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The fourth series of Open Source Tuberculosis (OSTB). The compounds are based on a set of functionalised open-chain polyamines.
The background to, and status of, this project are described in the wiki (right). Active project questions are discussed in the Issues (link above).
Open source drug discovery operates with a few basic rules. If you'd like to get in touch to discuss something, please raise an issue (above) or reach out on Twitter (@opensourcetb) or, as a last resort, email opensourcetb@gmail.com.
Unless otherwise stated the licence for everything in OSTB is CC-BY-4.0, meaning you can do whatever you want with the contents, provided you cite OSTB.
The Aims and Objectives page contains an overview of the kind of molecules we're trying to make. Anyone is welcome to start making some of the suggested modifications - currently, only one line of modification (the nature of the hydrophobic group) is being investigated, so there's plenty of options!
Check out what compounds we're working on already and which ones you can jump in to help us out with here.
You can advise on work from Klementine's lab notebook - look for Issues with the tag "help wanted".
Otherwise, the OSTB Series 4 Issues tab is the place to go to find problems we need help with, progress updates and more. You can open your own issue to request help or make a suggestion - all contributions are welcome!