0, 312.4 387.4 Q 313.4 386.7, 315.2 386.7 L 316.4 386.7 L 316.4 386.4 Q 316.4 385.4, 315.9 385.0 Q 315.6 384.6, 314.6 384.6 Q 314.0 384.6, 313.5 384.7 Q 313.0 384.9, 312.3 385.2 L 311.9 384.2 Q 313.3 383.5, 314.6 383.5 Q 316.3 383.5, 317.0 384.2 Q 317.8 384.9, 317.8 386.4 L 317.8 391.3 L 316.7 391.3 Q 316.7 391.3, 316.6 391.0 Q 316.6 390.8, 316.5 390.4 Q 315.4 391.5, 314.0 391.5 Q 312.8 391.5, 312.1 390.9 Q 311.4 390.3, 311.4 389.3 M 312.8 389.2 Q 312.8 389.8, 313.2 390.1 Q 313.6 390.4, 314.2 390.4 Q 314.8 390.4, 315.4 390.1 Q 316.0 389.9, 316.4 389.4 L 316.4 387.7 L 315.3 387.7 Q 314.1 387.7, 313.5 388.1 Q 312.8 388.5, 312.8 389.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 321.1 390.2 L 325.4 390.2 L 325.4 391.3 L 319.5 391.3 L 319.5 390.4 L 323.5 384.8 L 319.7 384.8 L 319.7 383.7 L 325.2 383.7 L 325.2 384.5 L 321.1 390.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 326.5 380.8 L 327.8 380.8 L 327.8 382.1 L 326.5 382.1 L 326.5 380.8 M 326.5 383.7 L 327.8 383.7 L 327.8 391.3 L 326.5 391.3 L 326.5 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 336.7 380.0 L 336.7 391.3 L 335.5 391.3 L 335.3 390.4 Q 334.5 391.4, 333.1 391.4 Q 331.5 391.4, 330.6 390.5 Q 329.7 389.5, 329.7 387.6 Q 329.7 385.7, 330.7 384.6 Q 331.8 383.5, 333.6 383.5 Q 334.4 383.5, 335.2 383.7 L 335.2 380.0 L 336.7 380.0 M 333.1 390.3 Q 333.9 390.3, 334.5 389.9 Q 335.0 389.5, 335.2 388.7 L 335.2 384.9 Q 334.5 384.6, 333.6 384.6 Q 332.5 384.6, 331.8 385.4 Q 331.1 386.2, 331.1 387.6 Q 331.1 388.9, 331.6 389.6 Q 332.2 390.3, 333.1 390.3 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 338.4 387.5 Q 338.4 385.6, 339.4 384.6 Q 340.3 383.5, 342.0 383.5 Q 343.7 383.5, 344.4 384.5 Q 345.2 385.5, 345.2 387.4 L 345.2 387.7 L 339.8 387.7 Q 339.9 389.0, 340.5 389.7 Q 341.0 390.3, 342.1 390.3 Q 342.7 390.3, 343.3 390.2 Q 343.8 390.1, 344.5 389.8 L 344.9 390.7 Q 344.1 391.1, 343.5 391.3 Q 342.8 391.4, 342.1 391.4 Q 340.3 391.4, 339.4 390.4 Q 338.4 389.4, 338.4 387.5 M 342.0 384.6 Q 341.1 384.6, 340.6 385.1 Q 340.1 385.6, 339.9 386.6 L 343.7 386.6 Q 343.6 385.6, 343.2 385.1 Q 342.8 384.6, 342.0 384.6 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 468.3,298.8 L 472.5,300.8 L 456.7,309.2 L 455.0,308.0 L 455.3,305.8 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-28 atom-15 atom-25\" d=\"M 468.9,281.0 L 472.5,300.8 L 468.3,298.8 L 465.7,284.3 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 455.0,308.0 L 456.7,309.2 L 454.5,325.6 L 450.8,325.1 L 453.0,308.7 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-17 atom-16 atom-18\" d=\"M 444.7,295.5 L 455.3,305.8 L 455.0,308.0 L 453.0,308.7 L 441.6,297.7 L 442.4,296.0 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 426.0,291.8 L 441.4,293.9 L 442.4,296.0 L 441.6,297.7 L 424.3,295.3 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-29 atom-18 atom-24\" d=\"M 450.0,280.3 L 451.1,282.3 L 444.7,295.5 L 442.4,296.0 L 441.4,293.9 L 447.8,280.7 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 414.8,281.1 L 426.0,291.8 L 424.3,295.3 L 410.3,281.9 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 419.1,263.8 L 421.3,267.8 L 414.8,281.1 L 410.3,281.9 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-21 atom-21 atom-22\" d=\"M 419.1,263.8 L 438.3,266.4 L 436.6,269.9 L 421.3,267.8 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-23 atom-22 atom-24\" d=\"M 438.3,266.4 L 450.9,278.5 L 450.0,280.3 L 447.8,280.7 L 436.6,269.9 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<path class=\"bond-24 atom-24 atom-25\" d=\"M 450.9,278.5 L 468.9,281.0 L 465.7,284.3 L 451.1,282.3 L 450.0,280.3 Z\" style=\"fill:#A1002419;fill-rule:evenodd;fill-opacity:0.1;stroke:#A1002419;stroke-width:0.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:0.1;\"/>\n",
              "<ellipse cx=\"470.4\" cy=\"299.8\" rx=\"4.4\" ry=\"5.8\" class=\"atom-15\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"455.0\" cy=\"308.0\" rx=\"3.5\" ry=\"3.5\" class=\"atom-16\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"452.6\" cy=\"325.4\" rx=\"5.3\" ry=\"6.0\" class=\"atom-17\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"442.4\" cy=\"296.0\" rx=\"3.5\" ry=\"3.5\" class=\"atom-18\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"425.2\" cy=\"293.6\" rx=\"3.5\" ry=\"3.5\" class=\"atom-19\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"412.6\" cy=\"281.5\" rx=\"3.5\" ry=\"3.5\" class=\"atom-20\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"420.2\" cy=\"265.8\" rx=\"3.5\" ry=\"3.5\" class=\"atom-21\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"437.5\" cy=\"268.2\" rx=\"3.5\" ry=\"3.5\" class=\"atom-22\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"450.0\" cy=\"280.3\" rx=\"3.5\" ry=\"3.5\" class=\"atom-24\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"467.3\" cy=\"282.6\" rx=\"3.5\" ry=\"3.5\" class=\"atom-25\" style=\"fill:#A1002419;fill-rule:evenodd;stroke:#A1002419;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 572.7,248.6 L 573.9,266.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 573.9,266.0 L 589.6,273.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 574.2,269.1 L 587.1,275.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 589.6,273.6 L 590.9,291.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 590.9,291.0 L 576.5,300.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 588.2,289.7 L 576.3,297.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 576.5,300.8 L 577.7,318.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-4 atom-6\" d=\"M 576.5,300.8 L 560.8,293.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 560.8,293.2 L 546.3,303.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 545.0,302.4 L 545.8,314.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 547.6,302.2 L 548.4,313.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-7 atom-9\" d=\"M 546.3,303.0 L 530.7,295.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 530.7,295.4 L 522.3,301.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 510.1,302.3 L 500.5,297.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 501.9,298.3 L 501.0,286.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 499.3,298.5 L 498.4,286.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-11 atom-13\" d=\"M 500.5,297.6 L 486.1,307.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 486.1,307.4 L 487.4,324.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-13 atom-15\" d=\"M 486.1,307.4 L 475.8,302.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 465.0,302.7 L 455.0,308.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 453.8,306.9 L 452.2,318.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 456.4,307.3 L 454.8,319.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-16 atom-18\" d=\"M 455.0,308.0 L 442.4,296.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 442.4,296.0 L 425.2,293.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 425.2,293.6 L 412.6,281.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 412.6,281.5 L 420.2,265.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-21 atom-22\" d=\"M 420.2,265.8 L 437.5,268.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-22 atom-23\" d=\"M 437.5,268.2 L 440.5,285.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-23 atom-22 atom-24\" d=\"M 437.5,268.2 L 450.0,280.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-24 atom-24 atom-25\" d=\"M 450.0,280.3 L 467.3,282.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-25 atom-25 atom-26\" d=\"M 467.6,284.2 L 474.2,277.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-25 atom-25 atom-26\" d=\"M 465.7,282.4 L 472.4,275.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-26 atom-6 atom-27\" d=\"M 560.8,293.2 L 559.5,275.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-26 atom-6 atom-27\" d=\"M 563.3,291.5 L 562.2,277.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-27 atom-27 atom-1\" d=\"M 559.5,275.8 L 573.9,266.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-28 atom-25 atom-15\" d=\"M 467.3,282.6 L 469.2,293.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-29 atom-24 atom-18\" d=\"M 450.0,280.3 L 442.4,296.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-30 atom-23 atom-19\" d=\"M 440.5,285.3 L 425.2,293.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 588.9,273.3 L 589.6,273.6 L 589.7,274.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 590.8,290.2 L 590.9,291.0 L 590.2,291.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 547.1,302.5 L 546.3,303.0 L 545.6,302.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 531.4,295.8 L 530.7,295.4 L 530.2,295.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 501.0,297.8 L 500.5,297.6 L 499.8,298.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 455.5,307.8 L 455.0,308.0 L 454.4,307.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 413.2,282.1 L 412.6,281.5 L 413.0,280.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 419.8,266.6 L 420.2,265.8 L 421.0,265.9\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 440.4,284.5 L 440.5,285.3 L 439.8,285.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 466.5,282.5 L 467.3,282.6 L 467.4,283.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 559.6,276.7 L 559.5,275.8 L 560.2,275.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-8\" d=\"M 543.8 320.4 Q 543.8 318.5, 544.8 317.4 Q 545.8 316.3, 547.6 316.3 Q 549.4 316.3, 550.4 317.4 Q 551.4 318.5, 551.4 320.4 Q 551.4 322.4, 550.4 323.6 Q 549.4 324.7, 547.6 324.7 Q 545.8 324.7, 544.8 323.6 Q 543.8 322.5, 543.8 320.4 M 547.6 323.8 Q 548.9 323.8, 549.5 322.9 Q 550.2 322.1, 550.2 320.4 Q 550.2 318.8, 549.5 318.0 Q 548.9 317.2, 547.6 317.2 Q 546.4 317.2, 545.7 318.0 Q 545.0 318.8, 545.0 320.4 Q 545.0 322.1, 545.7 322.9 Q 546.4 323.8, 547.6 323.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-10\" d=\"M 512.4 305.2 Q 512.4 303.3, 513.4 302.2 Q 514.4 301.1, 516.2 301.1 Q 518.0 301.1, 519.0 302.2 Q 520.0 303.3, 520.0 305.2 Q 520.0 307.2, 519.0 308.4 Q 518.0 309.5, 516.2 309.5 Q 514.4 309.5, 513.4 308.4 Q 512.4 307.2, 512.4 305.2 M 516.2 308.6 Q 517.5 308.6, 518.1 307.7 Q 518.8 306.9, 518.8 305.2 Q 518.8 303.6, 518.1 302.8 Q 517.5 302.0, 516.2 302.0 Q 515.0 302.0, 514.3 302.8 Q 513.6 303.6, 513.6 305.2 Q 513.6 306.9, 514.3 307.7 Q 515.0 308.6, 516.2 308.6 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 495.5 280.2 Q 495.5 278.3, 496.5 277.2 Q 497.4 276.1, 499.3 276.1 Q 501.1 276.1, 502.1 277.2 Q 503.0 278.3, 503.0 280.2 Q 503.0 282.2, 502.0 283.4 Q 501.1 284.5, 499.3 284.5 Q 497.4 284.5, 496.5 283.4 Q 495.5 282.3, 495.5 280.2 M 499.3 283.6 Q 500.5 283.6, 501.2 282.7 Q 501.9 281.9, 501.9 280.2 Q 501.9 278.6, 501.2 277.8 Q 500.5 277.0, 499.3 277.0 Q 498.0 277.0, 497.3 277.8 Q 496.6 278.6, 496.6 280.2 Q 496.6 281.9, 497.3 282.7 Q 498.0 283.6, 499.3 283.6 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-15\" d=\"M 468.6 295.7 L 471.3 300.0 Q 471.5 300.5, 472.0 301.3 Q 472.4 302.0, 472.4 302.1 L 472.4 295.7 L 473.5 295.7 L 473.5 303.9 L 472.4 303.9 L 469.5 299.2 Q 469.2 298.6, 468.8 298.0 Q 468.4 297.3, 468.3 297.1 L 468.3 303.9 L 467.3 303.9 L 467.3 295.7 L 468.6 295.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-17\" d=\"M 448.9 325.3 Q 448.9 323.4, 449.8 322.3 Q 450.8 321.1, 452.6 321.1 Q 454.5 321.1, 455.4 322.3 Q 456.4 323.4, 456.4 325.3 Q 456.4 327.3, 455.4 328.5 Q 454.4 329.6, 452.6 329.6 Q 450.8 329.6, 449.8 328.5 Q 448.9 327.3, 448.9 325.3 M 452.6 328.7 Q 453.9 328.7, 454.6 327.8 Q 455.3 327.0, 455.3 325.3 Q 455.3 323.7, 454.6 322.9 Q 453.9 322.1, 452.6 322.1 Q 451.4 322.1, 450.7 322.9 Q 450.0 323.7, 450.0 325.3 Q 450.0 327.0, 450.7 327.8 Q 451.4 328.7, 452.6 328.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-26\" d=\"M 475.6 270.1 Q 475.6 268.1, 476.6 267.0 Q 477.6 265.9, 479.4 265.9 Q 481.2 265.9, 482.2 267.0 Q 483.2 268.1, 483.2 270.1 Q 483.2 272.1, 482.2 273.2 Q 481.2 274.3, 479.4 274.3 Q 477.6 274.3, 476.6 273.2 Q 475.6 272.1, 475.6 270.1 M 479.4 273.4 Q 480.7 273.4, 481.3 272.6 Q 482.0 271.7, 482.0 270.1 Q 482.0 268.5, 481.3 267.6 Q 480.7 266.8, 479.4 266.8 Q 478.1 266.8, 477.5 267.6 Q 476.8 268.5, 476.8 270.1 Q 476.8 271.7, 477.5 272.6 Q 478.1 273.4, 479.4 273.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 419.3 386.0 Q 419.3 383.4, 420.6 382.0 Q 421.8 380.6, 424.1 380.6 Q 426.3 380.6, 427.5 382.2 L 426.5 383.0 Q 425.7 381.9, 424.1 381.9 Q 422.5 381.9, 421.7 382.9 Q 420.9 384.0, 420.9 386.0 Q 420.9 388.1, 421.7 389.2 Q 422.6 390.3, 424.3 390.3 Q 425.5 390.3, 426.8 389.6 L 427.3 390.7 Q 426.7 391.0, 425.9 391.3 Q 425.0 391.5, 424.1 391.5 Q 421.8 391.5, 420.6 390.1 Q 419.3 388.7, 419.3 386.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 434.5 383.7 L 435.9 383.7 L 431.9 395.0 L 430.7 395.0 L 431.9 391.3 L 431.3 391.3 L 428.6 383.7 L 430.1 383.7 L 432.3 390.1 L 434.5 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 436.6 384.7 L 436.6 383.7 L 438.0 383.7 L 438.3 381.4 L 439.3 381.4 L 439.3 383.7 L 441.7 383.7 L 441.7 384.7 L 439.3 384.7 L 439.3 389.0 Q 439.3 390.3, 440.4 390.3 Q 440.9 390.3, 441.5 390.1 L 441.8 391.1 Q 441.0 391.4, 440.2 391.4 Q 439.2 391.4, 438.5 390.8 Q 437.9 390.2, 437.9 389.0 L 437.9 384.7 L 436.6 384.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 442.7 387.5 Q 442.7 385.6, 443.6 384.6 Q 444.6 383.5, 446.3 383.5 Q 448.1 383.5, 449.0 384.6 Q 450.0 385.6, 450.0 387.5 Q 450.0 389.3, 449.0 390.4 Q 448.1 391.4, 446.3 391.4 Q 444.6 391.4, 443.6 390.4 Q 442.7 389.3, 442.7 387.5 M 444.1 387.5 Q 444.1 388.9, 444.7 389.6 Q 445.3 390.3, 446.3 390.3 Q 447.4 390.3, 447.9 389.6 Q 448.5 388.9, 448.5 387.5 Q 448.5 386.1, 447.9 385.4 Q 447.4 384.6, 446.3 384.6 Q 445.3 384.6, 444.7 385.4 Q 444.1 386.1, 444.1 387.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 451.2 387.5 Q 451.2 385.6, 452.1 384.6 Q 453.0 383.5, 454.8 383.5 Q 456.6 383.5, 457.5 384.8 L 456.6 385.5 Q 456.2 385.1, 455.8 384.9 Q 455.4 384.6, 454.8 384.6 Q 453.8 384.6, 453.2 385.4 Q 452.6 386.1, 452.6 387.5 Q 452.6 388.9, 453.2 389.6 Q 453.8 390.3, 454.9 390.3 Q 455.6 390.3, 456.0 390.2 Q 456.4 390.1, 457.0 389.8 L 457.4 390.8 Q 456.2 391.4, 454.8 391.4 Q 453.0 391.4, 452.1 390.4 Q 451.2 389.3, 451.2 387.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 462.4 383.5 Q 463.6 383.5, 464.3 384.2 Q 464.9 384.9, 464.9 386.3 L 464.9 391.3 L 463.5 391.3 L 463.5 386.4 Q 463.5 385.4, 463.2 385.0 Q 462.8 384.6, 462.0 384.6 Q 461.3 384.6, 460.7 385.0 Q 460.2 385.3, 459.8 385.8 L 459.8 391.3 L 458.4 391.3 L 458.4 380.0 L 459.8 380.0 L 459.8 384.6 Q 460.8 383.5, 462.4 383.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 466.6 389.3 Q 466.6 388.0, 467.6 387.4 Q 468.6 386.7, 470.4 386.7 L 471.5 386.7 L 471.5 386.4 Q 471.5 385.4, 471.1 385.0 Q 470.7 384.6, 469.8 384.6 Q 469.1 384.6, 468.7 384.7 Q 468.2 384.9, 467.4 385.2 L 467.0 384.2 Q 468.4 383.5, 469.8 383.5 Q 471.4 383.5, 472.2 384.2 Q 472.9 384.9, 472.9 386.4 L 472.9 391.3 L 471.8 391.3 Q 471.8 391.3, 471.8 391.0 Q 471.7 390.8, 471.6 390.4 Q 470.5 391.5, 469.1 391.5 Q 468.0 391.5, 467.3 390.9 Q 466.6 390.3, 466.6 389.3 M 468.0 389.2 Q 468.0 389.8, 468.4 390.1 Q 468.7 390.4, 469.4 390.4 Q 470.0 390.4, 470.5 390.1 Q 471.1 389.9, 471.5 389.4 L 471.5 387.7 L 470.5 387.7 Q 469.2 387.7, 468.6 388.1 Q 468.0 388.5, 468.0 389.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 474.6 380.0 L 476.0 380.0 L 476.0 391.3 L 474.6 391.3 L 474.6 380.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 477.8 389.3 Q 477.8 388.0, 478.8 387.4 Q 479.7 386.7, 481.5 386.7 L 482.7 386.7 L 482.7 386.4 Q 482.7 385.4, 482.3 385.0 Q 481.9 384.6, 480.9 384.6 Q 480.3 384.6, 479.8 384.7 Q 479.4 384.9, 478.6 385.2 L 478.2 384.2 Q 479.6 383.5, 481.0 383.5 Q 482.6 383.5, 483.3 384.2 Q 484.1 384.9, 484.1 386.4 L 484.1 391.3 L 483.0 391.3 Q 483.0 391.3, 482.9 391.0 Q 482.9 390.8, 482.8 390.4 Q 481.7 391.5, 480.3 391.5 Q 479.1 391.5, 478.5 390.9 Q 477.8 390.3, 477.8 389.3 M 479.2 389.2 Q 479.2 389.8, 479.5 390.1 Q 479.9 390.4, 480.6 390.4 Q 481.2 390.4, 481.7 390.1 Q 482.3 389.9, 482.7 389.4 L 482.7 387.7 L 481.6 387.7 Q 480.4 387.7, 479.8 388.1 Q 479.2 388.5, 479.2 389.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 486.2 389.7 Q 486.9 390.0, 487.3 390.2 Q 487.8 390.3, 488.4 390.3 Q 489.0 390.3, 489.4 390.0 Q 489.8 389.7, 489.8 389.2 Q 489.8 388.8, 489.6 388.6 Q 489.4 388.4, 489.1 388.3 Q 488.9 388.2, 488.2 388.0 Q 488.1 387.9, 487.4 387.7 Q 486.7 387.5, 486.4 387.0 Q 486.0 386.4, 486.0 385.7 Q 486.0 384.8, 486.7 384.1 Q 487.4 383.5, 488.8 383.5 Q 489.4 383.5, 489.9 383.7 Q 490.4 383.8, 491.0 384.0 L 490.6 385.1 Q 490.2 384.9, 489.7 384.8 Q 489.3 384.7, 488.8 384.7 Q 488.1 384.7, 487.8 385.0 Q 487.4 385.2, 487.4 385.7 Q 487.4 386.1, 487.7 386.3 Q 488.0 386.5, 488.6 386.7 Q 488.8 386.8, 488.9 386.8 L 489.3 387.0 Q 489.9 387.2, 490.3 387.4 Q 490.7 387.6, 490.9 388.0 Q 491.2 388.4, 491.2 389.1 Q 491.2 390.3, 490.4 390.9 Q 489.6 391.5, 488.4 391.5 Q 487.6 391.5, 487.0 391.3 Q 486.4 391.1, 485.8 390.9 L 486.2 389.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 492.5 380.8 L 493.9 380.8 L 493.9 382.1 L 492.5 382.1 L 492.5 380.8 M 492.5 383.7 L 493.9 383.7 L 493.9 391.3 L 492.5 391.3 L 492.5 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 499.7 383.5 Q 500.9 383.5, 501.6 384.2 Q 502.2 384.9, 502.2 386.3 L 502.2 391.3 L 500.8 391.3 L 500.8 386.4 Q 500.8 385.4, 500.5 385.0 Q 500.1 384.6, 499.3 384.6 Q 498.6 384.6, 498.1 385.0 Q 497.5 385.3, 497.1 385.8 L 497.1 391.3 L 495.7 391.3 L 495.7 383.7 L 496.9 383.7 L 497.0 384.7 Q 498.0 383.5, 499.7 383.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 516.4 380.0 L 516.4 391.3 L 515.2 391.3 L 515.1 390.4 Q 514.2 391.4, 512.8 391.4 Q 511.2 391.4, 510.3 390.5 Q 509.4 389.5, 509.4 387.6 Q 509.4 385.7, 510.5 384.6 Q 511.5 383.5, 513.3 383.5 Q 514.1 383.5, 515.0 383.7 L 515.0 380.0 L 516.4 380.0 M 512.9 390.3 Q 513.6 390.3, 514.2 389.9 Q 514.8 389.5, 515.0 388.7 L 515.0 384.9 Q 514.2 384.6, 513.4 384.6 Q 512.2 384.6, 511.5 385.4 Q 510.8 386.2, 510.8 387.6 Q 510.8 388.9, 511.4 389.6 Q 511.9 390.3, 512.9 390.3 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 518.1 387.5 Q 518.1 385.6, 519.0 384.6 Q 520.0 383.5, 521.7 383.5 Q 523.4 383.5, 524.1 384.5 Q 524.9 385.5, 524.9 387.4 L 524.9 387.7 L 519.5 387.7 Q 519.6 389.0, 520.1 389.7 Q 520.7 390.3, 521.8 390.3 Q 522.4 390.3, 523.0 390.2 Q 523.5 390.1, 524.2 389.8 L 524.6 390.7 Q 523.8 391.1, 523.1 391.3 Q 522.5 391.4, 521.7 391.4 Q 520.0 391.4, 519.1 390.4 Q 518.1 389.4, 518.1 387.5 M 521.7 384.6 Q 520.8 384.6, 520.3 385.1 Q 519.8 385.6, 519.6 386.6 L 523.4 386.6 Q 523.3 385.6, 522.9 385.1 Q 522.5 384.6, 521.7 384.