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Subclonality #11

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DrFraserGovil opened this issue Apr 22, 2024 · 0 comments
Open

Subclonality #11

DrFraserGovil opened this issue Apr 22, 2024 · 0 comments

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@DrFraserGovil
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The current statistical model assumes 100% clonality in the sample -- this is visibly making things worse than we would like, and so it is necessary to at least consider how subclonality will affect our data.

This is a very complex mathematical issue though, and if taken in a "clever but stupid" direction runs the risk of becoming ludicrously complex & non-convergent.

A simpler means of inference seems like it would be for the best -- some kind of marginalisation in the PDF?
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@DrFraserGovil