Contemporary epidemiology of hospitalised heart failure with reduced versus preserved ejection fraction in England: a retrospective, cohort study of whole-population electronic health records
Robert A Fletcher, Patrick Rockenschaub, Brendon L Neuen, Isabel Johanna Walter, Nathalie Conrad, Mehrdad A Mizani, Thomas Bolton, Claire A Lawson, Christopher Tomlinson, Stelios Boulitsakis Logothetis, Carmen Petitjean, Luigi Filippo Brizzi, Stephen Kaptoge, Elena Raffetti, Patrick A Calvert, Emanuele Di Angelantonio, Amitava Banerjee, Mamas A Mamas, Iain Squire, Spiros Denaxas, Theresa A McDonagh, Cathie Sudlow, Steffen E Petersen, Glenn M Chertow, Kamlesh Khunti, Johan Sundström, Clare Arnott, John G F Cleland, John Danesh, John J V McMurray, Muthiah Vaduganathan, Angela M Wood, on behalf of the CVD-COVID-UK/COVID-IMPACT Consortium
This study aims to address key evidence gaps in the understanding of hospitalised heart failure in England, particularly over the COVID-19 pandemic period. Despite the increasing burden of heart failure, its contemporary epidemiology in this setting remains incompletely characterised, especially with respect to trends in re-hospitalisation and mortality, differences between heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), the impact of co-existing chronic medical conditions, and the implementation of newer guideline-recommended therapies.
Fletcher RA, Rockenschaub P, Neuen BL, et al. Contemporary epidemiology of hospitalised heart failure with reduced versus preserved ejection fraction in England: a retrospective, cohort study of whole-population electronic health records. Lancet Public Health. 2024;9(11):e871-e885. doi:https://10.1016/S2468-2667(24)00215-9
- View the analysis code used in NHS England's SDE for England
- View the phenotyping algorithms and codelists used in NHS England's SDE for England
This is a sub-project of project CCU045 approved by the CVD-COVID-UK / COVID-IMPACT Approvals & Oversight Board (sub-project: CCU045_02).
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