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 527.1 383.7 L 527.3 384.7 Q 528.1 383.5, 529.4 383.5 Q 529.8 383.5, 530.4 383.7 L 530.2 384.9 Q 529.5 384.8, 529.2 384.8 Q 528.5 384.8, 528.1 385.0 Q 527.7 385.3, 527.4 385.9 L 527.4 391.3 L 526.0 391.3 L 526.0 383.7 L 527.1 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 531.1 380.8 L 532.5 380.8 L 532.5 382.1 L 531.1 382.1 L 531.1 380.8 M 531.1 383.7 L 532.5 383.7 L 532.5 391.3 L 531.1 391.3 L 531.1 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 540.2 383.7 L 541.5 383.7 L 538.8 391.3 L 537.0 391.3 L 534.3 383.7 L 535.8 383.7 L 538.0 390.1 L 540.2 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 542.2 389.3 Q 542.2 388.0, 543.2 387.4 Q 544.2 386.7, 546.0 386.7 L 547.1 386.7 L 547.1 386.4 Q 547.1 385.4, 546.7 385.0 Q 546.3 384.6, 545.4 384.6 Q 544.7 384.6, 544.3 384.7 Q 543.8 384.9, 543.0 385.2 L 542.6 384.2 Q 544.0 383.5, 545.4 383.5 Q 547.0 383.5, 547.8 384.2 Q 548.5 384.9, 548.5 386.4 L 548.5 391.3 L 547.4 391.3 Q 547.4 391.3, 547.4 391.0 Q 547.3 390.8, 547.2 390.4 Q 546.1 391.5, 544.7 391.5 Q 543.6 391.5, 542.9 390.9 Q 542.2 390.3, 542.2 389.3 M 543.6 389.2 Q 543.6 389.8, 544.0 390.1 Q 544.3 390.4, 545.0 390.4 Q 545.6 390.4, 546.1 390.1 Q 546.7 389.9, 547.1 389.4 L 547.1 387.7 L 546.1 387.7 Q 544.8 387.7, 544.2 388.1 Q 543.6 388.5, 543.6 389.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 550.2 384.7 L 550.2 383.7 L 551.6 383.7 L 551.9 381.4 L 552.9 381.4 L 552.9 383.7 L 555.3 383.7 L 555.3 384.7 L 552.9 384.7 L 552.9 389.0 Q 552.9 390.3, 554.0 390.3 Q 554.5 390.3, 555.2 390.1 L 555.4 391.1 Q 554.6 391.4, 553.8 391.4 Q 552.8 391.4, 552.2 390.8 Q 551.5 390.2, 551.5 389.0 L 551.5 384.7 L 550.2 384.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 556.3 380.8 L 557.7 380.8 L 557.7 382.1 L 556.3 382.1 L 556.3 380.8 M 556.3 383.7 L 557.7 383.7 L 557.7 391.3 L 556.3 391.3 L 556.3 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 565.3 383.7 L 566.7 383.7 L 564.0 391.3 L 562.2 391.3 L 559.5 383.7 L 560.9 383.7 L 563.1 390.1 L 565.3 383.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 567.3 387.5 Q 567.3 385.6, 568.3 384.6 Q 569.2 383.5, 570.9 383.5 Q 572.6 383.5, 573.4 384.5 Q 574.1 385.5, 574.1 387.4 L 574.1 387.7 L 568.8 387.7 Q 568.8 389.0, 569.4 389.7 Q 570.0 390.3, 571.1 390.3 Q 571.7 390.3, 572.2 390.2 Q 572.8 390.1, 573.4 389.8 L 573.8 390.7 Q 573.1 391.1, 572.4 391.3 Q 571.7 391.4, 571.0 391.4 Q 569.2 391.4, 568.3 390.4 Q 567.3 389.4, 567.3 387.5 M 570.9 384.6 Q 570.1 384.6, 569.5 385.1 Q 569.0 385.6, 568.8 386.6 L 572.7 386.6 Q 572.5 385.6, 572.1 385.1 Q 571.7 384.6, 570.9 384.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 575.7 389.7 Q 576.3 390.0, 576.8 390.2 Q 577.3 390.3, 577.8 390.3 Q 578.5 390.3, 578.9 390.0 Q 579.3 389.7, 579.3 389.2 Q 579.3 388.8, 579.0 388.6 Q 578.9 388.4, 578.6 388.3 Q 578.4 388.2, 577.7 388.0 Q 577.6 387.9, 576.9 387.7 Q 576.2 387.5, 575.8 387.0 Q 575.5 386.4, 575.5 385.7 Q 575.5 384.8, 576.2 384.1 Q 576.9 383.5, 578.3 383.5 Q 578.9 383.5, 579.4 383.7 Q 579.9 383.8, 580.5 384.0 L 580.1 385.1 Q 579.6 384.9, 579.2 384.8 Q 578.8 384.7, 578.3 384.7 Q 577.6 384.7, 577.2 385.0 Q 576.9 385.2, 576.9 385.7 Q 576.9 386.1, 577.2 386.3 Q 577.5 386.5, 578.1 386.7 Q 578.2 386.8, 578.4 386.8 L 578.7 387.0 Q 579.4 387.2, 579.7 387.4 Q 580.1 387.6, 580.4 388.0 Q 580.7 388.4, 580.7 389.1 Q 580.7 390.3, 579.9 390.9 Q 579.1 391.5, 577.8 391.5 Q 577.1 391.5, 576.5 391.3 Q 575.9 391.1, 575.2 390.9 L 575.7 389.7 \" fill=\"#000000\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "execution_count": 34,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "img"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "b-bynRQNRDS_"
      },
      "outputs": [],
      "source": [
        "with open(\"figures/ch02/glaxo_alerts_matches.svg\", \"w\") as f:\n",
        "  f.write(img.data)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "QupR5jbmSqXd",
        "outputId": "4883d29f-3de1-4bc6-b16f-9f187073c943"
      },
      "outputs": [
        {
          "data": {
            "text/plain": [
              "(61372, 10)"
            ]
          },
          "execution_count": 36,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "specs_filtered.shape"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "EbRZ6gLHdJj9"
      },
      "source": [
        "## 4️⃣ Fingerprints: Representing Molecules as Numbers"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "86mMTw0u1w62"
      },
      "source": [
        "### Fingerprinting our Library"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "pOJAiv4zXtMT"
      },
      "outputs": [],
      "source": [
        "from rdkit import DataStructs\n",
        "from rdkit.Chem import AllChem\n",
        "\n",
        "def compute_fingerprint(mol, r, nBits):\n",
        "    fp = AllChem.GetMorganFingerprintAsBitVect(mol, r, nBits=nBits)\n",
        "    return fp"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "n5VxEwOHnMdg",
        "outputId": "42175383-2faa-4e13-8ac1-8436b35c20fb"
      },
      "outputs": [
        {
          "name": "stderr",
          "output_type": "stream",
          "text": [
            "<ipython-input-38-5908e449411e>:1: SettingWithCopyWarning: \n",
            "A value is trying to be set on a copy of a slice from a DataFrame.\n",
            "Try using .loc[row_indexer,col_indexer] = value instead\n",
            "\n",
            "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n",
            "  specs_filtered[\"morgan_fp_r2_b2048\"] = specs_filtered[\"mol\"].apply(compute_fingerprint, r=2, nBits=2048)\n"
          ]
        }
      ],
      "source": [
        "specs_filtered[\"morgan_fp_r2_b2048\"] = specs_filtered[\"mol\"].apply(compute_fingerprint, r=2, nBits=2048)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "R6jSME3-17RP"
      },
      "source": [
        "**Code for Figure 2.15. Example decomposition of a molecule into several fingerprint features**"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "LvdiF3s-nCSr"
      },
      "outputs": [],
      "source": [
        "def draw_fragment_from_bit(mol, bit_number):\n",
        "  \"\"\" Given an rdkit mol, draws the local fragment that corresponds to the set bit of ecfp featurization.\n",
        "\n",
        "  If the bit is not set, will throw an error.\n",
        "  \"\"\"\n",
        "  bi = {}\n",
        "  fp = AllChem.GetMorganFingerprintAsBitVect(mol, radius=2, bitInfo=bi)\n",
        "  try:\n",
        "    svg = Draw.DrawMorganBit(mol, bit_number, bi, useSVG=True)\n",
        "  except:\n",
        "    raise ValueError(f\"Featurization of mol doesn't have bit {bit_number} set\")\n",
        "  return svg"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 221
        },
        "id": "ounqHe2jZhKo",
        "outputId": "f5c17ced-7315-4f2f-f6bf-3af7bacfacee"
      },
      "outputs": [
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"200px\" height=\"200px\" viewBox=\"0 0 200 200\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"200.0\" height=\"200.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 9.1,102.8 L 28.4,107.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 28.4,107.6 L 35.2,100.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 49.2,94.9 L 61.6,98.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 59.9,97.5 L 63.5,110.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 62.7,96.7 L 66.4,109.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-3 atom-5\" d=\"M 61.6,98.0 L 75.3,83.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 75.3,83.6 L 69.8,64.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 77.7,81.1 L 73.1,65.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 69.8,64.5 L 83.6,50.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 83.6,50.1 L 102.9,54.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 84.5,53.4 L 100.5,57.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 102.9,54.8 L 110.5,46.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 122.9,42.0 L 136.0,45.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 136.0,45.2 L 145.6,37.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 156.9,35.8 L 168.2,42.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 167.7,44.6 L 180.2,39.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 166.6,41.8 L 179.1,36.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-12 atom-14\" d=\"M 168.2,42.8 L 165.2,54.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-14 atom-15\" d=\"M 169.6,69.5 L 176.3,77.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 176.3,77.4 L 169.5,96.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 169.5,96.1 L 149.9,99.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 168.4,99.4 L 152.2,102.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 149.9,99.6 L 143.2,118.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 143.2,118.4 L 156.1,133.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 146.6,117.8 L 157.2,130.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 156.1,133.6 L 149.3,152.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 147.6,152.6 L 154.8,161.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 149.9,150.7 L 157.1,159.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-20 atom-22\" d=\"M 149.3,152.3 L 136.7,154.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-22 atom-23\" d=\"M 127.0,163.4 L 123.0,174.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-23 atom-19 atom-24\" d=\"M 156.1,133.6 L 175.7,130.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-24 atom-24 atom-25\" d=\"M 175.7,130.1 L 182.4,111.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-24 atom-24 atom-25\" d=\"M 173.4,127.4 L 179.0,111.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-25 atom-14 atom-26\" d=\"M 157.2,62.6 L 143.6,63.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-26 atom-26 atom-27\" d=\"M 142.9,61.9 L 136.4,72.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-26 atom-26 atom-27\" d=\"M 145.4,63.5 L 138.9,73.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-27 atom-8 atom-28\" d=\"M 102.9,54.8 L 108.5,73.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-28 atom-28 atom-29\" d=\"M 108.5,73.9 L 94.7,88.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-28 atom-28 atom-29\" d=\"M 105.1,73.1 L 93.7,85.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-29 atom-29 atom-5\" d=\"M 94.7,88.3 L 75.3,83.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-30 atom-26 atom-10\" d=\"M 143.6,63.6 L 136.0,45.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-31 atom-25 atom-16\" d=\"M 182.4,111.3 L 169.5,96.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 27.5,107.4 L 28.4,107.6 L 28.8,107.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 60.9,97.8 L 61.6,98.0 L 62.2,97.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 70.1,65.4 L 69.8,64.5 L 70.5,63.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 82.9,50.8 L 83.6,50.1 L 84.5,50.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 167.6,42.5 L 168.2,42.8 L 168.0,43.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 175.9,77.0 L 176.3,77.4 L 175.9,78.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 150.9,99.5 L 149.9,99.6 L 149.6,100.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 143.5,117.4 L 143.2,118.4 L 143.8,119.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 149.6,151.4 L 149.3,152.3 L 148.7,152.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 174.7,130.2 L 175.7,130.1 L 176.0,129.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 182.1,112.2 L 182.4,111.3 L 181.7,110.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 144.2,63.6 L 143.6,63.6 L 143.2,62.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 108.2,73.0 L 108.5,73.9 L 107.8,74.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 95.4,87.6 L 94.7,88.3 L 93.7,88.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-2\" d=\"M 37.9 93.2 Q 37.9 91.0, 39.0 89.7 Q 40.1 88.5, 42.2 88.5 Q 44.3 88.5, 45.4 89.7 Q 46.5 91.0, 46.5 93.2 Q 46.5 95.5, 45.4 96.8 Q 44.3 98.1, 42.2 98.1 Q 40.1 98.1, 39.0 96.8 Q 37.9 95.5, 37.9 93.2 M 42.2 97.0 Q 43.6 97.0, 44.4 96.1 Q 45.2 95.1, 45.2 93.2 Q 45.2 91.4, 44.4 90.5 Q 43.6 89.5, 42.2 89.5 Q 40.8 89.5, 40.0 90.4 Q 39.2 91.4, 39.2 93.2 Q 39.2 95.1, 40.0 96.1 Q 40.8 97.0, 42.2 97.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-4\" d=\"M 62.8 117.1 Q 62.8 114.8, 63.9 113.6 Q 65.0 112.3, 67.1 112.3 Q 69.2 112.3, 70.3 113.6 Q 71.4 114.8, 71.4 117.1 Q 71.4 119.4, 70.3 120.7 Q 69.2 122.0, 67.1 122.0 Q 65.0 122.0, 63.9 120.7 Q 62.8 119.4, 62.8 117.1 M 67.1 120.9 Q 68.6 120.9, 69.3 120.0 Q 70.1 119.0, 70.1 117.1 Q 70.1 115.3, 69.3 114.3 Q 68.6 113.4, 67.1 113.4 Q 65.7 113.4, 64.9 114.3 Q 64.1 115.2, 64.1 117.1 Q 64.1 119.0, 64.9 120.0 Q 65.7 120.9, 67.1 120.9 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-9\" d=\"M 114.6 35.7 L 117.7 40.7 Q 118.0 41.2, 118.5 42.1 Q 119.0 43.0, 119.0 43.0 L 119.0 35.7 L 120.2 35.7 L 120.2 45.1 L 119.0 45.1 L 115.6 39.7 Q 115.3 39.1, 114.9 38.3 Q 114.5 37.6, 114.3 37.4 L 114.3 45.1 L 113.1 45.1 L 113.1 35.7 L 114.6 35.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-9\" d=\"M 113.0 25.4 L 114.3 25.4 L 114.3 29.4 L 119.1 29.4 L 119.1 25.4 L 120.4 25.4 L 120.4 34.8 L 119.1 34.8 L 119.1 30.5 L 114.3 30.5 L 114.3 34.8 L 113.0 34.8 L 113.0 25.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-11\" d=\"M 148.6 35.6 Q 148.7 35.6, 149.1 35.8 Q 149.6 36.0, 150.0 36.1 Q 150.5 36.2, 151.0 36.2 Q 151.9 36.2, 152.4 35.8 Q 152.9 35.3, 152.9 34.6 Q 152.9 34.1, 152.7 33.7 Q 152.4 33.4, 152.0 33.2 Q 151.6 33.1, 150.9 32.9 Q 150.1 32.6, 149.6 32.4 Q 149.1 32.1, 148.8 31.6 Q 148.4 31.1, 148.4 30.3 Q 148.4 29.1, 149.2 28.4 Q 150.0 27.6, 151.6 27.6 Q 152.7 27.6, 153.9 28.2 L 153.6 29.2 Q 152.5 28.7, 151.7 28.7 Q 150.7 28.7, 150.2 29.1 Q 149.7 29.5, 149.7 30.1 Q 149.7 30.6, 150.0 30.9 Q 150.3 31.2, 150.6 31.4 Q 151.0 31.6, 151.7 31.8 Q 152.5 32.0, 153.0 32.3 Q 153.5 32.6, 153.9 33.1 Q 154.2 33.7, 154.2 34.6 Q 154.2 35.9, 153.4 36.6 Q 152.5 37.3, 151.1 37.3 Q 150.2 37.3, 149.6 37.1 Q 149.0 36.9, 148.2 36.6 L 148.6 35.6 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-13\" d=\"M 182.3 35.3 Q 182.3 33.1, 183.4 31.8 Q 184.5 30.5, 186.6 30.5 Q 188.7 30.5, 189.8 31.8 Q 190.9 33.1, 190.9 35.3 Q 190.9 37.6, 189.8 38.9 Q 188.7 40.2, 186.6 40.2 Q 184.5 40.2, 183.4 38.9 Q 182.3 37.6, 182.3 35.3 M 186.6 39.1 Q 188.0 39.1, 188.8 38.2 Q 189.6 37.2, 189.6 35.3 Q 189.6 33.5, 188.8 32.5 Q 188.0 31.6, 186.6 31.6 Q 185.2 31.6, 184.4 32.5 Q 183.6 33.5, 183.6 35.3 Q 183.6 37.2, 184.4 38.2 Q 185.2 39.1, 186.6 39.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-14\" d=\"M 161.3 57.5 L 164.4 62.4 Q 164.7 62.9, 165.2 63.8 Q 165.7 64.7, 165.7 64.8 L 165.7 57.5 L 167.0 57.5 L 167.0 66.9 L 165.7 66.9 L 162.4 61.4 Q 162.0 60.8, 161.6 60.0 Q 161.2 59.3, 161.1 59.1 L 161.1 66.9 L 159.8 66.9 L 159.8 57.5 L 161.3 57.5 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-21\" d=\"M 157.9 167.6 Q 157.9 165.3, 159.0 164.0 Q 160.1 162.8, 162.2 162.8 Q 164.3 162.8, 165.4 164.0 Q 166.5 165.3, 166.5 167.6 Q 166.5 169.8, 165.4 171.1 Q 164.2 172.4, 162.2 172.4 Q 160.1 172.4, 159.0 171.1 Q 157.9 169.9, 157.9 167.6 M 162.2 171.4 Q 163.6 171.4, 164.4 170.4 Q 165.2 169.4, 165.2 167.6 Q 165.2 165.7, 164.4 164.8 Q 163.6 163.8, 162.2 163.8 Q 160.7 163.8, 160.0 164.8 Q 159.2 165.7, 159.2 167.6 Q 159.2 169.5, 160.0 170.4 Q 160.7 171.4, 162.2 171.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-22\" d=\"M 125.4 155.9 Q 125.4 153.6, 126.5 152.4 Q 127.6 151.1, 129.7 151.1 Q 131.8 151.1, 132.9 152.4 Q 134.0 153.6, 134.0 155.9 Q 134.0 158.2, 132.9 159.5 Q 131.8 160.8, 129.7 160.8 Q 127.6 160.8, 126.5 159.5 Q 125.4 158.2, 125.4 155.9 M 129.7 159.7 Q 131.1 159.7, 131.9 158.7 Q 132.7 157.8, 132.7 155.9 Q 132.7 154.0, 131.9 153.1 Q 131.1 152.2, 129.7 152.2 Q 128.3 152.2, 127.5 153.1 Q 126.7 154.0, 126.7 155.9 Q 126.7 157.8, 127.5 158.7 Q 128.3 159.7, 129.7 159.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-27\" d=\"M 128.7 80.6 Q 128.7 78.3, 129.9 77.1 Q 131.0 75.8, 133.1 75.8 Q 135.1 75.8, 136.3 77.1 Q 137.4 78.3, 137.4 80.6 Q 137.4 82.9, 136.2 84.2 Q 135.1 85.5, 133.1 85.5 Q 131.0 85.5, 129.9 84.2 Q 128.7 82.9, 128.7 80.6 M 133.1 84.4 Q 134.5 84.4, 135.3 83.4 Q 136.0 82.5, 136.0 80.6 Q 136.0 78.7, 135.3 77.8 Q 134.5 76.9, 133.1 76.9 Q 131.6 76.9, 130.8 77.8 Q 130.1 78.7, 130.1 80.6 Q 130.1 82.5, 130.8 83.4 Q 131.6 84.4, 133.1 84.4 \" fill=\"#000000\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "execution_count": 43,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "example_mol = specs_filtered.mol.iloc[0]\n",
        "img = Draw.MolsToGridImage(\n",
        "  mols=[example_mol], molsPerRow=1, useSVG=True, drawOptions=dopts,\n",
        ")\n",
        "with open(f\"figures/ch02/fp_decomposition_example_mol.svg\", \"w\") as f:\n",
        "  f.write(img.data)\n",
        "img"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "2MVQBCVKn-9I"
      },
      "outputs": [],
      "source": [
        "example_fp = specs_filtered.morgan_fp_r2_b2048.iloc[0]"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "PM-nlmpyovS1"
      },
      "outputs": [],
      "source": [
        "fp_hit_indices = [idx for idx, bit in enumerate(example_fp) if bit][:5]"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "IGJz65jypmF7",
        "outputId": "e6c7a9d7-4b9e-42e7-f7f0-ca124abd93bb"
      },
      "outputs": [
        {
          "data": {
            "text/plain": [
              "[5, 66, 74, 80, 145]"
            ]
          },
          "execution_count": 46,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "fp_hit_indices"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "NBVInNSHpyKv"
      },
      "outputs": [],
      "source": [
        "example_bits = [draw_fragment_from_bit(example_mol, hit_idx) for hit_idx in fp_hit_indices]"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "sn0dPhFkyYn9"
      },
      "outputs": [],
      "source": [
        "for i, bit_img in enumerate(example_bits):\n",
        "  with open(f\"figures/ch02/fp_decomposition_bit{i}.svg\", \"w\") as f:\n",
        "    f.write(bit_img.data)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 789
        },
        "id": "iGiXjar6p-rn",
        "outputId": "8a862117-6bad-441e-cef7-738600d55a63"
      },
      "outputs": [
