This website was built primarily using data from the clinicaltrials.gov API to identify studies that included a keyword or condition listing of Aphasia (excluding primary progressive aphasia and other dementias.)
-It was last updated on January 01 2024
+It was last updated on January 08 2024
To add your study to this website, submit the study to clinicaltrials.gov. This has a number of benefits for the research community and general public. While submission to clinicaltrials.gov is required for funded clinical trials in the US, voluntary submission is also permitted for other studies.
If submitting your study to clinicaltrials.gov is not feasible or is overly burdensome, you can add an IRB-approved flyer to the website by submitting an issue on github.com. Note that you will will need to create a github account. This is free and helps me keep track of submissions.
If you notice an error on the website, please contact me or file an issue here.
diff --git a/docs/data/clinical_trials_clean.csv b/docs/data/clinical_trials_clean.csv index 61aba81..7378786 100644 --- a/docs/data/clinical_trials_clean.csv +++ b/docs/data/clinical_trials_clean.csv @@ -235,7 +235,7 @@ Exclusion Criteria: prior history of dementia, neurologic illness (other than stroke), or substance abuse; significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing; -per self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise.","No","18 Years","All","Berkeley","94720","California","Maria Ivanova","United States",1,"no",-122.258521,37.870482,2023-12-12 +per self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise.","No","18 Years","All","Berkeley","94720","California","Maria Ivanova","United States",1,"no",-122.258027,37.870308,2023-12-12 "10",6,"Effects of High-intensity Exercise Training on Physical Fitness, Cognition, Language in Post-stroke Aphasia","Aphasia, Acquired Aphasia Aphasia, Fluent Aphasia Non Fluent","December 12, 2023","NCT06185023","University of California, Berkeley Hayward California United States","University of California, Berkeley","Recruiting","The goal of this clinical trial is to establish the feasibility and fidelity of a high-intensity exercise program for individuals with post-stroke aphasia. The main questions it aims to answer are: Is it feasible for stroke survivors with aphasia to participate in a long in-person physical exercise program? @@ -258,7 +258,7 @@ Exclusion Criteria: prior history of dementia, neurologic illness (other than stroke), or substance abuse; significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing; -per self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise.","No","18 Years","All","Hayward","94542","California","Maria Ivanova","United States",1,"no",-122.266823,37.868359,2023-12-12 +per self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise.","No","18 Years","All","Hayward","94542","California","Maria Ivanova","United States",1,"no",-122.259058,37.870394,2023-12-12 "11",6,"Effects of High-intensity Exercise Training on Physical Fitness, Cognition, Language in Post-stroke Aphasia","Aphasia, Acquired Aphasia Aphasia, Fluent Aphasia Non Fluent","December 12, 2023","NCT06185023","University of California, Berkeley San Francisco California United States","University of California, Berkeley","Recruiting","The goal of this clinical trial is to establish the feasibility and fidelity of a high-intensity exercise program for individuals with post-stroke aphasia. The main questions it aims to answer are: Is it feasible for stroke survivors with aphasia to participate in a long in-person physical exercise program? @@ -900,29 +900,7 @@ Previous head trauma with loss of consciousness for more than 5 minutes Psychiatric illness (We note that subjects will be assessed with the 15-item Geriatric Depression scale. Because depression is very difficult to evaluate in aphasic subjects, potential subjects will not be excluded on the basis of the depression score) Chronic exposure to medications that might be expected to have lasting consequences for the central nervous system (e.g. haloperidol, dopaminergics) History of or neuropsychological findings suggestive of dementia","No","18 Years","All","Philadelphia","19104","Pennsylvania","H. Branch Coslett","United States",1,"no",-75.1940565,39.9529705,2019-03-28 -"37",29,"Efficacy of a Combined Linguistic/Communication Therapy in Acute Aphasia After Stroke","Aphasia, Acquired","March 1, 2018","NCT03287544","University Hospital, Toulouse Toulouse Midi-Pyrénées France","University Hospital, Toulouse","Recruiting","Linguistic training is traditionally the gold standard for rehabilitation of aphasia after stroke and efficacy criteria count early stage, intensity as well as personalized treatment. To date, no clear evidence showed a specific effect of any therapy in the acute phase of aphasia after stroke. This study aims to compare the effect of a combined therapy (linguistic/communication) versus a linguistic therapy on communication performance in patients in the acute phase of aphasia after a first stroke.","Twenty to 25% of strokes cause aphasia. Speech and language therapy is the well-known standard treatment of aphasia after stroke although it is based on weak scientific evidence. To date, the efficacy criteria of aphasia rehabilitation are early stage, intensity as well as personalized treatment. Usually these patients receive in acute phase a linguistic training focused on the linguistic impairment. This approach is based on the cerebral plasticity postulate. However the superiority of this practice compared to other methods has never been shown. Moreover the benefit of the combination gathering linguistic treatment with communication treatment has to our knowledge never been studied. - -In the present study investigators propose to compare the effect of a combined linguistic/communication rehabilitation versus a linguistic treatment. To do so, investigators will recruit patients with aphasia after a first stroke, in the acute phase. After a allocation to the "" combined "" and "" linguistic "" groups, all the patients will have a comprehensive language and neuropsychological assessment before and after 3 months of rehabilitation, and finally 6 months after the onset. - -The ""linguistic"" group will have a rehabilitation only focused on linguistic processes whereas the ""combined"" group will have a linguistic training as well as communication training. The therapy will be personalized and the therapists will exclusively use standardized linguistic and/or communication toolboxes of rehabilitation containing dedicated activities.","Aphasia Rehabilitation Communication Linguistics","Interventional","Inclusion Criteria: - -First stroke -Inclusion at the acute phase (< 7 days) -Patient registered at the social security system -French as usual language -Aphasia severity score measured by the Boston Diagnostic Aphasia Examination (BDAE) scale ≥ 1 and ≤ 4 -Consent signed by the patient or if not, by the caregiver - -Exclusion Criteria: - -Cognitive impairment before the onset (IQCode > 3.4) -Alcohol or drug addiction -Untreated psychiatric disease, -Uncorrected sensory impairment -Evolutive pathology -Adults protected by Law -Participation to another research","No","18 Years","All","Toulouse","31059","Midi-Pyrénées",NA,"France",1,"no",1.444247,43.604462,2018-03-01 -"38",30,"Effects of rTMS Based on Hemodynamic Activity for Language Recovery in Early Poststroke Aphasia","Stroke Aphasia","November 2015","NCT02591719","Seoul National University Bundang Hospital Seongnam-si Korea, Gyeonggi-do Korea, Republic of","Seoul National University Bundang Hospital","Recruiting","The aim of this study is to assess the safety and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) based on hemodynamic brain activity pattern with functional near infrared spectroscopy (fNIRS) in early poststroke nonfluent aphasia patients.","Most conventional rTMS studies employed an inhibitory low frequency protocol for the contralesional homologs of Broca's area. +"37",29,"Effects of rTMS Based on Hemodynamic Activity for Language Recovery in Early Poststroke Aphasia","Stroke Aphasia","November 2015","NCT02591719","Seoul National University Bundang Hospital Seongnam-si Korea, Gyeonggi-do Korea, Republic of","Seoul National University Bundang Hospital","Recruiting","The aim of this study is to assess the safety and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) based on hemodynamic brain activity pattern with functional near infrared spectroscopy (fNIRS) in early poststroke nonfluent aphasia patients.","Most conventional rTMS studies employed an inhibitory low frequency protocol for the contralesional homologs of Broca's area. In the present randomized controlled trial, investigators will perform fNIRS prior to rTMS treatment to select the stimulation method. Stimulation site (perilesional or contralesional) and frequency (excitatory high or inhibitory low) will be determined by activation pattern from the fNIRS with language task in individual patients. @@ -946,7 +924,7 @@ Severe cognitive impairment (MMSE less than 16) Skin lesion in the stimulation site of scalp Metal implants in the body (cardiac pacemaker or aneurysm clip) Pregnancy, breastfeeding","No","18 Years","All","Seongnam-si","463-707","Korea, Gyeonggi-do","Nam-Jong Paik","Korea, Republic of",1,"no",127.1232505,37.351887,2015-11-20 -"39",31,"Neuro Device for Aphasia","Post-stroke Aphasia","September 6, 2023","NCT05194566","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.","There are about 15 million strokes worldwide each year. Of this group, about 30% suffer from aphasia. Aphasia is a speech-language disorder associated with exceptional difficulty performing daily communication activities. If no improvement is observed within the first months after the stroke, a complete recovery is unlikely, and the therapy can last for years. +"38",30,"Neuro Device for Aphasia","Post-stroke Aphasia","September 6, 2023","NCT05194566","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The aim of the trial is to determine whether 75Hz transcranial alternating current stimulation (tACS) synchronized with therapeutic linguistic tasks is an effective form of therapy for post-stroke aphasia.","There are about 15 million strokes worldwide each year. Of this group, about 30% suffer from aphasia. Aphasia is a speech-language disorder associated with exceptional difficulty performing daily communication activities. If no improvement is observed within the first months after the stroke, a complete recovery is unlikely, and the therapy can last for years. Up to date, speech and language therapy is a standard of care for post-stroke aphasia, however the process is long and demanding. @@ -993,7 +971,7 @@ Withdrawal criteria: high intolerance to stimulation (participants experience severe discomfort during stimulation); occurrence of an epileptic seizure; other previously absent neurological, physical or mental symptoms.","No","18 Years","All","New York","10029","New York","Miguel Escalon","United States",1,"no",-73.953275,40.7898205,2023-09-06 -"40",32,"Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.","Stroke Aphasia","October 18, 2022","NCT04432883","University of New Mexico Albuquerque New Mexico United States","University of New Mexico","Recruiting","62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.","Our long-term goal is to develop safe and effective treatments for the communication problems of Aphasia due to stroke that restore patients to higher levels of functioning, decrease disability, and promote higher quality of life. While language therapy for aphasia is effective, improvements are typically slow, and gains may be small. Noninvasive brain stimulation has been suggested as a method to enhance outcomes from language therapy. This study will examine whether outcomes for language therapy with brain stimulation are different from outcomes for language therapy without brain stimulation in people with aphasia. Our central hypotheses are (1) targeted right hemisphere HDtDCS (RH-HD-tDCS) administered in combination with language treatment will result in greater changes in naming accuracy than language treatment with the sham RH-HD-tDCS (2) RH-HD-tDCS plus language treatment will result in greater increases in communication within the affected hemisphere compared to language treatment plus sham RH-HD-tDCS (3) RH-HD-tDCS plus language treatment will result in greater increases in perilesional areas working together immediately post-treatment compared to language treatment plus sham RH-HD-tDCS","Stroke Aphasia brain stimulation communication problems speech and language therapy","Interventional","Inclusion Criteria: +"39",31,"Targeted TDCS to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia.","Stroke Aphasia","October 18, 2022","NCT04432883","University of New Mexico Albuquerque New Mexico United States","University of New Mexico","Recruiting","62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.","Our long-term goal is to develop safe and effective treatments for the communication problems of Aphasia due to stroke that restore patients to higher levels of functioning, decrease disability, and promote higher quality of life. While language therapy for aphasia is effective, improvements are typically slow, and gains may be small. Noninvasive brain stimulation has been suggested as a method to enhance outcomes from language therapy. This study will examine whether outcomes for language therapy with brain stimulation are different from outcomes for language therapy without brain stimulation in people with aphasia. Our central hypotheses are (1) targeted right hemisphere HDtDCS (RH-HD-tDCS) administered in combination with language treatment will result in greater changes in naming accuracy than language treatment with the sham RH-HD-tDCS (2) RH-HD-tDCS plus language treatment will result in greater increases in communication within the affected hemisphere compared to language treatment plus sham RH-HD-tDCS (3) RH-HD-tDCS plus language treatment will result in greater increases in perilesional areas working together immediately post-treatment compared to language treatment plus sham RH-HD-tDCS","Stroke Aphasia brain stimulation communication problems speech and language therapy","Interventional","Inclusion Criteria: aged 25-85 must be greater than 1 year post-stroke @@ -1010,7 +988,7 @@ substance/alcohol dependence or abuse within the past year presence of any implanted electrical device or contraindications to tDCS or MRI recent medical instability (within 4 weeks) pregnancy","No","25 Years","All","Albuquerque","87106","New Mexico","Jessica Richardson","United States",1,"no",-106.6208755,35.083292,2022-10-18 -"41",33,"Studying Language With Brain Stimulation in Aphasia","Stroke Aphasia","January 9, 2023","NCT05660304","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.","The brain is made up of networks that communicate with each other to help us think and communicate. After a stroke, networks between different areas of the brain can lose connection. In the case of aphasia, networks in the language areas of the brain are often disrupted. There is currently no ""fix"" to restore these specific