Second Set of Compounds
A set of 9 compounds were sent to collaborators at the UCL Centre for Clinical Microbiology. The MIC of these targets were evaluated against drug sensitive (DS) and drug resistant (DR) Mycobacterium tuberculosis (Mtb) clinical isolates and the reference laboratory strain H37Rv.
DS, DR and H37Rv biofilms were also prepared as models of a NR state and used for MIC testing of the 9 compounds.
Summary of Biological data and original report from Priya Solanki can be found here
MIC results for DS, DR and H37Rv
MIC data extracted from the BD EpiCenter™ software showed resistance, with >40 µM, in clinical isolates and H37Rv.
Table 1. MIC results for targets tested against DS, DR and H37Rv (Aromatic modification)
Table 2. MIC results for targets tested against DS, DR and H37Rv (Linker modification)
MIC results for DS, DR and H37Rv biofilms
Resistance was also observed in the biofilms, with MIC values at > 40 µM.
Table 3. MIC results for targets tested against DS, DR and H37Rv biofilms (Aromatic modification)
Table 4. MIC results for targets tested against DS, DR and H37Rv biofilms (Linker modification)
*The MIC results for the H37Rv biofilm should be repeated due to the BD EpiCenter™ software going offline. The GU of the GC was at approximately 10 000 when the test was stopped, as opposed to 400.