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"150px\" height=\"150px\" viewBox=\"0 0 150 150\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"150.0\" height=\"150.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<ellipse cx=\"52.1\" cy=\"50.3\" rx=\"8.7\" ry=\"8.7\" class=\"atom-1\" style=\"fill:#CCCCCC;fill-rule:evenodd;stroke:#CCCCCC;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"112.1\" cy=\"87.4\" rx=\"8.7\" ry=\"8.7\" class=\"atom-4\" style=\"fill:#CCCCCC;fill-rule:evenodd;stroke:#CCCCCC;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"68.6\" cy=\"90.7\" rx=\"8.7\" ry=\"8.7\" class=\"atom-6\" style=\"fill:#9999E5;fill-rule:evenodd;stroke:#9999E5;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 13.0,40.7 L 52.1,50.3\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:2.3px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 52.1,50.3 L 84.4,22.9\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:2.3px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-3 atom-4\" d=\"M 122.3,45.9 L 114.0,79.8\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:2.3px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-4 atom-5\" d=\"M 118.2,94.7 L 135.9,115.6\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:2.3px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-6\" d=\"M 106.0,87.9 L 87.3,89.3\" style=\"fill:none;fill-rule:evenodd;stroke:#0000FF;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-6\" d=\"M 87.3,89.3 L 68.6,90.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-6 atom-7\" d=\"M 67.1,86.9 L 57.3,102.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-6 atom-7\" d=\"M 57.3,102.6 L 47.6,118.3\" style=\"fill:none;fill-rule:evenodd;stroke:#FF0000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-6 atom-7\" d=\"M 72.6,90.4 L 62.9,106.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-6 atom-7\" d=\"M 62.9,106.1 L 53.2,121.8\" style=\"fill:none;fill-rule:evenodd;stroke:#FF0000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-1\" d=\"M 68.6,90.7 L 52.1,50.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 69.5,90.6 L 68.6,90.7 L 67.8,88.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-0\" d=\"M 7.4 38.5 L 9.2 36.7 L 6.8 36.2 L 7.2 34.9 L 9.4 36.0 L 9.1 33.6 L 10.4 33.6 L 10.0 36.0 L 12.3 35.0 L 12.7 36.2 L 10.2 36.6 L 12.0 38.5 L 10.9 39.3 L 9.7 37.0 L 8.5 39.3 L 7.4 38.5 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-2\" d=\"M 83.1 20.7 L 84.9 18.9 L 82.5 18.4 L 82.9 17.2 L 85.1 18.3 L 84.8 15.8 L 86.1 15.8 L 85.7 18.3 L 87.9 17.2 L 88.3 18.4 L 85.9 18.8 L 87.6 20.7 L 86.6 21.5 L 85.4 19.2 L 84.1 21.5 L 83.1 20.7 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-3\" d=\"M 120.2 43.7 L 122.0 41.9 L 119.6 41.4 L 119.9 40.1 L 122.1 41.2 L 121.8 38.8 L 123.1 38.8 L 122.8 41.2 L 125.0 40.2 L 125.4 41.4 L 123.0 41.8 L 124.7 43.7 L 123.6 44.5 L 122.4 42.2 L 121.2 44.5 L 120.2 43.7 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-4\" d=\"M 109.4 81.3 L 113.4 87.8 Q 113.8 88.5, 114.5 89.6 Q 115.1 90.8, 115.1 90.9 L 115.1 81.3 L 116.8 81.3 L 116.8 93.6 L 115.1 93.6 L 110.7 86.5 Q 110.2 85.6, 109.7 84.7 Q 109.2 83.7, 109.0 83.4 L 109.0 93.6 L 107.4 93.6 L 107.4 81.3 L 109.4 81.3 \" fill=\"#0000FF\"/>\n",
              "<path class=\"atom-5\" d=\"M 137.9 119.4 L 139.7 117.5 L 137.3 117.0 L 137.7 115.8 L 139.9 116.9 L 139.6 114.5 L 140.9 114.5 L 140.5 116.9 L 142.8 115.8 L 143.2 117.0 L 140.7 117.5 L 142.5 119.4 L 141.4 120.1 L 140.2 117.8 L 139.0 120.1 L 137.9 119.4 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-7\" d=\"M 40.0 127.8 Q 40.0 124.8, 41.4 123.1 Q 42.9 121.5, 45.6 121.5 Q 48.4 121.5, 49.8 123.1 Q 51.3 124.8, 51.3 127.8 Q 51.3 130.8, 49.8 132.5 Q 48.3 134.2, 45.6 134.2 Q 42.9 134.2, 41.4 132.5 Q 40.0 130.8, 40.0 127.8 M 45.6 132.8 Q 47.5 132.8, 48.5 131.5 Q 49.5 130.2, 49.5 127.8 Q 49.5 125.3, 48.5 124.1 Q 47.5 122.9, 45.6 122.9 Q 43.7 122.9, 42.7 124.1 Q 41.7 125.3, 41.7 127.8 Q 41.7 130.3, 42.7 131.5 Q 43.7 132.8, 45.6 132.8 \" fill=\"#FF0000\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "metadata": {},
          "output_type": "display_data"
        },
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"150px\" height=\"150px\" viewBox=\"0 0 150 150\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"150.0\" height=\"150.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<ellipse cx=\"48.2\" cy=\"34.6\" rx=\"6.6\" ry=\"6.6\" class=\"atom-1\" style=\"fill:#CCCCCC;fill-rule:evenodd;stroke:#CCCCCC;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"73.3\" cy=\"13.4\" rx=\"6.6\" ry=\"6.6\" class=\"atom-2\" style=\"fill:#CCCCCC;fill-rule:evenodd;stroke:#CCCCCC;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"101.2\" cy=\"30.7\" rx=\"6.6\" ry=\"6.6\" class=\"atom-3\" style=\"fill:#CCCCCC;fill-rule:evenodd;stroke:#CCCCCC;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"93.4\" cy=\"62.6\" rx=\"6.6\" ry=\"6.6\" class=\"atom-5\" style=\"fill:#9999E5;fill-rule:evenodd;stroke:#9999E5;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"103.5\" cy=\"118.6\" rx=\"6.6\" ry=\"6.6\" class=\"atom-7\" style=\"fill:#E5E533;fill-rule:evenodd;stroke:#E5E533;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"60.6\" cy=\"65.0\" rx=\"6.6\" ry=\"6.6\" class=\"atom-9\" style=\"fill:#CCCCCC;fill-rule:evenodd;stroke:#CCCCCC;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 18.8,27.4 L 48.2,34.6\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.8px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 48.2,34.6 L 69.2,16.8\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.8px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 77.4,15.9 L 89.3,23.3\" style=\"fill:none;fill-rule:evenodd;stroke:#CCCC00;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 89.3,23.3 L 101.2,30.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 100.5,33.6 L 113.8,28.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 113.8,28.2 L 127.2,22.7\" style=\"fill:none;fill-rule:evenodd;stroke:#FF0000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 98.6,29.1 L 112.0,23.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 112.0,23.6 L 125.3,18.2\" style=\"fill:none;fill-rule:evenodd;stroke:#FF0000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-3 atom-5\" d=\"M 101.2,30.7 L 98.0,43.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-3 atom-5\" d=\"M 98.0,43.8 L 94.8,56.9\" style=\"fill:none;fill-rule:evenodd;stroke:#0000FF;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 98.0,68.0 L 106.3,77.9\" style=\"fill:none;fill-rule:evenodd;stroke:#0000FF;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 106.3,77.9 L 114.6,87.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 114.6,87.7 L 103.5,118.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 104.4,115.9 L 74.0,121.4\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.8px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 105.3,120.7 L 74.9,126.2\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.8px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:6,4\"/>\n",
              "<path class=\"bond-8 atom-5 atom-9\" d=\"M 88.8,62.9 L 74.7,64.0\" style=\"fill:none;fill-rule:evenodd;stroke:#0000FF;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-5 atom-9\" d=\"M 74.7,64.0 L 60.6,65.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 59.5,62.2 L 52.2,74.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 52.2,74.0 L 44.8,85.8\" style=\"fill:none;fill-rule:evenodd;stroke:#FF0000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 63.7,64.8 L 56.3,76.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 56.3,76.6 L 49.0,88.4\" style=\"fill:none;fill-rule:evenodd;stroke:#FF0000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-9 atom-1\" d=\"M 60.6,65.0 L 48.2,34.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-7\" d=\"M 119.5,141.4 L 100.7,119.1\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.8px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-7\" d=\"M 123.3,138.2 L 104.4,115.9\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.8px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:6,4\"/>\n",
              "<path d=\"M 100.6,30.3 L 101.2,30.7 L 101.1,31.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 114.2,87.2 L 114.6,87.7 L 114.0,89.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 61.3,65.0 L 60.6,65.0 L 60.0,63.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-0\" d=\"M 14.6 25.7 L 15.9 24.3 L 14.1 24.0 L 14.4 23.0 L 16.1 23.9 L 15.8 22.1 L 16.8 22.0 L 16.5 23.9 L 18.2 23.1 L 18.5 24.0 L 16.7 24.3 L 18.0 25.7 L 17.2 26.3 L 16.3 24.6 L 15.4 26.3 L 14.6 25.7 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-2\" d=\"M 70.7 16.6 Q 70.8 16.6, 71.2 16.8 Q 71.6 17.0, 72.1 17.1 Q 72.6 17.2, 73.1 17.2 Q 73.9 17.2, 74.5 16.8 Q 75.0 16.4, 75.0 15.6 Q 75.0 15.1, 74.7 14.8 Q 74.5 14.5, 74.1 14.3 Q 73.7 14.1, 73.0 13.9 Q 72.2 13.7, 71.7 13.4 Q 71.2 13.2, 70.8 12.7 Q 70.5 12.2, 70.5 11.4 Q 70.5 10.2, 71.3 9.5 Q 72.1 8.7, 73.7 8.7 Q 74.8 8.7, 76.0 9.3 L 75.7 10.3 Q 74.6 9.8, 73.7 9.8 Q 72.8 9.8, 72.3 10.2 Q 71.8 10.6, 71.8 11.2 Q 71.8 11.7, 72.1 12.0 Q 72.3 12.3, 72.7 12.5 Q 73.1 12.7, 73.7 12.8 Q 74.6 13.1, 75.1 13.4 Q 75.6 13.6, 75.9 14.2 Q 76.3 14.7, 76.3 15.6 Q 76.3 16.9, 75.4 17.6 Q 74.6 18.3, 73.1 18.3 Q 72.3 18.3, 71.7 18.1 Q 71.0 17.9, 70.3 17.6 L 70.7 16.6 \" fill=\"#CCCC00\"/>\n",
              "<path class=\"atom-4\" d=\"M 127.3 18.3 Q 127.3 16.1, 128.5 14.8 Q 129.6 13.6, 131.6 13.6 Q 133.7 13.6, 134.8 14.8 Q 135.9 16.1, 135.9 18.3 Q 135.9 20.6, 134.8 21.8 Q 133.7 23.1, 131.6 23.1 Q 129.6 23.1, 128.5 21.8 Q 127.3 20.6, 127.3 18.3 M 131.6 22.1 Q 133.0 22.1, 133.8 21.1 Q 134.6 20.2, 134.6 18.3 Q 134.6 16.5, 133.8 15.5 Q 133.0 14.6, 131.6 14.6 Q 130.2 14.6, 129.4 15.5 Q 128.7 16.5, 128.7 18.3 Q 128.7 20.2, 129.4 21.1 Q 130.2 22.1, 131.6 22.1 \" fill=\"#FF0000\"/>\n",
              "<path class=\"atom-5\" d=\"M 91.3 57.9 L 94.4 62.9 Q 94.7 63.3, 95.2 64.2 Q 95.7 65.1, 95.7 65.2 L 95.7 57.9 L 96.9 57.9 L 96.9 67.2 L 95.6 67.2 L 92.4 61.9 Q 92.0 61.2, 91.6 60.5 Q 91.2 59.8, 91.1 59.6 L 91.1 67.2 L 89.9 67.2 L 89.9 57.9 L 91.3 57.9 \" fill=\"#0000FF\"/>\n",
              "<path class=\"atom-8\" d=\"M 69.4 123.4 L 70.8 122.0 L 69.0 121.6 L 69.2 120.7 L 70.9 121.5 L 70.7 119.7 L 71.6 119.7 L 71.4 121.5 L 73.1 120.7 L 73.4 121.6 L 71.5 121.9 L 72.8 123.3 L 72.0 123.9 L 71.1 122.2 L 70.2 123.9 L 69.4 123.4 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-10\" d=\"M 39.1 92.9 Q 39.1 90.7, 40.2 89.5 Q 41.3 88.2, 43.3 88.2 Q 45.4 88.2, 46.5 89.5 Q 47.6 90.7, 47.6 92.9 Q 47.6 95.2, 46.5 96.5 Q 45.4 97.8, 43.3 97.8 Q 41.3 97.8, 40.2 96.5 Q 39.1 95.2, 39.1 92.9 M 43.3 96.7 Q 44.8 96.7, 45.5 95.8 Q 46.3 94.8, 46.3 92.9 Q 46.3 91.1, 45.5 90.2 Q 44.8 89.3, 43.3 89.3 Q 41.9 89.3, 41.1 90.2 Q 40.4 91.1, 40.4 92.9 Q 40.4 94.8, 41.1 95.8 Q 41.9 96.7, 43.3 96.7 \" fill=\"#FF0000\"/>\n",
              "<path class=\"atom-11\" d=\"M 122.9 142.6 L 124.3 141.2 L 122.5 140.9 L 122.8 139.9 L 124.4 140.8 L 124.2 138.9 L 125.2 138.9 L 124.9 140.8 L 126.6 140.0 L 126.9 140.9 L 125.0 141.2 L 126.4 142.6 L 125.6 143.2 L 124.7 141.4 L 123.7 143.2 L 122.9 142.6 \" fill=\"#191919\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "metadata": {},
          "output_type": "display_data"
        },
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"150px\" height=\"150px\" viewBox=\"0 0 150 150\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"150.0\" height=\"150.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<ellipse cx=\"13.1\" cy=\"80.6\" rx=\"6.3\" ry=\"6.3\" class=\"atom-1\" style=\"fill:#E5E533;fill-rule:evenodd;stroke:#E5E533;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"34.7\" cy=\"58.0\" rx=\"6.3\" ry=\"6.3\" class=\"atom-2\" style=\"fill:#E5E533;fill-rule:evenodd;stroke:#E5E533;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"65.1\" cy=\"65.5\" rx=\"6.3\" ry=\"6.3\" class=\"atom-3\" style=\"fill:#9999E5;fill-rule:evenodd;stroke:#9999E5;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"117.2\" cy=\"50.3\" rx=\"6.3\" ry=\"6.3\" class=\"atom-5\" style=\"fill:#CCCCCC;fill-rule:evenodd;stroke:#CCCCCC;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"73.9\" cy=\"95.5\" rx=\"6.3\" ry=\"6.3\" class=\"atom-7\" style=\"fill:#E5E533;fill-rule:evenodd;stroke:#E5E533;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"52.2\" cy=\"118.1\" rx=\"6.3\" ry=\"6.3\" class=\"atom-8\" style=\"fill:#E5E533;fill-rule:evenodd;stroke:#E5E533;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 20.2,105.1 L 13.1,80.6\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.7px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 24.7,103.8 L 18.3,81.9\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.7px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 13.1,80.6 L 34.7,58.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 34.7,58.0 L 65.1,65.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 36.2,63.2 L 61.4,69.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 65.1,65.5 L 73.8,56.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 73.8,56.5 L 82.4,47.5\" style=\"fill:none;fill-rule:evenodd;stroke:#0000FF;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 91.2,44.0 L 104.2,47.1\" style=\"fill:none;fill-rule:evenodd;stroke:#0000FF;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 104.2,47.1 L 117.2,50.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 117.2,50.3 L 140.4,30.7\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.7px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-3 atom-7\" d=\"M 65.1,65.5 L 73.9,95.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 73.9,95.5 L 52.2,118.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 68.6,94.2 L 50.7,112.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-0\" d=\"M 52.2,118.1 L 24.2,111.3\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.7px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-5\" d=\"M 126.8,73.8 L 117.2,50.3\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:1.7px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 13.3,81.2 L 13.1,80.6 L 13.6,80.0\" style=\"fill:none;stroke:#E5E5E5;stroke-width:1.7px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 33.7,59.1 L 34.7,58.0 L 36.3,58.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 73.4,94.0 L 73.9,95.5 L 72.8,96.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 52.8,117.6 L 52.2,118.1 L 51.5,118.0\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-0\" d=\"M 20.1 109.7 L 21.5 108.4 L 19.7 108.0 L 20.0 107.1 L 21.6 107.9 L 21.4 106.2 L 22.3 106.2 L 22.0 107.9 L 23.6 107.2 L 23.9 108.0 L 22.2 108.3 L 23.4 109.7 L 22.7 110.2 L 21.8 108.6 L 20.9 110.2 L 20.1 109.7 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-4\" d=\"M 84.8 38.4 L 87.7 43.1 Q 88.0 43.6, 88.5 44.4 Q 88.9 45.3, 89.0 45.3 L 89.0 38.4 L 90.1 38.4 L 90.1 47.3 L 88.9 47.3 L 85.8 42.2 Q 85.5 41.6, 85.1 40.9 Q 84.7 40.2, 84.6 40.0 L 84.6 47.3 L 83.4 47.3 L 83.4 38.4 L 84.8 38.4 \" fill=\"#0000FF\"/>\n",
              "<path class=\"atom-4\" d=\"M 83.3 28.7 L 84.5 28.7 L 84.5 32.5 L 89.1 32.5 L 89.1 28.7 L 90.3 28.7 L 90.3 37.6 L 89.1 37.6 L 89.1 33.5 L 84.5 33.5 L 84.5 37.6 L 83.3 37.6 L 83.3 28.7 \" fill=\"#0000FF\"/>\n",
              "<path class=\"atom-6\" d=\"M 139.4 29.1 L 140.7 27.8 L 139.0 27.5 L 139.3 26.6 L 140.8 27.4 L 140.6 25.6 L 141.6 25.6 L 141.3 27.4 L 142.9 26.6 L 143.2 27.5 L 141.4 27.8 L 142.7 29.1 L 141.9 29.7 L 141.1 28.0 L 140.2 29.7 L 139.4 29.1 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-9\" d=\"M 127.3 78.3 L 128.7 77.0 L 126.9 76.6 L 127.2 75.8 L 128.8 76.6 L 128.6 74.8 L 129.5 74.8 L 129.2 76.5 L 130.8 75.8 L 131.1 76.6 L 129.4 77.0 L 130.6 78.3 L 129.9 78.9 L 129.0 77.2 L 128.1 78.9 L 127.3 78.3 \" fill=\"#191919\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "metadata": {},
          "output_type": "display_data"
        },
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"150px\" height=\"150px\" viewBox=\"0 0 150 150\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"150.0\" height=\"150.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<ellipse cx=\"85.6\" cy=\"100.3\" rx=\"15.2\" ry=\"15.2\" class=\"atom-1\" style=\"fill:#9999E5;fill-rule:evenodd;stroke:#9999E5;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 17.7,83.6 L 85.6,100.3\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:4.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 85.6,100.3 L 136.7,46.9\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:4.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 82.2,99.4 L 85.6,100.3 L 88.2,97.6\" style=\"fill:none;stroke:#E5E5E5;stroke-width:4.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-0\" d=\"M 7.9 79.8 L 11.0 76.6 L 6.8 75.7 L 7.5 73.6 L 11.3 75.5 L 10.8 71.3 L 13.0 71.3 L 12.4 75.5 L 16.3 73.7 L 17.0 75.7 L 12.7 76.5 L 15.8 79.8 L 13.9 81.1 L 11.8 77.1 L 9.7 81.1 L 7.9 79.8 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-2\" d=\"M 134.0 43.1 L 137.2 39.9 L 133.0 39.0 L 133.7 36.9 L 137.5 38.8 L 137.0 34.6 L 139.2 34.6 L 138.6 38.8 L 142.5 37.0 L 143.2 39.0 L 138.9 39.8 L 142.0 43.1 L 140.1 44.4 L 138.0 40.4 L 135.9 44.4 L 134.0 43.1 \" fill=\"#191919\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "metadata": {},
          "output_type": "display_data"
        },
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"150px\" height=\"150px\" viewBox=\"0 0 150 150\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"150.0\" height=\"150.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<ellipse cx=\"75.0\" cy=\"89.2\" rx=\"7.9\" ry=\"7.9\" class=\"atom-2\" style=\"fill:#9999E5;fill-rule:evenodd;stroke:#9999E5;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<ellipse cx=\"102.3\" cy=\"60.7\" rx=\"7.9\" ry=\"7.9\" class=\"atom-4\" style=\"fill:#E5E533;fill-rule:evenodd;stroke:#E5E533;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 13.4,104.1 L 30.3,86.5\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:2.1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 43.1,81.3 L 59.1,85.2\" style=\"fill:none;fill-rule:evenodd;stroke:#FF0000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 59.1,85.2 L 75.0,89.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 71.7,88.3 L 76.4,104.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 76.4,104.6 L 81.1,120.9\" style=\"fill:none;fill-rule:evenodd;stroke:#FF0000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 77.4,86.7 L 82.1,103.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 82.1,103.0 L 86.8,119.2\" style=\"fill:none;fill-rule:evenodd;stroke:#FF0000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-2 atom-4\" d=\"M 75.0,89.2 L 102.3,60.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 105.6,61.5 L 94.3,22.8\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:2.1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 99.9,63.2 L 88.6,24.4\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:2.1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:6,4\"/>\n",