language connections. However, transcranial magnetic stimulation (TMS) might help the areas reconnect through alternative pathways. +"40",32,"Studying Language With Brain Stimulation in Aphasia","Stroke Aphasia","January 9, 2023","NCT05660304","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The overall goal of this study is to evaluate whether stimulation of two brain areas alongside behavioral speech-language therapy increases connectivity to improve language functions in stroke-aphasia patients.","The brain is made up of networks that communicate with each other to help us think and communicate. After a stroke, networks between different areas of the brain can lose connection. In the case of aphasia, networks in the language areas of the brain are often disrupted. There is currently no ""fix"" to restore these specific language connections. However, transcranial magnetic stimulation (TMS) might help the areas reconnect through alternative pathways. TMS is a non-invasive procedure (in other words, it takes place outside your body). A coil will be placed over your head. The coil sends magnetic pulses to your brain to stimulate, or excite, neurons. Most studies using TMS stimulate one area of the brain at a time, but this does not tell us how to improve the network connections between brain areas. @@ -1042,7 +1020,7 @@ Ménière's disease Medications that increase risk of seizures, for instance antipsychotic and antidepressant medications acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants Non-prescribed drug use, for instance recreational marijuana Unable to refrain from using any alcohol and nicotine products for at least 24 hours before the study Visits.","No","18 Years","All","Chicago","60611","Illinois","Julio C Hernandez Pavon","United States",1,"no",-87.618428,41.893889,2023-01-09 -"42",34,"Genetic and Cognitive Predictors of Aphasia Treatment Response","Aphasia","October 23, 2020","NCT05179538","Ohio State University Columbus Ohio United States","Ohio State University","Recruiting","Aphasia, or language impairment after a stroke, affects approximately 2 million people in the United States, with an estimated 180,000 new cases each year. The medical community cannot predict how well someone with aphasia will respond to treatment, as some people with aphasia are poor responders to intervention even when participating in empirically supported treatments. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. This study will investigate whether two genes and cognitive abilities, such as memory, predict responsiveness to aphasia therapy for word-retrieval difficulties.","Incomplete understanding of patient-specific factors that determine whether someone will respond well to language therapy after stroke limits the development of methods to target or account for sources of variability. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. The long-term goal of this line of work is to maximize response to aphasia therapy by incorporating patient-specific factors into decisions related to treatment planning. The overall objective of this application is to identify patterns of patient-specific factors including two candidate genes and cognitive skills that show a relationship with treatment outcomes. The central hypothesis is that there will be a relationship between ApoE and BDNF genotypes, and working memory on stimulus generalization. The rationale for the proposed project is that the identification of factors that impact treatment responsiveness will allow for better estimation of prognosis, improved triage of individuals into appropriate therapy regimens and direct targeting of cognitive factors to maximize behavioral gains. The two specific aims of the project are to determine the degree to which (1) ApoE and BDNF genotypes influence how individuals with aphasia respond to therapy, and (2) working memory abilities are related to stimulus acquisition and stimulus generalization after anomia therapy. Individuals with chronic post-stroke aphasia will undergo cognitive and language assessment, and provide a saliva sample for genetic analysis prior to participating in a cued picture-naming therapy for anomia. The expected outcomes are to integrate cognitive scores and genotypes for BDNF and ApoE into formulating probabilities of individual patient responsiveness to restorative therapy. Improvement in word retrieval abilities will be evaluated using the percentage of pictures named correctly. This contribution is expected to be significant because it will allow for more informed clinical decision making and better allocation of resources to appropriate treatments, thereby making advances in the field toward more personalized medicine, as opposed to a one-size-fits-all clinical approach. +"41",33,"Genetic and Cognitive Predictors of Aphasia Treatment Response","Aphasia","October 23, 2020","NCT05179538","Ohio State University Columbus Ohio United States","Ohio State University","Recruiting","Aphasia, or language impairment after a stroke, affects approximately 2 million people in the United States, with an estimated 180,000 new cases each year. The medical community cannot predict how well someone with aphasia will respond to treatment, as some people with aphasia are poor responders to intervention even when participating in empirically supported treatments. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. This study will investigate whether two genes and cognitive abilities, such as memory, predict responsiveness to aphasia therapy for word-retrieval difficulties.","Incomplete understanding of patient-specific factors that determine whether someone will respond well to language therapy after stroke limits the development of methods to target or account for sources of variability. There is a strong likelihood that genetics play a role in language recovery after stroke, but very little research has been dedicated to investigating this link. The long-term goal of this line of work is to maximize response to aphasia therapy by incorporating patient-specific factors into decisions related to treatment planning. The overall objective of this application is to identify patterns of patient-specific factors including two candidate genes and cognitive skills that show a relationship with treatment outcomes. The central hypothesis is that there will be a relationship between ApoE and BDNF genotypes, and working memory on stimulus generalization. The rationale for the proposed project is that the identification of factors that impact treatment responsiveness will allow for better estimation of prognosis, improved triage of individuals into appropriate therapy regimens and direct targeting of cognitive factors to maximize behavioral gains. The two specific aims of the project are to determine the degree to which (1) ApoE and BDNF genotypes influence how individuals with aphasia respond to therapy, and (2) working memory abilities are related to stimulus acquisition and stimulus generalization after anomia therapy. Individuals with chronic post-stroke aphasia will undergo cognitive and language assessment, and provide a saliva sample for genetic analysis prior to participating in a cued picture-naming therapy for anomia. The expected outcomes are to integrate cognitive scores and genotypes for BDNF and ApoE into formulating probabilities of individual patient responsiveness to restorative therapy. Improvement in word retrieval abilities will be evaluated using the percentage of pictures named correctly. This contribution is expected to be significant because it will allow for more informed clinical decision making and better allocation of resources to appropriate treatments, thereby making advances in the field toward more personalized medicine, as opposed to a one-size-fits-all clinical approach. The investigators will determine genotypes for BDNF and ApoE, which will yield four separate groups. At least 20 participants will be enrolled for each genotype group.","","Interventional","Inclusion Criteria: @@ -1059,7 +1037,7 @@ Severe depression. Diffuse injury or disease of the brain Uncorrected vision or hearing difficulties Contraindications for MRI (e.g. cardiac pacemaker, ferrous metal implants, claustrophobia, pregnancy).","No","18 Years","All","Columbus","43210","Ohio",NA,"United States",1,"no",-83.0122685,40.0010725,2020-10-23 -"43",36,"Stepped Care for Aphasia","Aphasia Stroke","March 31, 2023","NCT05851573","Medical University of South Carolina Charleston South Carolina United States","Medical University of South Carolina","Recruiting","This study is recruiting people who had a stroke at least 1 month ago and now have a language impairment called aphasia. Living with aphasia can have devastating effects on communication and quality of life, and it is not uncommon for survivors with aphasia to face psychological problems like depression and anxiety. Participants who are eligible for this study will undergo baseline testing, engage in a 5-week treatment focused on psychological well-being, undergo post-treatment testing, and then testing again 1-month later. Check-in phone calls will be conducted during the 1-month off period and participants will be interviewed about their experience at the end of the study as well. Compensation will be provided to participants with aphasia.",NA,"","Interventional","Inclusion Criteria: +"42",35,"Stepped Care for Aphasia","Aphasia Stroke","March 31, 2023","NCT05851573","Medical University of South Carolina Charleston South Carolina United States","Medical University of South Carolina","Recruiting","This study is recruiting people who had a stroke at least 1 month ago and now have a language impairment called aphasia. Living with aphasia can have devastating effects on communication and quality of life, and it is not uncommon for survivors with aphasia to face psychological problems like depression and anxiety. Participants who are eligible for this study will undergo baseline testing, engage in a 5-week treatment focused on psychological well-being, undergo post-treatment testing, and then testing again 1-month later. Check-in phone calls will be conducted during the 1-month off period and participants will be interviewed about their experience at the end of the study as well. Compensation will be provided to participants with aphasia.",NA,"","Interventional","Inclusion Criteria: 18-81 years old Native English speaker (English fluency by age 7) @@ -1075,7 +1053,7 @@ Uncorrected hearing or visual impairment that prevents completion of experimenta History of other neurological disorder or disease beside stroke (e.g., dementia, traumatic brain injury) as determined by self-report and/or medical records Self-reported history of premorbid learning disability Severe auditory comprehension deficits (as indicated by a score of more than two standard deviations below norms on the Auditory Verbal section of WAB-R)","No","18 Years","All","Charleston","29425","South Carolina","Deena Blackett","United States",1,"no",-79.947297,32.784808,2023-03-31 -"44",37,"Adaptive Trial Scheduling in Naming Treatment for Aphasia","Aphasia Stroke","September 21, 2023","NCT05653466","University of Pittsburgh Pittsburgh Pennsylvania United States","University of Pittsburgh","Recruiting","Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Picture-based naming treatments for anomia are widely used in aphasia rehabilitation, but current treatment approaches do not address the long-term retention of naming abilities and do not focus on using these naming abilities in daily life. The current research aims to evaluate novel anomia treatment approaches to improve long-term retention and generalization to everyday life. +"43",36,"Adaptive Trial Scheduling in Naming Treatment for Aphasia","Aphasia Stroke","September 21, 2023","NCT05653466","University of Pittsburgh Pittsburgh Pennsylvania United States","University of Pittsburgh","Recruiting","Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Picture-based naming treatments for anomia are widely used in aphasia rehabilitation, but current treatment approaches do not address the long-term retention of naming abilities and do not focus on using these naming abilities in daily life. The current research aims to evaluate novel anomia treatment approaches to improve long-term retention and generalization to everyday life. This study is one of two that are part of a larger grant. This record is for sub-study 2, which will evaluate the benefits of adaptive trial spacing.","Study 2: Evaluate the benefits of adaptive trial scheduling. @@ -1092,8 +1070,8 @@ Exclusion Criteria: History of other acquired or progressive neurological disease. Significant language comprehension impairments (per performance on the CAT - individuals will be excluded if their spoken language comprehension mean modality T- score on the CAT falls below 40). Unmanaged drug / alcohol dependence. -Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.955683,40.443921,2023-09-21 -"45",38,"Modulating Intensity and Dosage of Aphasia Scripts","Aphasia","September 21, 2020","NCT04138940","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia following a stroke. Using a computer based speech and language therapy program, participants will practice conversational scripts that are either short or long. Participants will practice for either 2 weeks (5 days a week) or for 5 weeks (2 days a week).","Determining the optimal intensity of treatment is essential to the design and implementation of any treatment program for aphasia. Yet, treatment intensity is a complex construct and information on the variables modulating it remain ambiguous and limited. Studies reported in the neuroscience and clinical literature support the need for intensive treatment to induce long-term neuroplastic changes while the cognitive psychology literature suggests that learning is best maintained with distributed schedules. A few studies have looked at dose parameters for single word naming tasks, but there is limited evidence regarding dose parameters for treatments that focus on training the production of larger units, such as sentences or even connected discourse. One approach that is frequently used clinically and has evidence for its efficacy is script training. Little is currently known regarding the optimum dose of script training (i.e., the number of repetitions over time of each sentence within the script) that is required to promote the best outcomes. +Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.958065,40.44047,2023-09-21 +"44",37,"Modulating Intensity and Dosage of Aphasia Scripts","Aphasia","September 21, 2020","NCT04138940","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","The purpose of this study is to evaluate how changing conditions of speech-language treatment (namely, amount of repetition and distribution of practice schedule) affects the language outcome of participants with aphasia following a stroke. Using a computer based speech and language therapy program, participants will practice conversational scripts that are either short or long. Participants will practice for either 2 weeks (5 days a week) or for 5 weeks (2 days a week).","Determining the optimal intensity of treatment is essential