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Readme improvements
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voloudakis committed Jan 14, 2025
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Expand Up @@ -212,8 +212,9 @@ A few useful column definitions across files are the following:

Average rank (`AvgRank`) distribution plots are also generated for diagnostic purposes. Please note that when using cluster comparison signatures, the z-scores of the disease signatures and the `AvgRank` distributions may not be normally distributed, but the pipeline is non-parametric and can accomodate for that.

![CDR AvgRank Distribution](/data-raw/RA_cdr_AvgRank_distribution_landscape.png)
![GTP AvgRank Distribution](/data-raw/RA_gtp_AvgRank_distribution_landscape.png)
![CDR AvgRank Distribution](/data-raw/readme.images/RA_cdr_AvgRank_distribution_landscape.png)

![GTP AvgRank Distribution](/data-raw/readme.images/RA_gtp_AvgRank_distribution_landscape.png)

# STEP 4: Additional figures
Additional figures can be prepared
Expand All @@ -231,7 +232,8 @@ showcase_method_cdr_gtp(
)
```
![actinomycin D in RA](/data-raw/RA.STARNET_BLD.actinomycin-d.CRCGN004_PC3_6H.BRD-A42383464-001-04-8.10.png)

![actinomycin D in RA](/data-raw/readme.images/RA.STARNET_BLD.actinomycin-d.CRCGN004_PC3_6H.BRD-A42383464-001-04-8.10.png)

## Generating a gene-target prioritization plot
```
Expand All @@ -244,6 +246,7 @@ gtp_pvalue_qqplot( ### Parameters
figure.name = "gtp_actions", # main body of the name of the figure
)
```
In this there is no actionable gene that demonstrates a FDR-significant compbined score while also having FDR-significant dysregulation in the disease signatures and antagonism via shRNA/overexpression/CRISPR
![actinomycin D in RA](/data-raw/prioritization.stouffer.scaled.before.png)
In this there is no actionable gene that demonstrates a FDR-significant compbined score while also having FDR-significant dysregulation in the disease signatures and antagonism via shRNA/overexpression/CRISPR.

![actinomycin D in RA](/data-raw/readme.images/prioritization.stouffer.scaled.before.png)

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