              "<path class=\"bond-5 atom-6 atom-4\" d=\"M 135.9,72.0 L 99.9,63.2\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:2.1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-6 atom-4\" d=\"M 137.3,66.3 L 101.3,57.4\" style=\"fill:none;fill-rule:evenodd;stroke:#E5E5E5;stroke-width:2.1px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;stroke-dasharray:6,4\"/>\n",
              "<path d=\"M 74.2,89.0 L 75.0,89.2 L 76.4,87.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-0\" d=\"M 7.4 107.0 L 9.0 105.3 L 6.8 104.9 L 7.1 103.7 L 9.2 104.8 L 8.9 102.6 L 10.0 102.5 L 9.7 104.7 L 11.8 103.8 L 12.1 104.9 L 9.9 105.3 L 11.5 107.0 L 10.5 107.7 L 9.4 105.6 L 8.3 107.7 L 7.4 107.0 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-1\" d=\"M 31.6 79.8 Q 31.6 77.1, 32.9 75.6 Q 34.3 74.1, 36.7 74.1 Q 39.2 74.1, 40.5 75.6 Q 41.8 77.1, 41.8 79.8 Q 41.8 82.5, 40.5 84.1 Q 39.2 85.6, 36.7 85.6 Q 34.3 85.6, 32.9 84.1 Q 31.6 82.5, 31.6 79.8 M 36.7 84.3 Q 38.4 84.3, 39.3 83.2 Q 40.3 82.0, 40.3 79.8 Q 40.3 77.6, 39.3 76.5 Q 38.4 75.4, 36.7 75.4 Q 35.0 75.4, 34.1 76.5 Q 33.2 77.6, 33.2 79.8 Q 33.2 82.1, 34.1 83.2 Q 35.0 84.3, 36.7 84.3 \" fill=\"#FF0000\"/>\n",
              "<path class=\"atom-3\" d=\"M 80.9 127.0 Q 80.9 124.3, 82.2 122.8 Q 83.5 121.4, 86.0 121.4 Q 88.5 121.4, 89.8 122.8 Q 91.1 124.3, 91.1 127.0 Q 91.1 129.7, 89.8 131.3 Q 88.5 132.8, 86.0 132.8 Q 83.5 132.8, 82.2 131.3 Q 80.9 129.8, 80.9 127.0 M 86.0 131.6 Q 87.7 131.6, 88.6 130.4 Q 89.6 129.3, 89.6 127.0 Q 89.6 124.8, 88.6 123.7 Q 87.7 122.6, 86.0 122.6 Q 84.3 122.6, 83.4 123.7 Q 82.5 124.8, 82.5 127.0 Q 82.5 129.3, 83.4 130.4 Q 84.3 131.6, 86.0 131.6 \" fill=\"#FF0000\"/>\n",
              "<path class=\"atom-5\" d=\"M 89.2 21.6 L 90.8 19.9 L 88.6 19.5 L 89.0 18.4 L 91.0 19.4 L 90.7 17.2 L 91.9 17.2 L 91.5 19.4 L 93.6 18.4 L 93.9 19.5 L 91.7 19.9 L 93.3 21.6 L 92.3 22.3 L 91.2 20.2 L 90.1 22.3 L 89.2 21.6 \" fill=\"#191919\"/>\n",
              "<path class=\"atom-6\" d=\"M 138.4 68.8 L 140.1 67.2 L 137.9 66.7 L 138.2 65.6 L 140.2 66.6 L 140.0 64.4 L 141.1 64.4 L 140.8 66.6 L 142.8 65.7 L 143.2 66.7 L 141.0 67.1 L 142.6 68.8 L 141.6 69.5 L 140.5 67.4 L 139.4 69.5 L 138.4 68.8 \" fill=\"#191919\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "metadata": {},
          "output_type": "display_data"
        }
      ],
      "source": [
        "display(*example_bits)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "RvGSjQy9dMW1"
      },
      "source": [
        "## 5️⃣ Similarity Searching"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "YbSM_-e82Ib_"
      },
      "source": [
        "### Searching against a Query"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "zenFd2QOb1q4",
        "outputId": "6e2a774d-8835-4ee1-b253-cfb62a168ac8"
      },
      "outputs": [
        {
          "name": "stderr",
          "output_type": "stream",
          "text": [
            "<ipython-input-48-19973eda0237>:8: SettingWithCopyWarning: \n",
            "A value is trying to be set on a copy of a slice from a DataFrame.\n",
            "Try using .loc[row_indexer,col_indexer] = value instead\n",
            "\n",
            "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n",
            "  specs_filtered[\"tanimoto_sim\"] = DataStructs.BulkTanimotoSimilarity(query, mols)\n",
            "<ipython-input-48-19973eda0237>:9: SettingWithCopyWarning: \n",
            "A value is trying to be set on a copy of a slice from a DataFrame.\n",
            "Try using .loc[row_indexer,col_indexer] = value instead\n",
            "\n",
            "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n",
            "  specs_filtered[\"dice_sim\"] = DataStructs.BulkDiceSimilarity(query, mols)\n"
          ]
        }
      ],
      "source": [
        "malaria_box = pd.read_excel(\"data/MalariaBox400compoundsDec2014.xls\", usecols=[\"HEOS_COMPOUND_ID\", \"Smiles\"])\n",
        "PandasTools.AddMoleculeColumnToFrame(malaria_box, 'Smiles', 'mol')\n",
        "malaria_box[\"morgan_fp_r2_b2048\"] = malaria_box[\"mol\"].apply(compute_fingerprint, r=2, nBits=2048)\n",
        "\n",
        "query = malaria_box.morgan_fp_r2_b2048.iloc[236]\n",
        "mols = specs_filtered.morgan_fp_r2_b2048.tolist()\n",
        "\n",
        "specs_filtered[\"tanimoto_sim\"] = DataStructs.BulkTanimotoSimilarity(query, mols)\n",
        "specs_filtered[\"dice_sim\"] = DataStructs.BulkDiceSimilarity(query, mols)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "JTu-yZEA2UfX"
      },
      "source": [
        "**Code for Figure 2.17. Tanimoto and Dice similarity scores of molecules with high and low similarity to a Malaria Box compound**"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 221
        },
        "id": "LVR2ao63aHIh",
        "outputId": "8e1c37e7-a160-4ee9-ba21-f5839bb5d93b"
      },
      "outputs": [
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"200px\" height=\"200px\" viewBox=\"0 0 200 200\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"200.0\" height=\"200.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 105.4,101.5 L 105.5,113.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 105.5,113.0 L 89.6,122.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 89.6,122.5 L 79.2,116.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 67.7,116.9 L 57.5,122.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 57.5,122.9 L 41.4,113.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 41.4,113.8 L 41.2,95.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 38.6,112.3 L 38.4,97.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 41.2,95.3 L 25.0,86.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 25.0,86.3 L 9.1,95.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 25.1,89.5 L 11.9,97.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 9.1,95.7 L 9.3,114.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 9.3,114.2 L 25.5,123.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 12.1,112.6 L 25.4,120.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-1 atom-11\" d=\"M 105.5,113.0 L 121.7,122.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 121.7,122.1 L 131.8,116.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 143.4,115.1 L 154.6,120.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 154.6,120.0 L 160.5,137.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 157.7,120.6 L 162.6,135.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-14 atom-15\" d=\"M 160.5,137.5 L 178.7,141.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 178.7,141.1 L 190.9,127.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 177.7,138.1 L 187.8,126.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 190.9,127.2 L 185.0,109.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 185.0,109.7 L 166.8,106.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 182.9,112.1 L 167.8,109.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 166.8,106.1 L 157.4,90.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 157.4,90.1 L 162.9,72.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 155.2,87.8 L 159.7,73.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 162.9,72.5 L 150.3,58.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-21 atom-22\" d=\"M 150.3,58.9 L 132.2,62.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-21 atom-22\" d=\"M 149.4,61.9 L 134.4,65.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-22 atom-23\" d=\"M 132.2,62.9 L 126.7,80.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-23 atom-23 atom-24\" d=\"M 126.7,80.6 L 139.3,94.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-23 atom-23 atom-24\" d=\"M 129.9,79.9 L 140.3,91.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-24 atom-10 atom-5\" d=\"M 25.5,123.3 L 41.4,113.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-25 atom-24 atom-12\" d=\"M 139.3,94.2 L 138.2,105.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-26 atom-18 atom-13\" d=\"M 166.8,106.1 L 154.6,120.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-27 atom-24 atom-19\" d=\"M 139.3,94.2 L 157.4,90.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 90.4,122.0 L 89.6,122.5 L 89.1,122.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 58.0,122.6 L 57.5,122.9 L 56.7,122.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 41.2,96.2 L 41.2,95.3 L 40.4,94.9\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 25.8,86.7 L 25.0,86.3 L 24.2,86.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 9.9,95.2 L 9.1,95.7 L 9.1,96.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 9.3,113.3 L 9.3,114.2 L 10.1,114.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 24.7,122.8 L 25.5,123.3 L 26.3,122.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 120.9,121.7 L 121.7,122.1 L 122.2,121.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 160.2,136.6 L 160.5,137.5 L 161.4,137.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 177.8,141.0 L 178.7,141.1 L 179.3,140.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 190.3,127.9 L 190.9,127.2 L 190.6,126.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 185.3,110.6 L 185.0,109.7 L 184.1,109.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 162.6,73.3 L 162.9,72.5 L 162.2,71.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 150.9,59.5 L 150.3,58.9 L 149.4,59.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 133.2,62.7 L 132.2,62.9 L 132.0,63.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 127.0,79.7 L 126.7,80.6 L 127.4,81.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-0\" d=\"M 101.3 94.6 Q 101.3 92.5, 102.3 91.3 Q 103.4 90.1, 105.3 90.1 Q 107.2 90.1, 108.3 91.3 Q 109.3 92.5, 109.3 94.6 Q 109.3 96.7, 108.3 97.9 Q 107.2 99.1, 105.3 99.1 Q 103.4 99.1, 102.3 97.9 Q 101.3 96.7, 101.3 94.6 M 105.3 98.1 Q 106.6 98.1, 107.3 97.2 Q 108.1 96.3, 108.1 94.6 Q 108.1 92.8, 107.3 92.0 Q 106.6 91.1, 105.3 91.1 Q 104.0 91.1, 103.2 92.0 Q 102.5 92.8, 102.5 94.6 Q 102.5 96.3, 103.2 97.2 Q 104.0 98.1, 105.3 98.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-0\" d=\"M 110.7 90.2 L 111.9 90.2 L 111.9 93.9 L 116.3 93.9 L 116.3 90.2 L 117.5 90.2 L 117.5 98.9 L 116.3 98.9 L 116.3 94.9 L 111.9 94.9 L 111.9 98.9 L 110.7 98.9 L 110.7 90.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 71.5 109.1 L 74.4 113.7 Q 74.7 114.2, 75.1 115.0 Q 75.6 115.8, 75.6 115.9 L 75.6 109.1 L 76.8 109.1 L 76.8 117.8 L 75.6 117.8 L 72.5 112.7 Q 72.1 112.2, 71.8 111.5 Q 71.4 110.8, 71.3 110.6 L 71.3 117.8 L 70.1 117.8 L 70.1 109.1 L 71.5 109.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 70.0 99.5 L 71.2 99.5 L 71.2 103.2 L 75.7 103.2 L 75.7 99.5 L 76.9 99.5 L 76.9 108.2 L 75.7 108.2 L 75.7 104.2 L 71.2 104.2 L 71.2 108.2 L 70.0 108.2 L 70.0 99.5 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 135.7 108.3 L 138.5 112.9 Q 138.8 113.4, 139.3 114.2 Q 139.7 115.0, 139.7 115.1 L 139.7 108.3 L 140.9 108.3 L 140.9 117.0 L 139.7 117.0 L 136.6 112.0 Q 136.3 111.4, 135.9 110.7 Q 135.5 110.0, 135.4 109.8 L 135.4 117.0 L 134.3 117.0 L 134.3 108.3 L 135.7 108.3 \" fill=\"#000000\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "execution_count": 50,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "img = Draw.MolsToGridImage(\n",
        "  mols=[malaria_box.mol.iloc[236]], molsPerRow=1, useSVG=True, drawOptions=dopts,\n",
        ")\n",
        "with open(\"figures/ch02/example_malaria_box_mol.svg\", \"w\") as f:\n",
        "  f.write(img.data)\n",
        "img"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "d79A-Ntau5Pg"
      },
      "outputs": [],
      "source": [
        "def visualize_similarity_extremes(df, sim_col, sim_col_2=None, n=3):\n",
        "  df_ordered = df.sort_values([sim_col], ascending=False).reset_index()\n",
        "  extremes = pd.concat([df_ordered[:n], df_ordered.dropna()[-n:]])\n",
        "\n",
        "  if sim_col_2:\n",
        "    legend_text=[f\"Tani: {x:.2f}\\tDice: {y:.2f}\" for x, y in zip(extremes[sim_col], extremes[sim_col_2])]\n",
        "  else:\n",
        "    legend_text=[f\"{x:.2f}\" for x in extremes[sim_col]]\n",
        "\n",
        "  return Draw.MolsToGridImage(\n",
        "    extremes.mol, molsPerRow=3, legends=legend_text, useSVG=True, drawOptions=dopts\n",
        "  )"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 421
        },
        "id": "YxSPUCxuwetd",
        "outputId": "1088f3af-f8b2-4dd6-eecb-0f5e29450349"
      },
      "outputs": [
        {
          "data": {
            "image/svg+xml": [
              "<svg xmlns=\"http://www.w3.org/2000/svg\" xmlns:rdkit=\"http://www.rdkit.org/xml\" xmlns:xlink=\"http://www.w3.org/1999/xlink\" version=\"1.1\" baseProfile=\"full\" xml:space=\"preserve\" width=\"600px\" height=\"400px\" viewBox=\"0 0 600 400\">\n",
              "<!-- END OF HEADER -->\n",
              "<rect style=\"opacity:1.0;fill:#FFFFFF;stroke:none\" width=\"600.0\" height=\"400.0\" x=\"0.0\" y=\"0.0\"> </rect>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 94.6,88.6 L 94.5,77.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 94.5,77.0 L 110.4,67.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 110.4,67.5 L 120.8,73.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 132.3,73.1 L 142.5,67.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 142.5,67.1 L 158.6,76.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 158.6,76.2 L 158.8,94.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 161.4,77.7 L 161.6,93.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 158.8,94.7 L 175.0,103.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 175.0,103.7 L 190.9,94.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 174.9,100.5 L 188.1,92.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 190.9,94.3 L 190.7,75.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 190.7,75.8 L 174.5,66.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 187.9,77.4 L 174.6,69.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-1 atom-11\" d=\"M 94.5,77.0 L 78.3,67.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 78.3,67.9 L 68.2,73.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 56.6,74.9 L 45.4,70.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 45.4,70.0 L 33.2,83.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 46.2,73.4 L 36.6,84.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-14 atom-15\" d=\"M 33.2,83.9 L 42.6,99.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 42.6,99.9 L 37.1,117.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 44.8,102.2 L 40.3,116.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 37.1,117.5 L 49.7,131.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 49.7,131.1 L 67.8,127.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 50.6,128.1 L 65.6,124.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 67.8,127.1 L 73.3,109.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 73.3,109.4 L 60.7,95.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 70.1,110.1 L 59.7,98.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-14 atom-21\" d=\"M 33.2,83.9 L 15.0,80.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-21 atom-22\" d=\"M 15.0,80.3 L 9.1,62.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-22 atom-23\" d=\"M 9.1,62.8 L 21.3,48.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-23 atom-23 atom-24\" d=\"M 21.3,48.9 L 39.5,52.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-24 atom-10 atom-5\" d=\"M 174.5,66.7 L 158.6,76.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-25 atom-20 atom-12\" d=\"M 60.7,95.8 L 61.8,84.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-26 atom-24 atom-13\" d=\"M 39.5,52.5 L 45.4,70.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-27 atom-20 atom-15\" d=\"M 60.7,95.8 L 42.6,99.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 109.6,68.0 L 110.4,67.5 L 110.9,67.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 142.0,67.4 L 142.5,67.1 L 143.3,67.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 158.8,93.8 L 158.8,94.7 L 159.6,95.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 174.2,103.3 L 175.0,103.7 L 175.8,103.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 190.1,94.8 L 190.9,94.3 L 190.9,93.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 190.7,76.7 L 190.7,75.8 L 189.9,75.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 175.3,67.2 L 174.5,66.7 L 173.7,67.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 79.1,68.3 L 78.3,67.9 L 77.8,68.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 37.4,116.7 L 37.1,117.5 L 37.8,118.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 49.1,130.5 L 49.7,131.1 L 50.6,130.9\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 66.8,127.3 L 67.8,127.1 L 68.0,126.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 73.0,110.3 L 73.3,109.4 L 72.6,108.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 15.9,80.5 L 15.0,80.3 L 14.7,79.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 9.4,63.6 L 9.1,62.8 L 9.7,62.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 20.7,49.6 L 21.3,48.9 L 22.2,49.0\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 38.6,52.3 L 39.5,52.5 L 39.8,53.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-0\" d=\"M 90.7 95.5 Q 90.7 93.4, 91.7 92.2 Q 92.8 91.1, 94.7 91.1 Q 96.6 91.1, 97.7 92.2 Q 98.7 93.4, 98.7 95.5 Q 98.7 97.6, 97.7 98.8 Q 96.6 100.0, 94.7 100.0 Q 92.8 100.0, 91.7 98.8 Q 90.7 97.6, 90.7 95.5 M 94.7 99.0 Q 96.0 99.0, 96.8 98.1 Q 97.5 97.2, 97.5 95.5 Q 97.5 93.8, 96.8 92.9 Q 96.0 92.0, 94.7 92.0 Q 93.4 92.0, 92.6 92.9 Q 91.9 93.8, 91.9 95.5 Q 91.9 97.3, 92.6 98.1 Q 93.4 99.0, 94.7 99.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-0\" d=\"M 100.1 91.2 L 101.3 91.2 L 101.3 94.9 L 105.7 94.9 L 105.7 91.2 L 106.9 91.2 L 106.9 99.9 L 105.7 99.9 L 105.7 95.9 L 101.3 95.9 L 101.3 99.9 L 100.1 99.9 L 100.1 91.