to the design and implementation of any treatment program for aphasia. Yet, treatment intensity is a complex construct and information on the variables modulating it remain ambiguous and limited. Studies reported in the neuroscience and clinical literature support the need for intensive treatment to induce long-term neuroplastic changes while the cognitive psychology literature suggests that learning is best maintained with distributed schedules. A few studies have looked at dose parameters for single word naming tasks, but there is limited evidence regarding dose parameters for treatments that focus on training the production of larger units, such as sentences or even connected discourse. One approach that is frequently used clinically and has evidence for its efficacy is script training. Little is currently known regarding the optimum dose of script training (i.e., the number of repetitions over time of each sentence within the script) that is required to promote the best outcomes. This study investigates the effects of modulating stimulus variables, specifically stimulus practice distribution and stimulus repetition. We use a baseline script treatment that has experimental support regarding its efficacy, and that allows the manipulation of these variables. To ensure independence and fidelity, treatment is provided in a controlled computer environment (desktop and tablet). To avoid clinician-related variables such as expertise and personality factors that may influence treatment, sentences are modeled during treatment by an anthropomorphic agent with high visual speech intelligibility and affective expressions. @@ -1116,7 +1094,7 @@ Exclusion Criteria: Any other neurological condition (other than cerebral vascular disease) that could potentially affect cognition or speech, such as Parkinson's Disease, Alzheimer's Dementia, traumatic brain injury Any significant psychiatric history prior to the stroke, such as severe major depression or psychotic disorder requiring hospitalization; subjects with mood disorders who are currently stable on treatment will be considered Active substance abuse","No","21 Years","All","Chicago","60611","Illinois","Leora Cherney","United States",1,"no",-87.618428,41.893889,2020-09-21 -"46",39,"High Definition Transcranial Alternating Current Stimulation (HD-tACS) for Post-stroke Aphasia","Transcranial Alternating Current Stimulation Post-stroke Aphasia Functional Magnetic Resonance Imaging","March 18, 2021","NCT05502822","Anhui Medical University Hefei NA China","Anhui Medical University","Recruiting","To investigate the intervention effect of high definition transcranial alternating current stimulation(HD-tACS) in chronic post-stroke aphasia and its underlying neural mechanism by MRI.","Aphasia is one of the most frequent cognitive deficits in poststroke survivor. More than 20% of stroke patients suffered from language impairment. The recovery of language dysfunction after stroke is highly variable. Some patients recover spontaneously in the early phases of stroke, but about two thirds of patients never fully restore language ability. The purpose of this study was to explore the intervention effect of high definition transcranial alternating current stimulation in chronic post-stroke aphasia. +"45",38,"High Definition Transcranial Alternating Current Stimulation (HD-tACS) for Post-stroke Aphasia","Transcranial Alternating Current Stimulation Post-stroke Aphasia Functional Magnetic Resonance Imaging","March 18, 2021","NCT05502822","Anhui Medical University Hefei NA China","Anhui Medical University","Recruiting","To investigate the intervention effect of high definition transcranial alternating current stimulation(HD-tACS) in chronic post-stroke aphasia and its underlying neural mechanism by MRI.","Aphasia is one of the most frequent cognitive deficits in poststroke survivor. More than 20% of stroke patients suffered from language impairment. The recovery of language dysfunction after stroke is highly variable. Some patients recover spontaneously in the early phases of stroke, but about two thirds of patients never fully restore language ability. The purpose of this study was to explore the intervention effect of high definition transcranial alternating current stimulation in chronic post-stroke aphasia. 40 patients with language disorder diagnosed by the Aphasia Battery of Chinese (ABC) were recruited from the first affiliated Hospital of Anhui Medical University. All participants underwent a structured interview and routine laboratory examination before and after receiving HD-tACS. After meeting the inclusion criteria and obtaining informed consent, each participant will complete the clinical evaluation, functional magnetic resonance imaging (fMRI) and HD-tACS treatment conducted by trained researchers at the Neuropsychological Synergetic Innovation Center of Anhui Medical University. @@ -1139,7 +1117,7 @@ severe dysarthria. a history of head injury or surgery. alcohol or substance abuse. cerebral tumor or abscess.","No","18 Years","All","Hefei",NA,NA,"WANG KAI","China",1,"no",117.349720247305,31.0729498560408,2021-03-18 -"47",40,"Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia","Aphasia Stroke","September 1, 2023","NCT05653440","University of Pittsburgh Pittsburgh Pennsylvania United States","University of Pittsburgh","Recruiting","Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Picture-based naming treatments for anomia are widely used in aphasia rehabilitation, but current treatment approaches do not address the long-term retention of naming abilities and do not focus on using these naming abilities in daily life. The current research aims to evaluate novel anomia treatment approaches to improve long-term retention and generalization to everyday life. +"46",39,"Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia","Aphasia Stroke","September 1, 2023","NCT05653440","University of Pittsburgh Pittsburgh Pennsylvania United States","University of Pittsburgh","Recruiting","Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of life. Anomia (i.e., word- finding difficulty) is a primary frustration for people with aphasia. Picture-based naming treatments for anomia are widely used in aphasia rehabilitation, but current treatment approaches do not address the long-term retention of naming abilities and do not focus on using these naming abilities in daily life. The current research aims to evaluate novel anomia treatment approaches to improve long-term retention and generalization to everyday life. This study is one of two that are part of a larger grant. This record is for sub-study 1, which will adaptively balance effort and accuracy using speeded naming deadlines.","Study 1: Evaluate the benefits of balancing effortful and errorless learning via adaptive naming deadlines. @@ -1156,8 +1134,8 @@ Exclusion Criteria: History of other acquired or progressive neurological disease. Significant language comprehension impairments (per performance on the CAT - individuals will be excluded if their spoken language comprehension mean modality T- score on the CAT falls below 40). Unmanaged drug / alcohol dependence. -Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.955683,40.443921,2023-09-01 -"48",41,"Improving Aphasia Using Electrical Brain Stimulation","Stroke Aphasia","July 12, 2021","NCT04963803","Syracuse University Syracuse New York United States","Syracuse University","Recruiting","Language and communication are essential for almost every aspect of human life, but for people who have aphasia, a language processing disorder that can occur after stroke or brain injury, even simple conversations can become a formidable challenge. Speech and language therapy can help people recover their language ability, but often requires months or even years of therapy before a person is able to overcome these challenges. This research will investigate non-invasive brain stimulation as a way to enhance the effects of speech and language therapy, which may ultimately lead to better and faster recovery from stroke and aphasia. The investigators hypothesize that participants with aphasia who receive speech and language therapy paired with active electrical brain stimulation will improve significantly more on a language comprehension task than those who receive speech and language therapy paired with sham stimulation.",NA,"tDCS attention language speech-language therapy","Interventional","Inclusion Criteria: +Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.","No","18 Years","All","Pittsburgh","15260","Pennsylvania","William Evans","United States",1,"no",-79.958065,40.44047,2023-09-01 +"47",40,"Improving Aphasia Using Electrical Brain Stimulation","Stroke Aphasia","July 12, 2021","NCT04963803","Syracuse University Syracuse New York United States","Syracuse University","Recruiting","Language and communication are essential for almost every aspect of human life, but for people who have aphasia, a language processing disorder that can occur after stroke or brain injury, even simple conversations can become a formidable challenge. Speech and language therapy can help people recover their language ability, but often requires months or even years of therapy before a person is able to overcome these challenges. This research will investigate non-invasive brain stimulation as a way to enhance the effects of speech and language therapy, which may ultimately lead to better and faster recovery from stroke and aphasia. The investigators hypothesize that participants with aphasia who receive speech and language therapy paired with active electrical brain stimulation will improve significantly more on a language comprehension task than those who receive speech and language therapy paired with sham stimulation.",NA,"tDCS attention language speech-language therapy","Interventional","Inclusion Criteria: 18 years or older. No diagnosis of neurological disorder (other than stroke). @@ -1192,7 +1170,7 @@ No aphasia or severe aphasia. Cognitive ability below functional limits. Unable to pass vision and/or hearing screening with use of corrective aids. Unwilling to allow audio-recording of study sessions.","No","18 Years","All","Syracuse","13244","New York",NA,"United States",1,"no",-76.152953,43.0507975,2021-07-12 -"49",43,"Speeded Anomia Treatment in Chronic Post-stroke Aphasia","Aphasia","January 15, 2023","NCT05512884","University of Cambridge Cambridge NA United Kingdom","University of Cambridge","Recruiting","The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).","The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production. +"48",42,"Speeded Anomia Treatment in Chronic Post-stroke Aphasia","Aphasia","January 15, 2023","NCT05512884","University of Cambridge Cambridge NA United Kingdom","University of Cambridge","Recruiting","The main aim of the study is to investigate the effect of a novel, speeded anomia therapy (Conroy et al., 2018) in a large population of patients with chronic post-stroke aphasia. The treatment will be delivered via a web application (QuickWord).","The main aim is to test the clinical efficacy of a novel, web based, rehabilitation approach to aphasic word-finding difficulties (QuickWord). In an initial development and case-series evaluation, Conroy et al (2018, Brain) found that training for both speed as well as accuracy of naming generated much better outcomes to picture naming accuracy and also augmented the carry-over to connected speech production. This is a randomised, crossover, clinical trial of QuickWord in a group of aphasic patients in the chronic post-stroke period. The comparison will be standard care. The main outcome measures are clinically relevant improvement in naming to confrontation, and spontaneous use of the target vocabulary in a connected speech sample (detailed picture description). Secondary outcome includes measured use of the vocabulary in a story-telling, connected speech assessment (retelling of the Cinderella story).","Anomia Speech Disorders Language Disorders Communication Disorders","Interventional","Inclusion Criteria: @@ -1217,7 +1195,7 @@ Unable to give informed consent Currently receiving Speech & Language therapy Insufficient repetition skills (<40% on an immediate word repetition test) Good naming performance (>90% in Boston Naming Test - Goodglass et al., 1983)","No","18 Years","All","Cambridge","CB2 7EF",NA,"Matthew A. Lambon Ralph","United Kingdom",1,"no",0.1216705,52.202776,2023-01-15 -"50",44,"Timing of Transcranial Direct Current Stimulation (tDCS) Combined With Speech and Language Therapy (SLT)","Aphasia","April 3, 2019","NCT03773406","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","Aphasia is an acquired (typically left-hemisphere) multi-modality disturbance of language that impacts around 2 million people in the USA. Aphasia impacts language production and comprehension as well as reading and writing. The ramifications of aphasia extend beyond language impairment to negatively impacting a person's social, vocational, and recreational activities. Currently, the most effective way to treat aphasia is with speech-language therapy (SLT). However, even if SLT is intensive, persons with aphasia are left with residual language delays. Recent research suggests that pairing SLT with transcranial direct current stimulation (tDCS) a non-invasive, safe, low-cost form of brain stimulation may aid language recovery in persons with aphasia. However, results from tDCS studies are inconclusive. The success of tDCS in combination with SLT could depend on the timing of tDCS since tDCS-induced effects depend on the neuronal state of the brain-networks at the time of the stimulation. In this study, the differential impact of tDCS before behavioral SLT (offline-before therapy), tDCS after SLT (offline-after therapy), and tDCS concurrently with SLT (online) on functional language recovery in persons with aphasia will be investigated. Sham tDCS (i.e., SLT alone) as a control group will also be included in the study. The investigators hypothesize that both offline and online tDCS will improve language functioning than sham tDCS.","tDCS Implementation: +"49",43,"Timing of Transcranial Direct Current Stimulation (tDCS) Combined With Speech and Language Therapy (SLT)","Aphasia","April 3, 2019","NCT03773406","Shirley Ryan AbilityLab Chicago Illinois United States","Shirley Ryan AbilityLab","Recruiting","Aphasia is an acquired (typically left-hemisphere) multi-modality disturbance of language that impacts around 2 million people in the USA. Aphasia impacts language production and comprehension as well as reading and writing. The ramifications of aphasia extend beyond language impairment to negatively impacting a person's social, vocational, and recreational activities. Currently, the most effective way to treat aphasia is with speech-language therapy (SLT). However, even if SLT is intensive, persons with aphasia are left with residual language delays. Recent research suggests that pairing SLT with transcranial direct current stimulation (tDCS) a non-invasive, safe, low-cost form of brain stimulation may aid language recovery in persons with aphasia. However, results from tDCS studies are inconclusive. The success of tDCS in combination