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Pombert-JF committed Jun 4, 2024
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* [Introduction](#Introduction)
* [Dependencies](#Dependencies)
* [Installation](#Installation)
* [Example](#Example)
* [Scripts](#Scripts)
* [Running MMH](#Running-MMH)
* [About runtime](#About-runtime)
* [Funding and acknowledgments](#Funding-and-acknowledgments)
* [References](#References)

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-db swiss
```

Note that due to its sheer size, running searches against the trEMBL databases will be slow. We recommend queries against the curated (but much smaller) Swiss-Prot database.

Options for run_mmh.pl are:
```
-f (--fasta) Directory containing fasta files to create HMM models from
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SOG00005 sp|P26659|RAD15_SCHPO 7.2e-233 General transcription and DNA repair factor IIH helicase subunit XPD Schizosaccharomyces Schizosaccharomyces pombe Schizosaccharomyces pombe (strain 972 / ATCC 24843)
```

## About runtime
Note that due to its sheer size, running searches against the trEMBL databases will be slow. We recommend queries against the curated (but much smaller) Swiss-Prot database. For example, using the HMM models generated from the FASTA files in the `Example/FASTA/` directory as queries, searches ran for 24 and 6573 seconds agaisnt the `swiss` and `trembl` databases, respectively (on an Intel i5-12500H mobile CPU).


## Funding and acknowledgments
This work was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (award number R15AI128627) to Jean-Francois Pombert. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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