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 124.6 72.2 L 127.5 76.8 Q 127.8 77.3, 128.2 78.1 Q 128.7 78.9, 128.7 79.0 L 128.7 72.2 L 129.9 72.2 L 129.9 80.9 L 128.7 80.9 L 125.6 75.9 Q 125.2 75.3, 124.8 74.6 Q 124.5 73.9, 124.4 73.7 L 124.4 80.9 L 123.2 80.9 L 123.2 72.2 L 124.6 72.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 123.1 81.8 L 124.3 81.8 L 124.3 85.5 L 128.8 85.5 L 128.8 81.8 L 130.0 81.8 L 130.0 90.5 L 128.8 90.5 L 128.8 86.5 L 124.3 86.5 L 124.3 90.5 L 123.1 90.5 L 123.1 81.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 60.5 73.0 L 63.3 77.6 Q 63.6 78.1, 64.1 78.9 Q 64.5 79.7, 64.6 79.8 L 64.6 73.0 L 65.7 73.0 L 65.7 81.7 L 64.5 81.7 L 61.5 76.7 Q 61.1 76.1, 60.7 75.4 Q 60.3 74.7, 60.2 74.5 L 60.2 81.7 L 59.1 81.7 L 59.1 73.0 L 60.5 73.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 27.6 184.8 L 24.1 184.8 L 24.1 183.5 L 32.4 183.5 L 32.4 184.8 L 29.1 184.8 L 29.1 194.8 L 27.6 194.8 L 27.6 184.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 32.9 192.6 Q 32.9 191.3, 33.9 190.6 Q 35.0 189.8, 36.9 189.8 L 38.2 189.8 L 38.2 189.5 Q 38.2 188.5, 37.7 188.1 Q 37.3 187.6, 36.3 187.6 Q 35.6 187.6, 35.1 187.8 Q 34.6 187.9, 33.8 188.2 L 33.4 187.2 Q 34.9 186.4, 36.3 186.4 Q 38.1 186.4, 38.9 187.2 Q 39.7 187.9, 39.7 189.5 L 39.7 194.8 L 38.5 194.8 Q 38.5 194.7, 38.4 194.5 Q 38.4 194.2, 38.3 193.8 Q 37.1 195.0, 35.6 195.0 Q 34.4 195.0, 33.6 194.3 Q 32.9 193.7, 32.9 192.6 M 34.4 192.6 Q 34.4 193.2, 34.8 193.5 Q 35.2 193.8, 35.9 193.8 Q 36.5 193.8, 37.1 193.5 Q 37.7 193.2, 38.2 192.7 L 38.2 191.0 L 37.0 191.0 Q 35.7 191.0, 35.1 191.4 Q 34.4 191.8, 34.4 192.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 45.7 186.4 Q 47.0 186.4, 47.7 187.2 Q 48.4 187.9, 48.4 189.4 L 48.4 194.8 L 46.9 194.8 L 46.9 189.5 Q 46.9 188.5, 46.5 188.1 Q 46.1 187.6, 45.3 187.6 Q 44.5 187.6, 43.9 188.0 Q 43.3 188.3, 42.9 188.9 L 42.9 194.8 L 41.4 194.8 L 41.4 186.6 L 42.6 186.6 L 42.8 187.7 Q 43.9 186.4, 45.7 186.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 50.1 183.5 L 51.6 183.5 L 51.6 184.9 L 50.1 184.9 L 50.1 183.5 M 50.1 186.6 L 51.6 186.6 L 51.6 194.8 L 50.1 194.8 L 50.1 186.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 53.4 192.9 L 55.0 192.9 L 55.0 194.5 L 53.4 194.5 L 53.4 192.9 M 53.4 187.4 L 55.0 187.4 L 55.0 189.0 L 53.4 189.0 L 53.4 187.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 66.7 194.9 Q 64.6 194.9, 63.6 193.4 Q 62.5 191.9, 62.5 189.1 Q 62.5 186.4, 63.6 184.9 Q 64.6 183.4, 66.7 183.4 Q 68.8 183.4, 69.8 184.9 Q 70.8 186.4, 70.8 189.1 Q 70.8 191.9, 69.8 193.4 Q 68.8 194.9, 66.7 194.9 M 66.7 193.7 Q 67.9 193.7, 68.6 192.5 Q 69.2 191.4, 69.2 189.1 Q 69.2 186.9, 68.6 185.8 Q 67.9 184.6, 66.7 184.6 Q 65.5 184.6, 64.8 185.8 Q 64.1 186.9, 64.1 189.1 Q 64.1 191.4, 64.8 192.5 Q 65.5 193.7, 66.7 193.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 72.3 193.2 L 73.9 193.2 L 73.9 194.8 L 72.3 194.8 L 72.3 193.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 79.9 187.7 Q 80.9 187.7, 81.7 188.2 Q 82.5 188.6, 82.9 189.4 Q 83.3 190.2, 83.3 191.2 Q 83.3 192.3, 82.8 193.1 Q 82.4 194.0, 81.5 194.5 Q 80.6 194.9, 79.5 194.9 Q 77.5 194.9, 76.5 193.6 Q 75.5 192.2, 75.5 189.5 Q 75.5 186.5, 76.7 184.9 Q 78.0 183.4, 80.4 183.4 Q 81.1 183.4, 81.7 183.5 Q 82.3 183.7, 82.9 184.0 L 82.3 185.1 Q 81.4 184.6, 80.4 184.6 Q 78.8 184.6, 78.0 185.7 Q 77.2 186.7, 77.1 188.8 Q 77.7 188.3, 78.4 188.0 Q 79.1 187.7, 79.9 187.7 M 79.5 193.6 Q 80.1 193.6, 80.6 193.3 Q 81.2 193.0, 81.4 192.4 Q 81.7 191.9, 81.7 191.2 Q 81.7 190.2, 81.2 189.6 Q 80.6 189.0, 79.6 189.0 Q 78.9 189.0, 78.2 189.3 Q 77.6 189.6, 77.1 190.1 Q 77.2 191.9, 77.7 192.8 Q 78.3 193.6, 79.5 193.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 88.5 183.4 Q 90.5 183.4, 91.5 184.7 Q 92.6 186.1, 92.6 188.8 Q 92.6 191.8, 91.3 193.4 Q 90.0 194.9, 87.6 194.9 Q 86.9 194.9, 86.3 194.8 Q 85.7 194.6, 85.1 194.3 L 85.8 193.2 Q 86.6 193.7, 87.6 193.7 Q 89.2 193.7, 90.0 192.6 Q 90.8 191.6, 90.9 189.5 Q 90.4 190.0, 89.6 190.3 Q 88.9 190.6, 88.1 190.6 Q 87.1 190.6, 86.3 190.1 Q 85.6 189.7, 85.1 188.9 Q 84.7 188.1, 84.7 187.1 Q 84.7 186.0, 85.2 185.2 Q 85.7 184.3, 86.5 183.8 Q 87.4 183.4, 88.5 183.4 M 86.3 187.1 Q 86.3 188.1, 86.9 188.7 Q 87.4 189.3, 88.4 189.3 Q 89.1 189.3, 89.8 189.0 Q 90.5 188.7, 90.9 188.2 Q 90.9 186.4, 90.3 185.5 Q 89.7 184.7, 88.5 184.7 Q 87.9 184.7, 87.4 185.0 Q 86.9 185.3, 86.6 185.9 Q 86.3 186.4, 86.3 187.1 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 111.0 183.5 Q 113.5 183.5, 114.9 185.0 Q 116.2 186.4, 116.2 189.1 Q 116.2 191.8, 114.8 193.3 Q 113.5 194.8, 111.0 194.8 L 107.3 194.8 L 107.3 183.5 L 111.0 183.5 M 111.0 193.5 Q 112.7 193.5, 113.7 192.4 Q 114.6 191.3, 114.6 189.1 Q 114.6 186.9, 113.7 185.8 Q 112.7 184.8, 111.0 184.8 L 108.9 184.8 L 108.9 193.5 L 111.0 193.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 117.4 183.5 L 118.9 183.5 L 118.9 184.9 L 117.4 184.9 L 117.4 183.5 M 117.4 186.6 L 118.9 186.6 L 118.9 194.8 L 117.4 194.8 L 117.4 186.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 120.7 190.7 Q 120.7 188.7, 121.7 187.6 Q 122.7 186.4, 124.7 186.4 Q 126.5 186.4, 127.5 187.8 L 126.5 188.6 Q 126.1 188.1, 125.7 187.9 Q 125.3 187.6, 124.7 187.6 Q 123.5 187.6, 122.9 188.4 Q 122.3 189.2, 122.3 190.7 Q 122.3 192.2, 122.9 193.0 Q 123.6 193.8, 124.8 193.8 Q 125.4 193.8, 125.9 193.6 Q 126.4 193.4, 126.9 193.2 L 127.4 194.2 Q 126.2 194.9, 124.7 194.9 Q 122.7 194.9, 121.7 193.8 Q 120.7 192.7, 120.7 190.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 128.4 190.7 Q 128.4 188.7, 129.4 187.6 Q 130.4 186.4, 132.2 186.4 Q 134.1 186.4, 134.9 187.5 Q 135.7 188.6, 135.7 190.6 L 135.7 190.9 L 129.9 190.9 Q 130.0 192.3, 130.6 193.0 Q 131.2 193.8, 132.4 193.8 Q 133.0 193.8, 133.6 193.6 Q 134.2 193.4, 134.9 193.1 L 135.4 194.2 Q 134.5 194.6, 133.8 194.8 Q 133.1 194.9, 132.3 194.9 Q 130.4 194.9, 129.4 193.8 Q 128.4 192.7, 128.4 190.7 M 132.2 187.6 Q 131.3 187.6, 130.7 188.2 Q 130.2 188.7, 130.0 189.8 L 134.1 189.8 Q 134.0 188.7, 133.5 188.2 Q 133.1 187.6, 132.2 187.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 136.8 192.9 L 138.4 192.9 L 138.4 194.5 L 136.8 194.5 L 136.8 192.9 M 136.8 187.4 L 138.4 187.4 L 138.4 189.0 L 136.8 189.0 L 136.8 187.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 150.0 194.9 Q 147.9 194.9, 146.9 193.4 Q 145.9 191.9, 145.9 189.1 Q 145.9 186.4, 146.9 184.9 Q 147.9 183.4, 150.0 183.4 Q 152.1 183.4, 153.1 184.9 Q 154.2 186.4, 154.2 189.1 Q 154.2 191.9, 153.1 193.4 Q 152.1 194.9, 150.0 194.9 M 150.0 193.7 Q 151.3 193.7, 151.9 192.5 Q 152.6 191.4, 152.6 189.1 Q 152.6 186.9, 151.9 185.8 Q 151.3 184.6, 150.0 184.6 Q 148.8 184.6, 148.1 185.8 Q 147.5 186.9, 147.5 189.1 Q 147.5 191.4, 148.1 192.5 Q 148.8 193.7, 150.0 193.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 155.7 193.2 L 157.3 193.2 L 157.3 194.8 L 155.7 194.8 L 155.7 193.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 164.6 188.8 Q 165.6 189.3, 166.2 189.9 Q 166.8 190.6, 166.8 191.7 Q 166.8 192.7, 166.3 193.4 Q 165.8 194.2, 164.9 194.6 Q 164.1 195.0, 162.9 195.0 Q 161.0 195.0, 159.9 194.1 Q 158.8 193.2, 158.8 191.7 Q 158.8 190.8, 159.3 190.1 Q 159.8 189.4, 160.8 188.9 Q 160.0 188.4, 159.6 187.8 Q 159.2 187.2, 159.2 186.2 Q 159.2 184.9, 160.2 184.1 Q 161.2 183.4, 162.8 183.4 Q 164.5 183.4, 165.4 184.1 Q 166.4 184.9, 166.4 186.2 Q 166.4 187.1, 165.9 187.7 Q 165.5 188.3, 164.6 188.8 M 162.8 184.6 Q 161.9 184.6, 161.3 185.0 Q 160.8 185.4, 160.8 186.2 Q 160.8 186.8, 161.2 187.2 Q 161.5 187.6, 162.0 187.8 Q 162.5 188.1, 163.5 188.4 Q 164.2 187.9, 164.5 187.4 Q 164.8 186.9, 164.8 186.2 Q 164.8 185.4, 164.3 185.0 Q 163.8 184.6, 162.8 184.6 M 162.9 193.8 Q 163.9 193.8, 164.6 193.2 Q 165.2 192.6, 165.2 191.7 Q 165.2 191.1, 164.9 190.7 Q 164.5 190.3, 164.0 190.1 Q 163.5 189.9, 162.6 189.6 L 161.9 189.3 Q 161.1 189.8, 160.8 190.4 Q 160.4 191.0, 160.4 191.7 Q 160.4 192.6, 161.1 193.2 Q 161.8 193.8, 162.9 193.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 168.3 185.6 Q 168.8 184.6, 169.8 184.0 Q 170.7 183.4, 172.1 183.4 Q 173.8 183.4, 174.8 184.3 Q 175.8 185.2, 175.8 186.9 Q 175.8 188.5, 174.5 190.1 Q 173.3 191.7, 170.7 193.5 L 175.9 193.5 L 175.9 194.8 L 168.3 194.8 L 168.3 193.7 Q 170.4 192.2, 171.7 191.1 Q 172.9 190.0, 173.5 189.0 Q 174.2 188.0, 174.2 186.9 Q 174.2 185.8, 173.6 185.2 Q 173.1 184.6, 172.1 184.6 Q 171.2 184.6, 170.6 185.0 Q 170.0 185.4, 169.6 186.2 L 168.3 185.6 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 217.7,101.6 L 234.4,93.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 218.9,104.1 L 234.2,96.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 234.4,93.5 L 249.7,103.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 249.7,103.9 L 260.6,98.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 272.1,99.7 L 281.7,106.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 281.7,106.2 L 298.4,98.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 298.4,98.1 L 299.2,86.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-5 atom-7\" d=\"M 298.4,98.1 L 313.7,108.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 313.7,108.5 L 324.6,103.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 336.1,103.4 L 346.7,109.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 346.7,109.1 L 351.1,127.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 349.8,110.0 L 353.5,124.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 351.1,127.1 L 368.9,132.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 368.9,132.2 L 382.3,119.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 368.2,129.1 L 379.2,118.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-12 atom-13\" d=\"M 382.3,119.3 L 377.8,101.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 377.8,101.4 L 360.0,96.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 375.5,103.6 L 360.8,99.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-14 atom-15\" d=\"M 360.0,96.2 L 351.9,79.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 351.9,79.6 L 358.9,62.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 350.0,77.1 L 355.7,62.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 358.9,62.4 L 347.5,47.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 347.5,47.8 L 329.2,50.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 346.3,50.8 L 331.1,52.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 329.2,50.4 L 322.2,67.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 322.2,67.5 L 333.6,82.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 325.4,67.1 L 334.8,79.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-8\" d=\"M 333.6,82.1 L 331.6,93.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-14 atom-9\" d=\"M 360.0,96.2 L 346.7,109.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-20 atom-15\" d=\"M 333.6,82.1 L 351.9,79.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 233.6,93.9 L 234.4,93.5 L 235.2,94.0\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 249.0,103.4 L 249.7,103.9 L 250.3,103.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 281.2,105.9 L 281.7,106.2 L 282.5,105.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 312.9,107.9 L 313.7,108.5 L 314.2,108.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 350.9,126.2 L 351.1,127.1 L 352.0,127.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 368.0,131.9 L 368.9,132.2 L 369.6,131.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 381.6,120.0 L 382.3,119.3 L 382.0,118.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 378.0,102.3 L 377.8,101.4 L 376.9,101.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 358.5,63.3 L 358.9,62.4 L 358.3,61.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 348.1,48.5 L 347.5,47.8 L 346.6,47.9\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 330.1,50.2 L 329.2,50.4 L 328.8,51.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 322.6,66.7 L 322.2,67.5 L 322.8,68.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-3\" d=\"M 264.4 91.4 L 267.3 96.1 Q 267.6 96.5, 268.0 97.3 Q 268.5 98.2, 268.5 98.2 L 268.5 91.4 L 269.7 91.4 L 269.7 100.2 L 268.5 100.2 L 265.4 95.1 Q 265.1 94.5, 264.7 93.8 Q 264.3 93.2, 264.2 92.9 L 264.2 100.2 L 263.1 100.2 L 263.1 91.4 L 264.4 91.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 263.0 81.8 L 264.1 81.8 L 264.1 85.5 L 268.6 85.5 L 268.6 81.8 L 269.8 81.8 L 269.8 90.6 L 268.6 90.6 L 268.6 86.5 L 264.1 86.5 L 264.1 90.6 L 263.0 90.6 L 263.0 81.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-6\" d=\"M 295.7 79.6 Q 295.7 77.5, 296.7 76.4 Q 297.7 75.2, 299.7 75.2 Q 301.6 75.2, 302.7 76.4 Q 303.7 77.5, 303.7 79.6 Q 303.7 81.8, 302.6 83.0 Q 301.6 84.2, 299.7 84.2 Q 297.8 84.2, 296.7 83.0 Q 295.7 81.8, 295.7 79.6 M 299.7 83.2 Q 301.0 83.2, 301.7 82.3 Q 302.5 81.4, 302.5 79.6 Q 302.5 77.9, 301.7 77.1 Q 301.0 76.2, 299.7 76.2 Q 298.3 76.2, 297.6 77.0 Q 296.9 77.9, 296.9 79.6 Q 296.9 81.4, 297.6 82.3 Q 298.3 83.2, 299.7 83.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-6\" d=\"M 305.1 75.3 L 306.2 75.3 L 306.2 79.0 L 310.7 79.0 L 310.7 75.3 L 311.9 75.3 L 311.9 84.0 L 310.7 84.0 L 310.7 80.0 L 306.2 80.0 L 306.2 84.0 L 305.1 84.0 L 305.1 75.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-8\" d=\"M 328.4 96.0 L 331.3 100.6 Q 331.6 101.1, 332.0 101.9 Q 332.5 102.7, 332.5 102.8 L 332.5 96.0 L 333.7 96.0 L 333.7 104.7 L 332.5 104.7 L 329.4 99.7 Q 329.0 99.1, 328.7 98.4 Q 328.3 97.7, 328.2 97.5 L 328.2 104.7 L 327.0 104.7 L 327.0 96.0 L 328.4 96.0 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 228.1 184.8 L 224.6 184.8 L 224.6 183.5 L 232.9 183.5 L 232.9 184.8 L 229.6 184.8 L 229.6 194.8 L 228.1 194.8 L 228.1 184.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 233.4 192.6 Q 233.4 191.3, 234.5 190.6 Q 235.5 189.8, 237.5 189.8 L 238.7 189.8 L 238.7 189.5 Q 238.7 188.5, 238.3 188.1 Q 237.8 187.6, 236.8 187.6 Q 236.2 187.6, 235.7 187.8 Q 235.1 187.9, 234.3 188.2 L 233.9 187.2 Q 235.4 186.4, 236.9 186.4 Q 238.6 186.4, 239.4 187.2 Q 240.2 187.9, 240.2 189.5 L 240.2 194.8 L 239.0 194.8 Q 239.0 194.7, 239.0 194.5 Q 238.9 194.2, 238.8 193.8 Q 237.7 195.0, 236.1 195.0 Q 234.9 195.0, 234.2 194.3 Q 233.4 193.7, 233.4 192.6 M 234.9 192.6 Q 234.9 193.2, 235.3 193.5 Q 235.7 193.8, 236.4 193.8 Q 237.1 193.8, 237.7 193.5 Q 238.3 193.2, 238.7 192.7 L 238.7 191.0 L 237.6 191.0 Q 236.3 191.0, 235.6 191.4 Q 234.9 191.8, 234.9 192.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 246.2 186.4 Q 247.5 186.4, 248.2 187.2 Q 248.9 187.9, 248.9 189.4 L 248.9 194.8 L 247.4 194.8 L 247.4 189.5 Q 247.4 188.5, 247.0 188.1 Q 246.6 187.6, 245.8 187.6 Q 245.1 187.6, 244.4 188.0 Q 243.8 188.3, 243.4 188.9 L 243.4 194.8 L 241.9 194.8 L 241.9 186.6 L 243.1 186.6 L 243.3 187.7 Q 244.4 186.4, 246.2 186.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 250.6 183.5 L 252.1 183.5 L 252.1 184.9 L 250.6 184.9 L 250.6 183.5 M 250.6 186.6 L 252.1 186.6 L 252.1 194.8 L 250.6 194.8 L 250.6 186.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 254.0 192.9 L 255.6 192.9 L 255.6 194.5 L 254.0 194.5 L 254.0 192.9 M 254.0 187.4 L 255.6 187.4 L 255.6 189.0 L 254.0 189.0 L 254.0 187.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 267.2 194.9 Q 265.1 194.9, 264.1 193.4 Q 263.1 191.9, 263.1 189.1 Q 263.1 186.4, 264.1 184.9 Q 265.1 183.4, 267.2 183.4 Q 269.3 183.4, 270.3 184.9 Q 271.3 186.4, 271.3 189.1 Q 271.3 191.9, 270.3 193.4 Q 269.3 194.9, 267.2 194.9 M 267.2 193.7 Q 268.4 193.7, 269.1 192.5 Q 269.7 191.4, 269.7 189.1 Q 269.7 186.9, 269.1 185.8 Q 268.4 184.6, 267.2 184.6 Q 266.0 184.6, 265.3 185.8 Q 264.7 186.9, 264.7 189.1 Q 264.7 191.4, 265.3 192.5 Q 266.0 193.7, 267.2 193.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 272.9 193.2 L 274.5 193.2 L 274.5 194.8 L 272.9 194.8 L 272.9 193.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 280.4 187.7 Q 281.4 187.7, 282.2 188.2 Q 283.0 188.6, 283.4 189.4 Q 283.9 190.2, 283.9 191.2 Q 283.9 192.3, 283.4 193.1 Q 282.9 194.0, 282.0 194.5 Q 281.2 194.9, 280.0 194.9 Q 278.0 194.9, 277.0 193.6 Q 276.0 192.2, 276.0 189.5 Q 276.0 186.5, 277.2 184.9 Q 278.5 183.4, 280.9 183.4 Q 281.6 183.4, 282.2 183.5 Q 282.8 183.7, 283.4 184.0 L 282.8 185.1 Q 282.0 184.6, 280.9 184.6 Q 279.3 184.6, 278.5 185.7 Q 277.7 186.7, 277.6 188.8 Q 278.2 188.3, 278.9 188.0 Q 279.6 187.7, 280.4 187.7 M 280.1 193.6 Q 280.7 193.6, 281.2 193.3 Q 281.7 193.0, 282.0 192.4 Q 282.3 191.9, 282.3 191.2 Q 282.3 190.2, 281.7 189.6 Q 281.1 189.0, 280.1 189.0 Q 279.5 189.0, 278.8 189.3 Q 278.1 189.6, 277.6 190.1 Q 277.7 191.9, 278.3 192.8 Q 278.9 193.6, 280.1 193.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 290.7 188.8 Q 291.8 189.2, 292.3 189.9 Q 292.8 190.6, 292.8 191.7 Q 292.8 192.7, 292.4 193.4 Q 291.9 194.2, 291.0 194.6 Q 290.1 195.0, 289.0 195.0 Q 287.7 195.0, 286.8 194.6 Q 285.9 194.1, 285.2 193.3 L 286.1 192.3 Q 286.8 193.1, 287.4 193.4 Q 288.0 193.7, 289.0 193.7 Q 290.0 193.7, 290.6 193.1 Q 291.2 192.6, 291.2 191.7 Q 291.2 190.5, 290.6 190.0 Q 289.9 189.5, 288.5 189.5 L 287.7 189.5 L 287.7 188.3 L 288.5 188.3 Q 289.7 188.3, 290.3 187.8 Q 291.0 187.3, 291.0 186.2 Q 291.0 185.5, 290.5 185.1 Q 289.9 184.6, 289.0 184.6 Q 288.0 184.6, 287.4 185.0 Q 286.9 185.3, 286.4 186.2 L 285.3 185.6 Q 285.7 184.6, 286.7 184.0 Q 287.6 183.4, 289.0 183.4 Q 290.6 183.4, 291.6 184.1 Q 292.6 184.9, 292.6 186.2 Q 292.6 187.2, 292.1 187.8 Q 291.6 188.5, 290.7 188.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 311.1 183.5 Q 313.6 183.5, 315.0 185.0 Q 316.3 186.4, 316.3 189.1 Q 316.3 191.8, 315.0 193.3 Q 313.6 194.8, 311.1 194.8 L 307.5 194.8 L 307.5 183.5 L 311.1 183.5 M 311.1 193.5 Q 312.9 193.5, 313.8 192.4 Q 314.7 191.3, 314.7 189.1 Q 314.7 186.9, 313.8 185.8 Q 312.9 184.8, 311.1 184.8 L 309.0 184.8 L 309.0 193.5 L 311.1 193.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 317.5 183.5 L 319.0 183.5 L 319.0 184.9 L 317.5 184.9 L 317.5 183.5 M 317.5 186.6 L 319.0 186.6 L 319.0 194.8 L 317.5 194.8 L 317.5 186.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 320.9 190.7 Q 320.9 188.7, 321.9 187.6 Q 322.9 186.4, 324.8 186.4 Q 326.7 186.4, 327.7 187.8 L 326.6 188.6 Q 326.3 188.1, 325.8 187.9 Q 325.4 187.6, 324.8 187.6 Q 323.7 187.6, 323.0 188.4 Q 322.4 189.2, 322.4 190.7 Q 322.4 192.2, 323.0 193.0 Q 323.7 193.8, 324.9 193.8 Q 325.6 193.8, 326.0 193.6 Q 326.5 193.4, 327.1 193.2 L 327.5 194.2 Q 326.3 194.9, 324.8 194.9 Q 322.9 194.9, 321.9 193.8 Q 320.9 192.7, 320.9 190.