Skip to content

Aims & Objectives

Jump to bottom
fidiris edited this page Mar 26, 2019 · 4 revisions

Our initial interest was directed towards exploring the roles of the various functional groups present in the active compound OSTBS83. The first set of compounds were designed and synthesised by Jessica Baiget Gonzalez at the University of Sydney, under the supervision of Professor Matthew Todd, in collaboration with GSK Tres Cantos.

The aim of this study was to answer three key questions:

  1. Is the hydroxyl group important for activity?
  2. Is the trichlorinated system essential and if not, which chlorine atoms can be replaced without loss of activity?
  3. Is the morpholine ring involved in activity and can it be exchanged for another amine?

Background

Latent TB

Models of Non-replicating M.tb

OSTB Series 3

Aims & Objectives

Sources of Data

Synthetic Chemistry

General Synthetic Strategy

Structure-Activity Relationships

First Set of Compounds

Toxicity

Second Set of Compounds

Relevant and Desirable Compounds

The Surrounding Chemical Space

Closely Related Classes of Compounds

Clone this wiki locally