with SLT could depend on the timing of tDCS since tDCS-induced effects depend on the neuronal state of the brain-networks at the time of the stimulation. In this study, the differential impact of tDCS before behavioral SLT (offline-before therapy), tDCS after SLT (offline-after therapy), and tDCS concurrently with SLT (online) on functional language recovery in persons with aphasia will be investigated. Sham tDCS (i.e., SLT alone) as a control group will also be included in the study. The investigators hypothesize that both offline and online tDCS will improve language functioning than sham tDCS.","tDCS Implementation: 2mA of direct current for 20 minutes will be delivered using a constant current stimulator via two electrodes in saline soaked sponges. To stimulate the left angular gyrus, a cathodal electrode inside a saline soaked sponge (5 x 3cm) will be placed over the CP5 according to the 10-20 international system for EEG electrode placement. The electrodes will be secured in position by a custom-built EEG cap that will be marked with the location for angular gyrus. The investigators will then confirm that the cathodal electrode is over the left angular through the use of neuronavigation. The ""return"" anode electrode will be placed in a saline soaked sponge (5 x 5cm) on the center of the supraorbital region. @@ -1246,7 +1224,7 @@ Exclusion Criteria: Any other neurological condition (other than cerebral vascular disease) that could impact language and cognition such as Alzheimer's disease, Parkinson's disease, primary progressive aphasia, and traumatic brain injury Active substance use Individuals with epilepsy","No","18 Years","All","Chicago","60611","Illinois","Leora Cherney","United States",1,"no",-87.618428,41.893889,2019-04-03 -"51",50,"Speech Entrainment Treatment for People With Aphasia","Aphasia, Acquired","January 25, 2023","NCT05687994","Albert Einstein Healthcare Network Elkins Park Pennsylvania United States","Albert Einstein Healthcare Network","Recruiting","The objective of this research is to experimentally delineate the direct effect of speech entrainment practice on independent speech production and identify practice conditions that enhance treatment benefits. The primary outcome measure (Correct Information Units per minute) tallies informativeness and efficiency of independent speech in treated stories.","Speech entrainment refers to speaking in unison with a model speaker by imitating the model in real time. The objective of the study is to (1) experimentally establish the direct effect of speech entrainment practice on independent speech production post-treatment, and (2) identify conditions that enhance treatment benefits. These aims are addressed in a within-subject efficacy study, where 40 people with aphasia produce different stories with entrainment support. Speaking without entrainment is evaluated one day before and one day after speech entrainment practice. Different practice stories will be randomized within participants to three experimental conditions to assess the effect of treatment (trained vs. untrained), training schedule (massed vs. distributed presentation of stories), and entrainment modality (practice with auditory-only or audiovisual model). Correct information units per minute for each story will be tallied to evaluate the differences between conditions and the associations with patient characteristics. For consistency with prior research, number of different words per minute will serve as a secondary outcome. The proposed research addresses a clinical need by testing and optimizing a promising treatment technique for enhancing aphasia rehabilitation. +"50",49,"Speech Entrainment Treatment for People With Aphasia","Aphasia, Acquired","January 25, 2023","NCT05687994","Albert Einstein Healthcare Network Elkins Park Pennsylvania United States","Albert Einstein Healthcare Network","Recruiting","The objective of this research is to experimentally delineate the direct effect of speech entrainment practice on independent speech production and identify practice conditions that enhance treatment benefits. The primary outcome measure (Correct Information Units per minute) tallies informativeness and efficiency of independent speech in treated stories.","Speech entrainment refers to speaking in unison with a model speaker by imitating the model in real time. The objective of the study is to (1) experimentally establish the direct effect of speech entrainment practice on independent speech production post-treatment, and (2) identify conditions that enhance treatment benefits. These aims are addressed in a within-subject efficacy study, where 40 people with aphasia produce different stories with entrainment support. Speaking without entrainment is evaluated one day before and one day after speech entrainment practice. Different practice stories will be randomized within participants to three experimental conditions to assess the effect of treatment (trained vs. untrained), training schedule (massed vs. distributed presentation of stories), and entrainment modality (practice with auditory-only or audiovisual model). Correct information units per minute for each story will be tallied to evaluate the differences between conditions and the associations with patient characteristics. For consistency with prior research, number of different words per minute will serve as a secondary outcome. The proposed research addresses a clinical need by testing and optimizing a promising treatment technique for enhancing aphasia rehabilitation. This proof-of-concept study is the first to evaluate the direct effect of speech entrainment practice on independent speech. Thus, the effect size for accurate power estimation is not known. The strategy for this study is to optimize experimental sensitivity by maximizing the number of observations per participants per condition within the constraints of feasibility. The results from this study will provide critical information for evaluating the effect size for a subsequent phase. Nevertheless, to estimate an optimal sample size, the investigators leveraged the data from our Pilot Study, which examines the speech entrainment effect on immediate performance rather than learning. With 13 participants, the investigators estimated 80% power to detect the effect of 0.8 (mean difference between groups divided by the pooled standard deviation) observed in our pilot study for speaking with audiovisual speech entrainment vs. independent speech (Aim 1). The calculation is based on a paired t-test with an alpha of .05 (two-tailed) and a correlation of 0.5 between groups. With 24 participants, there is 80% power to detect the observed effect of 0.6 for speaking with audiovisual speech entrainment vs. auditory-only speech entrainment (alpha is set to .05, two-tailed, correlation between groups is .57; Aim 2b). The investigators have substantially increased the sample size (N=40) with the consideration that learning effects (the focus of the present study) are expected to be smaller than performance effects (the focus of the Pilot Study).","","Interventional","Inclusion Criteria: @@ -1261,7 +1239,7 @@ Exclusion Criteria: History of learning disabilities History of other comorbid neurological impairments","No","18 Years","All","Elkins Park","19027","Pennsylvania","Marja-Liisa Mailend, PhD","United States",1,"no",-75.120418,40.035597,2023-01-25 -"52",52,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron Cedex NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. +"51",51,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron Cedex NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. The aim of this study is to show that a motor training with a tool (pliers) can improve short-term and long-term language abilities of aphasic patients who had a stroke at least 3 months ago. @@ -1300,7 +1278,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Bron Cedex","69500",NA,NA,"France",1,"no",4.83742,45.759372,2023-05-26 -"53",52,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. +"52",51,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Bron NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. The aim of this study is to show that a motor training with a tool (pliers) can improve short-term and long-term language abilities of aphasic patients who had a stroke at least 3 months ago. @@ -1339,7 +1317,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Bron","69500",NA,NA,"France",1,"no",4.83742,45.759372,2023-05-26 -"54",52,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Saint-Genis-Laval NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. +"53",51,"Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia","Stroke Aphasia","May 26, 2023","NCT05776368","Hospices Civils de Lyon Saint-Genis-Laval NA France","Hospices Civils de Lyon","Recruiting","Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke. Nowadays, aphasia rehabilitation is supported by speech therapists and is based on oral and written language, comprehension and expression. However recent studies have shown links between language and motor function (especially tool use). Two domains that share neural substrates (Broca's area, basal ganglia) and that can influence each other. The aim of this study is to show that a motor training with a tool (pliers) can improve short-term and long-term language abilities of aphasic patients who had a stroke at least 3 months ago. @@ -1378,7 +1356,7 @@ Recurrence of a stroke impacting the reorganisation of neural networks Persons deprived of their liberty by a judicial or administrative decision Persons of legal age under a legal protection measure (guardianship, curatorship) Pregnant women, women in labour or nursing mothers, confirmed by questioning the participant Participation in another study at the same time as this one","Accepts Healthy Volunteers","18 Years","All","Saint-Genis-Laval","69230",NA,NA,"France",1,"no",4.792883,45.695002,2023-05-26 -"55",53,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"54",52,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1401,7 +1379,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2021-07-18 -"56",53,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Charleston South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"55",52,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Charleston South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1424,7 +1402,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Charleston","29425","South Carolina",NA,"United States",1,"no",-80.10815,32.792398,2021-07-18 -"57",53,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Columbia South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. +"56",52,"Escitalopram and Language Intervention for Subacute Aphasia","Aphasia Stroke","July 18, 2021","NCT03843463","Johns Hopkins University Columbia South Carolina United States","Johns Hopkins University","Recruiting","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).","In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke). There has been no previous randomized controlled trial (RCT) to evaluate the effect of daily SSRI in the first three months after stroke on improvement of language in people undergoing aphasia treatment. It is plausible that SSRIs, which elevate synaptic serotonin, might enhance recovery by augmenting synaptic plasticity. The investigators propose to conduct a Phase 2 multi-center, randomized, double blind, placebo-controlled trial of escitalopram for augmenting language intervention in subacute stroke. The investigators hypothesize that daily escitalopram for 90 days after stroke results in greater improvement (compared to placebo) in naming untrained pictures, as well as greater increase in content of picture description and greater improvement in morphosyntactic production, when combined with speech and language treatment (SALT). A second aim is to evaluate the mechanisms of language recovery in individuals who receive active medical treatment and those who receive placebo, using resting state functional magnetic resonance imaging (rsfMRI) and genetic testing. The investigators hypothesize that greater improvement in language is associated with increased connectivity within the left hemisphere language network on rsfMRI in participants who receive escitalopram than in those who receive placebo, independently of improvement in depression. The investigators also hypothesize that the effects are greatest in individuals with val/val allele of brain-derived neurotrophic factor (BDNF) - (consistent with previous studies showing a greater response to treatment and greater neuroplasticity in people with the val/val allele than those with one or more met alleles.","","Interventional","Inclusion Criteria: @@ -1447,7 +1425,7 @@ Use of any medication approved by the FDA for treatment of depression at the tim Concomitant use of any monoamine oxidase inhibitors (MAOIs) or pimozide, or other drugs that prolong the QT/QTc interval, triptans (and other 5-Hydroxytryptamine Receptor Agonists), or other contraindications to escitalopram that may be identified. A QTc greater than 450 milliseconds on electrocardiogram or evidence of hyponatremia (Na < 130) at baseline Pregnancy at the time of stroke or planning to become pregnant during the study term.","No","18 Years","All","Columbia","29208","South Carolina",NA,"United States",1,"no",-81.034331,34.000749,2021-07-18 -"58",54,"HD-tDCS for Phonological Impairment in Aphasia","Aphasia Stroke","August 25, 2023","NCT06010030","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). +"57",53,"HD-tDCS for Phonological Impairment in Aphasia","Aphasia Stroke","August 25, 2023","NCT06010030","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). This study will examine the effects of tDCS during speech therapy to further examine which method or methods is best for patient recovery. Patients enrolled in the study will undergo language testing that covers a broad range of language functions. Functional Magnetic Resonance Imaging (fMRI) will be completed before and after speech therapy intervention arms to investigate the neural processes affected by tDCS and speech therapy. @@ -1481,8 +1459,8 @@ Contraindications to MRI such as claustrophobia, implanted electronic devices, M Younger than 18 or older than 85. -< 6 months post tumor resection.","No","18 Years","All","Milwaukee","53226","Wisconsin","Sara Pillay","United States",1,"no",-88.022002,43.04338,2023-08-25 -"59",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Aachen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +< 6 months post tumor resection.","No","18 Years","All","Milwaukee","53226","Wisconsin","Sara Pillay","United States",1,"no",-87.885429,43.057098,2023-08-25 +"58",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Aachen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1507,7 +1485,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Aachen","52074",NA,NA,"Germany",1,"no",6.083862,50.776351,2019-12-06 -"60",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Allensbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"59",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Allensbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1532,7 +1510,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Allensbach","78476",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"61",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Aibling NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"60",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Aibling NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1557,7 +1535,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Aibling","83209",NA,NA,"Germany",1,"no",12.009768,47.86405,2019-12-06 -"62",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Homburg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"61",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Homburg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1582,7 +1560,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Homburg","61348",NA,NA,"Germany",1,"no",8.618313,50.228032,2019-12-06 -"63",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Klosterlausnitz NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"62",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Klosterlausnitz NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1607,7 +1585,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Klosterlausnitz","07639",NA,NA,"Germany",1,"no",11.86817,50.916262,2019-12-06 -"64",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Sülze NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"63",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Bad Sülze NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1632,7 +1610,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Bad Sülze","18334",NA,NA,"Germany",1,"no",12.658113,54.111965,2019-12-06 -"65",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Berlin NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"64",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Berlin NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1657,7 +1635,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Berlin","10115",NA,NA,"Germany",1,"no",13.3888599,52.5170365,2019-12-06 -"66",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Gailingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"65",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Gailingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1682,7 +1660,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Gailingen","78262",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"67",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"66",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1707,7 +1685,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Greifswald","17475",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"68",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"67",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Greifswald NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1732,7 +1710,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Greifswald","17491",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"69",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Göppingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"68",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Göppingen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1757,7 +1735,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Göppingen","73035",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"70",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Heidelberg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"69",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Heidelberg NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1782,7 +1760,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Heidelberg","69117",NA,NA,"Germany",1,"no",8.7112746,49.4121677,2019-12-06 -"71",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Kempen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"70",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Kempen NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1807,7 +1785,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Kempen","47906",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"72",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Leipzig NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"71",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Leipzig NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1832,7 +1810,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Leipzig","04103",NA,NA,"Germany",1,"no",12.374733,51.340632,2019-12-06 -"73",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Lindlar NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"72",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Lindlar NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1857,7 +1835,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Lindlar","51789",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"74",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Marbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"73",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Marbach NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1882,7 +1860,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Marbach","71672",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"75",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Meerbusch NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"74",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Meerbusch NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1907,7 +1885,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Meerbusch","40670",NA,NA,"Germany",1,"no",13.3747075,54.09471,2019-12-06 -"76",56,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Vechta NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: +"75",55,"Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia","Aphasia Post-stroke","December 6, 2019","NCT03930121","University Medicine Greifswald Vechta NA Germany","University Medicine Greifswald","Recruiting","The aim of the study is to investigate whether intensive speech-language therapy (SLT) combined with anodal transcranial direct current stimulation (tDCS) leads to better communication performance than SLT combined with placebo stimulation (using sham-tDCS).","Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, but effect sizes are moderate. This highlights the pressing need to explore adjunct strategies, such as transcranial direct current stimulation (tDCS), to enhance training effectiveness. Recently, the investigators provided evidence from a single-center randomized controlled trial (RCT) suggesting that anodal-tDCS of the left primary motor cortex (M1) improves naming and communication ability in chronic post-stroke aphasia, with medium-to-large effect sizes. However, prior to integration into clinical routine, a multi-center RCT with adequate power, duration, and outcomes relevant to everyday life is required, which is the goal of the present study. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines.","Rehabilitation Intensive speech-language therapy Transcranial direct current stimulation","Interventional","Inclusion Criteria: left-hemisphere cortical or subcortical stroke with first-ever aphasic symptoms at least 6 months post-onset of stroke; @@ -1932,7 +1910,7 @@ severe non-verbal cognitive deficits, as indicated by the Corsi Block-Tapping Ta severe uncontrolled medical problems; severely impaired vision or hearing that prevents patients from engaging in intensive SLT; changes in centrally active drugs within 2 weeks prior to study inclusion.","No","18 Years","All","Vechta","49377",NA,NA,"Germany",1,"no",13.381524,54.095791,2019-12-06 -"77",59,"Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia","Aphasia Apraxia of Speech","December 4, 2018","NCT05248295","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.","Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.","","Interventional","Inclusion Criteria: +"76",58,"Investigating the Effects of Rhythm and Entrainment on Fluency in People With Aphasia","Aphasia Apraxia of Speech","December 4, 2018","NCT05248295","MGH Institute of Health Professions Boston Massachusetts United States","MGH Institute of Health Professions","Recruiting","Speaking in unison with another person is included as a part of many treatment approaches for aphasia. It is not well understood why and how this technique works. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech are most helpful. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? A possible mechanism for this benefit is examined, by testing whether the degree of alignment of a person's speech with that of another speaker can account for unison benefit.","Aphasia is an acquired language disorder, most commonly due to stroke. It can affect an individual's ability to speak, understand spoken language, read, and write. Many treatments designed to improve spoken language in persons with aphasia (PWAs) use unison speech, having the person with aphasia speak along with the clinician or with a recording. One goal of this study is to determine who benefits from speaking in unison, and what characteristics of speech help them the most. Another goal is to investigate a possible mechanism for this benefit: why does speaking in unison help? This knowledge is important because understanding who benefits from this commonly used and potentially powerful therapy component, under which conditions they benefit, and why they do, is critical for customizing therapy so it can be as effective and efficient as possible. Unison speech is conducted using one of two different timing patterns: (1) a natural conversational pattern, which is used in everyday conversations, or (2) a metrical pattern, which follows a beat-based timing framework, as in songs or some poems. In either case, precisely aligning one's speech with that of another person (i.e., entraining one's speech) requires prediction: each speaker must plan their own speech motor commands before having heard the other speaker say the words they are planning. Natural conversational timing requires the speaker to make use of knowledge about language, particularly grammar, to align with the other person. In contrast, a metrical pattern allows a speaker to predict speech timing without relying heavily on language-based knowledge. Given that many PWAs have impaired grammar, we hypothesize that most PWAs will benefit more from speaking in unison to sentences with metrical vs. conversational timing patterns. However, there is great variation in linguistic, motor speech, and timing skills across PWAs, so metrical and conversational timing patterns are likely to have different degrees of effectiveness for different individuals. Results from this study will demonstrate how individual characteristics and speech timing affect whether or not a person with aphasia benefits from speaking in unison. Results will also indicate whether a speaker's ability to predict speech timing is necessary for a benefit of unison speech. Prediction ability will be measured by how closely the speaker aligns their speech with a spoken model.","","Interventional","Inclusion Criteria: Native-speaker fluency in American English (prior to stroke for people with aphasia) Controls must report no history of speech, language, neurological disorders, or stroke @@ -1944,7 +1922,7 @@ Inadequate hearing ability to reliably complete task: fail hearing screen Inadequate cognitive ability to understand and remember task: fail cognition screening (different measures for controls and people with aphasia) Inadequate speech repetition ability to complete task, or to be considered a control: fail speech repetition screening (different thresholds for controls and people with aphasia) Inadequate auditory comprehension ability to understand task: fail auditory comprehension screen (people with aphasia only)","Accepts Healthy Volunteers","18 Years","All","Boston","02129","Massachusetts","Lauryn Zipse, Ph.D., CCC-SLP","United States",1,"no",-71.0537615,42.3756115,2018-12-04 -"78",62,"Individualized Precision rTMS for Language Recovery in Patients After Ischemic Stroke: a Multi-center RCT","Stroke, Ischemic Aphasia","June 5, 2023","NCT05842304","Changping Laboratory Beijing NA China","Changping Laboratory","Recruiting","The current multi-center study aims to evaluate the efficacy and safety of pBFS-guided rTMS Neuromodulation Treatment for the rehabilitation of language functions in ischemic stroke aphasic patients.","Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a multi-center, double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized TMS intervention in post-stroke aphasic patients. +"77",61,"Individualized Precision rTMS for Language Recovery in Patients After Ischemic Stroke: a Multi-center RCT","Stroke, Ischemic Aphasia","June 5, 2023","NCT05842304","Changping Laboratory Beijing NA China","Changping Laboratory","Recruiting","The current multi-center study aims to evaluate the efficacy and safety of pBFS-guided rTMS Neuromodulation Treatment for the rehabilitation of language functions in ischemic stroke aphasic patients.","Increasing evidence suggests that rTMS has been effective in treating various psychological and neurological diseases, including treating post-stroke symptoms. Using the personalized brain functional sectors (pBFS) technique, we could precisely identify individualized brain functional networks and the personalized language-related stimulation site based on the resting-state functional MRI data. The current study proposes to conduct a multi-center, double-blinded, randomized and parallel controlled design trial, to investigate the efficacy and safety of pBFS-guided personalized TMS intervention in post-stroke aphasic patients. Subjects will be randomly assigned to the following two groups: active continuous TBS (cTBS) group, or a sham control group. The allocation ratio will be 2:1. Subjects will receive a 3-week treatment for 21 consecutive days. The stimulation procedure will be assisted with real-time neuronavigation to ensure its precision.","","Interventional","Inclusion Criteria: @@ -1973,7 +1951,7 @@ History of alcohol, drug, and/or other abuse. Patients with other test abnormalities judged by the investigator to be unsuitable for the trial. Women of childbearing age who are pregnant or preparing for pregnancy. Patients who are participating in other clinical research trials.","No","35 Years","All","Beijing",NA,NA,NA,"China",1,"no",116.225091,40.219646,2023-06-05 -"79",66,"Treatment Outcomes With tDCS in Post-Stroke Aphasia","Aphasia","September 3, 2019","NCT03929432","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.","Aphasia is a language impairment that commonly occurs following brain damage (e.g., stroke). While language rehabilitation can yield improved language functioning, treatment outcomes vary greatly across individuals. In chronic aphasia, language gains occur through the brain's inherent ability to reorganize (i.e., neuroplasticity). +"78",65,"Treatment Outcomes With tDCS in Post-Stroke Aphasia","Aphasia","September 3, 2019","NCT03929432","University of Arkansas Little Rock Arkansas United States","University of Arkansas","Recruiting","The purpose this study is to test the utility of pairing external neuromodulation with behavioral language treatment to boost therapy outcomes and to investigate the mechanisms associated with recovery. Because all PWA have word retrieval deficits, this project will test if greater language gains can be achieved by supplementing anomia intervention with excitatory brain stimulation to the left hemisphere and will evaluate associated functional brain changes to aid the optimization of neural reorganization to facilitate language processing.","Aphasia is a language impairment that commonly occurs following brain damage (e.g., stroke). While language rehabilitation can yield improved language functioning, treatment outcomes vary greatly across individuals. In chronic aphasia, language gains occur through the brain's inherent ability to reorganize (i.e., neuroplasticity). While Speech-language therapy (SLT) can target various language skills and modalities, the most pervasive deficit across all persons with aphasia (PWA) is difficulty with word finding. Thus, aphasia treatment often includes some form of intervention focused on improving naming abilities. As with language function in general, naming abilities in PWA seems to be associated with left hemisphere recruitment, particularly with the viable tissue at the rim of the lesion (perilesional areas). This project investigates an innovative approach to improving current therapy by examining the benefits of using excitatory transcranial direct current stimulation (tDCS) stimulation/neuromodulation during anomia treatment (i.e. word-finding treatment). @@ -2000,7 +1978,7 @@ Co-occurring history of neurological disease/disorder/injury (e.g., traumatic br Co-occurring history of a major mental illness (e.g., schizophrenia, drug addiction, bipolar) Clinical conditions contraindicated for MRI or tDCS (e.g., implanted electrical devices, claustrophobia, seizure disorder) Positive pregnancy test (for females)","No","18 Years","All","Little Rock","72205","Arkansas",NA,"United States",1,"no",-92.3396525,34.7224165,2019-09-03 -"80",75,"Transcranial Alternating Current Stimulation (tACS) in Aphasia","Aphasia Stroke","January 4, 2020","NCT04375722","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States (NIH-NIDCD, 2015). Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits by providing brain stimulation concurrent with therapies. Transcranial direct current stimulation (tDCS) is one of the most widely used such technique. While tDCS has had relative success in chronic aphasia (>6 months after stroke), it has not been efficacious during subacute stages (<3 months after stroke). But enhancing language recovery early after stroke is desirable because of its potential impact on long-term language outcomes and quality-of-life. +"79",74,"Transcranial Alternating Current Stimulation (tACS) in Aphasia","Aphasia Stroke","January 4, 2020","NCT04375722","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke as well as healthy language functions.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States (NIH-NIDCD, 2015). Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits by providing brain stimulation concurrent with therapies. Transcranial direct current stimulation (tDCS) is one of the most widely used such technique. While tDCS has had relative success in chronic aphasia (>6 months after stroke), it has not been efficacious during subacute stages (<3 months after stroke). But enhancing language recovery early after stroke is desirable because of its potential impact on long-term language outcomes and quality-of-life. The current study will investigate the efficacy of high-definition tACS (HD-tACS) to help restore neural oscillatory activity in aphasia. TACS differs from tDCS in that sinusoidal, alternating currents are delivered rather than constant currents. TACS can manipulate the ongoing oscillatory neuronal activity and potentially increase functional synchronization (or connectivity) between targeted areas. This feature of tACS is quite attractive, given the new body of evidence suggesting that language impairments stem from diminished functional connectivity and disruptions in the language network due to stroke. The selection of tACS frequencies in this study is guided by our preliminary work examining pathological neural oscillations found near stroke-lesioned areas (or perilesional) in aphasia. By exogenously tuning the perilesional oscillations with tACS, the investigators hope to up-regulate communication across these areas and other connected areas to improve language outcome. If successful, tACS will be a powerful and novel treatment approach with reverberating positive impact on long-term recovery. @@ -2031,8 +2009,8 @@ The presence of cardiac stimulators or pacemakers Any metal implants in the skull Contraindications to MRI or tACS History of seizures -History of dyslexia or other developmental learning disabilities","Accepts Healthy Volunteers","18 Years","All","Milwaukee","53226","Wisconsin","Priyanka Shah-Basak, PhD","United States",1,"no",-88.022002,43.04338,2020-01-04 -"81",79,"Treatment of Grammatical Time Marking in Post-Stroke Aphasia","Brain Injury, Vascular Aphasia Stroke","December 30, 2022","NCT05656638","University of Neuchatel Neuchâtel NA Switzerland","University of Neuchatel","Recruiting","The study aims to assess a individual or group therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. +History of dyslexia or other developmental learning disabilities","Accepts Healthy Volunteers","18 Years","All","Milwaukee","53226","Wisconsin","Priyanka Shah-Basak, PhD","United States",1,"no",-87.885429,43.057098,2020-01-04 +"80",78,"Treatment of Grammatical Time Marking in Post-Stroke Aphasia","Brain Injury, Vascular Aphasia Stroke","December 30, 2022","NCT05656638","University of Neuchatel Neuchâtel NA Switzerland","University of Neuchatel","Recruiting","The study aims to assess a individual or group therapy's effectiveness in grammatical time marking. The main objective is to examine whether the therapy improves grammatical time marking of inflected verbs treated on the sessions. We also explore whether the observed progress can be transferred to untrained items, more ecological contexts and if is maintained two and four weeks after the end of treatment. This therapy will be administered to nine individuals with brain lesions after stroke. Five individuals will take part of the individual therapy and four individuals will take part of the group therapy (two individuals per group). The therapy will last one month, at the rate of three weekly sessions of approximately one hour.",NA,"","Interventional","Inclusion Criteria: @@ -2049,7 +2027,7 @@ Have significant impairments in oral/written comprehension. Present apraxia of speech or a severe arthritic disorder Present hemineglect Present impaired judgment and discernment, objectified by a neuropsychological evaluation","No","18 Years","All","Neuchâtel","2000",NA,"Marion Fossard","Switzerland",1,"no",6.931074,46.993392,2022-12-30 -"82",80,"Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia","Stroke Aphasia Apraxia of Speech","July 22, 2020","NCT04816799","Arizona State University Tempe Arizona United States","Arizona State University","Recruiting","A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted. Subjects and assessors will be blinded to the condition making the experiment double blind. Specifically, subjects will be told that we are exploring a new therapy that using different sounds to improve therapy. Parallel group design will ensure that subjects in the Control group are unaware that their ""sounds"" are softer than the START group. Trainers may become aware that a loud sound is present thus a unique Assessor will evaluate clinical performance before and after training making the study double-blind. Fifty-four subjects will undergo baseline testing in the laboratory to establish their capacity for functional and expressive speech as well as their self-reported health-related quality of life (power analysis below). Next, subjects will participate in a high-frequency, word-picture verification/ auditory-repetition treatment, 2 hr/day for 5 consecutive days focusing on expression of words of functional significance (e.g., water, fall). Subjects will either receive training with START or without (Control). Subjects will be re-tested immediately following training as well as one-month post to assess retention. Aim 1 will evaluate capacity of START to enhance SLT outcomes by assessing the % change in clinical assessment of functional and expressive speech. Our preliminary data points to a robust response [details]. Aim 2 will focus on the capacity of these changes to 1) be retained and 2) impact subject's reported quality of life. NOTE: While we are planning in-person baseline, end, and retention testing, in response to COVID, we have established remote clinical screening using peer-reviewed validated techniques for WAB and ABA-2 (see Alternative Solutions). All preliminary data collected for this proposal were collected remotely via no-contact protocols.",NA,"","Interventional","Inclusion Criteria: +"81",79,"Efficacy of START (Startle Rehabilitation Therapy) in the Treatment Stroke-induced Aphasia/Apraxia","Stroke Aphasia Apraxia of Speech","July 22, 2020","NCT04816799","Arizona State University Tempe Arizona United States","Arizona State University","Recruiting","A stratified, parallel-group, double-blind, randomized controlled trial of remotely delivered START treatment to individuals with severe-to-moderate stroke (with recruitment focused on individuals with low SES) will be conducted. Subjects and assessors will be blinded to the condition making the experiment double blind. Specifically, subjects will be told that we are exploring a new therapy that using different sounds to improve therapy. Parallel group design will ensure that subjects in the Control group are unaware that their ""sounds"" are softer than the START group. Trainers may become aware that a loud sound is present thus a unique Assessor will evaluate clinical performance before and after training making the study double-blind. Fifty-four subjects will undergo baseline testing in the laboratory to establish their capacity for functional and expressive speech as well as their self-reported health-related quality of life (power analysis below). Next, subjects will participate in a high-frequency, word-picture verification/ auditory-repetition treatment, 2 hr/day for 5 consecutive days focusing on expression of words of functional significance (e.g., water, fall). Subjects will either receive training with START or without (Control). Subjects will be re-tested immediately following training as well as one-month post to assess retention. Aim 1 will evaluate capacity of START to enhance SLT outcomes by assessing the % change in clinical assessment of functional and expressive speech. Our preliminary data points to a robust response [details]. Aim 2 will focus on the capacity of these changes to 1) be retained and 2) impact subject's reported quality of life. NOTE: While we are planning in-person baseline, end, and retention testing, in response to COVID, we have established remote clinical screening using peer-reviewed validated techniques for WAB and ABA-2 (see Alternative Solutions). All preliminary data collected for this proposal were collected remotely via no-contact protocols.",NA,"","Interventional","Inclusion Criteria: 18 years old Native English Speakers @@ -2063,7 +2041,7 @@ Corrected pure tone threshold (octave frequencies 250- 4000 Hz) norms for their Exclusion Criteria: Severe concurrent uncontrolled medical problems (e.g. cardiorespiratory impairment).","No","18 Years","All","Tempe","85287","Arizona","Claire Honeycutt","United States",1,"no",-111.932727,33.416893,2020-07-22 -"83",82,"tDCS Effects on Brain Plasticity in Aphasia Treatment","Aphasia Stroke","November 1, 2021","NCT05483556","The Hong Kong Polytechnic University Kowloon NA Hong Kong","The Hong Kong Polytechnic University","Recruiting","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI. +"82",81,"tDCS Effects on Brain Plasticity in Aphasia Treatment","Aphasia Stroke","November 1, 2021","NCT05483556","The Hong Kong Polytechnic University Kowloon NA Hong Kong","The Hong Kong Polytechnic University","Recruiting","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI.","The efficacy of conventional speech therapy alone for aphasia recovery is inconclusive. The prospective study will monitor the effects of combined language therapy and tDCS through structural and functional MRI. This randomized, placebo-controlled, double-blinded pilot study will recruit ten chronic stroke patients with Broca's Aphasia randomly assigned either to sham or an anodal tDCS groups. Following speech and language assessment, all the participants will receive 20 minutes of individualized language therapy daily for ten days in two consecutive weeks. Simultaneously, the treatment group will receive 20 minutes of 2mA anodal HD-tDCS over the left IFG, while the sham group will receive the 30s of 2mA anodal HD-tDCS. Structural, resting state and task activated functional MRI will be performed. Data acquisition will be performed before, immediately after and two months after the treatment. @@ -2084,7 +2062,7 @@ Wernicke's aphasia and other speech disorders, degenerative, psychiatric or meta Deaf, blind, pregnant/ or preparing for pregnancy, cognitive issues, tattoos Have cochlear implants, pacemaker, surgical nails for bone fracture, artificial joints, dental braces, dentures Taking anti-depressant medications","No","18 Years","All","Kowloon",NA,NA,"Dr Min Wong","Hong Kong",1,"no",114.179821,22.3046025,2021-11-01 -"84",84,"Effects of Verb Network Strengthening Treatment (VNeST) on Word Finding in Aphasia","Anomia Aphasia Stroke","January 16, 2022","NCT05152979","Göteborg University Gothenburg Västra Götaland Sweden","Göteborg University","Recruiting","Although there is evidence that speech-language therapy may improve speech in language disorders following left hemisphere stroke there is still a lack of evidence for which types of therapy are effective. Furthermore, in Sweden, as well as in several other countries, access to speech-language therapy is limited. The purpose of this clinical trial is to compare outcome from Verb Network Strengthening Treatment (VNeST) provided as In-Clinic therapy (I-CT) or as synchronous telepractice therapy (TP-T).","Every year thousands of persons in Sweden suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia is one of the most common and persistent symptoms of aphasia following a left hemisphere stroke, but it is also common in in progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). There is evidence that more intensive speech language therapy may improve speech even in a chronic (> six month post stroke) phase of aphasia. However, access to the necessary amount of speech language therapy is limited due to lack of financial resources as well as to limitations to service providers in more rural areas. +"83",83,"Effects of Verb Network Strengthening Treatment (VNeST) on Word Finding in Aphasia","Anomia Aphasia Stroke","January 16, 2022","NCT05152979","Göteborg University