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 328.5 190.7 Q 328.5 188.7, 329.5 187.6 Q 330.5 186.4, 332.4 186.4 Q 334.2 186.4, 335.0 187.5 Q 335.8 188.6, 335.8 190.6 L 335.8 190.9 L 330.1 190.9 Q 330.1 192.3, 330.7 193.0 Q 331.3 193.8, 332.5 193.8 Q 333.1 193.8, 333.7 193.6 Q 334.3 193.4, 335.1 193.1 L 335.5 194.2 Q 334.7 194.6, 333.9 194.8 Q 333.2 194.9, 332.4 194.9 Q 330.6 194.9, 329.5 193.8 Q 328.5 192.7, 328.5 190.7 M 332.4 187.6 Q 331.4 187.6, 330.9 188.2 Q 330.3 188.7, 330.1 189.8 L 334.2 189.8 Q 334.1 188.7, 333.7 188.2 Q 333.2 187.6, 332.4 187.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 336.9 192.9 L 338.5 192.9 L 338.5 194.5 L 336.9 194.5 L 336.9 192.9 M 336.9 187.4 L 338.5 187.4 L 338.5 189.0 L 336.9 189.0 L 336.9 187.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 350.1 194.9 Q 348.1 194.9, 347.0 193.4 Q 346.0 191.9, 346.0 189.1 Q 346.0 186.4, 347.0 184.9 Q 348.0 183.4, 350.1 183.4 Q 352.2 183.4, 353.3 184.9 Q 354.3 186.4, 354.3 189.1 Q 354.3 191.9, 353.2 193.4 Q 352.2 194.9, 350.1 194.9 M 350.1 193.7 Q 351.4 193.7, 352.0 192.5 Q 352.7 191.4, 352.7 189.1 Q 352.7 186.9, 352.0 185.8 Q 351.4 184.6, 350.1 184.6 Q 348.9 184.6, 348.3 185.8 Q 347.6 186.9, 347.6 189.1 Q 347.6 191.4, 348.3 192.5 Q 348.9 193.7, 350.1 193.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 355.8 193.2 L 357.4 193.2 L 357.4 194.8 L 355.8 194.8 L 355.8 193.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 364.9 184.8 L 358.9 184.8 L 358.9 183.5 L 366.5 183.5 L 366.5 184.6 L 361.9 194.8 L 360.3 194.8 L 364.9 184.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 373.2 188.8 Q 374.2 189.3, 374.8 189.9 Q 375.4 190.6, 375.4 191.7 Q 375.4 192.7, 374.9 193.4 Q 374.4 194.2, 373.5 194.6 Q 372.6 195.0, 371.5 195.0 Q 369.6 195.0, 368.5 194.1 Q 367.4 193.2, 367.4 191.7 Q 367.4 190.8, 367.9 190.1 Q 368.4 189.4, 369.4 188.9 Q 368.6 188.4, 368.2 187.8 Q 367.8 187.2, 367.8 186.2 Q 367.8 184.9, 368.8 184.1 Q 369.8 183.4, 371.4 183.4 Q 373.1 183.4, 374.0 184.1 Q 375.0 184.9, 375.0 186.2 Q 375.0 187.1, 374.5 187.7 Q 374.1 188.3, 373.2 188.8 M 371.4 184.6 Q 370.5 184.6, 369.9 185.0 Q 369.4 185.4, 369.4 186.2 Q 369.4 186.8, 369.8 187.2 Q 370.1 187.6, 370.6 187.8 Q 371.1 188.1, 372.1 188.4 Q 372.8 187.9, 373.1 187.4 Q 373.4 186.9, 373.4 186.2 Q 373.4 185.4, 372.9 185.0 Q 372.4 184.6, 371.4 184.6 M 371.5 193.8 Q 372.5 193.8, 373.2 193.2 Q 373.8 192.6, 373.8 191.7 Q 373.8 191.1, 373.5 190.7 Q 373.1 190.3, 372.6 190.1 Q 372.1 189.9, 371.2 189.6 L 370.5 189.3 Q 369.7 189.8, 369.4 190.4 Q 369.0 191.0, 369.0 191.7 Q 369.0 192.6, 369.7 193.2 Q 370.4 193.8, 371.5 193.8 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 557.0,147.3 L 551.2,129.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 551.2,129.7 L 533.1,125.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 550.2,126.6 L 535.2,123.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 533.1,125.9 L 527.3,108.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 527.3,108.3 L 539.6,94.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 530.4,109.0 L 540.6,97.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 539.6,94.5 L 557.7,98.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 557.7,98.3 L 563.5,115.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 555.6,100.7 L 560.4,115.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-5 atom-7\" d=\"M 557.7,98.3 L 566.9,82.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 566.9,82.2 L 554.5,68.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 563.5,82.6 L 553.8,71.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 554.5,68.5 L 543.4,73.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 531.8,72.8 L 521.5,66.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 521.5,66.9 L 505.5,76.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 505.5,76.2 L 505.6,87.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-11 atom-13\" d=\"M 505.5,76.2 L 489.5,67.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-13 atom-14\" d=\"M 489.5,67.0 L 479.2,73.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-14 atom-15\" d=\"M 467.7,73.1 L 457.4,67.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-15 atom-16\" d=\"M 457.4,67.2 L 441.4,76.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 441.4,76.5 L 425.3,67.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-16 atom-17\" d=\"M 438.6,78.1 L 425.3,70.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-17 atom-17 atom-18\" d=\"M 425.3,67.3 L 409.3,76.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 409.3,76.6 L 409.4,95.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-18 atom-18 atom-19\" d=\"M 412.1,78.2 L 412.2,93.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-19 atom-19 atom-20\" d=\"M 409.4,95.1 L 425.5,104.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 425.5,104.3 L 441.5,95.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-20 atom-20 atom-21\" d=\"M 425.5,101.1 L 438.7,93.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-21 atom-8 atom-22\" d=\"M 554.5,68.5 L 560.1,50.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-22 atom-23\" d=\"M 561.7,50.5 L 555.1,43.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-22 atom-22 atom-23\" d=\"M 559.6,52.4 L 553.0,45.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-23 atom-22 atom-24\" d=\"M 560.1,50.9 L 578.2,46.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-24 atom-24 atom-25\" d=\"M 578.2,46.9 L 590.7,60.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-25 atom-25 atom-26\" d=\"M 590.7,60.7 L 585.0,78.3\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-26 atom-6 atom-1\" d=\"M 563.5,115.9 L 551.2,129.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-27 atom-26 atom-7\" d=\"M 585.0,78.3 L 566.9,82.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-28 atom-9 atom-4\" d=\"M 538.3,82.9 L 539.6,94.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-29 atom-21 atom-16\" d=\"M 441.5,95.0 L 441.4,76.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 534.0,126.1 L 533.1,125.9 L 532.8,125.0\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 527.6,109.2 L 527.3,108.3 L 527.9,107.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 563.2,115.0 L 563.5,115.9 L 562.9,116.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 522.0,67.2 L 521.5,66.9 L 520.7,67.4\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 490.3,67.5 L 489.5,67.0 L 488.9,67.3\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 457.9,67.5 L 457.4,67.2 L 456.6,67.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 426.1,67.7 L 425.3,67.3 L 424.5,67.8\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 410.1,76.1 L 409.3,76.6 L 409.3,77.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 409.4,94.2 L 409.4,95.1 L 410.2,95.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 424.7,103.9 L 425.5,104.3 L 426.3,103.9\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 440.7,95.5 L 441.5,95.0 L 441.5,94.1\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 559.9,51.7 L 560.1,50.9 L 561.0,50.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 577.3,47.1 L 578.2,46.9 L 578.9,47.6\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 590.1,60.0 L 590.7,60.7 L 590.4,61.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 585.3,77.4 L 585.0,78.3 L 584.1,78.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-9\" d=\"M 535.7 71.7 L 538.5 76.4 Q 538.8 76.8, 539.3 77.6 Q 539.7 78.5, 539.8 78.5 L 539.8 71.7 L 540.9 71.7 L 540.9 80.5 L 539.7 80.5 L 536.6 75.4 Q 536.3 74.8, 535.9 74.1 Q 535.5 73.5, 535.4 73.2 L 535.4 80.5 L 534.3 80.5 L 534.3 71.7 L 535.7 71.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 501.6 94.8 Q 501.6 92.7, 502.6 91.5 Q 503.7 90.3, 505.6 90.3 Q 507.5 90.3, 508.6 91.5 Q 509.6 92.7, 509.6 94.8 Q 509.6 96.9, 508.6 98.1 Q 507.5 99.3, 505.6 99.3 Q 503.7 99.3, 502.6 98.1 Q 501.6 96.9, 501.6 94.8 M 505.6 98.3 Q 506.9 98.3, 507.7 97.4 Q 508.4 96.5, 508.4 94.8 Q 508.4 93.1, 507.7 92.2 Q 506.9 91.3, 505.6 91.3 Q 504.3 91.3, 503.5 92.2 Q 502.8 93.0, 502.8 94.8 Q 502.8 96.5, 503.5 97.4 Q 504.3 98.3, 505.6 98.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 511.0 90.4 L 512.2 90.4 L 512.2 94.1 L 516.6 94.1 L 516.6 90.4 L 517.8 90.4 L 517.8 99.2 L 516.6 99.2 L 516.6 95.1 L 512.2 95.1 L 512.2 99.2 L 511.0 99.2 L 511.0 90.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-14\" d=\"M 471.5 72.0 L 474.4 76.6 Q 474.7 77.1, 475.1 77.9 Q 475.6 78.7, 475.6 78.8 L 475.6 72.0 L 476.8 72.0 L 476.8 80.7 L 475.6 80.7 L 472.5 75.7 Q 472.1 75.1, 471.8 74.4 Q 471.4 73.7, 471.3 73.5 L 471.3 80.7 L 470.1 80.7 L 470.1 72.0 L 471.5 72.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-14\" d=\"M 470.0 81.6 L 471.2 81.6 L 471.2 85.3 L 475.7 85.3 L 475.7 81.6 L 476.9 81.6 L 476.9 90.3 L 475.7 90.3 L 475.7 86.3 L 471.2 86.3 L 471.2 90.3 L 470.0 90.3 L 470.0 81.6 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-23\" d=\"M 543.7 37.2 Q 543.7 35.1, 544.7 33.9 Q 545.8 32.7, 547.7 32.7 Q 549.6 32.7, 550.7 33.9 Q 551.7 35.1, 551.7 37.2 Q 551.7 39.3, 550.7 40.5 Q 549.6 41.7, 547.7 41.7 Q 545.8 41.7, 544.7 40.5 Q 543.7 39.3, 543.7 37.2 M 547.7 40.7 Q 549.0 40.7, 549.7 39.8 Q 550.5 38.9, 550.5 37.2 Q 550.5 35.5, 549.7 34.6 Q 549.0 33.7, 547.7 33.7 Q 546.4 33.7, 545.6 34.6 Q 544.9 35.5, 544.9 37.2 Q 544.9 38.9, 545.6 39.8 Q 546.4 40.7, 547.7 40.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 428.7 184.8 L 425.2 184.8 L 425.2 183.5 L 433.5 183.5 L 433.5 184.8 L 430.2 184.8 L 430.2 194.8 L 428.7 194.8 L 428.7 184.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 434.0 192.6 Q 434.0 191.3, 435.1 190.6 Q 436.1 189.8, 438.1 189.8 L 439.3 189.8 L 439.3 189.5 Q 439.3 188.5, 438.9 188.1 Q 438.4 187.6, 437.4 187.6 Q 436.8 187.6, 436.2 187.8 Q 435.7 187.9, 434.9 188.2 L 434.5 187.2 Q 436.0 186.4, 437.4 186.4 Q 439.2 186.4, 440.0 187.2 Q 440.8 187.9, 440.8 189.5 L 440.8 194.8 L 439.6 194.8 Q 439.6 194.7, 439.6 194.5 Q 439.5 194.2, 439.4 193.8 Q 438.3 195.0, 436.7 195.0 Q 435.5 195.0, 434.8 194.3 Q 434.0 193.7, 434.0 192.6 M 435.5 192.6 Q 435.5 193.2, 435.9 193.5 Q 436.3 193.8, 437.0 193.8 Q 437.7 193.8, 438.3 193.5 Q 438.9 193.2, 439.3 192.7 L 439.3 191.0 L 438.2 191.0 Q 436.9 191.0, 436.2 191.4 Q 435.5 191.8, 435.5 192.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 446.8 186.4 Q 448.1 186.4, 448.8 187.2 Q 449.5 187.9, 449.5 189.4 L 449.5 194.8 L 448.0 194.8 L 448.0 189.5 Q 448.0 188.5, 447.6 188.1 Q 447.2 187.6, 446.4 187.6 Q 445.7 187.6, 445.0 188.0 Q 444.4 188.3, 444.0 188.9 L 444.0 194.8 L 442.5 194.8 L 442.5 186.6 L 443.7 186.6 L 443.9 187.7 Q 445.0 186.4, 446.8 186.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 451.2 183.5 L 452.7 183.5 L 452.7 184.9 L 451.2 184.9 L 451.2 183.5 M 451.2 186.6 L 452.7 186.6 L 452.7 194.8 L 451.2 194.8 L 451.2 186.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 454.5 192.9 L 456.1 192.9 L 456.1 194.5 L 454.5 194.5 L 454.5 192.9 M 454.5 187.4 L 456.1 187.4 L 456.1 189.0 L 454.5 189.0 L 454.5 187.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 467.8 194.9 Q 465.7 194.9, 464.7 193.4 Q 463.6 191.9, 463.6 189.1 Q 463.6 186.4, 464.7 184.9 Q 465.7 183.4, 467.8 183.4 Q 469.9 183.4, 470.9 184.9 Q 471.9 186.4, 471.9 189.1 Q 471.9 191.9, 470.9 193.4 Q 469.9 194.9, 467.8 194.9 M 467.8 193.7 Q 469.0 193.7, 469.7 192.5 Q 470.3 191.4, 470.3 189.1 Q 470.3 186.9, 469.7 185.8 Q 469.0 184.6, 467.8 184.6 Q 466.6 184.6, 465.9 185.8 Q 465.2 186.9, 465.2 189.1 Q 465.2 191.4, 465.9 192.5 Q 466.6 193.7, 467.8 193.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 473.4 193.2 L 475.0 193.2 L 475.0 194.8 L 473.4 194.8 L 473.4 193.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 480.7 187.7 Q 481.7 187.7, 482.5 188.2 Q 483.3 188.6, 483.8 189.4 Q 484.2 190.2, 484.2 191.2 Q 484.2 192.4, 483.6 193.2 Q 483.1 194.1, 482.2 194.5 Q 481.2 194.9, 480.2 194.9 Q 479.1 194.9, 478.2 194.6 Q 477.2 194.2, 476.6 193.4 L 477.5 192.4 Q 478.0 193.0, 478.8 193.3 Q 479.5 193.6, 480.2 193.6 Q 481.2 193.6, 481.9 193.0 Q 482.6 192.4, 482.6 191.3 Q 482.6 190.1, 481.9 189.5 Q 481.2 188.9, 480.1 188.9 Q 479.1 188.9, 478.0 189.4 L 477.1 188.9 L 477.7 183.5 L 483.5 183.5 L 483.4 184.8 L 479.0 184.8 L 478.7 188.1 Q 479.7 187.7, 480.7 187.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 486.1 193.5 L 488.6 193.5 L 488.6 185.1 L 485.8 185.9 L 485.5 185.0 L 488.9 183.4 L 490.1 183.6 L 490.1 193.5 L 492.3 193.5 L 492.3 194.8 L 486.1 194.8 L 486.1 193.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 510.3 183.5 Q 512.8 183.5, 514.2 185.0 Q 515.5 186.4, 515.5 189.1 Q 515.5 191.8, 514.1 193.3 Q 512.8 194.8, 510.3 194.8 L 506.6 194.8 L 506.6 183.5 L 510.3 183.5 M 510.3 193.5 Q 512.0 193.5, 513.0 192.4 Q 513.9 191.3, 513.9 189.1 Q 513.9 186.9, 513.0 185.8 Q 512.0 184.8, 510.3 184.8 L 508.2 184.8 L 508.2 193.5 L 510.3 193.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 516.7 183.5 L 518.2 183.5 L 518.2 184.9 L 516.7 184.9 L 516.7 183.5 M 516.7 186.6 L 518.2 186.6 L 518.2 194.8 L 516.7 194.8 L 516.7 186.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 520.0 190.7 Q 520.0 188.7, 521.0 187.6 Q 522.0 186.4, 524.0 186.4 Q 525.8 186.4, 526.8 187.8 L 525.8 188.6 Q 525.4 188.1, 525.0 187.9 Q 524.5 187.6, 524.0 187.6 Q 522.8 187.6, 522.2 188.4 Q 521.6 189.2, 521.6 190.7 Q 521.6 192.2, 522.2 193.0 Q 522.9 193.8, 524.1 193.8 Q 524.7 193.8, 525.2 193.6 Q 525.7 193.4, 526.2 193.2 L 526.7 194.2 Q 525.5 194.9, 524.0 194.9 Q 522.0 194.9, 521.0 193.8 Q 520.0 192.7, 520.0 190.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 527.7 190.7 Q 527.7 188.7, 528.7 187.6 Q 529.7 186.4, 531.5 186.4 Q 533.3 186.4, 534.1 187.5 Q 535.0 188.6, 535.0 190.6 L 535.0 190.9 L 529.2 190.9 Q 529.3 192.3, 529.9 193.0 Q 530.5 193.8, 531.7 193.8 Q 532.3 193.8, 532.9 193.6 Q 533.5 193.4, 534.2 193.1 L 534.6 194.2 Q 533.8 194.6, 533.1 194.8 Q 532.4 194.9, 531.6 194.9 Q 529.7 194.9, 528.7 193.8 Q 527.7 192.7, 527.7 190.7 M 531.5 187.6 Q 530.6 187.6, 530.0 188.2 Q 529.5 188.7, 529.3 189.8 L 533.4 189.8 Q 533.3 188.7, 532.8 188.2 Q 532.4 187.6, 531.5 187.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 536.1 192.9 L 537.7 192.9 L 537.7 194.5 L 536.1 194.5 L 536.1 192.9 M 536.1 187.4 L 537.7 187.4 L 537.7 189.0 L 536.1 189.0 L 536.1 187.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 549.3 194.9 Q 547.2 194.9, 546.2 193.4 Q 545.1 191.9, 545.1 189.1 Q 545.1 186.4, 546.2 184.9 Q 547.2 183.4, 549.3 183.4 Q 551.4 183.4, 552.4 184.9 Q 553.4 186.4, 553.4 189.1 Q 553.4 191.9, 552.4 193.4 Q 551.4 194.9, 549.3 194.9 M 549.3 193.7 Q 550.5 193.7, 551.2 192.5 Q 551.8 191.4, 551.8 189.1 Q 551.8 186.9, 551.2 185.8 Q 550.5 184.6, 549.3 184.6 Q 548.1 184.6, 547.4 185.8 Q 546.7 186.9, 546.7 189.1 Q 546.7 191.4, 547.4 192.5 Q 548.1 193.7, 549.3 193.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 555.0 193.2 L 556.6 193.2 L 556.6 194.8 L 555.0 194.8 L 555.0 193.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 562.5 187.7 Q 563.5 187.7, 564.3 188.2 Q 565.1 188.6, 565.5 189.4 Q 565.9 190.2, 565.9 191.2 Q 565.9 192.3, 565.4 193.1 Q 565.0 194.0, 564.1 194.5 Q 563.2 194.9, 562.1 194.9 Q 560.1 194.9, 559.1 193.6 Q 558.1 192.2, 558.1 189.5 Q 558.1 186.5, 559.3 184.9 Q 560.6 183.4, 563.0 183.4 Q 563.7 183.4, 564.3 183.5 Q 564.9 183.7, 565.5 184.0 L 564.9 185.1 Q 564.0 184.6, 563.0 184.6 Q 561.4 184.6, 560.6 185.7 Q 559.8 186.7, 559.7 188.8 Q 560.3 188.3, 561.0 188.0 Q 561.7 187.7, 562.5 187.7 M 562.1 193.6 Q 562.7 193.6, 563.2 193.3 Q 563.8 193.0, 564.0 192.4 Q 564.3 191.9, 564.3 191.2 Q 564.3 190.2, 563.8 189.6 Q 563.2 189.0, 562.2 189.0 Q 561.5 189.0, 560.8 189.3 Q 560.2 189.6, 559.7 190.1 Q 559.8 191.9, 560.3 192.8 Q 560.9 193.6, 562.1 193.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 573.2 184.8 L 567.3 184.8 L 567.3 183.5 L 574.8 183.5 L 574.8 184.6 L 570.2 194.8 L 568.7 194.8 L 573.2 184.8 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 63.8,293.2 L 75.0,297.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 65.1,290.1 L 76.3,294.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 62.5,296.2 L 73.7,300.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 75.0,297.8 L 92.1,304.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-2 atom-3\" d=\"M 92.1,304.9 L 96.5,322.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 96.5,322.9 L 103.5,305.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 103.5,305.8 L 110.6,288.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-5 atom-6\" d=\"M 110.6,288.6 L 127.7,295.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-6 atom-7\" d=\"M 127.7,295.7 L 134.8,278.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 134.8,278.6 L 113.6,329.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 113.6,329.9 L 120.6,312.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 120.6,312.8 L 132.2,317.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-7 atom-11\" d=\"M 134.8,278.6 L 117.7,271.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-12\" d=\"M 117.7,271.5 L 113.4,261.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-12 atom-11 atom-2\" d=\"M 117.7,271.5 L 92.1,304.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-13 atom-8 atom-3\" d=\"M 113.6,329.9 L 96.5,322.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-14 atom-9 atom-4\" d=\"M 120.6,312.8 L 103.5,305.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-15 atom-11 atom-5\" d=\"M 117.7,271.5 L 110.6,288.6\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-16 atom-9 atom-6\" d=\"M 120.6,312.8 L 127.7,295.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 74.4,297.6 L 75.0,297.8 L 75.9,298.2\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-0\" d=\"M 56.0 286.4 L 58.8 291.0 Q 59.1 291.5, 59.6 292.3 Q 60.0 293.1, 60.0 293.2 L 60.0 286.4 L 61.2 286.4 L 61.2 295.1 L 60.0 295.1 L 56.9 290.1 Q 56.6 289.5, 56.2 288.8 Q 55.8 288.1, 55.7 287.9 L 55.7 295.1 L 54.6 295.1 L 54.6 286.4 L 56.0 286.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-10\" d=\"M 139.0 319.7 Q 139.9 319.9, 140.3 320.4 Q 140.7 320.9, 140.7 321.7 Q 140.7 322.9, 140.0 323.6 Q 139.2 324.3, 137.7 324.3 L 134.8 324.3 L 134.8 315.5 L 137.4 315.5 Q 138.9 315.5, 139.6 316.1 Q 140.4 316.7, 140.4 317.8 Q 140.4 319.2, 139.0 319.7 M 136.0 316.5 L 136.0 319.2 L 137.4 319.2 Q 138.2 319.2, 138.7 318.9 Q 139.1 318.5, 139.1 317.8 Q 139.1 316.5, 137.4 316.5 L 136.0 316.5 M 137.7 323.3 Q 138.6 323.3, 139.0 322.9 Q 139.5 322.5, 139.5 321.7 Q 139.5 321.0, 139.0 320.6 Q 138.5 320.2, 137.5 320.2 L 136.0 320.2 L 136.0 323.3 L 137.7 323.