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The FAIR Data Cube is an important infrastructure component in the Netherlands [X-Omics](https://x-omics.nl/) initiative to make -omics data FAIR at the source, facilitate the reuse of -omics data, and facilitate the integration of different layers of -omics data.

To facilitate the creation of FAIR multi-omics data and metadata, We adopt and develop metadata schemas for different omics data types, and make use of the Investigation-Study-Assay (ISA) metadata framework to capture experimental metadata. Example workflows to create ISA metadata are publicly shared. A set of accompanying tools facilitates the dataset owner to import the general study metadata to a FAIR Data Point (FDP) instance, which serves as a public metadata registry inside the FDCube.

Researchers can search for interesting datasets and query multi-omics studies via the FDP instance, which links to the public or access-protected data repositories. A set of accompanying tools allows performing semantic queries on additional metadata on samples, phenotypes, or molecular features represented in an RDF-based knowledge graph. A semantic enhanced search and ranking function is also being developed to enable a more powerful search experience on the FDP.

In order to allow an analysis of access-protected data, we further integrate a vantage6 component to allow bioinformaticians to send containerized computing requests to access-controlled omics data storage and receive aggregated results generated under the dataset owner’s supervision. This arrangement follows the idea of bringing algorithms to data to ensure the concerns over data set security.

A prototype FDCube implementation is being developed in collaboration with the Trusted World of Corona (TWOC), in which we use public COVID-19 multi-omics data sources to demonstrate the strength and added value of the FDCube and its FAIR-based methodologies.

1. Preliminary

1.1 FAIR Principles

1.2 Metadata in multi-omics studies

1.3 Investigation-Study-Assay

2. FAIR Data Cube

2.1 Architecture of FAIR Data Cube Architecture of FAIR Data Cube

2.2. Setting up

2.2.1 Apply workspace from SURF Research Cloud

2.2.2 FAIR Data Point

2.2.2.1 Resource definition for ISA metadata schema

3. Demonstration

3.1 ACTION