Gothenburg Västra Götaland Sweden","Göteborg University","Recruiting","Although there is evidence that speech-language therapy may improve speech in language disorders following left hemisphere stroke there is still a lack of evidence for which types of therapy are effective. Furthermore, in Sweden, as well as in several other countries, access to speech-language therapy is limited. The purpose of this clinical trial is to compare outcome from Verb Network Strengthening Treatment (VNeST) provided as In-Clinic therapy (I-CT) or as synchronous telepractice therapy (TP-T).","Every year thousands of persons in Sweden suffer from brain damage resulting in anomia, that is, word finding difficulties affecting their ability to talk to other people. Anomia is one of the most common and persistent symptoms of aphasia following a left hemisphere stroke, but it is also common in in progressive neurological diseases such as Parkinson's disease or multiple sclerosis (MS). There is evidence that more intensive speech language therapy may improve speech even in a chronic (> six month post stroke) phase of aphasia. However, access to the necessary amount of speech language therapy is limited due to lack of financial resources as well as to limitations to service providers in more rural areas. It has been suggested that telepractice may increase the access to speech-language therapy for more people but there is a lack of knowledge of whether there is a difference in outcome from interventions provided as In-Clinic therapy (I-CT) or as telepractice therapy (TP-T). @@ -2106,7 +2084,7 @@ Moderately or severely impaired comprehension Moderate-severe apraxia of speech or dysarthria which may interfere with assessment Participation in any other speech-language treatment during the study Active substance dependence","No","18 Years","All","Gothenburg","40530","Västra Götaland",NA,"Sweden",1,"no",11.961307,57.6970935,2022-01-16 -"85",85,"Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia","Aphasia Non Fluent Stroke","May 5, 2022","NCT04433351","University Hospital, Grenoble Grenoble NA France","University Hospital, Grenoble","Recruiting","SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.","In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.","post-stroke aphasia non-fluent aphasia speech rehabilitation neuroimaging neural reorganization recovery","Interventional","Inclusion Criteria: +"84",84,"Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia","Aphasia Non Fluent Stroke","May 5, 2022","NCT04433351","University Hospital, Grenoble Grenoble NA France","University Hospital, Grenoble","Recruiting","SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.","In this project, the investigators propose to evaluate the effectiveness of a new rehabilitation program, based on illustration of speech articulators, to improve speech in patients with non-fluent aphasia. The instigators' method is based on the reinforcement of the interaction between perceptual and motor representations, thanks to the innovative Ultraspeech device. The investigators will exploit a fundamental psycholinguistic principle, which postulates that speech is based both on the activation of the system controlling the motricity of effectors related to word articulation (action) and on the auditory or visual representation of words (perception). The sensory-motor interaction method that the investigators propose allows the patient to perceive phonemes and visualize on a computer screen the movements of the tongue and lips previously recorded by a healthy speaker, typically a speech therapist. Through repeated exercises, the patient is trained to produce sounds correctly, using the correct pronunciation and articulatory movements of the reference speaker as a model. The investigators will compare patients who will follow a classical speech and language therapy rehabilitation program followed by an 'enriched' rehabilitation program including rehabilitation based on sensory-motor interaction associated with speech and language therapy, and vice versa. In order to judge the favorable effect of the rehabilitation program including sensory-motor integration, the following measures will be considered: (a) language skills, (b) phonemic quality, (c) inner speech abilities and (d) cognitive function. Brain language networks will be evaluated with neuroimaging.","post-stroke aphasia non-fluent aphasia speech rehabilitation neuroimaging neural reorganization recovery","Interventional","Inclusion Criteria: patients with late sub-acute and chronic post-stroke (> 4 months) non-fluent aphasia after lesion in the dominant hemisphere for language native speakers of French @@ -2116,7 +2094,7 @@ satisfying all criteria for the MRI examination Exclusion Criteria: patients with comprehension deficits, hemi-spatial neglect or upper limb apraxia","No","55 Years","All","Grenoble","38043",NA,NA,"France",1,"no",5.735782,45.18756,2022-05-05 -"86",89,"Effects of Transcranial Direct Current Stimulation (tDCS) on Language","Stroke Aphasia","December 1, 2019","NCT04166513","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). +"85",88,"Effects of Transcranial Direct Current Stimulation (tDCS) on Language","Stroke Aphasia","December 1, 2019","NCT04166513","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will investigate the effects of mild electrical stimulation in conjunction with speech therapy for people with post-stroke aphasia to enhance language recovery.","Aphasia is a disturbance of language, primarily caused by brain injury to the left cerebral hemisphere. Aphasia treatments include speech and language therapy and pharmacologic therapy, but several studies have found that these treatments are not completely effective for patients with aphasia, leaving them with residual deficits that significantly add to the cost of stroke-related care. Additionally, the amount and frequency of speech and language therapy delivered may have a critical effect on recovery. Therefore, there is a need for new treatments or adjuncts to existing treatments, such as brain stimulation interventions, that have the potential to show greater improvements in patients with aphasia. One such new approach for non-invasive brain stimulation is transcranial direct current stimulation (tDCS). This study will examine the effects of tDCS during speech therapy to further examine which method or methods is best for patient recovery. Patients enrolled in the study will undergo language testing that covers a broad range of language functions. Functional Magnetic Resonance Imaging (fMRI) will be completed before and after speech therapy intervention arms to investigate the neural processes affected by tDCS and speech therapy. @@ -2133,8 +2111,8 @@ Exclusion Criteria: Advanced neurodegenerative disease (i.e. Stage 3 Alzheimer's disease) or neurologic disorder (e.g. idiopathic epilepsy, Parkinson's disease, ALS) Severe psychopathology (e.g. schizophrenia, bipolar disorder, acute major depressive episode) No suspected or diagnosed uncorrectable hearing or vision difficulties, or developmental disabilities (i.e. intellectual disability or learning disability). -Contraindications to MRI such as claustrophobia, implanted electronic devices, MRI-incompatible metal in the body, extreme obesity, pregnancy, inability to lie flat, and inability to see or hear stimulus materials","No","18 Years","All","Milwaukee","53226","Wisconsin","Sara Pillay","United States",1,"no",-88.022002,43.04338,2019-12-01 -"87",91,"Intention Treatment for Anomia","Aphasia Stroke","May 24, 2021","NCT04267198","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As the population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, the investigators will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge the investigators gain will have direct implications for the selecting the right treatment approach for the right Veteran.","Difficulty retrieving words is one of the most common language complaints in individuals with stroke-induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, the investigators currently know very little about optimal treatment administration parameters, and the investigators know even less about predictors of treatment response. To make the best use of the limited clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, the investigators must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. This study takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and by identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Specifically, the investigators will address the following aims: +Contraindications to MRI such as claustrophobia, implanted electronic devices, MRI-incompatible metal in the body, extreme obesity, pregnancy, inability to lie flat, and inability to see or hear stimulus materials","No","18 Years","All","Milwaukee","53226","Wisconsin","Sara Pillay","United States",1,"no",-87.885429,43.057098,2019-12-01 +"86",90,"Intention Treatment for Anomia","Aphasia Stroke","May 24, 2021","NCT04267198","VA Office of Research and Development Decatur Georgia United States","VA Office of Research and Development","Recruiting","Every year approximately 15,000 Veterans are hospitalized for stroke, and up to 40% of those Veterans will experience stroke-related language impairment (i.e., aphasia). Stroke-induced aphasia results in increased healthcare costs and decreased quality of life. As the population of Veterans continues to age, there will be an increasing number for Veterans living with the aphasia and its consequences. Those Veterans deserve to receive aphasia treatment designed to facilitate the best possible outcomes. In the proposed study, the investigators will investigate optimal treatment intensity and predictors of treatment response for a novel word retrieval treatment. The knowledge the investigators gain will have direct implications for the selecting the right treatment approach for the right Veteran.","Difficulty retrieving words is one of the most common language complaints in individuals with stroke-induced aphasia. The negative consequences related to word retrieval impairment include increased health care costs and decreased quality of life. A variety of treatment approaches exist to improve word retrieval, and most of the treatments result in immediate improvement on trained words. However, long-term improvement and improvement on untrained words or behaviors is less common. Additionally, the investigators currently know very little about optimal treatment administration parameters, and the investigators know even less about predictors of treatment response. To make the best use of the limited clinical resources available for aphasia treatment, and to maximize outcomes for Veterans with aphasia, the investigators must: 1) develop clinically translatable treatments that yield widespread and lasting effects and 2) develop clinically accessible ways of identifying who will acquire benefit from a specific treatment approach. This study takes on these two challenges by investigating dose frequency (massed vs. distributed practice) effects and by identifying the language, cognitive and neural predictors of response to Intention treatment (INT), a novel word retrieval treatment. Specifically, the investigators will address the following aims: Aim 1: To investigate dose frequency effects on maintenance and generalization of INT gains. Outcome measure: Word retrieval accuracy for trained and untrained words. @@ -2153,7 +2131,7 @@ Exclusion Criteria: Severe apraxia of speech or dysarthria Clinically significant depression For MRI safety: implanted medical devices, metal in the body and claustrophobia.","No","21 Years","All","Decatur","30033-4004","Georgia",NA,"United States",1,"no",-84.296069,33.773758,2021-05-24 -"88",93,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. +"87",93,"The Impact of Group Singing on Patients With Stroke and Their Personal Caregivers","Stroke and Aphasia","April 4, 2014","NCT02328573","Icahn School of Medicine at Mount Sinai New York New York United States","Icahn School of Medicine at Mount Sinai","Recruiting","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care","The study will focus on the impact of communal singing on patients with stroke and their personal caregivers. Forty post-stroke patients will be randomly assigned to two groups: the first group of 20 stroke survivors and their caregivers (up to 40 total participants) will receive 6 months (approximately 24 sessions) of music therapy. The second control groups of 20 stroke survivors and their caregivers will receive standard post-stroke care. All enrolled participants will be assessed on their mood, past music experience and music genre preference (music therapy assessment). They will complete the abridged Beck (BDI-2-fastscreen) questionnaire, the stoke and aphasia quality of life scale; a Likert which measures distress; the Western Aphasia Battery (WAB); the NIH Stroke Scale (SS); the Figely compassion scale; and the driving scene test (Stern and White); and the Rankin. In additional we will take saliva samples from all participants to measure hormone levels. @@ -2164,7 +2142,7 @@ Stroke victim, regardless of level of stroke Exclusion Criteria: None","No","18 Years","All","New York","10003","New York","Joanne Loewy","United States",1,"no",-73.953275,40.7898205,2014-04-04 -"89",98,"Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke","Stroke Aphasia","November 2023","NCT06048159","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States. Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits, potentially with brain stimulation concurrent with therapies. +"88",98,"Transcranial Alternating Current Stimulation (tACS) for the Recovery of Phonological Short-Term Memory in Patients With Aphasia After Stroke","Stroke Aphasia","November 2023","NCT06048159","Medical College of Wisconsin Milwaukee Wisconsin United States","Medical College of Wisconsin","Recruiting","This study will assess the effects of transcranial alternating current stimulation (tACS) on language recovery after stroke.","Aphasia is a debilitating disorder, typically resulting from damage to the left hemisphere, that can impair a range of communication abilities, including language production and comprehension, reading, and writing. Approximately 180,000 new cases of aphasia are identified per year, and approximately 1 million or 1 in 250 are living with aphasia in the United States. Treatments are limited and provide modest benefits at best. The current emphasis in aphasia rehabilitation is to formulate intensive speech and language therapies and augment therapeutic benefits, potentially with brain stimulation concurrent with therapies. The current study will investigate the efficacy of high-definition tACS (HD-tACS) to help restore neural oscillatory activity in stroke survivors with aphasia. TACS differs from trancranial direct current stimulation (tDCS), a widely used brain stimulation paradigm, in that sinusoidal or alternating currents are delivered rather than direct currents. TACS is shown to manipulate ongoing oscillatory brain activity and also to modulate synchronization (or connectivity) between targeted brain areas. This feature of tACS is quite attractive, given the new body of evidence suggesting that language impairments stem from diminished brain connectivity and ensuing disruptions in the language network due to stroke. @@ -2183,8 +2161,8 @@ A chronic medical condition that is not treated or is unstable The presence of cardiac stimulators or pacemakers Contraindications to MRI or tACS, e.g. patients with metallic implants, and/or history of skull fractures, pregnancy, skin diseases History of ongoing or unmanaged seizures -History of dyslexia or other developmental learning disabilities","No","18 Years","All","Milwaukee","53226","Wisconsin","Priyanka Shah-Basak, PhD","United States",1,"no",-88.022002,43.04338,2023-11-20 -"90",101,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: +History of dyslexia or other developmental learning disabilities","No","18 Years","All","Milwaukee","53226","Wisconsin","Priyanka Shah-Basak, PhD","United States",1,"no",-87.885429,43.057098,2023-11-20 +"89",101,"Brain-based Understanding of Individual Language Differences After Stroke","Aphasia Stroke Alexia","November 1, 2018","NCT04991519","Georgetown University Washington District of Columbia United States","Georgetown University","Recruiting","Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique course of recovery. The BUILD study aims to understand the brain basis of these individual differences in stroke outcome. Participants with stroke as well as controls matched in age, educational background, race, and sex are examined using a combination of standardized and in-house tests of language and cognition to provide a detailed profile of strengths and weaknesses. Each participant will have between three and six sessions, including an MRI to measure details of the structure, function, and connections in the brain. The data are analyzed to test how patterns in the stroke lesion explain the patterns of communication and cognitive difficulties, and how patterns in the uninjured parts of the brain explain resilience and recovery from the stroke. Ultimately, we hope that BUILD will guide us toward new targets for brain stimulation treatments or other biologically based treatments that improve language and cognitive abilities after stroke.",NA,"aphasia stroke brain injury speech language reading alexia apraxia","Observational","Inclusion Criteria: Stroke Survivors: @@ -2209,7 +2187,7 @@ Additional Exclusion Criteria for MRIs: Pacemaker or magnetic metal in the body that is not MRI compatible Pregnancy Claustrophobia","Accepts Healthy Volunteers","18 Years","All","Washington","20057","District of Columbia",NA,"United States",1,"no",-77.078807,38.911961,2018-11-01 -"91",103,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: +"90",103,"Producing Increasingly Complex Themes Using Right-hemisphere Engagement (PICTURE) Implemented With Telemedicine","Aphasia Stroke","May 31, 2023","NCT05845047","Johns Hopkins University Baltimore Maryland United States","Johns Hopkins University","Recruiting","The investigators propose a pilot crossover trial of 2 behavioral language treatments, with randomized order of treatments and blinded assessors, to determine if a therapy designed to stimulate right hemisphere functions (Producing Increasingly Complex Themes Using Right-hemisphere Engagement Implemented with Telemedicine - PICTURE IT; described below) is more effective in improving discourse than a published computer delivered lexical treatment (shown previously to improve naming) in subacute post-stroke aphasia.","The investigators will carry out a crossover study with randomized order of treatment conditions and blinded assessors, to compare changes in content and efficiency of discourse (primary outcome measures) from before treatment to immediately after treatment, to compare intervention focused on engaging the right hemisphere (PICTURE IT; see below) to a purely lexical treatment (see details below). Secondary outcome measures will be: (1) changes in discourse from pre-treatment to 2 weeks post-treatment, and (2) changes in naming of objects and actions from immediately before treatment to immediately after treatment, and (3) changes in naming of objects and actions from pre-treatment to 2 months after both treatments. The investigators will also carry out resting state functional near infrared spectroscopy (fNIRS) before and after each treatment to evaluate degree and location (e.g. intrahemispheric right versus left) of changes in connectivity associated with each treatment and with changes in each outcome measure. The investigators will also take saliva samples from participants who agree to this optional part of the study to determine the participants brain-derived neurotrophic factor status.","","Interventional","Inclusion Criteria: Diagnosis of aphasia secondary to stroke and presence of naming deficits (at least 20% errors on the Boston Naming Test or Hopkins Action Naming Assessment) Capable of giving informed consent or indicating another to provide informed consent @@ -2223,7 +2201,7 @@ Lack of English proficiency (by self/legally authorized representative report) Prior history of neurologic disease affecting the brain (e.g., brain tumor, multiple sclerosis, traumatic brain injury) other than stroke Prior history of severe psychiatric illness, developmental disorders or intellectual disability (e.g., PTSD, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders) Uncorrected severe visual loss or hearing loss by self-report and medical records","No","18 Years","All","Baltimore","21287","Maryland",NA,"United States",1,"no",-76.6204945,39.3289375,2023-05-31 -"92",106,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. +"91",106,"Effects of Transcranial Direct Current Stimulation (tDCS) on Brain Organization and Naming in Aphasic Patients.","Stroke Aphasia","October 24, 2022","NCT05570578","University Hospital, Geneva Geneva GE Switzerland","University Hospital, Geneva","Recruiting","High-Definition Transcranial Direct Current Stimulation (HD-tDCS) allows to induce, in a non-invasive way, a transient inhibitory or excitatory neuromodulation of a given cerebral region and to obtain a very focused cortical effect. Previous studies using HD-tDCS have shown the effectiveness of this stimulation technique for enhancing language recovery in patients with aphasia. However, language processes are not determined solely by local neural activity at a single site, but rather by the interaction between neural networks. This is because a large cortical network is involved in language processes and, therefore, the same language disorder may result from lesions at different locations in this network. @@ -2249,7 +2227,7 @@ Impaired alertness or delirium Severe co-morbidity affecting speech Contraindication to tDCS: pregnant women, patients with active implants such as pacemakers or cochlear implants, patients with one or more seizures, metal objects in the brain Occurrence of a new stroke during the study protocol.","No","18 Years","All","Geneva","1211","GE","Adrian Guggisberg","Switzerland",1,"no",6.1486155,46.1937405,2022-10-24 -"93",116,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: +"92",116,"Longitudinal Imaging of Microglial Activation in Different Clinical Variants of Alzheimer's Disease","Alzheimer Disease","November 17, 2020","NCT04576793","Columbia University New York New York United States","Columbia University","Recruiting","The purpose of this study is to determine how inflammation is related to other changes in the brain that occur during the progression of Alzheimer's disease. The investigators are also studying how inflammation is related to the symptoms that first occur in patients with Alzheimer's disease (AD). For this reason, the investigators are asking people with different versions of Alzheimer's disease to participate. This includes patients with either: Posterior cortical atrophy - a version of Alzheimer's disease with vision difficulties Logopenic variant primary progressive aphasia - a version of Alzheimer's disease with language difficulties @@ -2283,7 +2261,7 @@ Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophob Exposure to research related radiation in the past year that, when combined with this study, would place subjects above the allowable limits. Participation in the last year in a clinical trial for a disease modifying drug for AD. Taking immunosuppressive medication (e.g., glucocorticoids, cytostatics, antibodies, drugs acting on immunophilins, interferons, tumor necrosis factor inhibitors). Nonsteroidal anti-inflammatory drugs (NSAIDs) are not exclusionary.","Accepts Healthy Volunteers","50 Years","All","New York","10032","New York","James M Noble, MD, MS, CPH, FAAN","United States",1,"no",-73.9622875,40.807223,2020-11-17 -"94",167,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: +"93",166,"Music Intervention and Transcranial Electrical Stimulation for Neurological Diseases","Disorder of Consciousness Stroke","September 1, 2022","NCT05706831","Istituti Clinici Scientifici Maugeri SpA Bari Ba Italy","Istituti Clinici Scientifici Maugeri SpA","Recruiting","The goal of this clinical trial is to evaluate the efficacy of a musical interventionand non-invasive brain stimulation in neurological patients. The main questions it aims to answer are: to evaluate the residual neuroplastic processes in DOC state related to music exposure to determine the putative modulation of the aforementioned processes and the clinical outcome of DOC patients by non-pharmacological strategies, i.e., electric (tDCS) and music stimulation @@ -2304,9 +2282,9 @@ No hystory of psychiatric disease Previous stroke use of alcohol and drugs premorbid dementia","No","18 Years","All","Bari","70025","Ba","Simona Spaccavento","Italy",1,"no",16.862029,41.125784,2022-09-01 -"95",NA,"Functional reorganization of the language and domain-general multiple demand systems in aphasia",NA,"March 1, 2022","manual1","Boston, MA","Boston University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Boston",NA,"Massachusetts","Swathi Kiran",NA,NA,"no",-71.058291,42.360253,2022-03-01 -"96",NA,"Characterizing inner speech in aphasia",NA,"March 9, 2022","manual2","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 -"97",NA,"Inner speech as a naming therapy predictor in aphasia",NA,"March 9, 2022","manual3","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 -"98",NA,"Measuring and understanding the experience of post-traumatic growth in aphasia",NA,"March 9, 2022","manual4","Reno, NV","University of Nevada Reno",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Reno",NA,"Nevada","Tami Brancamp",NA,NA,"Online",-119.812658,39.526121,2022-03-09 -"99",NA,"Reading in Aphasia",NA,"January 1, 2020","manual5","Atlanta, GA","Georgia State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Atlanta",NA,"GA","Rachael Harrington",NA,NA,"Online",-84.390264,33.748992,2020-01-01 -"100",NA,"Assessment of anomia: Improving efficiency and utility using item response theory",NA,"August 31, 2020","manual6","Portland, OR","Portland State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Portland",NA,"OR","Gerasimos Fergadiotis",NA,NA,"no",-122.674195,45.520247,2020-08-31 +"94",NA,"Functional reorganization of the language and domain-general multiple demand systems in aphasia",NA,"March 1, 2022","manual1","Boston, MA","Boston University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Boston",NA,"Massachusetts","Swathi Kiran",NA,NA,"no",-71.058291,42.360253,2022-03-01 +"95",NA,"Characterizing inner speech in aphasia",NA,"March 9, 2022","manual2","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 +"96",NA,"Inner speech as a naming therapy predictor in aphasia",NA,"March 9, 2022","manual3","Bloomington, IN","Indiana University Bloomington",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Bloomington",NA,"Indiana","Brielle C. Stark",NA,NA,"Online",-86.534288,39.16704,2022-03-09 +"97",NA,"Measuring and understanding the experience of post-traumatic growth in aphasia",NA,"March 9, 2022","manual4","Reno, NV","University of Nevada Reno",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Reno",NA,"Nevada","Tami Brancamp",NA,NA,"Online",-119.812658,39.526121,2022-03-09 +"98",NA,"Reading in Aphasia",NA,"January 1, 2020","manual5","Atlanta, GA","Georgia State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Atlanta",NA,"GA","Rachael Harrington",NA,NA,"Online",-84.390264,33.748992,2020-01-01 +"99",NA,"Assessment of anomia: Improving efficiency and utility using item response theory",NA,"August 31, 2020","manual6","Portland, OR","Portland State University",NA,NA,NA,NA,NA,NA,NA,NA,NA,"Portland",NA,"OR","Gerasimos Fergadiotis",NA,NA,"no",-122.674195,45.520247,2020-08-31 diff --git a/docs/data/contact.rds b/docs/data/contact.rds index 6291685..d4df8d6 100644 Binary files a/docs/data/contact.rds and b/docs/data/contact.rds differ diff --git a/docs/data/data_dt.rds b/docs/data/data_dt.rds index fe0068c..d5b4384 100644 Binary files a/docs/data/data_dt.rds and b/docs/data/data_dt.rds differ diff --git a/docs/data/location.rds b/docs/data/location.rds index 42fc469..f8bc48d 100644 Binary files a/docs/data/location.rds and b/docs/data/location.rds differ diff --git a/docs/data/study_info.rds b/docs/data/study_info.rds index 374e231..ee661bc 100644 Binary files a/docs/data/study_info.rds and b/docs/data/study_info.rds differ diff --git a/docs/list_view.html b/docs/list_view.html index c052129..f1ce67c 100644 --- a/docs/list_view.html +++ b/docs/list_view.html @@ -5470,140 +5470,6 @@danet.l@chu-toulouse.fr, delrutte.s@chu-toulouse.fr
-| -Lola Danet, PhD - | -|
| -Phone: - | --5 61 77 95 17 - | -
| -Email: - | --danet.l@chu-toulouse.fr - | -
| -Stéphanie Delrutte, PhD - | -|
| -Phone: - | --5 61 77 56 13 - | -
| -Email: - | --delrutte.s@chu-toulouse.fr - | -
njpaik@snu.ac.kr, bluebelll@naver.com
aidan.rogers@mountsinai.org, Courtney.McSweeney@mountsinai.org
jdrichardson@unm.edu, hhubbard@unm.edu
julio.hpavon@northwestern.edu, lkinsey@sralab.org
aphasialab@osu.edu, harnish.18@osu.edu
blackett@musc.edu
ays41@pitt.edu
lkinsey@sralab.org
wangkai1964@126.com, baiyunong1990@163.com
ays41@pitt.edu
earil100@syr.edu
Elena.Zevgolatakou@mrc-cbu.cam.ac.uk, Ajay.Halai@mrc-cbu.cam.ac.uk
lcherney@sralab.org, sameer.ashaie@northwestern.edu
shauna.zodrow@jefferson.edu
claudio.brozzoli@inserm.fr, mallory.augier@gmail.com
argye@jhmi.edu, md.stockbridge@jhmi.edu
sschoenrock@mcw.edu, sapillay@mcw.edu
agnes.floeel@uni-greifswald.de, nina.unger@uni-greifswald.de
lzipse@mghihp.edu
ruiqipanedu@163.com
DRMoser@uams.edu, PSCarr@uams.edu
sdrane@mcw.edu
marion.fossard@unine.ch, celia.ericson@unine.ch
claire.honeycutt@asu.edu
min.wong@polyu.edu.hk, faisal.n.baig@polyu.edu.hk
charlotta.saldert@neuro.gu.se, francesca.longoni@neuro.gu.se
tmontagnon@chu-grenoble.fr
sschoenrock@mcw.edu
amy.rodriguez@va.gov, Laura.Britan_Lang@va.gov
joanne.loewy@mountsinai.org
sschoenrock@mcw.edu, prishah@mcw.edu
al1579@georgetown.edu, ehl4@georgetown.edu
argye@jhmi.edu, md.stockbridge@jhmi.edu
Adrian.Guggisberg@insel.ch
gfz2102@cumc.columbia.edu, eg2972@cumc.columbia.edu
simona.spaccavento@icsmaugeri.it
aphasiaresearchlaboratory@gmail.com
bcstark@iu.edu
bcstark@iu.edu
tbrancamp@med.unr.edu
rharrington2@gsu.edu
aphasialab@pdx.edu