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-10\" d=\"M 142.7 317.9 L 142.9 318.8 Q 143.5 317.8, 144.6 317.8 Q 145.0 317.8, 145.4 317.9 L 145.2 319.0 Q 144.7 318.8, 144.4 318.8 Q 143.9 318.8, 143.5 319.1 Q 143.2 319.2, 142.9 319.7 L 142.9 324.3 L 141.8 324.3 L 141.8 317.9 L 142.7 317.9 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 106.0 254.2 Q 106.8 254.4, 107.3 255.0 Q 107.7 255.5, 107.7 256.2 Q 107.7 257.4, 106.9 258.1 Q 106.1 258.8, 104.7 258.8 L 101.8 258.8 L 101.8 250.1 L 104.3 250.1 Q 105.8 250.1, 106.6 250.7 Q 107.3 251.3, 107.3 252.4 Q 107.3 253.7, 106.0 254.2 M 102.9 251.0 L 102.9 253.8 L 104.3 253.8 Q 105.2 253.8, 105.6 253.4 Q 106.1 253.1, 106.1 252.4 Q 106.1 251.0, 104.3 251.0 L 102.9 251.0 M 104.7 257.8 Q 105.5 257.8, 106.0 257.4 Q 106.5 257.0, 106.5 256.2 Q 106.5 255.5, 106.0 255.1 Q 105.5 254.8, 104.5 254.8 L 102.9 254.8 L 102.9 257.8 L 104.7 257.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-12\" d=\"M 109.7 252.5 L 109.8 253.3 Q 110.5 252.3, 111.6 252.3 Q 111.9 252.3, 112.4 252.5 L 112.2 253.5 Q 111.7 253.4, 111.4 253.4 Q 110.8 253.4, 110.5 253.6 Q 110.2 253.8, 109.9 254.3 L 109.9 258.8 L 108.7 258.8 L 108.7 252.5 L 109.7 252.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 26.5 384.8 L 23.0 384.8 L 23.0 383.5 L 31.3 383.5 L 31.3 384.8 L 28.0 384.8 L 28.0 394.8 L 26.5 394.8 L 26.5 384.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 31.8 392.6 Q 31.8 391.3, 32.9 390.6 Q 34.0 389.8, 35.9 389.8 L 37.1 389.8 L 37.1 389.5 Q 37.1 388.5, 36.7 388.1 Q 36.3 387.6, 35.2 387.6 Q 34.6 387.6, 34.1 387.8 Q 33.6 387.9, 32.8 388.2 L 32.3 387.2 Q 33.8 386.4, 35.3 386.4 Q 37.0 386.4, 37.8 387.2 Q 38.6 387.9, 38.6 389.5 L 38.6 394.8 L 37.4 394.8 Q 37.4 394.7, 37.4 394.5 Q 37.3 394.2, 37.2 393.8 Q 36.1 395.0, 34.5 395.0 Q 33.3 395.0, 32.6 394.3 Q 31.8 393.7, 31.8 392.6 M 33.3 392.6 Q 33.3 393.2, 33.7 393.5 Q 34.1 393.8, 34.8 393.8 Q 35.5 393.8, 36.1 393.5 Q 36.7 393.2, 37.1 392.7 L 37.1 391.0 L 36.0 391.0 Q 34.7 391.0, 34.0 391.4 Q 33.3 391.8, 33.3 392.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 44.6 386.4 Q 45.9 386.4, 46.6 387.2 Q 47.3 387.9, 47.3 389.4 L 47.3 394.8 L 45.8 394.8 L 45.8 389.5 Q 45.8 388.5, 45.4 388.1 Q 45.1 387.6, 44.2 387.6 Q 43.5 387.6, 42.9 388.0 Q 42.2 388.3, 41.8 388.9 L 41.8 394.8 L 40.3 394.8 L 40.3 386.6 L 41.6 386.6 L 41.7 387.7 Q 42.8 386.4, 44.6 386.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 49.1 383.5 L 50.5 383.5 L 50.5 384.9 L 49.1 384.9 L 49.1 383.5 M 49.1 386.6 L 50.5 386.6 L 50.5 394.8 L 49.1 394.8 L 49.1 386.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 52.4 392.9 L 54.0 392.9 L 54.0 394.5 L 52.4 394.5 L 52.4 392.9 M 52.4 387.4 L 54.0 387.4 L 54.0 389.0 L 52.4 389.0 L 52.4 387.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 65.7 394.9 Q 63.6 394.9, 62.5 393.4 Q 61.5 391.9, 61.5 389.1 Q 61.5 386.4, 62.5 384.9 Q 63.6 383.4, 65.7 383.4 Q 67.8 383.4, 68.8 384.9 Q 69.8 386.4, 69.8 389.1 Q 69.8 391.9, 68.8 393.4 Q 67.7 394.9, 65.7 394.9 M 65.7 393.7 Q 66.9 393.7, 67.6 392.5 Q 68.2 391.4, 68.2 389.1 Q 68.2 386.9, 67.6 385.8 Q 66.9 384.6, 65.7 384.6 Q 64.5 384.6, 63.8 385.8 Q 63.1 386.9, 63.1 389.1 Q 63.1 391.4, 63.8 392.5 Q 64.5 393.7, 65.7 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 71.3 393.2 L 72.9 393.2 L 72.9 394.8 L 71.3 394.8 L 71.3 393.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 78.6 394.9 Q 76.5 394.9, 75.5 393.4 Q 74.5 391.9, 74.5 389.1 Q 74.5 386.4, 75.5 384.9 Q 76.5 383.4, 78.6 383.4 Q 80.7 383.4, 81.7 384.9 Q 82.8 386.4, 82.8 389.1 Q 82.8 391.9, 81.7 393.4 Q 80.7 394.9, 78.6 394.9 M 78.6 393.7 Q 79.9 393.7, 80.5 392.5 Q 81.2 391.4, 81.2 389.1 Q 81.2 386.9, 80.5 385.8 Q 79.9 384.6, 78.6 384.6 Q 77.4 384.6, 76.7 385.8 Q 76.1 386.9, 76.1 389.1 Q 76.1 391.4, 76.7 392.5 Q 77.4 393.7, 78.6 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 88.5 394.9 Q 86.4 394.9, 85.3 393.4 Q 84.3 391.9, 84.3 389.1 Q 84.3 386.4, 85.3 384.9 Q 86.4 383.4, 88.5 383.4 Q 90.5 383.4, 91.6 384.9 Q 92.6 386.4, 92.6 389.1 Q 92.6 391.9, 91.6 393.4 Q 90.5 394.9, 88.5 394.9 M 88.5 393.7 Q 89.7 393.7, 90.3 392.5 Q 91.0 391.4, 91.0 389.1 Q 91.0 386.9, 90.3 385.8 Q 89.7 384.6, 88.5 384.6 Q 87.2 384.6, 86.6 385.8 Q 85.9 386.9, 85.9 389.1 Q 85.9 391.4, 86.6 392.5 Q 87.2 393.7, 88.5 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 111.0 383.5 Q 113.5 383.5, 114.9 385.0 Q 116.2 386.4, 116.2 389.1 Q 116.2 391.8, 114.8 393.3 Q 113.5 394.8, 111.0 394.8 L 107.3 394.8 L 107.3 383.5 L 111.0 383.5 M 111.0 393.5 Q 112.7 393.5, 113.7 392.4 Q 114.6 391.3, 114.6 389.1 Q 114.6 386.9, 113.7 385.8 Q 112.7 384.8, 111.0 384.8 L 108.9 384.8 L 108.9 393.5 L 111.0 393.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 117.4 383.5 L 118.9 383.5 L 118.9 384.9 L 117.4 384.9 L 117.4 383.5 M 117.4 386.6 L 118.9 386.6 L 118.9 394.8 L 117.4 394.8 L 117.4 386.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 120.8 390.7 Q 120.8 388.7, 121.8 387.6 Q 122.7 386.4, 124.7 386.4 Q 126.6 386.4, 127.5 387.8 L 126.5 388.6 Q 126.2 388.1, 125.7 387.9 Q 125.3 387.6, 124.7 387.6 Q 123.6 387.6, 122.9 388.4 Q 122.3 389.2, 122.3 390.7 Q 122.3 392.2, 122.9 393.0 Q 123.6 393.8, 124.8 393.8 Q 125.5 393.8, 125.9 393.6 Q 126.4 393.4, 127.0 393.2 L 127.4 394.2 Q 126.2 394.9, 124.7 394.9 Q 122.7 394.9, 121.8 393.8 Q 120.8 392.7, 120.8 390.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 128.4 390.7 Q 128.4 388.7, 129.4 387.6 Q 130.4 386.4, 132.3 386.4 Q 134.1 386.4, 134.9 387.5 Q 135.7 388.6, 135.7 390.6 L 135.7 390.9 L 130.0 390.9 Q 130.0 392.3, 130.6 393.0 Q 131.2 393.8, 132.4 393.8 Q 133.1 393.8, 133.6 393.6 Q 134.2 393.4, 135.0 393.1 L 135.4 394.2 Q 134.6 394.6, 133.8 394.8 Q 133.1 394.9, 132.3 394.9 Q 130.5 394.9, 129.5 393.8 Q 128.4 392.7, 128.4 390.7 M 132.3 387.6 Q 131.3 387.6, 130.8 388.2 Q 130.2 388.7, 130.0 389.8 L 134.1 389.8 Q 134.0 388.7, 133.6 388.2 Q 133.1 387.6, 132.3 387.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 136.8 392.9 L 138.4 392.9 L 138.4 394.5 L 136.8 394.5 L 136.8 392.9 M 136.8 387.4 L 138.4 387.4 L 138.4 389.0 L 136.8 389.0 L 136.8 387.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 150.1 394.9 Q 148.0 394.9, 147.0 393.4 Q 145.9 391.9, 145.9 389.1 Q 145.9 386.4, 147.0 384.9 Q 148.0 383.4, 150.1 383.4 Q 152.2 383.4, 153.2 384.9 Q 154.2 386.4, 154.2 389.1 Q 154.2 391.9, 153.2 393.4 Q 152.2 394.9, 150.1 394.9 M 150.1 393.7 Q 151.3 393.7, 152.0 392.5 Q 152.6 391.4, 152.6 389.1 Q 152.6 386.9, 152.0 385.8 Q 151.3 384.6, 150.1 384.6 Q 148.9 384.6, 148.2 385.8 Q 147.5 386.9, 147.5 389.1 Q 147.5 391.4, 148.2 392.5 Q 148.9 393.7, 150.1 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 155.8 393.2 L 157.4 393.2 L 157.4 394.8 L 155.8 394.8 L 155.8 393.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 163.0 394.9 Q 161.0 394.9, 159.9 393.4 Q 158.9 391.9, 158.9 389.1 Q 158.9 386.4, 159.9 384.9 Q 160.9 383.4, 163.0 383.4 Q 165.1 383.4, 166.2 384.9 Q 167.2 386.4, 167.2 389.1 Q 167.2 391.9, 166.1 393.4 Q 165.1 394.9, 163.0 394.9 M 163.0 393.7 Q 164.3 393.7, 164.9 392.5 Q 165.6 391.4, 165.6 389.1 Q 165.6 386.9, 164.9 385.8 Q 164.3 384.6, 163.0 384.6 Q 161.8 384.6, 161.2 385.8 Q 160.5 386.9, 160.5 389.1 Q 160.5 391.4, 161.2 392.5 Q 161.8 393.7, 163.0 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 172.9 394.9 Q 170.8 394.9, 169.7 393.4 Q 168.7 391.9, 168.7 389.1 Q 168.7 386.4, 169.7 384.9 Q 170.8 383.4, 172.9 383.4 Q 175.0 383.4, 176.0 384.9 Q 177.0 386.4, 177.0 389.1 Q 177.0 391.9, 176.0 393.4 Q 174.9 394.9, 172.9 394.9 M 172.9 393.7 Q 174.1 393.7, 174.8 392.5 Q 175.4 391.4, 175.4 389.1 Q 175.4 386.9, 174.8 385.8 Q 174.1 384.6, 172.9 384.6 Q 171.6 384.6, 171.0 385.8 Q 170.3 386.9, 170.3 389.1 Q 170.3 391.4, 171.0 392.5 Q 171.6 393.7, 172.9 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 311.9,266.6 L 312.6,271.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 309.1,267.1 L 309.9,271.4\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 320.6,279.9 L 324.0,280.7\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-1 atom-3\" d=\"M 306.7,282.9 L 298.3,289.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 298.3,289.9 L 306.7,297.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 324.0,300.6 L 324.3,300.5\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 323.4,297.9 L 323.7,297.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-4 atom-6\" d=\"M 311.3,308.7 L 310.5,313.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-3 atom-7\" d=\"M 298.3,289.9 L 289.0,306.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-8\" d=\"M 289.0,306.0 L 277.0,306.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-8 atom-8 atom-9\" d=\"M 266.5,299.1 L 261.2,289.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-9 atom-9 atom-10\" d=\"M 261.2,289.9 L 266.5,280.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-10 atom-10 atom-11\" d=\"M 277.0,273.9 L 289.0,273.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-11 atom-11 atom-3\" d=\"M 289.0,273.9 L 298.3,289.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path d=\"M 289.5,305.2 L 289.0,306.0 L 288.4,306.0\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 261.5,290.4 L 261.2,289.9 L 261.5,289.5\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path d=\"M 288.4,273.9 L 289.0,273.9 L 289.5,274.7\" style=\"fill:none;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1;\"/>\n",
              "<path class=\"atom-0\" d=\"M 305.2 259.8 Q 305.2 257.7, 306.3 256.5 Q 307.3 255.4, 309.2 255.4 Q 311.2 255.4, 312.2 256.5 Q 313.3 257.7, 313.3 259.8 Q 313.3 261.9, 312.2 263.2 Q 311.2 264.4, 309.2 264.4 Q 307.3 264.4, 306.3 263.2 Q 305.2 262.0, 305.2 259.8 M 309.2 263.4 Q 310.6 263.4, 311.3 262.5 Q 312.0 261.6, 312.0 259.8 Q 312.0 258.1, 311.3 257.2 Q 310.6 256.4, 309.2 256.4 Q 307.9 256.4, 307.2 257.2 Q 306.5 258.1, 306.5 259.8 Q 306.5 261.6, 307.2 262.5 Q 307.9 263.4, 309.2 263.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-1\" d=\"M 310.5 273.7 L 313.4 278.3 Q 313.7 278.7, 314.1 279.6 Q 314.6 280.4, 314.6 280.4 L 314.6 273.7 L 315.8 273.7 L 315.8 282.4 L 314.6 282.4 L 311.5 277.3 Q 311.1 276.7, 310.8 276.1 Q 310.4 275.4, 310.3 275.2 L 310.3 282.4 L 309.1 282.4 L 309.1 273.7 L 310.5 273.7 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-1\" d=\"M 317.4 275.2 L 319.0 275.2 L 319.0 273.6 L 319.6 273.6 L 319.6 275.2 L 321.2 275.2 L 321.2 275.8 L 319.6 275.8 L 319.6 277.5 L 319.0 277.5 L 319.0 275.8 L 317.4 275.8 L 317.4 275.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-2\" d=\"M 326.5 282.2 Q 326.5 280.1, 327.5 278.9 Q 328.6 277.8, 330.5 277.8 Q 332.4 277.8, 333.5 278.9 Q 334.5 280.1, 334.5 282.2 Q 334.5 284.3, 333.5 285.6 Q 332.4 286.7, 330.5 286.7 Q 328.6 286.7, 327.5 285.6 Q 326.5 284.4, 326.5 282.2 M 330.5 285.8 Q 331.8 285.8, 332.6 284.9 Q 333.3 284.0, 333.3 282.2 Q 333.3 280.5, 332.6 279.6 Q 331.8 278.8, 330.5 278.8 Q 329.2 278.8, 328.4 279.6 Q 327.7 280.5, 327.7 282.2 Q 327.7 284.0, 328.4 284.9 Q 329.2 285.8, 330.5 285.8 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-2\" d=\"M 335.8 279.2 L 338.8 279.2 L 338.8 279.9 L 335.8 279.9 L 335.8 279.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-4\" d=\"M 310.5 297.5 L 313.4 302.1 Q 313.7 302.5, 314.1 303.4 Q 314.6 304.2, 314.6 304.3 L 314.6 297.5 L 315.8 297.5 L 315.8 306.2 L 314.6 306.2 L 311.5 301.1 Q 311.1 300.6, 310.8 299.9 Q 310.4 299.2, 310.3 299.0 L 310.3 306.2 L 309.1 306.2 L 309.1 297.5 L 310.5 297.5 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-4\" d=\"M 317.4 299.0 L 319.0 299.0 L 319.0 297.4 L 319.6 297.4 L 319.6 299.0 L 321.2 299.0 L 321.2 299.6 L 319.6 299.6 L 319.6 301.3 L 319.0 301.3 L 319.0 299.6 L 317.4 299.6 L 317.4 299.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 326.5 297.7 Q 326.5 295.6, 327.5 294.4 Q 328.6 293.3, 330.5 293.3 Q 332.4 293.3, 333.5 294.4 Q 334.5 295.6, 334.5 297.7 Q 334.5 299.8, 333.5 301.0 Q 332.4 302.2, 330.5 302.2 Q 328.6 302.2, 327.5 301.0 Q 326.5 299.8, 326.5 297.7 M 330.5 301.2 Q 331.8 301.2, 332.6 300.3 Q 333.3 299.4, 333.3 297.7 Q 333.3 296.0, 332.6 295.1 Q 331.8 294.2, 330.5 294.2 Q 329.2 294.2, 328.4 295.1 Q 327.7 296.0, 327.7 297.7 Q 327.7 299.5, 328.4 300.3 Q 329.2 301.2, 330.5 301.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-6\" d=\"M 305.2 320.1 Q 305.2 318.0, 306.3 316.8 Q 307.3 315.6, 309.2 315.6 Q 311.2 315.6, 312.2 316.8 Q 313.3 318.0, 313.3 320.1 Q 313.3 322.2, 312.2 323.4 Q 311.2 324.6, 309.2 324.6 Q 307.3 324.6, 306.3 323.4 Q 305.2 322.2, 305.2 320.1 M 309.2 323.6 Q 310.6 323.6, 311.3 322.7 Q 312.0 321.8, 312.0 320.1 Q 312.0 318.4, 311.3 317.5 Q 310.6 316.6, 309.2 316.6 Q 307.9 316.6, 307.2 317.5 Q 306.5 318.4, 306.5 320.1 Q 306.5 321.9, 307.2 322.7 Q 307.9 323.6, 309.2 323.6 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-6\" d=\"M 314.5 317.1 L 317.5 317.1 L 317.5 317.7 L 314.5 317.7 L 314.5 317.1 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-8\" d=\"M 266.5 306.0 Q 266.5 303.9, 267.5 302.7 Q 268.6 301.5, 270.5 301.5 Q 272.4 301.5, 273.5 302.7 Q 274.5 303.9, 274.5 306.0 Q 274.5 308.1, 273.5 309.3 Q 272.4 310.5, 270.5 310.5 Q 268.6 310.5, 267.5 309.3 Q 266.5 308.1, 266.5 306.0 M 270.5 309.5 Q 271.8 309.5, 272.6 308.6 Q 273.3 307.7, 273.3 306.0 Q 273.3 304.3, 272.6 303.4 Q 271.8 302.5, 270.5 302.5 Q 269.2 302.5, 268.4 303.4 Q 267.7 304.3, 267.7 306.0 Q 267.7 307.8, 268.4 308.6 Q 269.2 309.5, 270.5 309.5 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-10\" d=\"M 266.5 273.9 Q 266.5 271.8, 267.5 270.7 Q 268.6 269.5, 270.5 269.5 Q 272.4 269.5, 273.5 270.7 Q 274.5 271.8, 274.5 273.9 Q 274.5 276.0, 273.5 277.3 Q 272.4 278.5, 270.5 278.5 Q 268.6 278.5, 267.5 277.3 Q 266.5 276.1, 266.5 273.9 M 270.5 277.5 Q 271.8 277.5, 272.6 276.6 Q 273.3 275.7, 273.3 273.9 Q 273.3 272.2, 272.6 271.3 Q 271.8 270.5, 270.5 270.5 Q 269.2 270.5, 268.4 271.3 Q 267.7 272.2, 267.7 273.9 Q 267.7 275.7, 268.4 276.6 Q 269.2 277.5, 270.5 277.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 226.5 384.8 L 223.0 384.8 L 223.0 383.5 L 231.3 383.5 L 231.3 384.8 L 228.0 384.8 L 228.0 394.8 L 226.5 394.8 L 226.5 384.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 231.8 392.6 Q 231.8 391.3, 232.9 390.6 Q 234.0 389.8, 235.9 389.8 L 237.1 389.8 L 237.1 389.5 Q 237.1 388.5, 236.7 388.1 Q 236.3 387.6, 235.2 387.6 Q 234.6 387.6, 234.1 387.8 Q 233.6 387.9, 232.8 388.2 L 232.3 387.2 Q 233.8 386.4, 235.3 386.4 Q 237.0 386.4, 237.8 387.2 Q 238.6 387.9, 238.6 389.5 L 238.6 394.8 L 237.4 394.8 Q 237.4 394.7, 237.4 394.5 Q 237.3 394.2, 237.2 393.8 Q 236.1 395.0, 234.5 395.0 Q 233.3 395.0, 232.6 394.3 Q 231.8 393.7, 231.8 392.6 M 233.3 392.6 Q 233.3 393.2, 233.7 393.5 Q 234.1 393.8, 234.8 393.8 Q 235.5 393.8, 236.1 393.5 Q 236.7 393.2, 237.1 392.7 L 237.1 391.0 L 236.0 391.0 Q 234.7 391.0, 234.0 391.4 Q 233.3 391.8, 233.3 392.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 244.6 386.4 Q 245.9 386.4, 246.6 387.2 Q 247.3 387.9, 247.3 389.4 L 247.3 394.8 L 245.8 394.8 L 245.8 389.5 Q 245.8 388.5, 245.4 388.1 Q 245.1 387.6, 244.2 387.6 Q 243.5 387.6, 242.9 388.0 Q 242.2 388.3, 241.8 388.9 L 241.8 394.8 L 240.3 394.8 L 240.3 386.6 L 241.6 386.6 L 241.7 387.7 Q 242.8 386.4, 244.6 386.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 249.1 383.5 L 250.5 383.5 L 250.5 384.9 L 249.1 384.9 L 249.1 383.5 M 249.1 386.6 L 250.5 386.6 L 250.5 394.8 L 249.1 394.8 L 249.1 386.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 252.4 392.9 L 254.0 392.9 L 254.0 394.5 L 252.4 394.5 L 252.4 392.9 M 252.4 387.4 L 254.0 387.4 L 254.0 389.0 L 252.4 389.0 L 252.4 387.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 265.7 394.9 Q 263.6 394.9, 262.5 393.4 Q 261.5 391.9, 261.5 389.1 Q 261.5 386.4, 262.5 384.9 Q 263.6 383.4, 265.7 383.4 Q 267.8 383.4, 268.8 384.9 Q 269.8 386.4, 269.8 389.1 Q 269.8 391.9, 268.8 393.4 Q 267.7 394.9, 265.7 394.9 M 265.7 393.7 Q 266.9 393.7, 267.6 392.5 Q 268.2 391.4, 268.2 389.1 Q 268.2 386.9, 267.6 385.8 Q 266.9 384.6, 265.7 384.6 Q 264.5 384.6, 263.8 385.8 Q 263.1 386.9, 263.1 389.1 Q 263.1 391.4, 263.8 392.5 Q 264.5 393.7, 265.7 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 271.3 393.2 L 272.9 393.2 L 272.9 394.8 L 271.3 394.8 L 271.3 393.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 278.6 394.9 Q 276.5 394.9, 275.5 393.4 Q 274.5 391.9, 274.5 389.1 Q 274.5 386.4, 275.5 384.9 Q 276.5 383.4, 278.6 383.4 Q 280.7 383.4, 281.7 384.9 Q 282.8 386.4, 282.8 389.1 Q 282.8 391.9, 281.7 393.4 Q 280.7 394.9, 278.6 394.9 M 278.6 393.7 Q 279.9 393.7, 280.5 392.5 Q 281.2 391.4, 281.2 389.1 Q 281.2 386.9, 280.5 385.8 Q 279.9 384.6, 278.6 384.6 Q 277.4 384.6, 276.7 385.8 Q 276.1 386.9, 276.1 389.1 Q 276.1 391.4, 276.7 392.5 Q 277.4 393.7, 278.6 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 288.5 394.9 Q 286.4 394.9, 285.3 393.4 Q 284.3 391.9, 284.3 389.1 Q 284.3 386.4, 285.3 384.9 Q 286.4 383.4, 288.5 383.4 Q 290.5 383.4, 291.6 384.9 Q 292.6 386.4, 292.6 389.1 Q 292.6 391.9, 291.6 393.4 Q 290.5 394.9, 288.5 394.9 M 288.5 393.7 Q 289.7 393.7, 290.3 392.5 Q 291.0 391.4, 291.0 389.1 Q 291.0 386.9, 290.3 385.8 Q 289.7 384.6, 288.5 384.6 Q 287.2 384.6, 286.6 385.8 Q 285.9 386.9, 285.9 389.1 Q 285.9 391.4, 286.6 392.5 Q 287.2 393.7, 288.5 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 311.0 383.5 Q 313.5 383.5, 314.9 385.0 Q 316.2 386.4, 316.2 389.1 Q 316.2 391.8, 314.8 393.3 Q 313.5 394.8, 311.0 394.8 L 307.3 394.8 L 307.3 383.5 L 311.0 383.5 M 311.0 393.5 Q 312.7 393.5, 313.7 392.4 Q 314.6 391.3, 314.6 389.1 Q 314.6 386.9, 313.7 385.8 Q 312.7 384.8, 311.0 384.8 L 308.9 384.8 L 308.9 393.5 L 311.0 393.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 317.4 383.5 L 318.9 383.5 L 318.9 384.9 L 317.4 384.9 L 317.4 383.5 M 317.4 386.6 L 318.9 386.6 L 318.9 394.8 L 317.4 394.8 L 317.4 386.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 320.8 390.7 Q 320.8 388.7, 321.8 387.6 Q 322.7 386.4, 324.7 386.4 Q 326.6 386.4, 327.5 387.8 L 326.5 388.6 Q 326.2 388.1, 325.7 387.9 Q 325.3 387.6, 324.7 387.6 Q 323.6 387.6, 322.9 388.4 Q 322.3 389.2, 322.3 390.7 Q 322.3 392.2, 322.9 393.0 Q 323.6 393.8, 324.8 393.8 Q 325.5 393.8, 325.9 393.6 Q 326.4 393.4, 327.0 393.2 L 327.4 394.2 Q 326.2 394.9, 324.7 394.9 Q 322.7 394.9, 321.8 393.8 Q 320.8 392.7, 320.8 390.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 328.4 390.7 Q 328.4 388.7, 329.4 387.6 Q 330.4 386.4, 332.3 386.4 Q 334.1 386.4, 334.9 387.5 Q 335.7 388.6, 335.7 390.6 L 335.7 390.9 L 330.0 390.9 Q 330.0 392.3, 330.6 393.0 Q 331.2 393.8, 332.4 393.8 Q 333.1 393.8, 333.6 393.6 Q 334.2 393.4, 335.0 393.1 L 335.4 394.2 Q 334.6 394.6, 333.8 394.8 Q 333.1 394.9, 332.3 394.9 Q 330.5 394.9, 329.5 393.8 Q 328.4 392.7, 328.4 390.7 M 332.3 387.6 Q 331.3 387.6, 330.8 388.2 Q 330.2 388.7, 330.0 389.8 L 334.1 389.8 Q 334.0 388.7, 333.6 388.2 Q 333.1 387.6, 332.3 387.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 336.8 392.9 L 338.4 392.9 L 338.4 394.5 L 336.8 394.5 L 336.8 392.9 M 336.8 387.4 L 338.4 387.4 L 338.4 389.0 L 336.8 389.0 L 336.8 387.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 350.1 394.9 Q 348.0 394.9, 347.0 393.4 Q 345.9 391.9, 345.9 389.1 Q 345.9 386.4, 347.0 384.9 Q 348.0 383.4, 350.1 383.4 Q 352.2 383.4, 353.2 384.9 Q 354.2 386.4, 354.2 389.1 Q 354.2 391.9, 353.2 393.4 Q 352.2 394.9, 350.1 394.9 M 350.1 393.7 Q 351.3 393.7, 352.0 392.5 Q 352.6 391.4, 352.6 389.1 Q 352.6 386.9, 352.0 385.8 Q 351.3 384.6, 350.1 384.6 Q 348.9 384.6, 348.2 385.8 Q 347.5 386.9, 347.5 389.1 Q 347.5 391.4, 348.2 392.5 Q 348.9 393.7, 350.1 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 355.8 393.2 L 357.4 393.2 L 357.4 394.8 L 355.8 394.8 L 355.8 393.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 363.0 394.9 Q 361.0 394.9, 359.9 393.4 Q 358.9 391.9, 358.9 389.1 Q 358.9 386.4, 359.9 384.9 Q 360.9 383.4, 363.0 383.4 Q 365.1 383.4, 366.2 384.9 Q 367.2 386.4, 367.2 389.1 Q 367.2 391.9, 366.1 393.4 Q 365.1 394.9, 363.0 394.9 M 363.0 393.7 Q 364.3 393.7, 364.9 392.5 Q 365.6 391.4, 365.6 389.1 Q 365.6 386.9, 364.9 385.8 Q 364.3 384.6, 363.0 384.6 Q 361.8 384.6, 361.2 385.8 Q 360.5 386.9, 360.5 389.1 Q 360.5 391.4, 361.2 392.5 Q 361.8 393.7, 363.0 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 372.9 394.9 Q 370.8 394.9, 369.7 393.4 Q 368.7 391.9, 368.7 389.1 Q 368.7 386.4, 369.7 384.9 Q 370.8 383.4, 372.9 383.4 Q 375.0 383.4, 376.0 384.9 Q 377.0 386.4, 377.0 389.1 Q 377.0 391.9, 376.0 393.4 Q 374.9 394.9, 372.9 394.9 M 372.9 393.7 Q 374.1 393.7, 374.8 392.5 Q 375.4 391.4, 375.4 389.1 Q 375.4 386.9, 374.8 385.8 Q 374.1 384.6, 372.9 384.6 Q 371.6 384.6, 371.0 385.8 Q 370.3 386.9, 370.3 389.1 Q 370.3 391.4, 371.0 392.5 Q 371.6 393.7, 372.9 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"bond-0 atom-0 atom-1\" d=\"M 521.8,282.7 L 514.5,289.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-1 atom-1 atom-2\" d=\"M 514.5,289.9 L 521.8,297.2\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-2 atom-1 atom-3\" d=\"M 514.5,289.9 L 506.7,297.8\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-3 atom-3 atom-4\" d=\"M 496.1,297.8 L 488.3,289.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-4 atom-4 atom-5\" d=\"M 488.3,289.9 L 478.2,300.0\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-5 atom-4 atom-6\" d=\"M 488.3,289.9 L 478.2,279.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-6 atom-4 atom-7\" d=\"M 488.3,289.9 L 496.1,282.1\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"bond-7 atom-7 atom-1\" d=\"M 506.7,282.1 L 514.5,289.9\" style=\"fill:none;fill-rule:evenodd;stroke:#000000;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1\"/>\n",
