diff --git a/.github/ISSUE_TEMPLATE/bug_report.yml b/.github/ISSUE_TEMPLATE/bug_report.yml
index ba05f23fcc..ec98af029e 100644
--- a/.github/ISSUE_TEMPLATE/bug_report.yml
+++ b/.github/ISSUE_TEMPLATE/bug_report.yml
@@ -27,7 +27,7 @@ body:
     attributes:
       label: Python Version
       description: Version of Python interpreter
-      placeholder: 3.8.5, 3.9, 3.10, etc.
+      placeholder: 3.9, 3.10, 3.11, etc.
     validations:
       required: true
   - type: input
diff --git a/.github/workflows/python-package.yml b/.github/workflows/python-package.yml
index 0c3c49d78d..d74df9ce67 100644
--- a/.github/workflows/python-package.yml
+++ b/.github/workflows/python-package.yml
@@ -15,13 +15,13 @@ jobs:
     runs-on: ubuntu-latest
     strategy:
       matrix:
-        python-version: ['3.8', '3.9', '3.10', '3.11']
-        numpy_version: ['>=1.22.0', '==1.20.*']
+        python-version: ['3.9', '3.10', '3.11']
+        numpy_version: ['>=1.22.0', '==1.21.*']
         exclude:
           - python-version: '3.10'
-            numpy_version: '==1.20.*'
+            numpy_version: '==1.21.*'
           - python-version: '3.11'
-            numpy_version: '==1.20.*'
+            numpy_version: '==1.21.*'
     services:
       redis:
         image: redis
diff --git a/.github/workflows/releases.yml b/.github/workflows/releases.yml
index 8d8512294d..31a7e2770c 100644
--- a/.github/workflows/releases.yml
+++ b/.github/workflows/releases.yml
@@ -19,7 +19,7 @@ jobs:
       - uses: actions/setup-python@v5.0.0
         name: Install Python
         with:
-          python-version: '3.8'
+          python-version: '3.9'
 
       - name: Install PyBuild
         run: |
diff --git a/.github/workflows/windows-testing.yml b/.github/workflows/windows-testing.yml
index eeee5b704d..5c3252c0ba 100644
--- a/.github/workflows/windows-testing.yml
+++ b/.github/workflows/windows-testing.yml
@@ -16,7 +16,7 @@ jobs:
     strategy:
       fail-fast: True
       matrix:
-        python-version: ['3.8', '3.9', '3.10', '3.11']
+        python-version: ['3.9', '3.10', '3.11']
     steps:
       - uses: actions/checkout@v4
         with:
diff --git a/docs/release.rst b/docs/release.rst
index c18e0b8c20..a3e0831ba4 100644
--- a/docs/release.rst
+++ b/docs/release.rst
@@ -49,6 +49,9 @@ Docs
 Maintenance
 ~~~~~~~~~~~
 
+* Drop Python 3.8 and NumPy 1.20
+  By :user:`Josh Moore <joshmoore>`; :issue:`1557`.
+
 * Cache result of ``FSStore._fsspec_installed()``.
   By :user:`Janick Martinez Esturo <ph03>` :issue:`1581`.
 
diff --git a/environment.yml b/environment.yml
index dc99507427..ff2f9eedef 100644
--- a/environment.yml
+++ b/environment.yml
@@ -4,7 +4,7 @@ channels:
 dependencies:
   - wheel
   - numcodecs >= 0.6.4
-  - numpy >= 1.20
+  - numpy >= 1.21
   - pip
   - pip:
     - asciitree
diff --git a/pyproject.toml b/pyproject.toml
index 33e8573830..a85e49e82c 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -10,10 +10,10 @@ readme = { file = "README.md", content-type = "text/markdown" }
 maintainers = [
     { name = "Alistair Miles", email = "alimanfoo@googlemail.com" }
 ]
-requires-python = ">=3.8"
+requires-python = ">=3.9"
 dependencies = [
     'asciitree',
-    'numpy>=1.20,!=1.21.0',
+    'numpy>=1.21.1',
     'fasteners',
     'numcodecs>=0.10.0',
 ]
@@ -30,7 +30,6 @@ classifiers = [
     'Topic :: Software Development :: Libraries :: Python Modules',
     'Operating System :: Unix',
     'Programming Language :: Python :: 3',
-    'Programming Language :: Python :: 3.8',
     'Programming Language :: Python :: 3.9',
     'Programming Language :: Python :: 3.10',
     'Programming Language :: Python :: 3.11',