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Change the way to exclude regions in hmmratac and fix the incorrect keep-duplicate option #689

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merged 1 commit into from
Feb 13, 2025

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@taoliu taoliu commented Feb 12, 2025

  1. We changed the behavior on the usage of 'blacklist' regions in hmmratac. We will remove the aligned fragments located in the 'blacklist' regions before the EM step to estimate fragment lengths distributions and HMM step to learn and predict nucleosome states. The reason is discussed in Bug: No peaks detected in not-blacklisted regions when a blacklist is given to macs3 hmmratac #680. To implement this feature, we added the exclude functions to PETrackI and PETrackII.
  2. hmmratac option --keep-duplicate had opposite effect previously as indicated by the name and description. It has been renamed as --remove-dup to reflect the actual behavior. hmmratac will not remove duplicated fragments unless this option is set.

… utilized after reading alignments #680; 3. rename  to  for ; 4. update docs
@taoliu taoliu self-assigned this Feb 12, 2025
@taoliu taoliu merged commit 4f451fb into master Feb 13, 2025
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