              "<path class=\"atom-0\" d=\"M 524.2 277.2 Q 524.2 275.0, 525.2 273.8 Q 526.3 272.7, 528.2 272.7 Q 530.0 272.7, 531.0 274.0 L 530.1 274.6 Q 529.4 273.7, 528.2 273.7 Q 526.9 273.7, 526.2 274.6 Q 525.5 275.5, 525.5 277.2 Q 525.5 278.9, 526.2 279.8 Q 526.9 280.7, 528.3 280.7 Q 529.3 280.7, 530.4 280.1 L 530.8 281.0 Q 530.3 281.3, 529.6 281.5 Q 528.9 281.6, 528.2 281.6 Q 526.3 281.6, 525.2 280.5 Q 524.2 279.3, 524.2 277.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-0\" d=\"M 531.8 272.2 L 533.0 272.2 L 533.0 281.5 L 531.8 281.5 L 531.8 272.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-2\" d=\"M 524.2 303.3 Q 524.2 301.2, 525.2 300.0 Q 526.3 298.9, 528.2 298.9 Q 530.0 298.9, 531.0 300.2 L 530.1 300.8 Q 529.4 299.9, 528.2 299.9 Q 526.9 299.9, 526.2 300.8 Q 525.5 301.7, 525.5 303.3 Q 525.5 305.1, 526.2 306.0 Q 526.9 306.8, 528.3 306.8 Q 529.3 306.8, 530.4 306.3 L 530.8 307.2 Q 530.3 307.5, 529.6 307.7 Q 528.9 307.8, 528.2 307.8 Q 526.3 307.8, 525.2 306.7 Q 524.2 305.5, 524.2 303.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-2\" d=\"M 531.8 298.4 L 533.0 298.4 L 533.0 307.7 L 531.8 307.7 L 531.8 298.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-3\" d=\"M 498.9 306.0 Q 499.0 306.1, 499.4 306.2 Q 499.8 306.4, 500.3 306.5 Q 500.7 306.6, 501.2 306.6 Q 502.0 306.6, 502.5 306.2 Q 503.0 305.8, 503.0 305.1 Q 503.0 304.6, 502.7 304.3 Q 502.5 304.0, 502.1 303.9 Q 501.8 303.7, 501.1 303.5 Q 500.4 303.3, 499.9 303.1 Q 499.4 302.9, 499.1 302.4 Q 498.8 301.9, 498.8 301.1 Q 498.8 300.0, 499.5 299.4 Q 500.3 298.7, 501.8 298.7 Q 502.8 298.7, 503.9 299.2 L 503.6 300.1 Q 502.6 299.7, 501.8 299.7 Q 500.9 299.7, 500.5 300.0 Q 500.0 300.4, 500.0 301.0 Q 500.0 301.5, 500.3 301.7 Q 500.5 302.0, 500.8 302.2 Q 501.2 302.3, 501.8 302.5 Q 502.6 302.8, 503.1 303.0 Q 503.5 303.3, 503.9 303.8 Q 504.2 304.3, 504.2 305.1 Q 504.2 306.3, 503.4 307.0 Q 502.6 307.6, 501.2 307.6 Q 500.5 307.6, 499.9 307.5 Q 499.3 307.3, 498.6 307.0 L 498.9 306.0 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 467.0 303.3 Q 467.0 301.2, 468.0 300.0 Q 469.1 298.9, 471.0 298.9 Q 472.8 298.9, 473.8 300.2 L 472.9 300.8 Q 472.2 299.9, 471.0 299.9 Q 469.7 299.9, 469.0 300.8 Q 468.3 301.7, 468.3 303.3 Q 468.3 305.1, 469.0 306.0 Q 469.7 306.8, 471.1 306.8 Q 472.1 306.8, 473.2 306.3 L 473.6 307.2 Q 473.1 307.5, 472.4 307.7 Q 471.7 307.8, 471.0 307.8 Q 469.1 307.8, 468.0 306.7 Q 467.0 305.5, 467.0 303.3 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-5\" d=\"M 474.6 298.4 L 475.8 298.4 L 475.8 307.7 L 474.6 307.7 L 474.6 298.4 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-6\" d=\"M 467.0 277.2 Q 467.0 275.0, 468.0 273.8 Q 469.1 272.7, 471.0 272.7 Q 472.8 272.7, 473.8 274.0 L 472.9 274.6 Q 472.2 273.7, 471.0 273.7 Q 469.7 273.7, 469.0 274.6 Q 468.3 275.5, 468.3 277.2 Q 468.3 278.9, 469.0 279.8 Q 469.7 280.7, 471.1 280.7 Q 472.1 280.7, 473.2 280.1 L 473.6 281.0 Q 473.1 281.3, 472.4 281.5 Q 471.7 281.6, 471.0 281.6 Q 469.1 281.6, 468.0 280.5 Q 467.0 279.3, 467.0 277.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-6\" d=\"M 474.6 272.2 L 475.8 272.2 L 475.8 281.5 L 474.6 281.5 L 474.6 272.2 \" fill=\"#000000\"/>\n",
              "<path class=\"atom-7\" d=\"M 498.9 279.9 Q 499.0 279.9, 499.4 280.1 Q 499.8 280.2, 500.3 280.3 Q 500.7 280.4, 501.2 280.4 Q 502.0 280.4, 502.5 280.0 Q 503.0 279.6, 503.0 278.9 Q 503.0 278.5, 502.7 278.2 Q 502.5 277.9, 502.1 277.7 Q 501.8 277.5, 501.1 277.4 Q 500.4 277.1, 499.9 276.9 Q 499.4 276.7, 499.1 276.2 Q 498.8 275.7, 498.8 275.0 Q 498.8 273.9, 499.5 273.2 Q 500.3 272.5, 501.8 272.5 Q 502.8 272.5, 503.9 273.0 L 503.6 273.9 Q 502.6 273.5, 501.8 273.5 Q 500.9 273.5, 500.5 273.9 Q 500.0 274.2, 500.0 274.8 Q 500.0 275.3, 500.3 275.6 Q 500.5 275.8, 500.8 276.0 Q 501.2 276.2, 501.8 276.3 Q 502.6 276.6, 503.1 276.8 Q 503.5 277.1, 503.9 277.6 Q 504.2 278.1, 504.2 278.9 Q 504.2 280.1, 503.4 280.8 Q 502.6 281.4, 501.2 281.4 Q 500.5 281.4, 499.9 281.3 Q 499.3 281.1, 498.6 280.8 L 498.9 279.9 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 426.5 384.8 L 423.0 384.8 L 423.0 383.5 L 431.3 383.5 L 431.3 384.8 L 428.0 384.8 L 428.0 394.8 L 426.5 394.8 L 426.5 384.8 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 431.8 392.6 Q 431.8 391.3, 432.9 390.6 Q 434.0 389.8, 435.9 389.8 L 437.1 389.8 L 437.1 389.5 Q 437.1 388.5, 436.7 388.1 Q 436.3 387.6, 435.2 387.6 Q 434.6 387.6, 434.1 387.8 Q 433.6 387.9, 432.8 388.2 L 432.3 387.2 Q 433.8 386.4, 435.3 386.4 Q 437.0 386.4, 437.8 387.2 Q 438.6 387.9, 438.6 389.5 L 438.6 394.8 L 437.4 394.8 Q 437.4 394.7, 437.4 394.5 Q 437.3 394.2, 437.2 393.8 Q 436.1 395.0, 434.5 395.0 Q 433.3 395.0, 432.6 394.3 Q 431.8 393.7, 431.8 392.6 M 433.3 392.6 Q 433.3 393.2, 433.7 393.5 Q 434.1 393.8, 434.8 393.8 Q 435.5 393.8, 436.1 393.5 Q 436.7 393.2, 437.1 392.7 L 437.1 391.0 L 436.0 391.0 Q 434.7 391.0, 434.0 391.4 Q 433.3 391.8, 433.3 392.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 444.6 386.4 Q 445.9 386.4, 446.6 387.2 Q 447.3 387.9, 447.3 389.4 L 447.3 394.8 L 445.8 394.8 L 445.8 389.5 Q 445.8 388.5, 445.4 388.1 Q 445.1 387.6, 444.2 387.6 Q 443.5 387.6, 442.9 388.0 Q 442.2 388.3, 441.8 388.9 L 441.8 394.8 L 440.3 394.8 L 440.3 386.6 L 441.6 386.6 L 441.7 387.7 Q 442.8 386.4, 444.6 386.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 449.1 383.5 L 450.5 383.5 L 450.5 384.9 L 449.1 384.9 L 449.1 383.5 M 449.1 386.6 L 450.5 386.6 L 450.5 394.8 L 449.1 394.8 L 449.1 386.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 452.4 392.9 L 454.0 392.9 L 454.0 394.5 L 452.4 394.5 L 452.4 392.9 M 452.4 387.4 L 454.0 387.4 L 454.0 389.0 L 452.4 389.0 L 452.4 387.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 465.7 394.9 Q 463.6 394.9, 462.5 393.4 Q 461.5 391.9, 461.5 389.1 Q 461.5 386.4, 462.5 384.9 Q 463.6 383.4, 465.7 383.4 Q 467.8 383.4, 468.8 384.9 Q 469.8 386.4, 469.8 389.1 Q 469.8 391.9, 468.8 393.4 Q 467.7 394.9, 465.7 394.9 M 465.7 393.7 Q 466.9 393.7, 467.6 392.5 Q 468.2 391.4, 468.2 389.1 Q 468.2 386.9, 467.6 385.8 Q 466.9 384.6, 465.7 384.6 Q 464.5 384.6, 463.8 385.8 Q 463.1 386.9, 463.1 389.1 Q 463.1 391.4, 463.8 392.5 Q 464.5 393.7, 465.7 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 471.3 393.2 L 472.9 393.2 L 472.9 394.8 L 471.3 394.8 L 471.3 393.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 478.6 394.9 Q 476.5 394.9, 475.5 393.4 Q 474.5 391.9, 474.5 389.1 Q 474.5 386.4, 475.5 384.9 Q 476.5 383.4, 478.6 383.4 Q 480.7 383.4, 481.7 384.9 Q 482.8 386.4, 482.8 389.1 Q 482.8 391.9, 481.7 393.4 Q 480.7 394.9, 478.6 394.9 M 478.6 393.7 Q 479.9 393.7, 480.5 392.5 Q 481.2 391.4, 481.2 389.1 Q 481.2 386.9, 480.5 385.8 Q 479.9 384.6, 478.6 384.6 Q 477.4 384.6, 476.7 385.8 Q 476.1 386.9, 476.1 389.1 Q 476.1 391.4, 476.7 392.5 Q 477.4 393.7, 478.6 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 488.5 394.9 Q 486.4 394.9, 485.3 393.4 Q 484.3 391.9, 484.3 389.1 Q 484.3 386.4, 485.3 384.9 Q 486.4 383.4, 488.5 383.4 Q 490.5 383.4, 491.6 384.9 Q 492.6 386.4, 492.6 389.1 Q 492.6 391.9, 491.6 393.4 Q 490.5 394.9, 488.5 394.9 M 488.5 393.7 Q 489.7 393.7, 490.3 392.5 Q 491.0 391.4, 491.0 389.1 Q 491.0 386.9, 490.3 385.8 Q 489.7 384.6, 488.5 384.6 Q 487.2 384.6, 486.6 385.8 Q 485.9 386.9, 485.9 389.1 Q 485.9 391.4, 486.6 392.5 Q 487.2 393.7, 488.5 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 511.0 383.5 Q 513.5 383.5, 514.9 385.0 Q 516.2 386.4, 516.2 389.1 Q 516.2 391.8, 514.8 393.3 Q 513.5 394.8, 511.0 394.8 L 507.3 394.8 L 507.3 383.5 L 511.0 383.5 M 511.0 393.5 Q 512.7 393.5, 513.7 392.4 Q 514.6 391.3, 514.6 389.1 Q 514.6 386.9, 513.7 385.8 Q 512.7 384.8, 511.0 384.8 L 508.9 384.8 L 508.9 393.5 L 511.0 393.5 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 517.4 383.5 L 518.9 383.5 L 518.9 384.9 L 517.4 384.9 L 517.4 383.5 M 517.4 386.6 L 518.9 386.6 L 518.9 394.8 L 517.4 394.8 L 517.4 386.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 520.8 390.7 Q 520.8 388.7, 521.8 387.6 Q 522.7 386.4, 524.7 386.4 Q 526.6 386.4, 527.5 387.8 L 526.5 388.6 Q 526.2 388.1, 525.7 387.9 Q 525.3 387.6, 524.7 387.6 Q 523.6 387.6, 522.9 388.4 Q 522.3 389.2, 522.3 390.7 Q 522.3 392.2, 522.9 393.0 Q 523.6 393.8, 524.8 393.8 Q 525.5 393.8, 525.9 393.6 Q 526.4 393.4, 527.0 393.2 L 527.4 394.2 Q 526.2 394.9, 524.7 394.9 Q 522.7 394.9, 521.8 393.8 Q 520.8 392.7, 520.8 390.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 528.4 390.7 Q 528.4 388.7, 529.4 387.6 Q 530.4 386.4, 532.3 386.4 Q 534.1 386.4, 534.9 387.5 Q 535.7 388.6, 535.7 390.6 L 535.7 390.9 L 530.0 390.9 Q 530.0 392.3, 530.6 393.0 Q 531.2 393.8, 532.4 393.8 Q 533.1 393.8, 533.6 393.6 Q 534.2 393.4, 535.0 393.1 L 535.4 394.2 Q 534.6 394.6, 533.8 394.8 Q 533.1 394.9, 532.3 394.9 Q 530.5 394.9, 529.5 393.8 Q 528.4 392.7, 528.4 390.7 M 532.3 387.6 Q 531.3 387.6, 530.8 388.2 Q 530.2 388.7, 530.0 389.8 L 534.1 389.8 Q 534.0 388.7, 533.6 388.2 Q 533.1 387.6, 532.3 387.6 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 536.8 392.9 L 538.4 392.9 L 538.4 394.5 L 536.8 394.5 L 536.8 392.9 M 536.8 387.4 L 538.4 387.4 L 538.4 389.0 L 536.8 389.0 L 536.8 387.4 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"\" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 550.1 394.9 Q 548.0 394.9, 547.0 393.4 Q 545.9 391.9, 545.9 389.1 Q 545.9 386.4, 547.0 384.9 Q 548.0 383.4, 550.1 383.4 Q 552.2 383.4, 553.2 384.9 Q 554.2 386.4, 554.2 389.1 Q 554.2 391.9, 553.2 393.4 Q 552.2 394.9, 550.1 394.9 M 550.1 393.7 Q 551.3 393.7, 552.0 392.5 Q 552.6 391.4, 552.6 389.1 Q 552.6 386.9, 552.0 385.8 Q 551.3 384.6, 550.1 384.6 Q 548.9 384.6, 548.2 385.8 Q 547.5 386.9, 547.5 389.1 Q 547.5 391.4, 548.2 392.5 Q 548.9 393.7, 550.1 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 555.8 393.2 L 557.4 393.2 L 557.4 394.8 L 555.8 394.8 L 555.8 393.2 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 563.0 394.9 Q 561.0 394.9, 559.9 393.4 Q 558.9 391.9, 558.9 389.1 Q 558.9 386.4, 559.9 384.9 Q 560.9 383.4, 563.0 383.4 Q 565.1 383.4, 566.2 384.9 Q 567.2 386.4, 567.2 389.1 Q 567.2 391.9, 566.1 393.4 Q 565.1 394.9, 563.0 394.9 M 563.0 393.7 Q 564.3 393.7, 564.9 392.5 Q 565.6 391.4, 565.6 389.1 Q 565.6 386.9, 564.9 385.8 Q 564.3 384.6, 563.0 384.6 Q 561.8 384.6, 561.2 385.8 Q 560.5 386.9, 560.5 389.1 Q 560.5 391.4, 561.2 392.5 Q 561.8 393.7, 563.0 393.7 \" fill=\"#000000\"/>\n",
              "<path class=\"legend\" d=\"M 572.9 394.9 Q 570.8 394.9, 569.7 393.4 Q 568.7 391.9, 568.7 389.1 Q 568.7 386.4, 569.7 384.9 Q 570.8 383.4, 572.9 383.4 Q 575.0 383.4, 576.0 384.9 Q 577.0 386.4, 577.0 389.1 Q 577.0 391.9, 576.0 393.4 Q 574.9 394.9, 572.9 394.9 M 572.9 393.7 Q 574.1 393.7, 574.8 392.5 Q 575.4 391.4, 575.4 389.1 Q 575.4 386.9, 574.8 385.8 Q 574.1 384.6, 572.9 384.6 Q 571.6 384.6, 571.0 385.8 Q 570.3 386.9, 570.3 389.1 Q 570.3 391.4, 571.0 392.5 Q 571.6 393.7, 572.9 393.7 \" fill=\"#000000\"/>\n",
              "</svg>"
            ],
            "text/plain": [
              "<IPython.core.display.SVG object>"
            ]
          },
          "execution_count": 59,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "img = visualize_similarity_extremes(specs_filtered, \"tanimoto_sim\", \"dice_sim\")\n",
        "img"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "-68Ldmj21t93"
      },
      "outputs": [],
      "source": [
        "with open(\"figures/ch02/example_tani_dice_sim.svg\", \"w\") as f:\n",
        "  f.write(img.data)"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "JL9sdA1X2ltm"
      },
      "source": [
        "**Code for Figure 2.18. Relationship between Tanimoto and Dice similarity scores**"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/",
          "height": 523
        },
        "id": "TKQWvoIH1YEd",
        "outputId": "56352c6f-ab42-4275-ea06-67841b4f1886"
      },
      "outputs": [
        {
          "data": {
            "text/plain": [
              "<Figure size 640x480 with 0 Axes>"
            ]
          },
          "metadata": {},
          "output_type": "display_data"
        },
        {
          "data": {
            "image/png": "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",
            "text/plain": [
              "<Figure size 500x500 with 6 Axes>"
            ]
          },
          "metadata": {},
          "output_type": "display_data"
        }
      ],
      "source": [
        "plt.figure()\n",
        "sns.pairplot(specs_filtered[[\"tanimoto_sim\", \"dice_sim\"]])\n",
        "plt.tight_layout()\n",
        "plt.savefig('figures/ch02/sim_pairplot.png', bbox_inches='tight', dpi=600)\n",
        "plt.savefig('figures/ch02/sim_pairplot.pdf', bbox_inches='tight', dpi=600);"
      ]
    },
    {
      "cell_type": "markdown",
      "metadata": {
        "id": "wphsGJsF2t6T"
      },
      "source": [
        "**Code for searching for similar matches and saving the top matches**"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "kWJW9Yzv1-MH",
        "outputId": "899b103c-6c13-4dd9-bdfb-122f75a51a66"
      },
      "outputs": [
        {
          "name": "stdout",
          "output_type": "stream",
          "text": [
            "1225\n"
          ]
        }
      ],
      "source": [
        "from collections import defaultdict\n",
        "specs_filtered = specs_filtered.reset_index(drop=True)\n",
        "mols = specs_filtered.morgan_fp_r2_b2048.tolist()\n",
        "matches = defaultdict(int)\n",
        "\n",
        "for query in malaria_box.morgan_fp_r2_b2048:\n",
        " dice_sim = DataStructs.BulkDiceSimilarity(query, mols)\n",
        " matches.update({\n",
        "    idx : max(sim, matches[idx]) for idx, sim in enumerate(dice_sim) if sim >= 0.65\n",
        " })\n",
        "\n",
        "print(len(matches))"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "uGbQa-pQ4bls"
      },
      "outputs": [],
      "source": [
        "import heapq\n",
        "budget = 1000\n",
        "heap = []\n",
        "for idx, sim in matches.items():\n",
        "  heapq.heappush(heap, (-1 * sim, idx))\n",
        "\n",
        "top_matches = []\n",
        "for i in range(budget):\n",
        "  top_matches.append(heapq.heappop(heap)[1])"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "colab": {
          "base_uri": "https://localhost:8080/"
        },
        "id": "opynWboy4Pkn",
        "outputId": "439dfcc6-8172-4ba7-9d81-e4e0076c75b1"
      },
      "outputs": [
        {
          "data": {
            "text/plain": [
              "[343, 58, 532, 156, 445, 49, 387, 485, 384, 34, 44, 30]"
            ]
          },
          "execution_count": 184,
          "metadata": {},
          "output_type": "execute_result"
        }
      ],
      "source": [
        "top_matches"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "aPZt1mP7555D"
      },
      "outputs": [],
      "source": [
        "specs_hits_to_malaria_box = specs_filtered.filter(items=top_matches, axis=0)"
      ]
    },
    {
      "cell_type": "code",
      "execution_count": null,
      "metadata": {
        "id": "8aj4hrNS7WXn"
      },
      "outputs": [],
      "source": [
        "specs_hits_to_malaria_box.to_csv(\"artifacts/ch02/specs_hits_to_malaria_box.csv\", columns=[\"PUBCHEM_SUBSTANCE_ID\", \"smiles\"], index=False)"
      ]
    }
  ],
  "metadata": {
    "colab": {
      "authorship_tag": "ABX9TyMRegTRg2PipukFdUEQeEKL",
      "include_colab_link": true,
      "provenance": []
    },
    "kernelspec": {
      "display_name": "Python 3",
      "name": "python3"
    },
    "language_info": {
      "codemirror_mode": {
        "name": "ipython",
        "version": 3
      },
      "file_extension": ".py",
      "mimetype": "text/x-python",
      "name": "python",
      "nbconvert_exporter": "python",
      "pygments_lexer": "ipython3",
      "version": "3.10.13"
    }
  },
  "nbformat": 4,
  "nbformat_minor": 0
}