Bis napthyl linear amines

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Klementine Burrell-Sander edited this page Dec 12, 2023 · 21 revisions

Synthetic route

Full bis-naphthylamine open cyclam synthesis

Steps

KBS23: Azidation of 1-naphthylamine - 73%

KBS28: Click coupling of 1 azidonaphthyl and propargyl alcohol - 89%

KBS29: Appel reaction on KBS28 - 62%

KBS30: N alkylation on diaminohexane with KBS29

KBS43: Nosyl protection of 1,6-diaminohexane - 32%

KBS45: Nosyl protection of 1,8-diaminooctane - 88%